DE285829C - - Google Patents
Info
- Publication number
- DE285829C DE285829C DENDAT285829D DE285829DA DE285829C DE 285829 C DE285829 C DE 285829C DE NDAT285829 D DENDAT285829 D DE NDAT285829D DE 285829D A DE285829D A DE 285829DA DE 285829 C DE285829 C DE 285829C
- Authority
- DE
- Germany
- Prior art keywords
- alkali
- air
- cannabis indica
- ether
- exclusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 235000005607 chanvre indien Nutrition 0.000 claims description 6
- 241000638023 Cannabis sativa subsp. indica Species 0.000 claims description 5
- 239000003960 organic solvent Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 5
- 230000003533 narcotic Effects 0.000 description 3
- 239000003208 petroleum Substances 0.000 description 3
- 235000011121 sodium hydroxide Nutrition 0.000 description 3
- 240000000218 Cannabis sativa Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 235000012765 hemp Nutrition 0.000 description 2
- 235000012766 marijuana Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- VBGLYOIFKLUMQG-UHFFFAOYSA-N Cannabinol Chemical compound C1=C(C)C=C2C3=C(O)C=C(CCCCC)C=C3OC(C)(C)C2=C1 VBGLYOIFKLUMQG-UHFFFAOYSA-N 0.000 description 1
- 229960003453 Cannabinol Drugs 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000004866 Hashish Substances 0.000 description 1
- 231100000601 Intoxication Toxicity 0.000 description 1
- KJFMBFZCATUALV-UHFFFAOYSA-N Phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 235000009120 camo Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000011487 hemp Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
- 230000002588 toxic Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
Die Hanfpräparate haben unter dem Namen »Haschisch« in orientalischen Ländern als narkotische Genußmittel eine ausgedehnte Verbreitung gefunden. Nicht so bedeutend dagegen ist die Verwendung der Präparate zu therapeutischen Zwecken. Anscheinend ist der Grund hierfür darin zu suchen, daß die bis jetzt angewandten Formen der wirksamen Verbindungen sich nicht als zweckentsprechendThe hemp preparations have been used as narcotic in oriental countries under the name "hashish" Luxury foods found widespread use. In contrast, the use of the preparations is not so important therapeutic purposes. Apparently the reason for this is to be found in the fact that the bis The forms of the active compounds now used are not found to be appropriate
ίο und geeignet erwiesen.ίο and proven suitable.
Es wurde nun gefunden, daß es gelingt, durch ein einfaches Verfahren die pharmakologisch wirksamen Bestandteile der Cannabis Indica zu trennen. Diese Trennung wird dadurch erzielt, daß man Cannabis Indica mit organischen Lösungsmitteln, die sich nicht mit Wasser mischen, unter Ausschluß von Luft auszieht und die erhaltene Lösung, ohne daß Luft dazu kommt, mit verdünnten Alkalien behandelt. Aus den beiden Lösungen kann man verschiedene Präparate isolieren, die sich sowohl in bezug auf Giftigkeit und narkotische Eigenschaften voneinander unterscheiden.It has now been found that it is possible to use a simple method to pharmacologically separate effective components of cannabis indica. This separation becomes through it achieves that one can cannabis indica with organic solvents that do not deal with Mix water, draw out with the exclusion of air and the resulting solution without Air is added, treated with dilute alkalis. From the two solutions can one can isolate various preparations that are both toxic and narcotic Distinguish properties from each other.
50 g Cannabis Indica (Droge) werden mit einem Gemisch von Petroläther und Äther, möglichst unter Ausschluß von Luft, extrahiert. Dann wird mit verdünnter Natronlauge ausgeschüttelt und die Lauge, ohne daß sie mit der Luft in Berührung kommt, also am besten im Wasserstoffstrom, mit Kohlensäure neutralisiert, bis die Reaktion auf Phenolphtaleinpapier verschwunden ist. Die Lösung in Natronlauge ist gelb; wenn sie mit Luft in Berührung kommt, so wird sie rot. Dann wird wieder mit Äther ausgeschüttelt und der Äther abgedampft. Der Rückstand des Äthers bzw. eines anderen organischen Lösungsmittels, also der alkaliunlösliche Teil, ist ein in der Kälte äußerst dickflüssiger Sirup, welcher sich in Alkohol klar löst, während er in Wasser unlöslich ist. Beim Behandeln mit Petroläther kann man diesen Anteil in einen darin unlöslichen festen Bestandteil und ein dickflüssiges Öl trennen. Die ursprüngliche, mit Alkali behandelte, petroläther-ätherische Lösung wird abgedampft und der Rückstand destilliert. Bei einer Temperatur von 220 ° erhält man bei einem Druck von 1 mm ein sehr dickflüssiges öl, welches in der Kälte fast fest wird.50 g cannabis indica (drug) are mixed with petroleum ether and ether, if possible with the exclusion of air, extracted. Then it is extracted with dilute sodium hydroxide solution and the lye, without coming into contact with the air, i.e. preferably in a stream of hydrogen, neutralized with carbonic acid, until the reaction to phenolphthalein paper has disappeared. The solution in caustic soda is yellow; when it comes into contact with air it turns red. Then it will be shaken out again with ether and the ether evaporated. The residue of the ether resp. Another organic solvent, i.e. the alkali-insoluble part, is one in the cold extremely viscous syrup, which dissolves clearly in alcohol, while it is insoluble in water is. When treating with petroleum ether, this part can be converted into an insoluble one Separate solid component and a thick oil. The original, with alkali treated, petroleum ether-ethereal solution is evaporated and the residue is distilled. At a temperature of 220 ° and a pressure of 1 mm you get a very viscous one oil, which becomes almost solid in the cold.
Dieses Produkt hat Ähnlichkeit mit dem Fränkelschen Cannabinol. Es zeigt diejenigen Wirkungen, welche dieser Forscher für sein Präparat beschreibt. Auch die Vergiftungssymptome fehlen nicht. Dieser Anteil ist in Alkohol bis auf einen geringen Rückstand löslich. Das Produkt aus der alkalischen Lösung zeigt keine ausgesprochenen Haschisch-Symptome; dagegen besitzt es in großen Dosen narkotische Eigenschaften.This product is similar to Frankel's cannabinol. It shows those Effects that this researcher describes for his preparation. The symptoms of intoxication are also not absent. This proportion is in Alcohol soluble except for a small residue. The product from the alkaline solution shows no pronounced hash symptoms; on the other hand it possesses in large doses narcotic properties.
Die Präparate sollen therapeutische Verwendung finden.The preparations are intended to be used therapeutically.
Claims (1)
Verfahren zur Trennung der pharmakologisch wirksamen Bestandteile der Cannabis Indica, dadurch gekennzeichnet, daß man Auszüge, die aus der Cannabis Indica mit organischen Lösungsmitteln, welche mit Wasser nicht mischbar sind, gewonnen werden, mit verdünntem Alkali unter Luftausschluß behandelt und aus den erhaltenen Lösungen sowohl die alkalilöslichen als auch die alkaliunlöslichen Anteile isoliert.Patent claim:
Process for the separation of the pharmacologically active components of the cannabis indica, characterized in that extracts which are obtained from the cannabis indica with organic solvents which are immiscible with water are treated with dilute alkali with exclusion of air and from the solutions obtained both the alkali-soluble as well as the alkali-insoluble fractions isolated.
Publications (1)
Publication Number | Publication Date |
---|---|
DE285829C true DE285829C (en) |
Family
ID=541197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DENDAT285829D Active DE285829C (en) |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE285829C (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2419936A (en) * | 1942-04-29 | 1947-05-06 | Adams Roger | Preparation of compounds with marihuana activity |
US2419935A (en) * | 1941-07-09 | 1947-05-06 | Adams Roger | Marihuana active compounds |
US2419934A (en) * | 1941-07-09 | 1947-05-06 | Adams Roger | Optically active tetrahydrodibenzopyrans having marihuana activity and process for making same |
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0
- DE DENDAT285829D patent/DE285829C/de active Active
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2419935A (en) * | 1941-07-09 | 1947-05-06 | Adams Roger | Marihuana active compounds |
US2419934A (en) * | 1941-07-09 | 1947-05-06 | Adams Roger | Optically active tetrahydrodibenzopyrans having marihuana activity and process for making same |
US2419936A (en) * | 1942-04-29 | 1947-05-06 | Adams Roger | Preparation of compounds with marihuana activity |
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