DE270672C - - Google Patents
Info
- Publication number
- DE270672C DE270672C DENDAT270672D DE270672DA DE270672C DE 270672 C DE270672 C DE 270672C DE NDAT270672 D DENDAT270672 D DE NDAT270672D DE 270672D A DE270672D A DE 270672DA DE 270672 C DE270672 C DE 270672C
- Authority
- DE
- Germany
- Prior art keywords
- solutions
- solution
- formaldehyde sulfoxylate
- dioxyarsenobenzene
- diamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical class OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims description 5
- 229940017705 formaldehyde sulfoxylate Drugs 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 241000031711 Cytophagaceae Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- SBGKURINHGJRFN-UHFFFAOYSA-N hydroxymethanesulfinic acid Chemical compound OCS(O)=O SBGKURINHGJRFN-UHFFFAOYSA-N 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/66—Arsenic compounds
- C07F9/70—Organo-arsenic compounds
- C07F9/74—Aromatic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
- JVl 270672 -KLASSE 30 h. GRUPPE - JVl 270672 - CLASS 30 h. GROUP
Formaldehydsulfoxylatlösungen.Formaldehyde sulfoxylate solutions.
Patentiert im Deutschen Reiche vom 26. Oktober 1912 ab.Patented in the German Empire on October 26, 1912.
Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Haltbarmachung von Lösungen des 3 · 31-Diamino-4 · 4x-dioxyarsenobenzol-Formaldehydsulfoxylats. The present invention relates to a process for preserving solutions of 3 × 3 1 -diamino-4 × 4 × -dioxyarsenobenzene-formaldehyde sulfoxylate.
Man hat es als einen großen Mißstand empfunden, daß diese wäßrigen Lösungen sich nach kurzer Zeit zersetzen, so daß sie sowohl bei subkutanen Einspritzungen als auch bei der neuerdings empfohlenen lokalen Anwendung völlig unbrauchbar werden und infolgedessen giftig wirken. Es ist nun gefunden worden, daß bei Verwendung von Salzen der schwefligen Säure die Haltbarkeit einer solchen Lösung eine weit größere ist als ohne diese Zusätze. Gute Erfolge sind erzielt worden, wenn man z. B. einer wäßrigen Lösung von 0,3 T. 3 · 3 * - Diamino - 4 · 41 - dioxyarsenobenzol-Formaldehydsulfoxylat : 100,0 aqua destillata gleiche Mengen einer 5prozentigen Natriumsulfitlösung beimischt.It has been found to be a great disadvantage that these aqueous solutions decompose after a short time so that they are completely useless both in the case of subcutaneous injections and in the recently recommended local application and are consequently toxic. It has now been found that when salts of sulphurous acid are used, the shelf life of such a solution is far greater than without these additives. Good results have been achieved when z. B. an aqueous solution of 0.3 T. 3 · 3 * - diamino - 4 · 4 1 - dioxyarsenobenzene-formaldehyde sulfoxylate: 100.0 aqua distillata mixed in equal amounts of a 5 percent sodium sulfite solution.
Zur Injektion geeignete, haltbare Lösungen können schon mit sehr geringen Mengen Sulfit hergestellt werden. So wirkt bei verdünnter Lösung schon ein Zusatz von 0,1 Prozent Sulfit für einige Zeit konservierend. Bei Anwendung einer konzentrierten Lösung wird man die Menge des Sulfits erhöhen, und zwar kann man ruhig bis zur Hälfte der absoluten Menge des angewandten 3 · 31 - Diamino-4 · 41 - dioxyarsenobenzol - Formaldehydsulfoxylats gehen, da dadurch die Giftigkeit der Lösung noch nicht gesteigert wird.Stable solutions suitable for injection can be made with very small amounts of sulfite. With a dilute solution, an addition of 0.1 percent sulfite has a preservative effect for some time. If a concentrated solution is used, the amount of sulfite will be increased, and you can go up to half of the absolute amount of the 3 · 3 1 - diamino-4 · 4 1 - dioxyarsenobenzene - formaldehyde sulfoxylate used, as this reduces the toxicity of the solution is not increased.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE270672C true DE270672C (en) | 1900-01-01 |
Family
ID=527395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT270672D Expired DE270672C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE270672C (en) |
-
0
- DE DENDAT270672D patent/DE270672C/de not_active Expired
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