DE2759166A1 - Grease-based suppositories prodn. for rectal or vaginal admin. - comprises dispersing gelatin-encapsulated drugs in base contained in mould prior to its hardening - Google Patents

Abstract

Pharmaceuticals which may be incompatible, with the grease base of a suppository, are encapsulated in gelatin prior to dispersion in the base. The base is contained in moulds and the capsules are dispersed therein before hardening. Used for rectal or vaginal admin.

Description

Method of making suppositories

for rectal or vaginal application to avoid incompatibilities the active ingredients and to improve the absorption of the active ingredients The invention relates to a process for the preparation of suppositories for rectal or vaginal Application to avoid incompatibilities of the active ingredients and to improve the absorption of the active ingredients. The rectal or vaginal application of active ingredients is generally made in the form of suppositories made on the basis of special Fats are built up such as hard fat D.A.B. 7, a mixture of triglycerides of fatty acids C12 - C13 with small amounts of di- and monoglycerides. There are however, other similar fat-like suppository compositions are in use.

The production of such dosage forms is generally carried out in the Way that the fatty masses are melted the active ingredients in the melted Mass are incorporated and the mixture is finally poured into suitable molds will. However, this method is often limited by two factors. Once There may be undesirable reactions between the active ingredients or the suppository mass coming For example, acidic substances can react with the salt of a less acidic ingredient.

However, other incompatibilities are also possible. On the other hand the linear conduction of active substances into fat-like masses is common, of medicinal substance different to drug, not optimal for rectal or vaginal absorption. The invention avoids these disadvantages of the conventional fat-based ones Guppositories.

The invention consists in that when pouring out the fat-like suppository masses a gelatin capsule is embedded in the still liquid mass, which contains an active ingredient Contains in solid or dissolved form. This is achieved once that it as a result the spatial separation does not lead to undesirable reactions between the active ingredients of the drug carrier or with the drug carrier itself. On the other hand In this way it is possible for each active substance to determine its absorption best excipients to use. For example, it is possible to enter the fat-like suppository mass to incorporate such active ingredients that best from this are absorbed, in the gelatin capsule, however, such active substances, their absorption is best done in solid form or in the form of suitable solutions.

The following examples illustrate the invention: Example 1 In a common fat-like suppository mass is made with any drug acidic character incorporated and poured the mass into molds. Before solidifying the suppository mass is embedded in a gelatin capsule, which is filled with the salt less acidic acid such as theophylline ethylenediamine or Phenobarbital Na.

Example 2 In a conventional fat-based suppository mass any medicinal substance is incorporated and the mass is poured into molds. Before the suppository mass solidifies, a gelatin capsule is embedded which contains an active ingredient dissolved in polyethylene glycol.

Composition of formulas theophylline-ethylenediamine Phenobarbital Na

Claims (1)

Claim Process for the production of fat-based suppositories for rectal or vaginal application with the aim of avoiding incompatibilities the active ingredients with each other or the active ingredient carrier and for better absorption of the active ingredients characterized in that they have not yet solidified in their forms Suppository masses are embedded in gelatin capsules with solid or dissolved Active ingredients are filled.