DE245193C - - Google Patents
Info
- Publication number
- DE245193C DE245193C DENDAT245193D DE245193DA DE245193C DE 245193 C DE245193 C DE 245193C DE NDAT245193 D DENDAT245193 D DE NDAT245193D DE 245193D A DE245193D A DE 245193DA DE 245193 C DE245193 C DE 245193C
- Authority
- DE
- Germany
- Prior art keywords
- ammonia
- ineffective
- alcoholic
- freed
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 7
- 230000001476 alcoholic Effects 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 229940092219 digitalis leaves Drugs 0.000 claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 229940079593 drugs Drugs 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000006011 modification reaction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 235000013325 dietary fiber Nutrition 0.000 description 3
- WDJUZGPOPHTGOT-XUDUSOBPSA-N Digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 description 2
- WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229940098465 Tincture Drugs 0.000 description 2
- 229960000648 digitoxin Drugs 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 241000031711 Cytophagaceae Species 0.000 description 1
- GUBGYTABKSRVRQ-UUNJERMWSA-N Lactose Natural products O([C@@H]1[C@H](O)[C@H](O)[C@H](O)O[C@@H]1CO)[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1 GUBGYTABKSRVRQ-UUNJERMWSA-N 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- -1 given above Chemical compound 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000001225 therapeutic Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
- JVl 245193 KLASSE 30h. GRUPPE- JVl 245193 CLASS 30 h. GROUP
KNOLL & CO. in LUDWIGSHAFEN a. Rh.KNOLL & CO. in LUDWIGSHAFEN a. Rh.
Verfahren zur Darstellung eines Präparats aus Digitalisblättern.Process for the representation of a specimen from digitalis leaves.
Zusatz zum Patent 227572 vom 11. Juli 1907.Addendum to patent 227572 of July 11, 1907.
Patentiert im Deutschen Reiche vom 21. August 1910 ab. Längste Dauer: 10. Juli 1922.Patented in the German Empire on August 21, 1910. Longest duration: July 10, 1922.
Das Hauptpatent 227572 betrifft ein Verfahren, wonach ein haltbares, die therapeutisch wichtigen Bestandteile der Droge enthaltendes, von unwirksamen und schädlichen Stoffen befreites Präparat aus Digitalisblättern erhalten wird, wenn der mittels hochprozentigen Alkohols gewonnene Auszug der Droge einer Behandlung mit Äther unterworfen wird. Bei dieser Behandlung werden unwirksame Ballaststoffe neben sehr geringen Mengen wirksamer Substanz ausgeschieden, während der Hauptteil der wirksamen Stoffe in die alkoholischätherische Lösung übergeht. The main patent 227572 relates to a method according to which a durable, therapeutic Containing important components of the drug, freed from ineffective and harmful substances Preparation from digitalis leaves is obtained when using high-proof alcohol The extract obtained from the drug is subjected to a treatment with ether. at This treatment will make ineffective fiber in addition to very small amounts more effective Substance excreted, while most of the active substances pass into the alcoholic-ethereal solution.
Es wurde nun bei weiterer Ausbildung dieses Verfahrens gefunden, daß diese unwirksamen Ballaststoffe durch eine Behandlung des absolut alkoholischen Auszuges mit gasförmigem Ammoniak oder mit Natrium- oder Kaliumalkoholat ebenfalls zum größten Teil entfernt werden.It has now been found with further development of this process that these are ineffective Dietary fiber through a treatment of the absolutely alcoholic extract with gaseous Ammonia or with sodium or potassium alcoholate also largely removed will.
In Hagers Handbuch der pharmazeutischen Praxis 1905, Bd. I, S. 1042 wird zwar eine durch Perkolation bereitete Tinktur vor dem Einstellen auf das richtige Gewicht mit ioprozentigern Ammoniak neutralisiert. Hierbei findet aber, da die Behandlung in wäßrigalkoholischer Lösung mit wäßrigem Ammoniak erfolgt, keine Abscheidung der Ballaststoffe statt; diese bleiben vielmehr in der Tinktur.In Hager's Handbook of Pharmaceutical Praxis 1905, Vol. I, p. 1042 is a tincture prepared by percolation before the Adjusting to the correct weight with iop percent Ammonia neutralizes. Here, however, takes place since the treatment in aqueous alcoholic Solution with aqueous ammonia takes place, no deposition of dietary fiber takes place; rather, these remain in the tincture.
Dagegen werden die Ballaststoffe beim Arbeiten nach dem vorliegenden Verfahren fast vollständig abgeschieden.On the other hand, when working according to the present method, the dietary fiber becomes almost completely deposited.
4545
10 kg feingepulverte Digitalisblätter werden einige Male mit 5 Teilen hochprozentigen Alkohols ausgezogen. Die Auszüge werden etwas eingeengt, vorteilhaft in der Luftleere, und dann erschöpfend mit gasförmigem Ammoniak behandelt. Der vom Niederschlag getrennte Auszug wird zur Entfernung von überschüssigem Ammoniak einige Zeit mit trockner Luft behandelt, unter Luftleere eingeengt, wobei das gelöste Ammoniak entweicht, und nach Zusatz von 2 Teilen Milchzucker oder eines sonst geeigneten Trägers völlig in Pulverform übergeführt.10 kg of finely powdered digitalis leaves are mixed with 5 parts of high-percentage alcohol a few times moved out. The extracts are somewhat narrowed, advantageously in the vacuum, and then treated exhaustively with gaseous ammonia. The separated from precipitation Extract is used for some time to remove excess ammonia with dry air treated, concentrated in a vacuum, whereby the dissolved ammonia escapes, and after Addition of 2 parts milk sugar or another suitable carrier completely in powder form convicted.
An Stelle des gasförmigen Ammoniaks können auch Alkalialkoholate in wasserfreien Lösungsmitteln Verwendung finden. Der alkoholische Auszug von 10 kg Digitalisblättern wird z. B. so lange mit einer 5prozentigen alkoholischen Lösung von Natriumalkoholat versetzt, als noch ein Niederschlag entsteht. Dieser wird durch Dekantieren entfernt und das überschüssige Alkali durch alkoholische Salzsäure neutralisiert. Die vom abgeschiedenen Kochsalz getrennte Lösung wird unter Luftleere eingeengt und mit Milchzucker, wie oben angegeben, in Pulverform übergeführt.Instead of the gaseous ammonia, alkali metal alcoholates in anhydrous solvents can also be used Find use. The alcoholic extract of 10 kg of digitalis leaves is z. B. so long with a 5 percent alcoholic solution of sodium alcoholate added when a precipitate is still formed. This is removed by decanting and the excess alkali is neutralized with alcoholic hydrochloric acid. The departed Saline separate solution is concentrated in a vacuum and with lactose, such as given above, converted into powder form.
Bei der Bestimmung des Digitoxins auf chemischem Wege und bei der physiologischen Bestimmung der Wertigkeit der vom Digitoxin befreiten Lösungen ergab sich im wesentlichenWhen determining digitoxin chemically and physiologically Determination of the valency of the solutions freed from digitoxin resulted essentially
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6060
Übereinstimmung der nach dem vorliegenden Verfahren erhaltenen Produkte mit den Produkten des Verfahrens des Hauptpatents.Conformity of the products obtained by the present process with the products the procedure of the main patent.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE245193C true DE245193C (en) |
Family
ID=504170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT245193D Active DE245193C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE245193C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453476A (en) * | 1993-08-23 | 1995-09-26 | Rohm And Haas Company | High solids copolymerization via in-situ isomerization |
-
0
- DE DENDAT245193D patent/DE245193C/de active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5453476A (en) * | 1993-08-23 | 1995-09-26 | Rohm And Haas Company | High solids copolymerization via in-situ isomerization |
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