NL7905993A - HYPO-BETA-LIPOPROTEINEMIC DIETECTIC, METHOD FOR THE PREPARATION AND USE THEREOF. - Google Patents

Description

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Merck Patent Gesellschart mit beschaktter Haftung,

Darmstadt, Federal Republic of Germany.

Eypo / 3-lipoproteinemic dietetic, process for its preparation and use.

The invention relates to a new hypo- / 3-lipoproteinemic dietetic containing vegetable protein and pectin, and to a process for the preparation and use thereof.

It is known that vegetable proteins, in particular soy protein (soybean protein), in contrast to proteins of animal origin, lower an elevated serum cholesterol level in animals and humans. In addition, they have proven to be useful in achieving weight reduction.

It is further known that pectin also effects a moderate reduction of an elevated cholesterol level. In addition to this activity, pectin also exhibits other therapeutically beneficial properties, e.g. administration of pectin shortens the gastrointestinal transit time, increases the gastrointestinal tone and thereby decreases the feeling of hunger, prevents digestive disorders such as constipation and decomposition, and adsorption of toxic intestinal ingredients. Pectin may therefore serve for the prophylaxis of gallstone diseases and of colonic diverticulosis.

Torch is known as a "cholesterol-minus diet" in powder form, which in addition to whole soy also contains apple pectin, which, however, contains a very high fat content (11 g in 100 g of product). In the available powder form, it is difficult to swallow and swallow.

It has now been found that the intake of a combination of soy protein and about 2-3 wt% pectin (based on the dry weight of the ready-to-use formulation), which is available in granular form, is unexpectedly better than a intake of the individual 7905993 <i ♦ * / j --2 * components and. also. "is better than. the intake of the well-known" cholesterol-minus diet "Thus, the combination achieves stronger cholesterol-level reductions. The cholesterol level decrease is mainly charged to it. DDL (low density lipoprotein) cholesterol level. It can be concluded from this that the particularly atherogenic LDL lipoprotein levels are also lowered. In addition, elevated triglyceride levels are also lowered. The overload of the pepsin / trypsin system by a high protein diet alone is prevented or at least reduced by the use of the combination. The pec-10 tin component of the combination swells up in the gastrointestinal tract, reducing both the feeling of hunger and an effect necessary for digestion. Therefore, the combination can be used as a slimming diet in patients with a. become overweight. It is compared to other known cholesterol— 1? mirror-lowering agents particularly well tolerated.

Due to its granular form, the new dietetic can be taken much more easily than the well-known "cholesterol-minus diet". It can be swallowed or chewed with or without liquid, whereby the acceptance properties of the pectin 20, which are disturbing acceptance, do not become noticeable due to the particularly advantageous preparation form. Thanks to the much lower fat content, the new dietetic is also physiologically more favorable than the known dietary powder.

The subject of the invention is therefore a hypo / 3-lipo-proteinemetic dietetic, containing soy protein and pectin, characterized in that it is available in granular form and about 2-3% by weight of pectin, based on the dry weight of the ready-to-use preparation.

The dietetic advantageously has a content of about 1 + 5 - 90 wt% pure protein and about 2 - 3 wt% pectin.

As soy protein, commercially available products with protein contents of e.g. 60 - 90% by weight are used. Therefore, the dietetic agent conveniently has a content of about 70-97% by weight of soy protein (commercially available preparation).

Citrus pectin is preferably used as pectin, and apple-dry pectin is also suitable.

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The dietetic according to the invention may additionally contain other active substances, in particular one or more vitamins and / or one or more inorganic salts.

In the first instance, as vitamins are considered: vitamin A 5 and its derivatives, e.g. the esters such as vitamin A palmate; vitamin B1 and its derivatives (e.g., its salts, such as the chloride hydrochloride or the nitrate); vitamin B2 and its derivatives (e.g., its esters, such as riboflavin-5'-phosphoric acid ester); vitamin B6 and its derivatives (e.g., its salts, such as pyridoxine hydrochloride); vitamin B12 and its derivatives (e.g. hydroxocobalamin); biotin; nicotinic acid and its derivatives, e.g. nieotin amide; folic acid and its derivatives; pantothenic acid and its derivatives, e.g. the salts such as sodium c- or calcium pantothenate; panthenol; ascorbic acid (vitamin C) and its salts, e.g., sodium, calcium or iron (H) ascorhate; .

vitamin E and its derivatives, e.g. oC-tocopherol acetate, o -tocopherol succinate; rutin and its derivatives, e.g. rutoside sulfuric acid ester sodium salts; vitamin D2. and D3 and its derivatives; vitamin K and its derivatives, e.g. menadiol diacetate.

As inorganic salts, the salts of potassium, e.g. potassium chloride, citrate; magnesium, e.g. basic magnesium carbonate, magnesium sulfate, citrate, levulinate, hydrogen phosphate; calcium, e.g. calcium citrate, fluoride, hydrogen phosphate, gluconate, lactate gluconate, lactobionate; ko-25 per, e.g. copper sulfate, gluconate; zinc, e.g. zinc sulfate; molybdenum, e.g. sodium molybdate; manganese, e.g. manganese chloride, sulfate, gluconate; iron, e.g. iron (H) ascorbate, gluconate, fumarate, phosphate, sulfate; cobalt, e.g. cobalt chloride, sulfate, gluconate; phosphorus, e.g. disodium hydrogen phosphate.

The dietetic according to the invention may additionally also contain additives, e.g. taste corrective agents. As such, e.g. sugar, such as dextrose (sucrose), glucose, fructose, lactose, sugar substitutes, such as sorbitol, mannitol, xylytol, glycerol, or sweeteners, such as saccharin and its salts, e.g.

Sodium saccharinate; taste-enhancing acids, such as citric or tartaric acid; spices and flavorings.

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The object of the invention is also a method for preparing a hypo- / 3-lipoproteinemic dietetic, characterized in that a mixture containing soy protein and about 2-3 wt. Pectin (calculated on the dry weight of the consumption) is used. 5 ready-to-use formulation).

Finally, subject of the; Invention the use of a soy protein and about 2-3 parts of pectin (calculated on the dry weight of the ready-to-use formulation) containing granulate as a hypo- / lipoproteinemic dietetic.

The granulate can be prepared from the mixture of the ingredients by conventional granulation methods (eg, using a granulation roller or by spray granulation, granulation or calendering).

The granulates expediently have particle sizes of about 0.5-5, preferably 1-3 mm.

The granulates can improve the taste and / or the shelf life and to facilitate. the digestion with arbitrary ·. coverings are provided. This is done in an advantageous manner; by ordering an enclosure in the usual manner using sugar or sugar substitutes. » or also by other conventional methods, e.g. by spraying. All conventional foodstuffs which are permissible under law can be used for the coating. If an enrichment with vitamins, inorganic substances, trace elements or other active substances or also for improving the taste with flavoring substances is desired, these can be incorporated in the coatings. Nutritional physiology is particularly advantageous e.g. a vitamin-containing coating, containing all leyens-necessary vitamins, and / or a drape coat, which is applied for the protection of the granules and for obtaining a smooth surface for facilitating digestion. If sugar substitutes such as sorbitol, xylytol or mannitol are used instead of sugar in the preparation of the drape jacket, sweetening agents may be added to enhance the sweetening power. In principle, all coating coatings which are also suitable for other foodstuffs or pharmaceutical preparations can be used.

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The granulates can, to vend! and excipients, e.g. bind explosives such as starch, lubricants such as alginic acid, adipic acid or its salts.

The dietetic can be dry or e.g. are taken with cold or warm water, of course also together with other drinks or foodstuffs, which are preferably as low in calories as possible, e.g. with fruit or vegetable juices, such as orange, lemon, currant, tomato or carrot juice; milk, in particular skimmed milk or buttermilk; coffee or tea; lean meat broth; apple sauce or yogurt.

A single dose of the dietetic according to the invention, which is preferably taken in place of a meal, expediently contains about 15-4o, preferably 20-30g of soy protein (corresponding to 80-120 calories) and consequently about 0 , 4 - 1.2, - preferably 0.5 - 1 g of pectin. With three meals a day, this corresponds to a daily dose of preferably about 60 - 90 g of soy protein and 1.5 - 3 g of pectin.

The separate dose advantageously additionally contains 1500 - 2500 (preferably 2000) interaational units of vitamin A, 0.3 - 0.7 (preferably 0.5) mg of vitamin B1, 0.5 - 1 (preferably 0.73 ) mg of vitamin B2, 0.5 - 1 (preferably 0.75) mg of vitamin B6, 1.2 - 3 (preferably 2) yg of vitamin B12, 20 - 60 (preferably 35) mg of vitamin C, 5-20 (preferably 12) mg of vitamin E, 3 - 10 (preferably 5) mg of nictonic acid amide, 2 - 8 (preferably 4) mg of pantothenic acid (expediently in the form of its calcium salt), 0.1 - 0.2 (at preferably 0.15) mg of folic acid, 200-500 (preferably 350) mg of calcium in the form of calcium salts, 3-10 (preferably 5) mg of iron in the form of iron salts-Example I Granules I:

Composition: 35 soy protein J0% 29.1 kg

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- 6 ~ i -c citrus pectin 0.9 kg sucrose. 3.0 kg and 33.0 kg. The starting powder was mixed / mixed with water. a fluidized bed dryer is spray granulated (inlet temperature 60 ° C). Before use, the dried granulate was stirred in suitable carriers (e.g., water, juice, yogurt, soup) and taken up.

Separate dose: 33 g

Example II 10 Granulate IX:

Composition: soy protein 70% 29.1 kg citrus pectin 0.9 kg 30.0 kg 15 The materials were mixed in a mixing kneader and added portionwise (55 dm @ 50 kg). roll granulator into a sausage granulate (length of the particles about 2 mm, diameter about 1.5 mm) processed through the fluidized layer at 60 ° C, and sieved (sieve ITo.V; mesh size about 0.8 mm).

Example ΙΙΓ '

Coated granulate:

Composition: granulate according to example II 30.00 kg 25 rapeseed 9.5 ** kg citric acid 0.06 kg methyl cellulose Q, U0 kg 1 + 0.00 kg

The untreated granulate was sprayed into the swirl layer with an aqueous solution of sugar, citric acid and methyl cellulose (entry temperature 80 ° 0).

Separate dose: g.

Example IV

Coated granulate with vitamins: 35 Composition: 7905995 "7 ~ untreated granulate according to example II 12.00 kg rapeseed 3.20 kg vitamin mineral salt mixture 0.60 kg cocoa powder 0.20 kg 5 ΐβ, ΟΟ kg

The untreated granulate was moistened with sugar syrup in a drainer and the vitamin mineral salt mixture was sprinkled on.

The application was subsequently repeated using a sugar-cocoa mixture.

10 Separate dose: HO g.

The said vitamin amine mineral eel salt mixture had the following composition: 2.8 g of vitamin A acetate, 0.2 g of thiamine mononitrate, 0.12 g of riboflavin, 0.1 * g of pyridoxol hydrochloride, 0 , 2 mg cyanocobalamin, X5 0.0k g folic acid, 1.2 g calcium D - (+) pantothenate, 1.6 g nicotinic amide, 12 g ascorbic acid »12 g vitamin E dry powder (25 #'s 21.1 * 8 g of calcium hydrogen phosphate, 0.16 g of copper sulfate, 8 g of iron (II) sulfate, 8 g of basic magnesium carbonate and 532 g of rapeseed.

Example V 20 Granulate:

A mixture of 29 kg of soybean protein, 0.8 g of apple-dry pectin, 2.5 kg of sorbitol and 0.5 kg of flavoring substances was ground (particle size: about 50-200 y), passed through a high speed screen (sieve size 1 *), mixed and sieved again. Subsequently, the powder mixture 25 was mixed with an approximately 50 ° C warm solution of 160 g pectin and 1 * 0 g sorbi-

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toll in 8 dm water sprayed in a soft bed dryer.

Before use, the dry granulate (individual dose: 33 g) was stirred in cold or warm water or using a

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spoon with a liquid (at least 150 cnr liquid).

Sorbitol can be replaced with the same amounts of turnip sugar, glucose, fructose, mannitol, xylytol or glycerol.

Example VI Granulate:

The procedure was carried out according to Example V, but pure water was used instead of the pectin-sorbitol solution for the spray granulation.

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Claims (1)

3 · Application of a. soy protein and about 2-3 parts by weight (calculated on the dry surface of the ready-to-use formulation) containing granulate as hypo-lipoproteinemic dietetic agent. 7905993