DE2862327D1 - Pentapeptide-n-alkylamides and their acid addition salts, methods for preparation of these compounds and pharmaceutical formulations containing them - Google Patents

Pentapeptide-n-alkylamides and their acid addition salts, methods for preparation of these compounds and pharmaceutical formulations containing them

Info

Publication number
DE2862327D1
DE2862327D1 DE7878100463T DE2862327T DE2862327D1 DE 2862327 D1 DE2862327 D1 DE 2862327D1 DE 7878100463 T DE7878100463 T DE 7878100463T DE 2862327 T DE2862327 T DE 2862327T DE 2862327 D1 DE2862327 D1 DE 2862327D1
Authority
DE
Germany
Prior art keywords
alkylamides
pentapeptide
compounds
preparation
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7878100463T
Other languages
English (en)
Inventor
Samuel Wilkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB30909/77A external-priority patent/GB1604644A/en
Priority claimed from GB48980/77A external-priority patent/GB1604850A/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of DE2862327D1 publication Critical patent/DE2862327D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/675—Beta-endorphins
    • C07K14/6755—Beta-endorphins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE7878100463T 1977-07-22 1978-07-21 Pentapeptide-n-alkylamides and their acid addition salts, methods for preparation of these compounds and pharmaceutical formulations containing them Expired DE2862327D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB30909/77A GB1604644A (en) 1977-07-22 1977-07-22 Biologically active pentapeptide amides
GB48980/77A GB1604850A (en) 1977-11-24 1977-11-24 Biologically active peptides

Publications (1)

Publication Number Publication Date
DE2862327D1 true DE2862327D1 (en) 1983-11-10

Family

ID=26260658

Family Applications (1)

Application Number Title Priority Date Filing Date
DE7878100463T Expired DE2862327D1 (en) 1977-07-22 1978-07-21 Pentapeptide-n-alkylamides and their acid addition salts, methods for preparation of these compounds and pharmaceutical formulations containing them

Country Status (4)

Country Link
EP (1) EP0000559B1 (de)
JP (1) JPS5424850A (de)
DE (1) DE2862327D1 (de)
IT (1) IT1107551B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178001B (en) * 1976-09-16 1982-02-28 Gyogyszekutato Intezet Process for preparing new pentapeptides with morphine-like activity and derivatives thereof
FR2424253A1 (fr) * 1978-04-27 1979-11-23 Brun Lab Sa Le Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique
NL8005121A (nl) * 1979-09-20 1981-03-24 Erba Farmitalia Biologisch actieve peptiden.
JPS58501861A (ja) * 1981-12-28 1983-11-04 ベツクマン・インストルメンツ・インコ−ポレ−テツド 下垂体成長ホルモン放出活性を有する合成ペプチド
ATE25090T1 (de) * 1982-02-05 1987-02-15 Wellcome Found Pharmazeutische verbindungen, deren herstellung, anwendung, deren zwischenverbindungen und herstellung.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2703109A1 (de) * 1976-01-26 1977-08-04 Wellcome Found Biologisch wirksame amide
NZ183712A (en) * 1976-04-08 1979-10-25 Ici Ltd Polypeptide analogues of enkephalins, and pharmaceutical compositions
FR2359817A1 (fr) * 1976-07-27 1978-02-24 Reckitt & Colmann Prod Ltd Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant
HU178001B (en) * 1976-09-16 1982-02-28 Gyogyszekutato Intezet Process for preparing new pentapeptides with morphine-like activity and derivatives thereof
US4259234A (en) * 1976-09-27 1981-03-31 Eli Lilly And Company Analgesic compounds

Also Published As

Publication number Publication date
IT1107551B (it) 1985-11-25
EP0000559B1 (de) 1983-10-05
IT7850431A0 (it) 1978-07-21
JPS5424850A (en) 1979-02-24
EP0000559A1 (de) 1979-02-07

Similar Documents

Publication Publication Date Title
DE3072122D1 (en) 7-acylamino-3-vinylcephalosporanic acid derivatives, processes for their preparation, pharmaceutical compositions containing them; their starting compounds and their preparation
DE3069559D1 (en) Beta-carbolin-3-carboxylic acid derivatives, pharmaceutical compositions containing them and their therapeutical use
IL56734A0 (en) Phemoxyalkylcarboxylic acid derivatives,process for their preparation and pharmaceutical compositions containing thesame
MY8700725A (en) O-substituted derivatives of (+)-cyanidan-3-ol, processes for their preparation and pharmaceutical compositions containing these compounds and their preparation
DE3062216D1 (en) Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them
IL56421A0 (en) 4-pyridone-3-carboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
PH13924A (en) Glavulanic acid derivatives,pharmaceutical compositions containing same and method of preparation thereof
IL54949A (en) Pharmaceutical compositions containing 4-hydroxy-2-oxoquinoline-3-carboxylic acid derivatives and novel compounds of this type
DE3067784D1 (en) 2-hydroxyoxanilic acid derivatives and salts, their preparation and pharmaceutical compositions containing them
DE2862327D1 (en) Pentapeptide-n-alkylamides and their acid addition salts, methods for preparation of these compounds and pharmaceutical formulations containing them
DE2860777D1 (en) N-substituted 2-hydrazono-propionic acid derivatives, process for their preparation and pharmaceutical compositions containing them
ZA784501B (en) Derivatives of n-substituted-2-aminobenzoic acid,processesfor their preparation and pharmaceutical compositions thereof
IL56240A0 (en) Novel derivatives of cyclobutenecarboxylic acid, their preparation and insecticidal compositions containing them
IL56461A (en) 1-naphthyl-acetic acid derivatives,their preparation and pharmaceutical compositions containing them
ZA786369B (en) New derivatives of 5h-benzocyclohepten-7-amine and their salts,process for preparing them and the pharmaceutical compositions containing them
ZA793720B (en) Substituted 2-phenylamino-imidazoline-(2)derivatives,acid addition salts thereof,processes for their preparation,and pharmaceutical compositions thereof
DE2860212D1 (en) 4-phenyl-8-amino-tetrahydroisoquinolines, pharmaceutical compositions containing them and process for preparation of these compositions
IL57735A (en) 7beta-aminothiazolyl-acetamido-3-cephem-4-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
GR63662B (en) Piperazinecarbodithioic acid derivatives process for their preparation and pharmaceutical compositions containing them
DE2860471D1 (en) Derivatives of benzenesulfonamide, method for their preparation and pharmaceutical compositions containing them
ZA793425B (en) Substituted 2-phenylamino-2-imidazolines and acid addition salts thereof,processes for their preparation,and pharmaceutical compositions containing these compounds
IL55253A (en) Benzimidazole-2-methanol and benzimidazole-2-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
DE2965938D1 (en) Clavulanic acid derivatives, processes for their preparation and pharmaceutical compositions containing them
IL55229A0 (en) New oxanilic acid derivatives,their preparation and pharmaceutical compositions containing them
DE2861078D1 (en) Indan-1-carboxylic acid derivatives,process for their preparation and pharmaceutical preparations containing these compounds

Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Free format text: SCHWABE, H., DIPL.-ING. SANDMAIR, K., DIPL.-CHEM. DR.JUR. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee