DE3038784A1 - DRY, EASILY SPREADABLE MIX - Google Patents

Description

Date i4.io.8O, Dr.R./bs Dry, easily spreadable mixture

The present invention relates to a dry, easily spreadable mixture, a process for its preparation and the use of anhydrous lactose for the production of dry, easily dispersible acids or acid mixtures.

Such mixtures are from the British patent No. 332,597, which describes a method based on the absorption of lactic acid by solid carbohydrates based, whereby they are obtained in an easily metered form in which they are used in powders can, as in those for the production of artificial breast milk with a high degree of digestibility. As a carbohydrate Powdered dextrose can be used, but you can absorb the lactic acid also in milk powder, in which naturally lactic acid with a single molecule of crystal water, also called lactose 1 aq, occurs as a carbohydrate.

Another method is that in the Dutch patent application No. 7703510 described process, after which easily scatterable, dry, acidic, powdery products are obtained which contain a maximum of 30% acid, whereby the concerned acid with a hydrolyzed starch product

-2-

130017/0846

878

with a DÄ (aDextrose Equivalence) value of less than mixes j brings the carbohydrate into an aqueous solution and distributes the acid therein and then in a known manner dries, e.g. by placing the liquid in a spray tower atomized. This method is suitable for both inorganic acids, such as phosphoric acid, and organic acids, like lactic acid and citric acid.

The disadvantages of the two methods described are, however, that they require a great deal of work and very expensive special equipment, and that almost always careful drying is necessary to get a fairly usable product. In the method according to the British patent specification although it does not require that the carbohydrate be brought into a solution first, so that a large amount Liquid needs to be evaporated and dried, but mixing the acid with the carbohydrate in solid form must take place very gradually in order to achieve a homogeneous distribution of the acid over the mass, while also Post-drying, preferably under vacuum, will always be desired.

The technical term "anhydrous lactose" used in the following is synonymous with "anhydrous lactose"

130017/0848

It has now been found that the disadvantages of the processes mentioned thereby can be avoided and that dry, easily scatterable powders can be produced in a simple manner that the acid in liquid form is mixed with anhydrous lactose in crystal or powder form. This method is particularly suitable for production of easily scatterable powders of acids, which at normal temperature do not occur in crystal form and their solutions cannot be dried in the usual ways by heating without conversion the acid takes place. Due to these favorable properties with regard to the loose and non-hygroscopic nature, the product is according to the invention Powder is particularly suitable as an additive to dry products, such as food and luxury foods, remedies, cosmetics, etc., whereby Acid addition is desired and the usual solid acids such as citric acid, fumaric acid or gluconodeltalactone are not suitable, and direct admixture of liquid acids leads to undesirable effects such as lump formation. The method is particularly suitable to bring lactic acid into an easily dispersible form.

It was found in a very surprising manner that according to the invention The powder obtained in the process only absorbed a small amount of moisture on storage, while lactic acid is known to be in anhydrous Shape is extremely hygroscopic. When carrying out the inven- According to the procedure it turned out that every simple Mixer is suitable, The invention is further based on the following Examples explained

example 1

In a Hobart mixer, such amounts of lactose and lactic acid were made mixed so that always 1 kg of product was obtained. Each acid / lactose mixture ratio used in this experiment became experiments performed with both anhydrous lactose and normal commercial pharmaceutical grade lactose.

The table shows the composition of the various mixtures Hand indicated the percentage of lactic acid in the product obtained, along with an assessment of the scatterability of the product .. The

130017/0 8 46

-Y * S

Lactic acid used contained 20% water and was sprayed onto the lactose.

Table I. % Lactic acid Type of lactose Nature of the Grief Product 10 anhydric easy to spread 1 A 15th ti It 2 A 20th If dd 3 A 10 pharmaceutical soggy 1 B. 15th Il It 2 B 20th It Il 3 B

As can be seen from Table I, all of them yielded mixtures of lactic acid Products containing anhydrous lactose can be easily sprinkled, in contrast to the mixtures of lactic acid with normal pharmaceutical lactose, whereby always more or less soggy products were obtained. A comparison of the loose texture by visual assessment was made in all cases in favor of products based on anhydrous lactose. The two products with $ 10 lactic acid were also made compared using the following test methods:

1. Flowability, which is defined as the maximum angle

with the horizontal line that the powder will make on a round bowl can.

2. Flow rate in a granule flow meter.

3. Percentage of the powder flowing out of a rotating cylinder with an opening of a certain diameter.

These comparative tests show the picture shown in Table 2.

130017/0846

Table 2

product

Fluidity

Flow rate of 50 g

Expiry percentage

Lactic acid with anhydrous lactose

Lactic acid with norm.pharm. lactose

, 2

immeasurable

3.5 g

Of the $ 15 lactic acid product with anhydrous lactose, the Moisture absorption during storage at several different relative humidities (RV) investigated. The "results in question were specified in the form of a graphic representation. In the graph, the time is on the X-axis in hours and the percentage of moisture absorption is plotted on the Y axis. Although lactic acid is highly hygroscopic in an anhydrous state, it was found that the product of $ 15 lactic acid with anhydrous Lactose absorbed relatively little moisture, while the loose character of the product was not lost.

Example II

Amounts of anhydrous lactose and 80% lactic acid were mixed in a simple household mixer to obtain an amount of 300 g of product with a lactic acid content of $ 10. The product had a dry grip and was easy to spread.

Comparative example I.

Working entirely according to the procedure of Example I, were mixed amounts of dextrose of the commercial product Cerelose 02001 and lactic acid in the Hobart mixer.

The products obtained were almost not fluffy and were very soggy.

13 0017/0846

Comparative example II

In the manner according to Example I, lactic acid was again mixed with anhydrous Cefelose 02 ^ 02 mixed dextrose. Even now were not get scatterable, sticky products.

Example III

In a 2 liter beaker, in which a Heidolph stirrer was attached and which was covered with a transparent lid, a quantity of anhydrous lactose was mixed with chemically pure acetic acid made by Merck, 9-6%. There was obtained a lockers product containing acetic acid, the 15% wt..

130017/0846

Blank page

Claims (6)

Claims 1. Dry, easily scatterable mixture, characterized in that it consists of an acid and anhydrous lactose (C ₁ OH ₂₀ O ₁₁ ) in crystal form or powder form. 2. Mixture according to claim 1, characterized in that the acid is an acid which cannot be crystallized at room temperature and cannot be dried by heating is. 3. Mixture according to claim 1 or 2, characterized in that that the acid is lactic acid. 4. Mixture according to one of claims 1 to 3, characterized marked that it additionally contains other dry components. 5. Process for the preparation of the mixture according to one of the Claims 1 to 4, characterized in that the anhydrous lactose is mixed with the acid. 6. Use of anhydrous lactose ( ^C ₁ 2 ^H 22 ° 11 ^ ^{according to} one of claims 1 to 5 for the production of
dry, easily dispersible acids. 130017/0846