DE289426C - - Google Patents
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- Publication number
- DE289426C DE289426C DENDAT289426D DE289426DA DE289426C DE 289426 C DE289426 C DE 289426C DE NDAT289426 D DENDAT289426 D DE NDAT289426D DE 289426D A DE289426D A DE 289426DA DE 289426 C DE289426 C DE 289426C
- Authority
- DE
- Germany
- Prior art keywords
- tertiary
- trichlorobutyl
- crystallizes
- well
- hydrochloric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 trichlorobutyl chloroacetate Chemical group 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 210000001772 Blood Platelets Anatomy 0.000 claims description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- 238000002844 melting Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- VGCXGMAHQTYDJK-UHFFFAOYSA-N Chloroacetyl chloride Chemical compound ClCC(Cl)=O VGCXGMAHQTYDJK-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical group 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- 150000003057 platinum Chemical class 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- ROSDSFDQCJNGOL-UHFFFAOYSA-N dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000005619 secondary aliphatic amines Chemical class 0.000 description 1
- 239000001187 sodium carbonate Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
2. Der Dimethylglycintertiär trichter butylester wird durch Behandeln von 20 g Chloressigsäuretertiärtrichlorbutylester mit 30 ecm 27prozentiger wäßriger Dirnethylaminolösung im geschlossenen Gefäß bei iio° unter Schütteln dargestellt. Die so erhaltene wäßrige Lösung wird mit Natriumcarbonat alkalisch gemacht, mit Äther ausgeschüttelt, der Äther und nicht in Reaktion getretenes Dimethylamin abdestilliert. Der Rückstand stellt dann den freien Ester in Form eines Öles dar. Die Salze sind gut kristallisiert. So bildet z. B. das salzsaure Salz rhombische Plättchen vom Fp. 220°. Das Chlorhydrat ist in Wasser ebenso wie das salzsaure Salz des Diäthylglycintertiärtrichlorbutylesters spielend löslich.2. The dimethylglycintertiary butyl ester funnel is made by treating 20 g of tertiary chloroacetic acid trichlorobutyl ester with 30 ecm of 27 percent aqueous dirnethylamino solution shown in a closed vessel at iio ° with shaking. The aqueous thus obtained Solution is made alkaline with sodium carbonate, shaken out with ether, the ether and dimethylamine which has not reacted is distilled off. The residue then represents represents the free ester in the form of an oil. The salts are well crystallized. So z. B. the hydrochloric acid salt, rhombic platelets with a melting point of 220 °. The hydrochloride is in water just like the hydrochloric acid salt of diethyl glycine tertiary trichlorobutyl ester easily soluble.
Verfahren zur Darstellung von Aminosäureestern, darin bestehend, daß man Monohalogenessigsäuretrichlortertiärbutylester mit sekundären aliphatischen Aminen kondensiert. Process for the preparation of amino acid esters, consisting in that monohaloacetic acid trichlorotertiary butyl ester condensed with secondary aliphatic amines.
Claims (1)
■ Der zur Darstellung des obigen Glycinesters verwandte Chloressigsäuretertiärtrichlorbutylester wird durch Kondensation von Chloracetylchlorid mit dem tertiären Trichlorbutylalkohol gewonnen; es ist eine Verbindung vom Smp. 490, die in hellen Nädelchen gut kristallisiert. an oil with a characteristic odor and can be distilled almost undecomposed in vacuo at about 142 to 145 ° under 20 mm pressure. The hydrochloric acid salt melts at 167 to 168 °; it crystallizes very well and is very easily soluble in water. The platinum salt crystallizes in beautiful platelets with a melting point of 212 °.
The tertiary trichlorobutyl chloroacetate used to prepare the above glycine ester is obtained by condensation of chloroacetyl chloride with the tertiary trichlorobutyl alcohol; it is a compound of mp. 49 0, the well crystallized in bright needles.
Publications (1)
Publication Number | Publication Date |
---|---|
DE289426C true DE289426C (en) |
Family
ID=544460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DENDAT289426D Active DE289426C (en) |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE289426C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5234571A (en) * | 1921-12-19 | 1993-08-10 | Microparts Gmbh | Stepped mold inserts, a process for the manufacture of stepped mold inserts, and stepped microstructural bodies with the mold inserts |
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0
- DE DENDAT289426D patent/DE289426C/de active Active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5234571A (en) * | 1921-12-19 | 1993-08-10 | Microparts Gmbh | Stepped mold inserts, a process for the manufacture of stepped mold inserts, and stepped microstructural bodies with the mold inserts |
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