DE2962602D1 - Process for solubilizing an insoluble drug and an aqueous solution prepared by this process - Google Patents

Process for solubilizing an insoluble drug and an aqueous solution prepared by this process

Info

Publication number
DE2962602D1
DE2962602D1 DE7979300202T DE2962602T DE2962602D1 DE 2962602 D1 DE2962602 D1 DE 2962602D1 DE 7979300202 T DE7979300202 T DE 7979300202T DE 2962602 T DE2962602 T DE 2962602T DE 2962602 D1 DE2962602 D1 DE 2962602D1
Authority
DE
Germany
Prior art keywords
solubilizing
aqueous solution
solution prepared
insoluble drug
insoluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7979300202T
Other languages
English (en)
Inventor
Pak-Kan Albert Lo
James Bown Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE2962602D1 publication Critical patent/DE2962602D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/609—Amides, e.g. salicylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE7979300202T 1978-02-13 1979-02-09 Process for solubilizing an insoluble drug and an aqueous solution prepared by this process Expired DE2962602D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/876,968 US4128632A (en) 1978-02-13 1978-02-13 Solubilization of Rafoxanide

Publications (1)

Publication Number Publication Date
DE2962602D1 true DE2962602D1 (en) 1982-06-09

Family

ID=25368975

Family Applications (1)

Application Number Title Priority Date Filing Date
DE7979300202T Expired DE2962602D1 (en) 1978-02-13 1979-02-09 Process for solubilizing an insoluble drug and an aqueous solution prepared by this process

Country Status (18)

Country Link
US (1) US4128632A (de)
EP (1) EP0003682B1 (de)
JP (1) JPS54117019A (de)
AR (1) AR221862A1 (de)
AT (1) AT363600B (de)
AU (1) AU522422B2 (de)
DE (1) DE2962602D1 (de)
DK (1) DK57479A (de)
HU (1) HU177873B (de)
IE (1) IE47833B1 (de)
IT (1) IT1113720B (de)
NZ (1) NZ189536A (de)
OA (1) OA06239A (de)
PH (1) PH13191A (de)
PL (1) PL114317B1 (de)
YU (1) YU25679A (de)
ZA (1) ZA79597B (de)
ZW (1) ZW3579A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
US4933360A (en) * 1983-03-16 1990-06-12 Boehringer Ingelheim Pharmaceuticals, Inc. Novel chlorthalidone process and product
YU43349B (en) * 1983-03-16 1989-06-30 Boehringer Ingelheim Ltd Process for making a watersoluble, pharmaceutically acceptible dispersion of chlortalidone in solid state
EP0305384A4 (de) * 1986-05-02 1989-06-13 Gaf Corp Wasserlösliche polyvinyl-lactam-arzneimittel-komplexe.
FR2640137A1 (fr) * 1988-12-08 1990-06-15 Texinfine Sa Systemes transporteurs de principes actifs lipophiles et leur procede d'obtention
EP1129713A1 (de) * 2000-02-29 2001-09-05 New Pharma Research Sweden AB Tierärztliche Zusammensetzungen zur Behandlung von Parasiterkrankungen
GB2386066A (en) * 2002-02-28 2003-09-10 Norbrook Lab Ltd Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species
DE102010051404B4 (de) 2010-11-16 2017-08-31 Marc de Cocq Verwendung von substituierten Salicylaniliden zur Behandlung von Fischen
DE102012009572A1 (de) 2012-05-15 2013-11-21 Marc de Cocq Die Verwendung von Glycerol-Formal als Lösungsvermittler für pharmazeutische Wirkstoffe bei der Bekämpfung von Fischkrankheiten
CN106176586A (zh) * 2016-07-22 2016-12-07 柳州市柳南区安顺养殖协会 一种牛羊用抗寄生虫病碘醚柳胺透皮溶液

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL184257C (nl) * 1974-06-19 1989-06-01 Merck & Co Inc Werkwijze voor het bereiden van rafoxanide preparaten.

Also Published As

Publication number Publication date
PL213352A1 (de) 1979-12-03
ATA106679A (de) 1981-01-15
EP0003682A1 (de) 1979-08-22
US4128632A (en) 1978-12-05
JPS54117019A (en) 1979-09-11
OA06239A (fr) 1981-06-30
IE47833B1 (en) 1984-06-27
ZW3579A1 (en) 1980-09-10
IT7947942A0 (it) 1979-02-08
HU177873B (en) 1982-01-28
EP0003682B1 (de) 1982-04-28
AU522422B2 (en) 1982-06-03
NZ189536A (en) 1981-02-11
IE790259L (en) 1979-08-13
PH13191A (en) 1980-01-16
ZA79597B (en) 1980-10-29
IT1113720B (it) 1986-01-20
DK57479A (da) 1979-08-14
AU4391479A (en) 1979-08-23
AR221862A1 (es) 1981-03-31
PL114317B1 (en) 1981-01-31
AT363600B (de) 1981-08-10
YU25679A (en) 1984-02-29

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee