DE2834227A1 - HYPO-BETA -LIPOPROTEINAEMIC DIETETIC, METHOD FOR THE PRODUCTION AND USE THEREOF - Google Patents

Description

Merck Patent Society August 3, 1978 with limited liability Darmstadt

Hypo-β-lipoproteinemic dietetic agent _t Process for its manufacture and use

30009/0041

Hypo-ß-lipoproteinemic dietetic, Process for its manufacture and use

The invention relates to a new hypo-β-lipoproteinemic dietetic, vegetable protein and pectin contains, as well as a process for its manufacture and its use.

It is known that vegetable proteins, in particular Soy protein. (Soybean protein), in contrast to proteins of animal origin, increased serum cholesterol levels lower in animals and humans; besides, they turn out to be to achieve weight loss as valuable.

'■. It is also known / that pectin also brings about a - moderate - reduction in elevated cholesterol levels. In addition to this effect pectin shows other therapeutically - table valuable properties; For example, the administration of pectin causes the gastrointestinal passage to be shortened. time, an increase in gastrointestinal tone and thus impairment of the feeling of hunger, prevention of digestive disorders such as constipation and putrefactive dyspepsia and the adsorption of toxic intestinal components. Accordingly, pectin can be used as a prophylaxis for gallstone disease and colon diverticulosis.

Furthermore, there is a "cholesterol-minus diet" in powder form known, which contains apple pectin in addition to whole soy, but which has a very high fat content (11 g in 100 g Product). In the present powder form, it is difficult to ingest and swallow.

9/0041

It has now been found that the administration of a combination of soy protein and about 2 to 3 percent by weight Pectin (based on the dry weight of the finished preparation), which is in granular form, in unexpected way of an application of the individual components and also the application of the well-known "cholesterol-minus diet" The combination produces greater cholesterol reductions. Lowering cholesterol is mainly at the expense of the LDL (low density lipoprotein) cholesterol content. From this can it can be concluded that the particularly atherogenic LDL lipoprotein levels are also reduced. Furthermore elevated triglyceride levels are also lowered. The overload of the pepsin / trypsin system by a protein-rich Diet alone is prevented or at least mitigated by the application of the combination. The pectin component the combination swells in the gastrointestinal tract; thus both the feeling of hunger is reduced as also has a beneficial effect on digestion.

Thus, the combination can be effective as a weight reduction diet in overweight patients. She is in comparison particularly well tolerated by other known cholesterol lowering agents.

Due to its granular form, the new dietetic is much easier to take than the familiar one "Cholesterol-Minus Diet". It can be swallowed or chewed with or without liquid, with the acceptance disturbing swelling properties of the pectin due to the particularly advantageous preparation form not noticeable will. Thanks to the much lower fat content, the new dietetic is also physiologically more favorable to assess than the well-known diet powder.

The invention accordingly relates to a hypo-ßlipoproteinemic Dietetic containing soy protein and pectin, characterized in that it is in granular form is present and contains about 2 to 3 percent by weight of pectin, based on the dry weight of the finished preparation.

030009/0041

The dietetic has expediently a content of about 45 to 90 percent by weight of pure protein and about 2 to 3 percent by weight pectin.

Commercially available products with protein contents of, for example, 60 to 90 percent by weight can be used as soy protein be used. Accordingly, the dietetic product expediently has a content of about 70 to 97 Weight percent soy protein (commercially available preparation).

Citrus pectin is preferably used as pectin, Apple dry pectin is also suitable.

The dietetic according to the invention can additionally contain further Contain active ingredients, in particular one or more vitamins and / or one or more mineral salts.

The main vitamins are:

Vitamin A and its derivatives, e.g. its esters such as Vitamin A palmitate; Vitamin B 1 and its derivatives (e.g. its salts such as chloride hydrochloride or the nitrate); Vitamin B 2 and its derivatives (e.g. its Esters such as riboflavin-5'-phosphoric acid ester); Vitamin B 6 and its derivatives (e.g. its salts such as pyridoxine hydrochloride); Vitamin B 12 and its derivatives (e.g. hydroxocobalamin); Biotin; Nicotinic acid and its derivatives, e.g., nicotinamide; Folic acid and its derivatives; Pantothenic acid and their derivatives, for example their salts such as sodium or calcium pantothenate, panthenol; Ascorbic acid (vitamin C) and their salts, e.g., sodium, calcium or iron (II) ascorbate; Vitamin E and its derivatives, e.g. oC-tocopherol acetate, od-tocopherol succinate; Rutin and its derivatives, e.g., rutoside sulfuric acid ester sodium salts; Vitamins D and D 3. and their derivatives; Vitamin K and its derivatives, e.g., meriol diacetate.

030009 / Ό 04!

As mineral salts come primarily into consideration Salts of potassium, e.g., potassium chloride, potassium citrate; Magnesium, e.g. basic magnesium carbonate, magnesium sulfate, citrate, levulinate, hydrogen phosphate; Calcium, e.g. calcium citrate ", -fluoride, -hydrogen phosphate, -gluconate, lactate gluconate, lactobionate; Copper, e.g. copper sulphate, -gluconate; Zinc, e.g., zinc sulfate; Molybdenum, e.g., sodium mQlybdate; Manganese, e.g. manganese chloride, sulfate, gluconate? Iron, e.g. iron (II) ascorbate, gluconate, fumarate, phosphate, sulfate; Cobalt, e.g., cobalt chloride, sulfate, gluconate; Phosphorus, e.g., dinatriura hydrogen phosphate.

The dietetic according to the invention can also contain additives contain, e.g. taste corrections. Sugars such as beet sugar, for example, are suitable as such (Sucrose), glucose, fructose, lactose, sugar substitutes such as sorbitol, mannitol, xylitol, glycerin, or ' Sweeteners such as saccharin and its salts, e.g. sodium saccharinate; taste-enhancing acids such as citric acid or Tartaric acid; Spices and flavors.

The invention also relates to a method for producing a hypo ~ ß-lipoproteinemic dietetic, characterized in that a mixture containing soy protein and about 2 to 3 percent by weight Pectin (based on the dry weight of the finished preparation) processed into granules.

Finally, the subject of the invention is the use of a soy protein and about 2 to 3 percent by weight of pectin (based on the dry weight of the finished preparation) containing granules as hypo-ß-lipoproteinemic Dietetic.

030009/0041

The granules can be produced from the mixture of the constituents by conventional granulation processes (e.g. with the help of a granulating roller or by spray granulation, pelletizing or calendering). The granules expediently have particle sizes between approximately 0.5. and 5, preferably between 1 and 3 mm.

The granules can be used to improve the taste and / or the shelf life and to facilitate consumption can be provided with any coatings. this is advantageously done by applying a coating in the usual way using sugar or sugar substitutes or by other customary methods, e.g. by spraying on. For wrapping can all common substances permitted by food law are used will. Is an enrichment with vitamins, minerals, trace elements or other active ingredients or to improve the taste with aromatic substances if desired, these can be incorporated into the coatings will. A vitamin-containing coating, for example, is particularly beneficial from a nutritional point of view, which covers all of the essentials of life Contains vitamins, and / or a coating, to protect the granules and to achieve a smooth surface to facilitate consumption is applied. Are sugar substitutes used instead of sugar during the manufacture of the coating such as sorbitol, xylitol or mannitol used, sweeteners can be added to increase the sweetening power. In principle, they are all coating coatings that are also suitable for other foods or pharmaceutical preparations possible.

030009/004 1

The granules can also contain auxiliaries, for example binders and disintegrants such as starch, lubricants such as alginic acid, adipic acid or their salts.

The dietetic can be taken dry or, for example, with cold or hot water, of course also together with other beverages or foods that should be as low in calories as possible, e.g. with fruit or Vegetable juices such as orange, lemon, currant, tomato or carrot juice; Milk, especially skimmed or buttermilk; Coffee or tea; lean broth; Applesauce or yogurt.

A single dose of the dietetic according to the invention, which is to be taken instead of a meal, contains expediently about 15 to 40, expediently 20 to 30 g of soy protein (corresponding to 80-120 calories) and accordingly about 0.4 to 1.2, expediently 0.5 to 1 g of pectin. With three meals a day, this corresponds to a daily dose of preferably about 60 to 90 g of soy protein and 1.5 to 3 g of pectin.

The single dose also contains appropriately

1500 to 2500 (preferably 2000) international

Units of vitamin A,

0.3 to 0.7 (preferably 0.5) mg of vitamin B 1,

0.5 to 1 (preferably 0.75) mg of vitamin B 2,

0.5 to 1 (preferably 0.75) mg vitamin B 6,

1.2 to 3 (preferably 2); ug vitamin B 12,

20 to 60 (preferably 35) mg vitamin C,

5 to 20 (preferably 12) mg vitamin E,

3 to 10 (preferably 5) mg nicotinic acid amide,

2 to 8 (preferably 4) mg pantothenic acid

Ö30ü09 / 0 £ H

. (expediently in the form of their calcium salt) -,

0.1 to 0.2 (preferably 0.15) mg of folic acid; 200 to 500 (preferably 350) mg calcium in

Form of calcium salts,

3 to 10 (preferably 5) mg of iron in the form

of iron salts.

example 1 granules I. kg Composition: kg Soy protein 70% 29 ,1 kg Citrus pectin 0 , 9 Sucrose 3 , 0

33.0 kg

The raw material powders are mixed with water in a fluidized bed dryer spray-granulated (inlet temperature 60 ⁰ C). For use, the dried granules are stirred into suitable carriers (e.g. water, juice, yoghurt, soup) and taken. Egg dose: 33 g.

Example 2 granules II kg Composition: kg Soy protein 70% 29 ,1 Citrus pectin 0 , 9

30.0 kg

The substances are mixed in a mixer and added water in portions (55 1 to 50 kg). The moist mass is added to a roller granulating machine a sausage granulate (length of the particles about 2mm,

030009/0041

Diameter about 1.5 mm) processed, dried in the fluidized bed at 60 C and gi
No. 4; Mesh size about 0.8 mm).

layer dried at 60 ° C and sieved (sieve insert

Example 3: Coated granules

Composition:

Raw granulate according to Example 2 30.00 kg

Beet sugar 9.54 kg

Citric acid 0.06 kg

Methyl cellulose 0.40 kg

40.00 kg

The raw granulate is sprayed in the fluidized bed with an aqueous solution of sugar, citric acid and methyl cellulose (inlet temperature 80 C).
Single dose: 40 g.

Example 4: coated granules with vitamins

Composition:

Raw granulate according to Example 2 12.00 kg

Beet sugar 3.20 kg

Vitamin-mineral salt mixture 0.60 kg

Cocoa powder 0.20 kg

16 _r 00 kg

The raw granulate is moistened with sugar syrup in the coating pan and the vitamin-mineral salt mixture is sprinkled. The jobs are then repeated using a sugar-cocoa mixture.
Single dose: 40 g.

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The above-mentioned vitamin-mineral salt mixture has the following Z üs amine settlement:

2/8 g vitamin A acetate, 0.2 g thiamine mononitrate, 0.12 g Riboflavin, 0.4 g pyridoxole hydrochloride, 0.2 mg cyanocobalamin, 0.04 g folic acid, 1.2 g calcium D - (+) - pantothe- • nat, 1.6 g nicotinic acid amide, 12 g ascorbic acid, 12 g Vitamin E dry powder (25%), 21.48 g calcium hydrogen phosphate, 0.16 g copper sulphate, 8 g iron (II) sulphate, 8 g basic magnesium carbonate and 532 g beet sugar.

Example 5: granules

A mixture of 29 kg soybean protein, 0.8 kg apple dry pectin, 2.5 kg of sorbitol and 0.5 kg of flavorings are ground (particle size: about 50 to 200; u), through a rapid sieve (sieve size 4). given, mixed and sieved again. Then the powder mixture is with an approx. 50 warm solution of 160 g pectin and 40 g Sorbitol spray granulated in 8 l of water in a fluidized bed dryer.

The dry granules (single dose: 33 g) stirred into cold or warm water or taken in spoonfuls with liquid (at least 150 ml Liquid). -

Sorbitol can be replaced by the same amount of beet sugar, glucose, fructose, mannitol, or xylitol Glycerin.

Example 6: Granules

The procedure is as in Example 5, but instead of the pectin-sorbitol solution, pure pectin-sorbitol solution is used for the spray granulation Water.

030009 / 00-41

Claims (3)

Merck Patent Society
with limited liability
Darmstadt Claims 1, hypo-ß-lipoproteinemic dietetic, containing soy protein and pectin, characterized in,
that it is in granular form and about 2 to Contains 3 percent by weight of pectin, based on the dry weight of the finished preparation. 2. Process for the preparation of a hypo-ß-lipoproteinemic Dietetic, characterized in that a mixture containing soy protein and about 2 to 3 percent by weight of pectin (based on the dry weight of the finished preparation) to form a granulate processed. 3. Using a soy protein and about 2 to 3 Percentage by weight of pectin (based on the dry matter; weight of the finished preparation) containing granules , as a hypo-ß-lipoproteinemic dietetic. 030009/0041