DE2838736A1 - Wound-covering medicament powder base - of hydroxyethyl starch for improved absorbence and inherent purity - Google Patents

Wound-covering medicament powder base - of hydroxyethyl starch for improved absorbence and inherent purity

Info

Publication number
DE2838736A1
DE2838736A1 DE19782838736 DE2838736A DE2838736A1 DE 2838736 A1 DE2838736 A1 DE 2838736A1 DE 19782838736 DE19782838736 DE 19782838736 DE 2838736 A DE2838736 A DE 2838736A DE 2838736 A1 DE2838736 A1 DE 2838736A1
Authority
DE
Germany
Prior art keywords
powder base
hydroxyethyl starch
wound
absorbence
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782838736
Other languages
German (de)
Inventor
Theodor Prof Dr Eckert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19782838736 priority Critical patent/DE2838736A1/en
Publication of DE2838736A1 publication Critical patent/DE2838736A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Hydroxyethyl starch (I) is used as a powder base for medicaments used to cover wounds. Irrespective of its mo. wt. (I) absorbs secretions better than known bases based on starch etc. and is not microbially infected like inorganic bases (e.g. talc, TiO2, SiO2, etc.).

Description

Verwendung von Hydroxyäthylestärke als Pudergrundlage Use of hydroxyethyl starch as a powder base

Bekanntlich sind Pudergrundlagen äußerlich anzuwendende pulverförmige Arzneimittel, die entweder als solche angewendet werden oder in Form von Gemischen mit Wirkstoffen. Als Pudergrundlagen haben sie dabei eine Eigenwirkung vor allem im Sinne einer Feuchtigkeitsufnahmefähigkeit gegenüber Wundsekreten. Als Pudergrundlagen kommen verschiedene Stärkearten zur Anwendung aber auch Talcum, hochdisperse Kieselsäure, Zinkoxid, Titandioxid oder auch andere organische oder anorganische Substanzen.It is well known that powder bases are powder-form to be used externally Medicinal products that are used either as such or in the form of mixtures with active ingredients. As a powder base, they have an effect of their own, above all in terms of moisture absorption against wound secretions. As powder bases different types of starch are used but also talc, highly dispersed silica, Zinc oxide, titanium dioxide or other organic or inorganic substances.

Allen bisher bekannten Pudergrundlagen haften jedoch vielfach schwerwiegende Nachteile an. So sind beispielsweise anorganische Pundergrundlagen vielfach mikrobiell verunreinigt. Das klifsaugevermögen von Stärl-en gegenüber Wundsekret ist nur begrenzt.However, all of the powder bases known so far have often serious ones Disadvantages. For example, inorganic powder bases are often microbial contaminated. The ability of starches to absorb wounds from wound secretions is only limited.

Überraschenderweise wurde nun gefunden, daß Hydroxyäthylstärke der verschiedensten Molekulargewichte über vorzügliche Äufsaugevermögen gegenüber Wundsekreten verfügt und infolgedessen als Pudergrundlage ausgezeichnet geeignet ist. Das Aufsaugevermögen wird zwar von dem Molekulargewicht der Hydroxyäthylstärke beeinflußt, ohne jedoch den grundsätzlichen Effekt zu verändern.Surprisingly, it has now been found that the hydroxyethyl starch various molecular weights over excellent suction capacity for wound secretions and is therefore ideally suited as a powder base. The absorption capacity is influenced by the molecular weight of the hydroxyethyl starch, but without to change the basic effect.

Claims (1)

Patentanspruch Verbesserte Aufsaugung von Wundsekreten durch eine Pudergrundlage, dadurch gekennzeichnet, daß als Pudergrundlage Hydroxyäthylstärke verwendet wird.Patent claim Improved suction of wound secretions by a Powder base, characterized in that the powder base is hydroxyethyl starch is used.
DE19782838736 1978-09-06 1978-09-06 Wound-covering medicament powder base - of hydroxyethyl starch for improved absorbence and inherent purity Withdrawn DE2838736A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19782838736 DE2838736A1 (en) 1978-09-06 1978-09-06 Wound-covering medicament powder base - of hydroxyethyl starch for improved absorbence and inherent purity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782838736 DE2838736A1 (en) 1978-09-06 1978-09-06 Wound-covering medicament powder base - of hydroxyethyl starch for improved absorbence and inherent purity

Publications (1)

Publication Number Publication Date
DE2838736A1 true DE2838736A1 (en) 1980-03-20

Family

ID=6048748

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782838736 Withdrawn DE2838736A1 (en) 1978-09-06 1978-09-06 Wound-covering medicament powder base - of hydroxyethyl starch for improved absorbence and inherent purity

Country Status (1)

Country Link
DE (1) DE2838736A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980002374A1 (en) * 1979-05-10 1980-11-13 American Hospital Supply Corp Hydroxyalkyl starch drug carrier
EP2203053A1 (en) 2008-01-14 2010-07-07 Starch Medical Inc. Modified starch material of biocompatible hemostasis

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980002374A1 (en) * 1979-05-10 1980-11-13 American Hospital Supply Corp Hydroxyalkyl starch drug carrier
EP0028641A1 (en) * 1979-05-10 1981-05-20 American Hospital Supply Corp Hydroxyalkyl starch drug carrier.
EP0028641A4 (en) * 1979-05-10 1981-09-01 American Hospital Supply Corp Hydroxyalkyl starch drug carrier.
EP0019403A3 (en) * 1979-05-10 1981-10-07 American Hospital Supply Corporation Hydroxyalkyl-starch drug carrier and method of administering a biologically active compound to an animal
EP2203053A1 (en) 2008-01-14 2010-07-07 Starch Medical Inc. Modified starch material of biocompatible hemostasis
JP2011509932A (en) * 2008-01-14 2011-03-31 スターチ メディカル インコーポレーテッド Biocompatible hemostasis, adhesion prevention, fusion promotion, surgically sealable modified starch material
EP2203053B1 (en) * 2008-01-14 2017-09-20 Xin Ji Modified starch material of biocompatible hemostasis

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