DE267219C - - Google Patents
Info
- Publication number
- DE267219C DE267219C DENDAT267219D DE267219DC DE267219C DE 267219 C DE267219 C DE 267219C DE NDAT267219 D DENDAT267219 D DE NDAT267219D DE 267219D C DE267219D C DE 267219DC DE 267219 C DE267219 C DE 267219C
- Authority
- DE
- Germany
- Prior art keywords
- alkaloids
- salts
- ether
- root
- chloroform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229930013930 alkaloids Natural products 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- HEDRZPFGACZZDS-UHFFFAOYSA-N chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 6
- VZGDMQKNWNREIO-UHFFFAOYSA-N Carbon tetrachloride Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229930012976 ipecacuanha alkaloids Natural products 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000012261 resinous substance Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 240000000306 Carapichea ipecacuanha Species 0.000 description 1
- 241000031711 Cytophagaceae Species 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000001476 alcoholic Effects 0.000 description 1
- DTGZHCFJNDAHEN-OZEXIGSWSA-N cephaeline Chemical compound N1CCC2=CC(O)=C(OC)C=C2[C@H]1C[C@H]1C[C@H]2C3=CC(OC)=C(OC)C=C3CCN2C[C@@H]1CC DTGZHCFJNDAHEN-OZEXIGSWSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000000095 emetic Effects 0.000 description 1
- 239000002895 emetic Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 229960005208 ipecacuanha Drugs 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G5/00—Alkaloids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Description
DEUTSCHES REICHGERMAN EMPIRE
REICHSPATENTAMTREICH PATENT OFFICE
PATENTSCHRIFTPATENT LETTERING
- M 267219-KLASSE 30 h. GRUPPE- M 267219 CLASS 30 h. GROUP
CHEMISCHE WERKE vorm. Dr. HEINRICH BYK in LEHNITZ, Nordbahn.CHEMICAL WORKS vorm. Dr. HEINRICH BYK in LEHNITZ, northern line.
Verfahren zur Gewinnung der Gesamtalkaloide der Brechwurzel. Patentiert im Deutschen Reiche vom 5.JuIi 1912 ab. Process for the extraction of the total alkaloids of the root. Patented in the German Empire on July 5, 1912.
Für die Darstellung der Alkaloide der Brechwurzel sind mehrere Verfahren bekannt, die sämtlich ziemlich umständlich sind und zum Teil - auf die Zersetzlichkeit der Alkaloide, insbesondere des Cephaelins, nicht die nötige Rücksicht nehmen.Several methods are known for the preparation of the alkaloids of the root all of them are rather cumbersome and in part - due to the decomposition of the alkaloids, especially of the Cephaelin, do not take the necessary consideration.
Es wurde nun gefunden, daß sich die Gesamtalkaloide der Ipecacuanha in Form, ihrer Salze nach dem folgenden Verfahren gewinnenIt has now been found that the total alkaloids of Ipecacuanha are in the form of their Obtain salts using the following procedure
ίο lassen, das weit einfacher ist als die bisher bekannten Methoden und zudem die Möglichkeit einer Zersetzung der wirksamen Alkaloide . völlig ausschließt.ίο let that is far easier than before known methods and also the possibility of decomposition of the effective alkaloids. completely excludes.
Das Verfahren gründet sich auf die merkwürdige, bisher nicht bekannte Tatsache, daß die Salze der Ipecacuanha-Alkaloide, insbesondere die Hydrochloride, in gewissen organischen Lösungsmitteln, wie Chloroform, Tetrachlorkohlenstoff, Benzol oder ähnliche Lösungsmittel, entweder ohne weiteres löslich sind oder doch in Mischungen von derartigen Lösungsmitteln · mit wenig Alkohol sich leicht auflösen; aus diesen Lösungen fallen die Salze der Alkaloide auf Zusatz von Äther oder Petroläther aus.The method is based on the strange, previously unknown fact that the salts of the ipecacuanha alkaloids, especially the hydrochlorides, are either readily soluble in certain organic solvents such as chloroform, carbon tetrachloride, benzene or similar solvents, or at least in mixtures of Such solvents · dissolve easily with little alcohol; From these solutions the salts of the alkaloids precipitate on the addition of ether or petroleum ether.
Man perkoliert z. B. gepulverte Brechwurzel mit einer Mischung von 95 Teilen Chloroform und 5 Teilen alkoholischer Salzsäure von 7 Prozent H Cl. Das gelbbraune Perkolat ver-One percolates z. B. powdered emetic root with a mixture of 95 parts of chloroform and 5 parts of alcoholic hydrochloric acid of 7 percent HCl. The yellow-brown percolate
mischt man mit der I1Z2 fachen Menge Äther, wodurch sich die salzsauren Salze der Ipecacuanha-Alkaloide als fast weißes Pulver abscheiden. Die so gewonnenen Salze sind in Wasser nicht ganz klar löslich, da bei ihrer Ausfällung durch Äther etwas harzartige Substanz mit niedergerissen wird. Diese harzartigen Substanzen können dadurch entfernt werden, daß man die trockenen Älkaloidsalze einige Zeit mit Essigäther auszieht, wobei die Verunreinigungen von Essigester gelöst werden. Man kann die Entfernung der harzartigen Bestandteile auch in der Weise bewirken, daß man das Produkt in wenig Wasser löst, die Verunreinigungen abfiltriert und das FiI-trat unter Lichtabschluß eindunstet.mixed with I 1 Z 2 times the amount of ether, whereby the hydrochloric acid salts of the Ipecacuanha alkaloids separate out as an almost white powder. The salts obtained in this way are not completely soluble in water, since some resinous substance is torn down by ether when they are precipitated. These resinous substances can be removed by extracting the dry alkaloids salts for some time with ethyl acetate, the impurities being dissolved by ethyl acetate. The resin-like constituents can also be removed by dissolving the product in a little water, filtering off the impurities and evaporating the filtrate in the dark.
Die Vorteile des neuen Verfahrens gegenüber den bisher bekannten bestehen neben der größeren Einfachheit darin, daß die Verwendung von Alkalien sowie jegliches Erwärmen vermieden wird, wodurch Zersetzungen der empfindlichen Alkaloide nach Möglichkeit vorgebeugt ist.The advantages of the new process over the previously known ones exist alongside the greater simplicity in that the use of alkalis as well as any heating is avoided, thereby decomposing the sensitive alkaloids if possible is prevented.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE267219C true DE267219C (en) |
Family
ID=524297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT267219D Active DE267219C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE267219C (en) |
-
0
- DE DENDAT267219D patent/DE267219C/de active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE267219C (en) | ||
| AT69244B (en) | Process for the extraction of the total alkaloids of the root. | |
| DE265852C (en) | ||
| DE1570586A1 (en) | Process for the production of solid poly-2-vinylpyridine-N-oxide | |
| DE263350C (en) | ||
| DE383480C (en) | Process for the preparation of a highly concentrated dry digital extract containing the total glycosides of the digitalis leaves | |
| DE722869C (en) | Process for upgrading coumarone resins | |
| DE574803C (en) | Process for the preparation of water-soluble depolymerization products of high molecular weight carbohydrates | |
| DE873699C (en) | Process for the preparation of oxygen-rich derivatives of unsaturated compounds of the androstane and pregnane series | |
| DE254438C (en) | ||
| AT69637B (en) | Process for the preparation of therapeutically active substances. | |
| DE310875C (en) | ||
| DE197154C (en) | Process for the preparation of rubber milk-like, filterable liquids from old rubber or rubber waste. | |
| DE86096C (en) | ||
| DE87098C (en) | ||
| DE202799C (en) | ||
| DE69250C (en) | Process for the preparation of O-amidoditolylamine | |
| DE269261C (en) | ||
| DE86334C (en) | ||
| DE660382C (en) | Process for the preparation and purification of OEstradiol | |
| DE839354C (en) | Process for the preparation of 3-oxy-í¸-12-alkoxycholenic acid alkyl esters from the corresponding 12-keto compounds | |
| DE89696C (en) | ||
| DE704818C (en) | Process for the preparation of pregnanolone degradation products | |
| DE331285C (en) | Method for removing tissue impregnations | |
| DE236988C (en) |