DE2353819A1 - METHODS FOR DISINFECTING HUMAN OR ANIMAL SKIN - Google Patents

Description

Attorney's file ^ t'505 26th October 19,? 3

DR. WILHEM HURKl IH LIESERBRÜCKE

(AUSTRIA)

Process for the disinfection of human or

animal skin

409846/0966

In the course of the development of disinfection technology, climbing goes more and more towards that on the disinfected Surface of e.g. objects or vou more human or animal skin, there are as few disinfectant residues as possible.

At the same time, of course, careful Disinfection required.

The method according to the invention will now meet these two requirements. The principle of the method according to the invention is a new so-called "double disinfection technique". This makes a significant contribution to renaturalization, d _o i. bringing substances back to their original, natural degree of purity.

The "double disinfection technology" is in the essential in the fact that two different types of disinfectants are used for disinfection »One type of disinfectant consists of disinfection with a disinfectant or a combination of disinfectants with a long-lasting effect. This is followed by disinfection with a disinfectant A, the is either volatile or residue-free, disintegrates into volatile conversion products, leaves a neutral residue or is subject to a metabolism on the skin that is skin-friendly.

This process ensures that the substance to be disinfected or the to be disinfected for a specific purpose disinfecting human or animal skin of all remenent v / Irkenden disinfectants is cleaned and so returned to its original state.

The inventive method for disinfecting human or animal skin, but also from germ-free objects to be used, is thus marked that the disinfection treatment in two Steps takes place, with a disinfectant immediately before hearing smoke or a disinfectant mixture

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is applied, the Tdzw. which are either volatile or residue-free is broken down into volatile conversion products, leaves a neutral residue or is subject to a metabolism on the skin that is skin-friendly (disinfectant medium A), and then a disinfectant or a disinfectant mixture is applied, dao bsw. the has a long-lasting, remanent disinfectant concentration (Disinfectant B).

The method according to the invention is of particular importance, for example. "During the milking process, the disinfection of the cow's udder is of great importance, because it prevents the transmission of harmful bacteria from outside to the udder through the milking process and disinfects udders that are already infected with harmful bacteria . Ishenso this is called the disinfection of HLaiden and body parts γοηV / ichtigksit, which come into contact with food, medicine and other products after the disinfection.

On the other hand, residues of the disinfectant stick to the skin, which can have a disruptive effect on a subsequent work process. During the subsequent milk production Z ₀ B ₀ , these residues then get into the milk and thus influence the taste, sweetness and cheesability of the milk.

V In the novel Desinfektionsverfchren; now ill z, B, the following v; else disinfected: Example 1: Before the milking process is the liuter 3, a disinfectant the G roup A cleaned "3eispielsv / it else can 36 fi-strength alcohol verv / ends with which a paper towel is soaked that is shrink-wrapped in an aluminum foil bag. In this way the teats are cleaned and disinfected for the subsequent milking process without leaving any residue on the teats.

After the lightning process has been completed the teats with a disinfectant from Group Bj- das has a long-lasting, remanent disinfectant effect,

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infected For example, a chlorhexidine gluconate or chlorhexidine lactate solution in 0.1 foigex concentration can be used here. It is advantageous to thaw the teats in such a disinfectant solution.

Before the next milking process, the teats are tortured again with a group A disinfectant and disinfected and the teats are cleaned of the residues of group B disinfectant and made ready for milking.

By using a disinfectant wipe before the milking process and a dipping solution after the milking process confusion of the solutions is easily avoided and the application is made very simple. The inventive Disinfection process is of course in its application not to the disinfection described above limited by cow udders, but can be used in all areas where disinfection is required or important is to be used. Further areas of application are, for example, the disinfection of the hands, the disinfection Of surgical instruments, and the Eeimfreimaohung "at the bottle washing mentioned.

The following can be used as group B disinfectants with long-lasting, remanent disinfectant effects Substances used:

1. Salts of quaternary ammonium bases in a concentration of 0.02 fo Ms 0.5 $>, ZoB .:

Dodecyldimethyl dichlorobenzylammonium chloride Dodecyldimetbyl-benzylammonium chloride Tetradecyldimethyl-benzylammonium chloride Dodeoyldimethyl-ethylbenzylammonium chloride, but other salts, especially the gluconates, lactates or cyclamates of these quaternary ammonium bases can also be used be used.

2. A salt of chlorhexidine, i.e .:

1,1 ^I -hexametbylen-T3is- / 5- (p-chloropbenylbiguanid _i 2 _i 7i-

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laws, the Di-gluconate and Di-Ia ο did from this. 3. -Ampholyte, z _o B .:

ή £ 2 / j2-Do de cylamlnoä tbyl) -amino7 äthyl j glycine Ϊί-hexadodecylglycine

ethyljaminqj methylj salicylic acid. .

N- ^ 2 / Γ2 octylaminoethyl) amino7ethy] glycine.

N-O-dodecylaminopropyl-ß-aminohutyric acid F- (3-dodecyloxypropyl) -ß-amino'butyric acid.

As disinfectants of group A, i.e. disinfectants that are volatile or in volatile Decomposition products disintegrate, leaving neutral residues or a skin-friendly .. metabolism are possible:

1. Alcohols of Cj Ms Q ^, branched or unbranched - paper towels are used with the. Soaked in alcohol and shrink-wrapped in aluminum foil bags,

. 2. ß-propiolactone in an application concentration of 0.05 / to 0.3 fo in water.

So 0.3 g of ß-propiolactone in 99.7 g of water solved.

3. Peracetic acid at a concentration of

0.2 - 0.5 i ° in alcohol or water or a mixture of alcohol and water. _ ■ "-.- ■ - ■

For example, 0.2 g of peracetic acid is dissolved in 99.8 g of 33% aqueous n-propanol and mixed ; ". '.

4. Peroxides:

Hydrogen peroxide in a concentration of 0.1-0.3 / ^ in aqueous solution. To this end, e.g. 0.66 g 30% hydrogen peroxide solution diluted to 200 ml with water.

Magnesium peroxide as a 0.2 solution in water:

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0.2 g of magnesium peroxide are dissolved in 99.3 g of water and mixed.

5ο sodium pearl dorate as 2.0 γ> aqueous solution and sodium percarbonate as 0.3 5 ^ aqueous solution, 2.0 g of sodium pearl dorate are dissolved in 98.0 g of water and mixed thoroughly. 0.5 g of sodium percarbonate are dissolved in 99.7 g of water and mixed thoroughly.

6. Sodium and potassium peroxide disulfate 7 ο benzoyl peroxide

S.Iialiumpermanganat and in 0.2 $ solution Oalciumpermanganato For example, "0.2 g of potassium permanganate dissolved in 99.8 g of water and blended.

9. Sodium and Potassium Dichromate

10. Grlutaraldehyde 0.02 io in aqueous alcoholic solution _{or similar}

For this, 0.02 g of G-lutaraldehyde in 99.98 g of 70% Dissolved ethanol.

11. Hypochlorite solutions in 0.01% solution. To prepare this solution, 2.0 g of a sodium hypochlorite solution be -versetzt with .einem content of 0.5 i ° of active chlorine with 98 g water and mixed well, "

12. Chlorine dioxide in 0.02% solution, 0.02 g of chlorine dioxide are "prepared in a known manner, dissolved in 99.98 g of water and mixed thoroughly.

13. Chloramine T, di ₀ : p-ioluolsulfon-Chloramid-Hatriuia, in 0.1-1.0% aqueous solution. For example, 0.2 g of chloramine T are dissolved in 99.8 g of water and mixed together

14 «, iodine in a concentration of 0.02 ^σ β,

0.02 g of iodine are dissolved in 99.98 g of ethanol for 90 years mixed.

15o iodophores in a concentration of approx. 0.02 io. 9 g of ethoxylated ethanol-iodine complex are dissolved and

9 g of nonylphenol-polyethoxy-ethanol-iodine complex in 72 g of water and stir well through _o

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Then add 10 g of phosphoric acid for stabilization and pH adjustment. This solution is used for the application in a ratio of 1: 100 with water Tordünnt. The iodine content will thereby set to 0.018 #. ■

16. Diethylpyrocarbonic acid ester in a concentration from 30-200 ppm. 0.02 g of diethylpyrocarbonic acid ester are dissolved in 99.98 g of 96% ethanol and mixed thoroughly.

With the solutions prepared in the examples, paper towels are then soaked in aluminum foil bags be welded. ! Of course the solution can such as such to be used for disinfection,

The disinfectants of group B can also be used as a solution or applied to a paper towel. Preferably, however, the disinfectants of group A should be used in the form of the soaked paper towels and the disinfectants of group B in 1 μm of the solution. ■ ■.
Example 2:
Hands of the injection ■

The hands will be used with a gate to the operation Group A disinfectant cleaned. For example 96 ^ alcohol can be used with a paper towel impregnated. is sealed in an aluminum foil bag. The hands will be like this for the next one Work process disinfected without leaving a residue » -.:.■■:"■-■

After the work process, the hands are treated with a disinfectant of group B, the long-lasting remanent Has disinfecting effect, disinfects.

For example, a solution of 0.1 follow Dodecylaminoäthylaminoäthylglycin.angewendet can here. This solution leaves a .bactericidal PiIm on the skin and keeps the surface of the hand germ-free "

Before the next work process, the residues of group B disinfectant

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a disinfectant of the group A, eg 96 % alcohol, removed and returned the skin to its original condition

Example;: Disinfection τοη surgical instruments

Before the surgical instruments are used, they are cleaned and disinfected with a disinfectant of group A. For example, a solution of 0.02 ^c / o peracetic acid in isopropanol can be used. The surgical instruments were disinfected for the subsequent work process without leaving a residue »

After use, the instruments are cleaned and disinfected for storage with a disinfectant of group B, which has xangan-containing, remant disinfection properties. For example, a solution of 0.1 ° ß> chlorhexidine gluconate in isopropanol can be used. This disinfectant solution leaves behind a residual protection against bacteria on the surface of the surgical instruments and keeps them during storage germ-free before the next use is again with a disinfectant the group ^ a, z ₀ B ": isopropanol with 0.02 i> peracetic acid," cleaned this , the residues of the disinfectant of the group B are removed again and the sterile instruments mu clean prepared for use.
Example 4:.
fflasohenwäsohe

Used bottles are washed after PiascLenwäsehe disinfected with a disinfectant of group B, .the has a long-lasting, remanent effect. For example, a solution of 0.1 ^ IT, N, H dodecyldimethyl-dicblorbensylaxTBioniumchlorid with an addition of 50 ppm silicone defoamer. The bottles are thereby

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Made germ-free and also kept germ-free during a possible storage. Are now the bottles with a disinfectant of the group A, for example with a solution of 0.1 prior to use? O OHI on or in £ (d _s i. P-Toluolsulfocbloramid-iTatriun in water) washed ,, In this manner, the radicals of the disinfectant of group B is removed and the bottles are clean and sterile for use "!", Example 5ί
Mas without disinfection

Machines in the food industry have to be disinfected again and again. "For this purpose, the machines are cleaned and disinfected before use" with a disinfectant from group A. This can be, for example, an aqueous solution of sodium hypochlorite with an active content of 0.2% After use and cleaning, the machine is treated with a disinfectant of group B "" to ensure lasting protection against germs. For example, the machine can be washed or sprayed with a solution of 0.2 fo dodecylaminoate nylaminoethylglycine in water Dodecylaminoätbylaminoäthylglycine forms a film and the sterility is ensured until the next use.

Immediately before use, the adhering disinfectant is again with an aqueous solution of Sodium hypocblorite containing 0.2 $ active chlorine washed and ready for the next step.

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Claims (4)

Claim e: (ΐ ^ method of disinfecting human or animal skin, but also, from germ-free to use objects to be reached, characterized in that the disinfection treatment takes place in two stages, wherein immediately before use, a disinfectant or disinfectant mixture is applied that or the is either volatile or residue-free, in volatile Conversion products disintegrates, leaves a neutral residue or is metabolized on the skin, which is skin-friendly (disinfectant A), and then a disinfectant or a disinfectant mixture is applied that has a long-lasting, remanent disinfectant effect (disinfectant B). 2 "Procedure according to. Claim. 1, characterized in that the disinfectant of group A, which is either volatile or residue-free, disintegrates into volatile conversion products, leaves a neutral residue or is subject to a metabolism on the skin that is skin-friendly, iodophores in a concentration of approx. 02 fo or diethylpyrocarbonic acid ester in a concentration of 30-200 ppm »is used. 5 »Procedure according to. Claim 1, characterized in that that the following substances are used as group B disinfectants' 1 ♦ salts of cuaternären ammonium bases in a concentration of 0.02 f "fo to 0.5, including: 409846/0955 Dodecyldimethyldichloro / benzylammonium chloride Dodecyldimet ^ yllDenzylainmoiiiumchlorid Tetradecyldiffiethylbenzylaminonium chloride Dodecyldimetbylethylbenzylaimaoniumchlorid, But also about other salts, especially the gluconates and lactates or cyclamates of these quaternary monoliths. 2. A salt of chlorhexidine, i.e .: 1,1 ⁱ -HBxamethylene-13is- / 5- (p-chloropbenylliiguanidj_7>"especially the digluconate. And dilactate thereof 3. Amplaolyte, e.g .: - (2- / T2-dodecylaminoätloyl) aminojäth.ylj glycine H-hexadodecylglycine 3, 5-Ms {{^ - 2TT2-I) odecylamino amino} methyl j salicylic acid. ΐί-j 2- / 2 ~ -0ctylaminoethyl) amino / äthyli, glycine ii- (5 - dodecylaminopropyl) -ß-amino "butyric acid M- (3-dodecyloxypropyl) -ß-aminobutyric acid ₀ 4. The method according to claims 1 and 2, characterized in that with the present in solution Disinfectant from group A, a piece of paper or a towel soaked and then sealed in an aluminum bag. ■■■■■ " 4098A6 / 0955