DE29903564U1 - Set for biological tests - Google Patents

Description

Set for biological tests :..<jM&bikp*01/9Ä· ·..· ..17.Q6.1999/19.02.1999

Biological Test Kit Sheet 3

Description:

The invention relates to a kit for biological tests, preferably for the ID microtyping system (gel centrifugation method).

Various methods and tools for biological tests, for example for antibody and antigen identification, have already been proposed. A comparative overview of these methods is given by W. Hitzler et al. III (see below). The authors come to the conclusion that the ID microtyping system has advantages over the other previously known solutions in terms of sensitivity (sensitivity and specificity), handling and interpretation. This result has since been confirmed by experience.

In the ID microtyping system (see among others: EP-PS 194.212; EP-PS 305.337; EP-PS 485.228), special aids have been used for at least ten years to carry out biological tests. These, generally referred to as a set (see: DUDEN foreign word dictionary. 5th revised and expanded edition. Mannheim et al.: 1990, Volume 5, p. 714, item 1.), are described in more detail by DiaMed AG 111 (see below).

The set listed in 121 is manufactured in one piece and is discarded in its entirety after intended use.

The aforementioned set has several reaction chambers rigidly connected in a magazine, which are suitable for cartridge ammunition (cf.: BROCKHAUS ENCYCLOPEDIA, nineteenth, completely revised and expanded edition. Mannheim 1998: F.A. Brockhaus. Eighth volume, p. 407, letter 2). The area of the reaction chamber that is suitable for the "bullet" contains the gel, the area immediately adjacent to it, suitable for the propellant casing, has a larger radius (hereinafter referred to as the pipetting extension). The end of the "casing" area of the reaction chamber is open at the top and can easily be sealed using conventional means.

There are basically no restrictions regarding the dimensions of the set and the reaction chamber or their number.

To use the set, a specially designed rotor is required in the centrifuge.

Ill Hitzler, W.: Johanson, C: Schömig-Brekner, J. and Mathias, D.:

"Comparative study of antibody identification in gel centrifugation assay (ID Microtyping System), solid phase antiglobulin assay (Solidsceen, Capture R, Ready ID) and tube assay."
Medical Lab. 37(1991), p. 137 ff

/2/DiaMed AG:

"DiaMed-ED Micro-Typing System."

DiaMed AG, Cressier sur Morat, 1994; printed in Switzerland, especially pages 4 to 15.

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Set for biological tests ^: uM Sclokö £&idigr;/99; : ."-;-: 19.02.1999

Description Sheet 4

The invention specified in claim 1 is based on the problem of creating a set for biological tests, preferably for the ID microtyping system, with which the environmental impact can be reduced in terms of mass and volume without limiting the advantages of the gel centrifugation process known per se.

This environmental problem, which has been known in general for decades and in particular since at least 1991, is solved by the features listed in claim 1.

The invention achieves a significant reduction in the overall environmental impact of biological waste in terms of mass and volume, without losing the advantages of the ID microtyping system such as sensitivity, handling and interpretation. The invention is not limited to a rotor of the required centrifuge specially manufactured for the gel centrifugation process.

Further advantageous embodiments of the invention are specified in claims 2 to 5.

The further training according to claim 2 enables the clear allocation of the various reaction chambers or reaction tubes in part (1), the magazine, to one another, even for the untrained employee.

The design of the invention according to claim 3 allows not only the use of linear rows of reaction chambers or reaction tubes, the magazine, but also the use of non-linearly arranged reaction chambers or reaction tubes, the magazine, for example according to the circular packing. The known rotors can therefore be used in centrifuges, and a special rotor is not required.

The further improvement of the invention according to claims 4 and 5 creates the possibility of further reducing the material used for the magazine and thus making it more mobile, i.e. the set of several reaction tubes is arranged linearly and is only flexibly connected, in particular welded, with known material in the extended upper area, the pipetting extension, and thus fixed. This rigid or flexible magazine represents the part (1) according to the invention.

There are basically no restrictions regarding the production of the two detachably connectable parts of the set according to the invention for biological tests, preferably for the ID microtyping system.

Claims (1)

Biological test kit Protection claims: Set for biological tests, preferably for the gel centrifugation method,
characterized, that the set consists of (at least) two parts (1) and (2), whereby the parts (1) and (2) are detachably connected, the contact surfaces of the two parts (I) and (2) are parallel and/or oblique to the circular cross-sectional area of the reaction chambers or reaction tubes and/or are rounded and/or practically fit, the parts (1) and (2) have at least one detachable plug connection and/or an adhesive and/or a Velcro fastener, the plug closure consists of elements known per se, which can be plugged together both vertically in the direction of the longitudinal axis of the reaction chambers or reaction tubes and laterally by overlapping the parts (1) and (2) and/or practically fitting together,
that the part (1) containing one or more of the reaction chambers permanently assembled from the gel cartridge and pipetting extension and/or one or more of the reaction tubes, where a reaction tube consists of a permanently connected cartridge and Kpettier extension, which, when connected together, form the magazine, and that the part (1), the magazine, is discarded after use, and that the part (2) represents the detachable base of the magazine of the reaction chambers and/or the detachable holder of the magazine of the reaction tubes and is reused. Set for biological tests according to protection claim 1, characterized in that the detachable connection of the parts (1) and (2) consists of at least one fitting plug closure, which does not necessarily have to be attached centrally, whereby the part (1) represents the magazine of one or more reaction tubes and the part (2) forms a holder for the reaction tubes of the magazine, which can be detachably inserted into the rotor of the centrifuge. Set for biological tests according to claim 1 or 2, characterized in that the part (2) represents a holder adapted to the rotor opening of the centrifuge for detachably receiving the magazine of one or more reaction tubes made of gel cartridge with pipetting extension, whereby the holder can be detachably filled with both linear and round or circularly arranged reaction tubes and preferably in the case of the round or circular arrangement of the reaction tubes has a cylindrical mandrel in the middle around which the reaction tubes are inserted individually or arranged in the magazine. Protection claims
- Page 2 - Protection claims sheet 2 Set for biological tests according to claim 3, characterized in that the holder is adapted to the reaction tube only up to the pipetting extension at its upper end, preferably in such a way that the lower attachment of the aforementioned tube extension rests detachably on the upper edge of the holder. Set for biological tests according to claim 3 or 4, characterized in that the part (1) represents a unitary arrangement of several reaction tubes next to one another, the reaction tubes being rigidly and/or flexibly connected to form a magazine only at the level of the pipetting extension. Description - Sheet 3 -