DE2964956D1 - Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them - Google Patents
Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing themInfo
- Publication number
- DE2964956D1 DE2964956D1 DE7979850071T DE2964956T DE2964956D1 DE 2964956 D1 DE2964956 D1 DE 2964956D1 DE 7979850071 T DE7979850071 T DE 7979850071T DE 2964956 T DE2964956 T DE 2964956T DE 2964956 D1 DE2964956 D1 DE 2964956D1
- Authority
- DE
- Germany
- Prior art keywords
- bradykinin
- preparation
- pharmaceutical preparations
- preparations containing
- tripeptide derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 101800004538 Bradykinin Proteins 0.000 title 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 title 1
- 102100035792 Kininogen-1 Human genes 0.000 title 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7807937 | 1978-07-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2964956D1 true DE2964956D1 (en) | 1983-04-07 |
Family
ID=20335467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE7979850071T Expired DE2964956D1 (en) | 1978-07-18 | 1979-07-16 | Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them |
Country Status (8)
Country | Link |
---|---|
US (1) | US4242329A (de) |
EP (1) | EP0009010B1 (de) |
JP (1) | JPS55500520A (de) |
AT (1) | AT387393B (de) |
DE (1) | DE2964956D1 (de) |
DK (1) | DK149630C (de) |
SU (1) | SU1034603A3 (de) |
WO (1) | WO1980000252A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3164437D1 (en) * | 1980-08-25 | 1984-08-02 | Kabivitrum Ab | Peptide substrates for determination of protease activity |
US4448715A (en) * | 1981-11-02 | 1984-05-15 | University Of Miami | Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein |
NZ214543A (en) * | 1984-12-14 | 1990-03-27 | Australian Commercial Research | Amino acid and peptide derivatives that inhibit human leucocytic elastase enzyme (hle) |
GB8622090D0 (en) * | 1986-09-12 | 1986-10-22 | Wellcome Found | Pharmacologically active compounds |
US5648333A (en) * | 1988-11-24 | 1997-07-15 | Hoechst Aktiengesellschaft | Peptides having bradykinin antagonist action |
GB9019558D0 (en) * | 1990-09-07 | 1990-10-24 | Szelke Michael | Enzyme inhibitors |
CA2106768C (en) | 1991-04-19 | 2000-09-19 | Donald J. Kyle | Bradykinin type peptides |
US6770741B1 (en) | 1991-04-19 | 2004-08-03 | Scios Inc. | Bradykinin antagonist peptides |
AU1873992A (en) * | 1991-04-19 | 1992-11-17 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
WO1993011789A1 (en) | 1991-12-12 | 1993-06-24 | Scios Nova Inc. | Modified position (7) bradykinin antagonist peptides |
TW199863B (de) * | 1991-12-21 | 1993-02-11 | Hoechst Ag | |
US5686565A (en) * | 1992-10-08 | 1997-11-11 | Scios Inc. | Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins |
US5610142A (en) * | 1992-10-08 | 1997-03-11 | Scios Inc. | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids |
US5541286A (en) * | 1992-10-08 | 1996-07-30 | Scios Nova Inc. | Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids |
US5521158A (en) * | 1992-10-08 | 1996-05-28 | Scios Nova Inc. | Pseudopeptide bradykinin receptor antagonists |
IL108031A0 (en) * | 1992-12-22 | 1994-04-12 | Procter & Gamble | Difluoro pentapeptide derivatives and pharmaceutical compositions containing them |
WO1994019372A1 (en) * | 1993-02-17 | 1994-09-01 | Scios Nova Inc. | Cyclic bradykinin antagonist peptides |
US5510380A (en) * | 1993-02-19 | 1996-04-23 | Sterling Winthrop, Inc. | Nonpeptide bradykinin antagonists |
US5817756A (en) * | 1993-09-09 | 1998-10-06 | Scios Inc. | Pseudo- and non-peptide bradykinin receptor antagonists |
US5486623A (en) | 1993-12-08 | 1996-01-23 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
WO1995024422A1 (en) * | 1994-03-09 | 1995-09-14 | Cortech, Inc. | Bradykinin antagonist peptides incorporating n-substituted glycines |
FR2794974B1 (fr) * | 1999-06-16 | 2001-08-17 | Exsymol Sa | Composition cosmetique pour l'amincissement a base de l-arginine, d'un analogue de l-arginine ou d'un de leurs derives, applicable par voie topique |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6808554A (de) * | 1967-06-30 | 1968-12-31 | ||
JPS5035061B1 (de) * | 1970-08-07 | 1975-11-13 | ||
JPS5010569B1 (de) * | 1970-08-12 | 1975-04-22 | ||
SE380257B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser |
DE2527932C2 (de) * | 1974-07-02 | 1983-04-21 | Pentapharm AG, 4052 Basel | Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein |
SE407571B (sv) * | 1975-07-11 | 1979-04-02 | Kabi Ab | Nya kromogena enzymsubstrat for serinproteaser |
NL7607683A (nl) * | 1976-07-12 | 1978-01-16 | Akzo Nv | Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan. |
-
1979
- 1979-07-16 EP EP79850071A patent/EP0009010B1/de not_active Expired
- 1979-07-16 JP JP50113479A patent/JPS55500520A/ja active Pending
- 1979-07-16 WO PCT/SE1979/000157 patent/WO1980000252A1/en unknown
- 1979-07-16 DE DE7979850071T patent/DE2964956D1/de not_active Expired
- 1979-07-16 AT AT0905679A patent/AT387393B/de not_active IP Right Cessation
- 1979-07-17 US US06/058,333 patent/US4242329A/en not_active Expired - Lifetime
-
1980
- 1980-03-18 DK DK116380A patent/DK149630C/da not_active IP Right Cessation
- 1980-08-21 SU SU802961995A patent/SU1034603A3/ru active
Also Published As
Publication number | Publication date |
---|---|
DK149630C (da) | 1987-01-26 |
EP0009010A1 (de) | 1980-03-19 |
US4242329A (en) | 1980-12-30 |
SU1034603A3 (ru) | 1983-08-07 |
JPS55500520A (de) | 1980-08-14 |
DK149630B (da) | 1986-08-18 |
WO1980000252A1 (en) | 1980-02-21 |
DK116380A (da) | 1980-03-18 |
EP0009010B1 (de) | 1983-03-02 |
AT387393B (de) | 1989-01-10 |
ATA905679A (de) | 1988-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE2964956D1 (en) | Bradykinin inhibiting tripeptide derivatives, process for their preparation and pharmaceutical preparations containing them | |
DE2966767D1 (en) | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | |
DE2861688D1 (en) | Quinazoline derivatives, process for their preparation, pharmaceutical preparations and their preparation | |
DE3067252D1 (en) | Cyclopeptides and pharmaceutical preparations thereof, process for their preparation and their use | |
DE3061586D1 (en) | Pancreozymin-cholezystokinin active peptides, process for their preparation and pharmaceutical compositions containing them | |
IL57901A0 (en) | Indanyl derivatives,process for their preparation and pharmaceutical preparations containing them | |
DE2964249D1 (en) | Isoquinoline derivatives, process for their preparation and pharmaceutical preparations containing them | |
DE3067258D1 (en) | Substituted 3-amino-sydnonimines, process for their synthesis and pharmaceutical preparations containing them | |
DE2963573D1 (en) | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | |
DE2964209D1 (en) | Spiro-furanohydantoin derivatives, process for their preparation and pharmaceutical compositions containing them | |
DE2861593D1 (en) | Peptides, pharmaceutical compositions containing the peptides and a process for the preparation of the peptides | |
IL62189A0 (en) | Acyl-derivatives of carnitine,process for preparing same and pharmaceutical preparations comprising same | |
DE2860111D1 (en) | New bispidine derivatives, process for their preparation and medicinal preparations containing them | |
DE2960675D1 (en) | Isoquinolines, process for their preparation, and pharmaceutical preparations containing them | |
ZA793336B (en) | Novel phenylpiperidine derivatives,processes for their preparation,pharmaceutical preparations containing these derivatives and their use | |
DE2961213D1 (en) | Thieno and furopyridone derivatives, process for their preparation and medicinal preparations containing them | |
ZA794156B (en) | Thio-substituted diazacycloalkenes,processes for their preparation and pharmaceutical preparations | |
DE2961524D1 (en) | Glycofuranosyl-nitrosourea derivatives, process for their manufacture and their pharmaceutical preparations | |
DE2961627D1 (en) | Azathianaphthalene derivatives, process for their preparation, pharmaceutical preparations containing them and their utilisation | |
IL65541A0 (en) | Alkylamino-2-propanols,process for their preparation and pharmaceutical preparations containing same | |
HU178239B (en) | Process for preparing thiobenzyl-prymidines and pharmaceutical preparations containing such compounds | |
HU173463B (hu) | Sposob poluchenija 1-metil-2-/fenil-oksimetil/-5-nitro-imidazola i lechebnykh preparatov soderzhahhikh takoe aktivnoe vehhestvo | |
DE2861078D1 (en) | Indan-1-carboxylic acid derivatives,process for their preparation and pharmaceutical preparations containing these compounds | |
ZA793854B (en) | Indanyl derivatives,process for their preparation and pharmaceutical preparations containing them | |
GB2011404B (en) | Sulphoximide derivatives processes for the preparations thereof and pharmaceutical composotions containing them |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |