DE2429166A1 - Verfahren zur selektiven spaltung der amidsaeurefunktion eines 7-(amidsaeure)cephalosporins - Google Patents

Verfahren zur selektiven spaltung der amidsaeurefunktion eines 7-(amidsaeure)cephalosporins

Info

Publication number
DE2429166A1
DE2429166A1 DE2429166A DE2429166A DE2429166A1 DE 2429166 A1 DE2429166 A1 DE 2429166A1 DE 2429166 A DE2429166 A DE 2429166A DE 2429166 A DE2429166 A DE 2429166A DE 2429166 A1 DE2429166 A1 DE 2429166A1
Authority
DE
Germany
Prior art keywords
acid
methyl
cephem
hydrazine
carboxylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE2429166A
Other languages
German (de)
English (en)
Inventor
Stjepan Paul Kukolja
Steven Robert Lammert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE2429166A1 publication Critical patent/DE2429166A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE2429166A 1973-06-18 1974-06-18 Verfahren zur selektiven spaltung der amidsaeurefunktion eines 7-(amidsaeure)cephalosporins Withdrawn DE2429166A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US371011A US3905966A (en) 1973-06-18 1973-06-18 Cephalosporin cleavage process

Publications (1)

Publication Number Publication Date
DE2429166A1 true DE2429166A1 (de) 1975-01-09

Family

ID=23462129

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2429166A Withdrawn DE2429166A1 (de) 1973-06-18 1974-06-18 Verfahren zur selektiven spaltung der amidsaeurefunktion eines 7-(amidsaeure)cephalosporins

Country Status (12)

Country Link
US (1) US3905966A (fr)
JP (1) JPS61352B2 (fr)
BE (1) BE816408A (fr)
CA (1) CA1018155A (fr)
CH (1) CH601313A5 (fr)
DE (1) DE2429166A1 (fr)
ES (2) ES427388A1 (fr)
FR (1) FR2233328B1 (fr)
GB (1) GB1474544A (fr)
IE (1) IE39253B1 (fr)
IL (1) IL44791A (fr)
NL (1) NL7408170A (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001239A (en) * 1973-06-18 1977-01-04 Eli Lilly And Company Cephalosporin cleavage process
US3994888A (en) * 1973-06-18 1976-11-30 Eli Lilly And Company Cephalosporin cleavage process
US4039535A (en) * 1973-12-10 1977-08-02 Eli Lilly And Company 7-[α-(GUANYL-1-UREIDO)PHENYLACETAMIDO]-3-SUBSTITUTED CEPHALOSPORIN ANTIBIOTICS
JPS52124221A (en) * 1976-04-10 1977-10-19 Toshizou Miyai Water tpa with selffclosing valve
US5169945A (en) * 1990-05-14 1992-12-08 Eli Lilly And Company Amino protecting group
US5239069A (en) * 1990-05-14 1993-08-24 Eli Lilly And Company Amino protecting group
CA2041897A1 (fr) * 1990-05-14 1991-11-15 Leland Otto Weigel Groupe de protection de fonctions amine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3487070A (en) * 1966-01-14 1969-12-30 Bristol Myers Co 3-blocked amino-4-sulfhydryl-2-azetidinones
US3487074A (en) * 1966-01-14 1969-12-30 Bristol Myers Co Derivatives of 6-amino-3-penamylcarboxylic acid and 7-amino-2,2-dimethyl-cephalosporanic acid
US3769281A (en) * 1970-07-09 1973-10-30 Lilly Co Eli Deblocking process for cephalosporin antibiotics

Also Published As

Publication number Publication date
IE39253B1 (en) 1978-08-30
JPS5036488A (fr) 1975-04-05
JPS61352B2 (fr) 1986-01-08
CA1018155A (fr) 1977-09-27
ES427388A1 (es) 1976-09-16
CH601313A5 (fr) 1978-07-14
US3905966A (en) 1975-09-16
BE816408A (fr) 1974-12-17
FR2233328A1 (fr) 1975-01-10
IL44791A0 (en) 1974-07-31
NL7408170A (fr) 1974-12-20
IE39253L (en) 1974-12-18
FR2233328B1 (fr) 1977-10-07
ES448016A1 (es) 1977-07-01
GB1474544A (en) 1977-05-25
IL44791A (en) 1976-09-30

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee