DE2860734D1 - Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them - Google Patents

Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
DE2860734D1
DE2860734D1 DE7878100095T DE2860734T DE2860734D1 DE 2860734 D1 DE2860734 D1 DE 2860734D1 DE 7878100095 T DE7878100095 T DE 7878100095T DE 2860734 T DE2860734 T DE 2860734T DE 2860734 D1 DE2860734 D1 DE 2860734D1
Authority
DE
Germany
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
somatostatin analogs
somatostatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7878100095T
Other languages
English (en)
Inventor
Daniel Frank Veber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE2860734D1 publication Critical patent/DE2860734D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE7878100095T 1977-06-08 1978-06-06 Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them Expired DE2860734D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80467877A 1977-06-08 1977-06-08

Publications (1)

Publication Number Publication Date
DE2860734D1 true DE2860734D1 (en) 1981-09-03

Family

ID=25189555

Family Applications (1)

Application Number Title Priority Date Filing Date
DE7878100095T Expired DE2860734D1 (en) 1977-06-08 1978-06-06 Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them

Country Status (7)

Country Link
US (1) US4146612A (de)
EP (1) EP0000053B1 (de)
JP (1) JPS543085A (de)
DE (1) DE2860734D1 (de)
DK (1) DK252778A (de)
IE (1) IE47421B1 (de)
IT (1) IT1105131B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU78191A1 (de) * 1977-09-28 1979-05-25 Ciba Geigy Ag Verfahren zur herstellung von neuen cyclopeptiden
US4190648A (en) * 1979-03-13 1980-02-26 Merck & Co., Inc. Peptides having somatostatin activity
NZ195303A (en) * 1979-10-31 1984-10-19 Merck & Co Inc Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4358439A (en) * 1979-12-21 1982-11-09 Ciba-Geigy Corporation Cyclooctapeptides
US4508711A (en) * 1983-04-18 1985-04-02 American Cyanamid Company Cyclic pentapeptide displaying somatostatin antagonism and method of treatment of mammals therewith
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
ZW11290A1 (en) * 1989-07-14 1990-10-31 Smithkline Beecham Corp Hemoregulatory peptides
CA2045495A1 (en) * 1989-11-08 1991-05-09 Masutaka Ohsaki Peptides and processes for producing cyclic peptides
US5700905A (en) * 1992-09-01 1997-12-23 The Trustees Of The University Of Pennsylvania Synthetic somatostatin mimics
US5965694A (en) * 1992-09-01 1999-10-12 The Trustees Of The University Of Pennsylvania Somatostatin mimics and synthetic methods therefor
US6001960A (en) * 1992-09-01 1999-12-14 The Trustees Of The University Of Pennsylvania Synthetic somatostatin mimics
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
DE4342907A1 (de) * 1993-12-16 1995-06-22 Bayer Ag Neue cyclische Depsipeptide mit 18 Ringatomen und ihre Verwendung zur Bekämpfung von Endoparasiten
US6506174B1 (en) 1994-11-03 2003-01-14 The Saunders Group, Inc. Portable traction device
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US7026289B2 (en) * 1997-05-13 2006-04-11 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Method and compositions for treating hyperlipidemia and other conditions
PT980253E (pt) * 1997-05-13 2004-08-31 Conseils De Rec Appl Scient S Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x
WO1998051331A1 (en) 1997-05-13 1998-11-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) Somatostatin and somatostatin agonists for decreasing body weight
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US6171273B1 (en) 1999-08-06 2001-01-09 The Saunders Group, Inc. Self-seating occiput wedge system for applying a therapeutic traction force
JP3996897B2 (ja) 2001-06-08 2007-10-24 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス ソマトスタチン−ドーパミンキメラ類似体
US7189214B1 (en) 2002-01-22 2007-03-13 The Saunders Group, Inc. Multi-axis cervical and lumbar traction table
US20040145462A1 (en) * 2003-01-29 2004-07-29 Honda Giken Kogyo Kabushiki Kaisha Variable electronic display apparatus for a vehicle, and method of using same
AU2004232314B2 (en) 2003-04-22 2007-11-22 Ipsen Pharma S.A.S. Peptide vectors
EP3590956A1 (de) 2008-06-12 2020-01-08 Ipsen Bioinnovation Limited Unterdrückung von neuroendokrinen erkrankungen
JP5799397B2 (ja) 2008-06-12 2015-10-28 イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ 癌の抑制
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US781610A (en) * 1904-01-11 1905-01-31 Winfield S Livengood Wagon-brake.
US3904594A (en) * 1973-07-02 1975-09-09 Salk Inst For Biological Studi Somatostatin and acylated des-(ala' 1', gly' 2') derivatives thereof
US3882098A (en) * 1974-01-03 1975-05-06 American Home Prod Synthesis of des-Ala{hu 1{b , Gly{hu 2{b , Asn{hu 5{b -SRIF and intermediates
DE2460469A1 (de) * 1974-12-20 1976-07-01 Hoechst Ag Neue peptide mit biologischer wirkung und verfahren zu ihrer herstellung
US3933784A (en) * 1975-01-27 1976-01-20 American Home Products Corporation Des-(ser13)-srif and intermediates
US4011182A (en) * 1975-03-21 1977-03-08 American Home Products Corporation Cyclic undecapeptide analogs of somatostatin and intermediates
CA1083143A (en) * 1976-01-02 1980-08-05 Nedumparambil A. Abraham Carba derivatives of somatostatin and process therefor

Also Published As

Publication number Publication date
EP0000053B1 (de) 1981-05-27
US4146612A (en) 1979-03-27
IT7849736A0 (it) 1978-06-06
DK252778A (da) 1978-12-09
IE47421B1 (en) 1984-03-07
IT1105131B (it) 1985-10-28
JPS543085A (en) 1979-01-11
IE781151L (en) 1978-12-08
EP0000053A1 (de) 1978-12-20

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee