DE2541685A1 - PROCESS FOR ENABLING THE RESORPTION OF ACTIVE SUBSTANCES FROM THE GOMARINAL CANAL WHICH USUALLY ARE NOT EFFECTIVE BY OS OR ANUM - Google Patents

PROCESS FOR ENABLING THE RESORPTION OF ACTIVE SUBSTANCES FROM THE GOMARINAL CANAL WHICH USUALLY ARE NOT EFFECTIVE BY OS OR ANUM

Info

Publication number
DE2541685A1
DE2541685A1 DE19752541685 DE2541685A DE2541685A1 DE 2541685 A1 DE2541685 A1 DE 2541685A1 DE 19752541685 DE19752541685 DE 19752541685 DE 2541685 A DE2541685 A DE 2541685A DE 2541685 A1 DE2541685 A1 DE 2541685A1
Authority
DE
Germany
Prior art keywords
enabling
usually
active substances
anum
microorganisms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19752541685
Other languages
German (de)
Inventor
Johann Baptist Prof Dr M Mayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TOEPFER GmbH
Original Assignee
TOEPFER GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TOEPFER GmbH filed Critical TOEPFER GmbH
Priority to DE19752541685 priority Critical patent/DE2541685A1/en
Priority to AT673176A priority patent/AT355716B/en
Priority to NL7610260A priority patent/NL7610260A/en
Priority to BE170727A priority patent/BE846331A/en
Priority to FR7628048A priority patent/FR2324312A1/en
Priority to DK421176A priority patent/DK421176A/en
Publication of DE2541685A1 publication Critical patent/DE2541685A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Description

Beschreibungdescription

Es ist allgemein bekannt, daß gewisse in der Therapie verwendete Wirkstoffe wie z.B. Hormone oder Permente im Magendarmkanal nicht resorbiert und deshalb nicht mit Erfolg oral oder rektal verabreicht werden können. Die vorliegende Erfindung erreicht die Resorption jedoch durch Inkorporierung solcher Wirkstoffe in Mikroorganismen und oraler oder rektaler Verabreichung derselben.It is well known that certain drugs used in therapy, such as hormones or permeates in the gastrointestinal canal not absorbed and therefore not with success orally or rectally can be administered. However, the present invention achieves absorption by Incorporation of such active ingredients in microorganisms and oral or rectal administration the same.

Beispiel:Example:

Man züchtet z.B. Lactobacillus bifidus, isoliert die Bakterien von der Nährlösung, vermischt sie mit Insulin, läßt sie eine gewisse Zeit stehen und verabreicht das ganze oral.For example, Lactobacillus bifidus is grown, the bacteria are isolated from the nutrient solution, and they are mixed with insulin, she lets it stand for a while and gives the whole thing orally.

Es ist auch möglich, die Bakterien vor der Insulinbehandlung schonend zu trocknen. Es ist weiter möglich, ohne oder mit vorausgegangener Trocknung der Bakterien, das Gesamtpräparat schonend zu trocknen.It is also possible to gently dry the bacteria before the insulin treatment. It is further possible, with or without prior drying of the bacteria, the entire preparation to dry gently.

709812/1046709812/1046

Claims (2)

χ- cj ti wj χ- cj ti wj β?« DiEIMAJINSUEO W AU6Ä8β? «DiEIMAJINSUEO W AU6Ä8 Patentanspruch J NACHGF;.r--.:'.,-:7r| Claim J NACHGF; .r --.:'.,-: 7r | Verfahren zur Herstellung von oral oder anal wirksamen Arzneimitteln und Futterzusatzstoffen, deren Wirkstoffe oral oder anal verabreicht, unverändert oder auch durch Umhüllung bekannter Art geschützt, bisher keine Wirksamkeit zeigten,Process for the production of orally or anally effective drugs and feed additives, whose active ingredients are administered orally or anally, unchanged or protected by wrapping of a known type, have so far not shown any effectiveness, dadurch gekennzeichnet:characterized: daß die Wirksamkeit solcher Wirkstoffe durch eine Inkorporierung dieser in Mikroorganismen, auch bei oraler oder analer Verabreichung aufrechterhalten wird.that the effectiveness of such active ingredients by incorporating them in Microorganisms, even when administered orally or anally, is maintained. UnteransprücheSubclaims Verfahren nach PatentanspruchMethod according to claim dadurch gekennzeichnet, daß die Mikroorganismen vor der Inkorporierung der Wirkstoffe getrocknet werdencharacterized in that the microorganisms prior to incorporation the active ingredients are dried 2. Verfahren nach Patentanspruch2. Method according to claim dadurch gekennzeichnet, daß das Gesamtpräparat, mit oder ohne vorausgegangene Trocknung der Mikroorganismen, getrocknet wird*characterized in that the entire preparation, with or without prior drying of the microorganisms, is dried * ORIGINAL INSPECTEDORIGINAL INSPECTED 709812/1046709812/1046 ma maumuu m alum ma maumuu m alum Verfahren zur Ermöglichung der Resorption von Wirkstoffen aus dem Magendarmkanal, die üblicherweise per os oder per anum verabreicht keine Wirksamkeit zeigenProcess for enabling the absorption of active substances from the gastrointestinal tract, which is usually when administered orally or per anum show no efficacy
DE19752541685 1975-09-18 1975-09-18 PROCESS FOR ENABLING THE RESORPTION OF ACTIVE SUBSTANCES FROM THE GOMARINAL CANAL WHICH USUALLY ARE NOT EFFECTIVE BY OS OR ANUM Withdrawn DE2541685A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE19752541685 DE2541685A1 (en) 1975-09-18 1975-09-18 PROCESS FOR ENABLING THE RESORPTION OF ACTIVE SUBSTANCES FROM THE GOMARINAL CANAL WHICH USUALLY ARE NOT EFFECTIVE BY OS OR ANUM
AT673176A AT355716B (en) 1975-09-18 1976-09-10 METHOD FOR THE PRODUCTION OF MEDICINAL PRODUCTS OR. OF FEED ADDITIVES
NL7610260A NL7610260A (en) 1975-09-18 1976-09-15 METHOD FOR THE PREPARATION OF ACTIVE MEDICINAL PRODUCTS FOR ORAL OR ANAL ADMINISTRATION.
BE170727A BE846331A (en) 1975-09-18 1976-09-17 PROCESS FOR THE PREPARATION OF ACTIVE MEDICINAL PRODUCTS BY ORAL OR ANAL APPLICATION
FR7628048A FR2324312A1 (en) 1975-09-18 1976-09-17 Active peptides for oral or rectal admin. - protected by mixing with dried microorganisms, esp. Lactobacillus bifidus
DK421176A DK421176A (en) 1975-09-18 1976-09-17 PROCEDURE FOR MANUFACTURE OF MEDICINAL PRODUCTS BY ORAL OR ANAL ADMINISTRATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752541685 DE2541685A1 (en) 1975-09-18 1975-09-18 PROCESS FOR ENABLING THE RESORPTION OF ACTIVE SUBSTANCES FROM THE GOMARINAL CANAL WHICH USUALLY ARE NOT EFFECTIVE BY OS OR ANUM

Publications (1)

Publication Number Publication Date
DE2541685A1 true DE2541685A1 (en) 1977-03-24

Family

ID=5956823

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752541685 Withdrawn DE2541685A1 (en) 1975-09-18 1975-09-18 PROCESS FOR ENABLING THE RESORPTION OF ACTIVE SUBSTANCES FROM THE GOMARINAL CANAL WHICH USUALLY ARE NOT EFFECTIVE BY OS OR ANUM

Country Status (6)

Country Link
AT (1) AT355716B (en)
BE (1) BE846331A (en)
DE (1) DE2541685A1 (en)
DK (1) DK421176A (en)
FR (1) FR2324312A1 (en)
NL (1) NL7610260A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053163A1 (en) * 1999-03-05 2000-09-14 Werner Lubitz Bacterial ghosts as carrier and targeting vehicles

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2542655B2 (en) * 1987-01-19 1996-10-09 日清製粉株式会社 Mixed feed for animals
IT1312090B1 (en) * 1999-04-22 2002-04-04 Ecoser S R L INACTIVATED MICROORGANISMS INCLUDING SOLUBLE AND / SOLUBILIZABLE SUBSTANCES FOR PHARMACOLOGICAL ACTIVITY AND / OR NUTRITIONAL SUBSTANCES
CN114146168A (en) * 2021-11-05 2022-03-08 中国科学院上海硅酸盐研究所 Microorganism inhibition composition and preparation method and application thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000053163A1 (en) * 1999-03-05 2000-09-14 Werner Lubitz Bacterial ghosts as carrier and targeting vehicles
US9763890B2 (en) 1999-03-05 2017-09-19 Werner Lubitz Bacterial ghosts as carrier and targeting vehicles

Also Published As

Publication number Publication date
AT355716B (en) 1980-03-25
NL7610260A (en) 1977-03-22
BE846331A (en) 1977-01-17
DK421176A (en) 1977-03-19
FR2324312B1 (en) 1979-02-16
FR2324312A1 (en) 1977-04-15
ATA673176A (en) 1979-08-15

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee