DE2311666C3 - Disinfectants and preservatives - Google Patents

Description

contain, in which Ri, R ₂ and R _{3 are} identical or different and represent straight or branched chain alkyl radicals with 1 to 8 carbon atoms or chlorine or bromine.

2. Disinfectant according to claim!, Characterized in that they contain phenols of the general formula I in which Ri and R _{3 are the} same.

3. Disinfectant according to claims 1 and

2, characterized in that they contain phenols of the general formula I in which Ri and R _{3 are} identical and denote bromine or an alkyl radical having 1 to 3 carbon atoms.

4. Disinfectant according to claims 1 to

3, characterized in that they contain phenols of the general formula I in which at least one of the substituents Rt, R ₂ and Rj is chlorine or bromine

5. Disinfectant according to claims 1 to

4, characterized in that they are one or more of the groups as aldehydes

a) aliphatic aldehydes with 1 to 12 carbon atoms,

b) aliphatic dialdehydes with 1 to 5 carbon atoms,

c) glyoxylic acid esters of aliphatic, cycloaliphatic or araliphatic alcohols,

d) glyoxylic acid

contain.

Exposure times in the suspension test. However, they have only low solubility in water and often do not meet the requirements placed on a good surface disinfectant. Another disadvantage of phenols is that they are difficult to biodegrade, which is particularly important for the frequently used pentachlorophenol or Sodium pentachlorophenolate applies already in the mixture has been used with aldehydes in order to

The gap between aldehydes and fungi and yeasts closes conclude. According to the guidelines of the German Society for Hygiene and Microbiology (DGHM), VgL Guidelines for testing chemical disinfectants, 3rd supplemented edition, Gustav-Fischer-Verlag,

π Stuttgart, a surface disinfectant must die Kill test germs within 6 hours - a prerequisite is that in the suspension test with the same Concentration a kill is achieved within 30 minutes. In the area test, after 1, 2, 4 and 6 hours tested, after 2> / 2 in the suspension test, 5> 15 and 30 minutes. A time shorter than 2 '/ 2 minutes is not provided because otherwise errors in the attempt in

Relation to the time would be too great. The execution of the suspension attempt and the

Area experiment with formaldehyde, glutaraldehyde and Glyoxal showed an extremely weak effect for formaldehyde and glyoxal in the suspension test. There have to be very high aldehyde concentrations those from those already mentioned can be applied

jo reasons are not possible in practice. the On the other hand, results in the area test are more advantageous. The effect of glutaraldehyde in the suspension experiment is better, but it has aldehyde due to its unpleasant smell none so far

r> further application found.

Table I.

Aldehydes

The invention relates to disinfectants and preservatives based on aldehydes or from Aldehyde-releasing substances and phenols.

Aldehydes are characterized by their good solubility in water and good effects when used as surface disinfectants. However, you are at the disadvantage afflicted that they require relatively long exposure times in the suspension test, so that for a rapid killing of all germs higher concentrations must be used, which risk a Cause irritation of the mucous membranes. Mixtures that contain aldehydes or aldehyde-releasing substances, In addition, at higher concentrations they often have an unpleasant odor and bad smell Skin and Matertal compatibility. Another disadvantage is that their effect on fungi and Yeast is unsatisfactory at the concentrations customary in practice, so aldehydes are an activity gap exhibit.

In contrast, phenols are short Suspension test Area test formaldehyde Glutaraldehyde

Glyoxal

more than 3 %

0.5%

more than 3%

0.2%

In contrast, disinfectants are on the base of germicidal phenol derivatives, such as those used, for. B. from US-PS 22 21 807, 22 21 808 and 22 87 443 known are to achieve the effect on the surface only through high concentrations. Commercially available disinfectants contain up to 30% phenol and must ill usually be used in 2% solution to achieve a safe effect against staphylococci, while the effect in the suspension test is achieved with much lower concentrations.

Table 2

Phenols Suspensions Area trial attempt 2-methylphenol 0.2% more than 2 .. 4-chloro-3-phenylphenol 0.2% more than 2% 2.6-I) ibromo-4-methyl- 0.2% more than 2 » p he iiol 4-urom-2. <>. Dimethyl- 0.2 ■ '·, more than 2 * phenol

Attempts to combine aldehydes with phenols have so far failed because between condensation occurs in these compounds, so that the effectiveness of such mixtures decreases rapidly

It has now surprisingly been found that certain Phenols, which themselves have a good antimicrobial effect, without undesired condensation reactions can be combined with aldehydes. With the addition of common emulsifiers, storage-stable disinfectants and preservatives are obtained, which have the advantages of both classes of compound in themselves unite and have high effectiveness and a broad spectrum of activity.

The invention accordingly relates to disinfectants and preservatives based on Aldehydes or substances splitting off aldehydes and phenols, the phenols of the general formula

OH

As aldehydes supplying compounds come, for. D. Hexamethylenetetramine and hexahydrotriazine as well O-acetals, such as the condensation product of acetaldehyde and ethanol, can be considered.

The disinfectants according to the invention can contain other customary additives, to those in the first place Line emulsifiers as well as organic solubilizers include.

Suitable emulsifiers are sodium alkyl sulfates, Sodium lauryl ether sulfate, triethanolammonium lauryl sulfate and sodium cumene sulfonate as solubilizers Above all, alcohols such as isopropanol, triethyene glycol and methylglycol are used

The disinfectants and preservatives according to the invention are both in the suspension test as also extremely effective for surface disinfection, whereby the effective concentration in the The suspension test differs only slightly from that in the area test, although the individual components in the combination are in smaller quantities are available than they would be required to achieve comparable results in suspension and area tests if used alone, such as Comparison of Table 3 below with Tables 1 and 2 above is illustrated

Table 3

contained in which Ri, R2 and R3 are identical or different are and straight or branched chain alkyl radicals with 1 represent up to 8 carbon atoms or chlorine or bromine.

Preferred phenols are those in which Ri and Rj are the same, especially gi-; ä results are obtained with phenols, ic which Ri and Rj bromine or a lower alkyl radical having 1 ^ ¹ s 3 carbon atoms, ie methyl, ethyl or propyl radical. Also advantageous are phenols of the formula given in which at least one of the substituents Ri, R2 and Rj is chlorine and especially bromine. The brominated phenols are preferred over the chlorinated ones mainly because they have a more pleasant odor and are more easily biodegraded.

Examples of suitable phenols are

4- bromo-2,6-dimethylphenol,

4- bromo-2,6-dielhylphenol,

2,6-dibromo-4-methylphenol,

2,6-dibromo-4-ethylphenol,

2,6-dibromo-4-neopentylphenol,

2,6-dibromo-4-octylphenol and

4-chloro-2,6-dimethylphenol.

Of these, 2,6-dibromo-4-methylphenol and 4-bromo-2,6-dimethylphenol have proven particularly useful.

The aldehydes and used in the disinfectants and preservatives according to the invention their bactericidal effects are well known. Examples of such aldehydes, which can also be mixed with one another can be used are:

a) oldphatic aldehydes with 1 to 12 carbon atoms, ti h. Formaldehyde to dodecanal.

d) aliphatic dialdehydes with 1 to 5 carbon atoms, ie glyoxal to glutaric acid,

c) Glyolylic acid esters aliphatic cycloaliphatic or ai of aliphatic alcohols and

Phenol + aldehyde

Suspension flat test

4-bromo-2,6-dimethylphenol 0.5% 1%

+ Formaldehyde

4-bromo-2,6-dimethylphenol 0.5% 1%

^Jl + glutaraldehydeJ

4-bromo-2,6-dimethylphenol 0.2% 0.2%

+ Glyoxal

-to With an effective concentration of the disinfectants and preservatives according to the invention of 0.2 to 1% in the area test, these agents are commercially available under the name »Tego51« clearly consider how the following test series

4; show results.

Area trial PVC H
H
H Staph.
lacquered
wood PVC H
H
H F .. coli
lacquered
wood concentration
to »Tego 51« > 6
> 6
> 6 > 6h
> 6h
> 6h > 6
> 6
4th > 6 h
> 6 h
I h 0.5%
1%
2%

According to this, a concentration of 2% of the known agent in the area test is not sufficient, probably but, as shown above, a concentration of 0.2% of a mixture of 4-bromo-2,6-dimethylphenol and Glyoxal.

Comparative experiments with formulations according to the invention (I to 4) and known formulations (5 to 8). whose compositions are indicated in wt .- "/ o in Table 4 below, led /.u in Tables 5 and b values indicated

Table 4 23 11 section 1 666 10.0 5 6th 6th 7th 6.0 the DGHM, section C 1113 a. 8th 8.0 5 5.0 10.0 10.0 3.6 phenol Formulations 23.0 OJ 4-bromo-2,6-dimethylphenol 1 3 4.0 4-chloro-3-methylphenol 4.0 3.0 25.0 2-phenylphenol 10.0 10.0 5.0 2.0 4-chloro-2-benzylphenol 3.0 5.0 aldehyde 7.5 2.5 Glyoxal 5.0 4Y Glutaraldehyde 25.0 J 5.0 formaldehyde 8.0 Glyoxylic acid 25.0 30.0 25.0 Trial ky lam inacetat 7.5 2.5 78.6 44.5 Sodium alkyl sulfonate 5.0 5.0 The effect in the suspension test was after the Sodium lauryl ether sulfate 2.5 15.0 2.5 Guidelines determined. Triethanolammonium lauryl sulfate 25.0 30.0 10.0 Sodium cumene sulfonate 15.0 15.0 15.0 Na ₂ HPO ₄ 5.0 10.0 5.0 20.5 Isopropanol 2.5 2.5 5.0 Triethylene glycol 25.0 20.0 42.5 Methyl glycol 15.0 turned 35 15.0 water C II 3, 10.0 34.5 20.0 The effectiveness in surface disinfection according to the guidelines of the DGHM,

determined.

Table 5 Curses. (Disinfection

Conc.

Staphylococci

PVC lacquer.

wood

E-coli PVC

paint. wood

Formulation 1

Formulation 5

Formulation 6

Formulation 7

Formulation 8

05%

1%

2%

03%

1%

2%

03%

1%

2%

03%

1%

2%

03%

1%
2%

2 hours. I hour

1 H.

6 hours 4 hours

2 hours.

> 6 hours > 6h > 6Sld.

> 6h 4 hours I hour

6 hours 4 SId. I sid.

4 hours 1 hour 1 hour 1 hour I hour 1 hour

I hours I hours t hours

> 6 hrs. 6 hrs. 4 SId.

> 6 hours> 6 hours > 6h

6 hours 2 hours I SId.

> 6h 4 SId. I Sld.

4 hours 6 hours

2 hours 2 hours

I Sld. I hour

4 hours 6 hours

1 hour 2 S (d.

1 hour 1 hour

2 hours 4 hours I hours 2 hours

1 hour I hour

4 hours 6 hours

2 mercenaries 2 mercenaries I Sld. I hour

10 ml of the suspensions to be examined were in each case 0.2 ml of a germ suspension in a glass dish pipettierL After 23; 5; Samples were taken with an eyelet for 15 and 30 minutes and inoculated into 10 ml nutrient broth or agar slant. After the standardized incubation time, the test tubes were read. In the following table 6 it is indicated after how many minutes the growth is inhibited; was.

These results also show the superiority of the Formulation 1 according to the invention compared to formulations 7 and 8, which only contain aldehydes contain.

Table 6 Suspension tests

Kon /. Slaph. B. coil Pseud. Proteus

Form- 0.25% lation I 03%

The results clearly show the superiority of the formulation I according to the invention compared to the Formulations 5 and 6 containing only phenols, especially with regard to the effect on staphylococci.

Formulation 7 0.5%

1%

Form- 0.25% lation 8 0.5% 1%

Form- 0.25% lieriing 5 0.5% 1%

23 ' 23 ' 23 '

30 ' 5 '

2.5 '

> 30 '
> 30 '
> 30 '

15 ' 5 ' 2.5 '

5 '

2.5 '

23 '

30 '15'

2.5 '

> 30 '> 30'> 30

15 '2.5' 2.5 ^r

30 '30' 2.5 '

60 '

15 '

> 30 '> 30'> 30 '

15 · 2S

> 60 '30'

> 30 '> 30> 3 (V

rnriM.'1 / iinj!

The advantageous effect of formulations according to the invention

formaldehyde,

Kon, .. SUPIT E. coli Pseud. Pro.eu, glutaraldehyde or glyoxal and 4-bromine 2 6-dimen-

thylphenol, compared to those that contain

S only these aldehydes or phenols as active ingredients

Form- 0.25% 15 '15'> 60 '15' also show the test results of

6 0.5% 2.5 '2.5' 30 '2.5' Tables 8 and 9. The composition of the test

1%

2.5 '2.5' 2.5 '2.5' th formulation is given in Table 7.

Table 7

Formaldehyde 20

Glulardialdehyde

Glyoxal

2-l'henylphenol

.Ι.ίΜ, .Γ. l.mxthvlnh.'rml

2.o-l) ibroni-4-methylphenol

4-Urom-2.h-d inlet hy! Phenol

l'ropanol-2 20

Alkyliirylpolyglykoliilhersiilliit (Na-Sal /) Dinalrium lauryl alcohol polyulykolälliersiilli) - S succinate

Triiithiinoliiminlaurylsuiriit 2

Water permutes

Hi I I

20th

I.? 13th

IO

lh 17 IS I ¹ )

20th

20th

IO 10

20th

20th

2 (1 20 20 20 20 20 20 20

20 20 20 20 20 20 20 20 20 20 20 SSS8S888S8

-iit-i-i-ii} ·) ·) ad IOP

Iahelle 8

^{l |} i I ornuldelud
KH Glutardialdeliyd
II) glyoxal

Ι-ί t IMItI (IIMlMtII 'l / i * ll »;

13) Glulardialdehyde I) MH ¹ I

14) Glyoxal ^J I) MH *)

15) 2-phenylphenol

IM 4-chloro-3-meth>! Phenol
I 7) 2.6-I) ihmm-4-methylphenol IS) 4-Hrom-2.d-dimeth \! Phenol 1 ')) blank value wage: Wirkstoll'ei Togo 51

Table 8 (continued)

Siispensions \ requests

■ \ hloluni! S / cit in minutes

(I.I "- 11.2 0.5.

Sliiph. I- C (Hi Ps.aer.Pn>! Staph I coli l'v.ier. L'rol Staph. I-.coli Ps a-r Prot

all> 30 '15'> 30 '15' 30 '27:' 30 '15' 30 '

all> 30 '15' 15 '> 3 ()' 2 7: '2 7:' 2 7: '5' 27: '

all ".'3O '15' 30 '3 (1' 5 '27:' 15 '5' 27: '

> 30 '> 30 15' 5 '15' 15 '2 /:' 2 /: '27:' 5 '27:' 27: '

all> 30 '30' M) ' 15' 27: '5' 5 '27: 27:'

3 (1 '15' 15 '5' 5 '2 7:' 2 /: '27:' 27: '27:' 27: '2 7:'

15 '5' 15 '5' 2 /: '2 /:' 2 / '2 /:' 27: '27:' 27: '27:'

2 7: '5' 2 7: '15' 2 7: '2 /:' 2 / · '3 /:' -

Suspension requests
Killing speed in mini ::. N

Slaph hcoli Ps.aer Pro! Staph. K. coli Ps.aer.Prot Staph. E. coli Ps.aer.Prot.

9) formaldehyde

10) glutaraldehyde

11) glyoxal

12.) Formaldehyde + DMB * (
13) glutaraldehyde + DMB * I ■ /: ' 15'

all> 30 '
all> 30 '

all> 30 'all> 30'

130 228/35

23 Π

Continuation

IO

14) Glyoxal + I) MH *)

15) 2-l'hcnvlphcnol

16) 4-chloro-.l-diethylphenol

1 7) 2,6-l) ibromo-4-melh>! Phenol IX) 4-Ii rom - 2.6-d im ethyl ρ he no I 14) Blank value without active ingredients! leyo 51

'lltMU .1 Mr. .,>, 1 ^ ..! .. ^. 'LlKllili ^ n,

Tabel

Suspension s attempts

Ablation / cit i> i minutes

1% 2% 3 V.

Staph. E. coil Ps.aer. Prot. Slaph V .. coli Ps.acr. Prot. Slaph ll. coli Ps.acr. Prot.

all> 30 '

all > M) '

I l.it h jmlc> uil ■. ■ ι- ί ν \ htnlun; \ / Ί.ί! · Η siu

Slaph - Uk - bra paint - 6h I C nh - 4h Uk - 4h (>.> ■■
Slaph - 4h hick - - 4h - I coil - 6h paint l '\ ( HuI / - 2h Fetch / - 4h PW - lh Fetch / - lh PVC - lh HnI / > 6h - lh > 6h P \ ( > 6h Moles / . -6h lh 6h lh ! H 6h !H ■ • (lh > 6h > 6h > 6h 4h 9) l-ormakk-lml Wed ■ 6h > 6h > 6h Ml > 6h 2h > 6h ■ 6h > 6h lh > 6h 2ii everything> 6h I ii K)) gliilardialdehyde ■ 6 h I h > 6h ^ -6 h 6li 4h lh ih I h > 6h lh until 5% I h > 6h I h ! I) (il.wixal You 2h You Want > 6h lh 6h 12) Iormalddnd · DMU ¹ 1 > 6h > 6h 6h 4h 13) Glutaraldehyde ■ DMB Ί (ih 4h -> 6 h 2h Oh 2h 14) Glyoxal + I) MB ') 4h 6h 2h 2h t. CoIi 15) 2-phenylphenol - PVC 4h 16) 4-chloro-3-methylphenl - , • (ih paint (ih I7i 2.ii-Dibromo-4-methylphenol - > 6h Fetch / lh ^ 6h IS) 4-broin-2,6-dimethylphenol > 6h 4h - -. 19) blank value (without active ingredient ·: · ι - . . - > 6h T ego 51 > 6h lh Table 9 (Kortset / uni;) Haehcmlesinu lh Coloring-zcil
t ·. rktinn - I ι
Staph. in hours -> ■ ' 4h PVC l ·. Coli paint. Staph. You paint. PVC Ho !? pvc wood 4h 2h lh 9) formaldehyde lh 2h - 10) glutaraldehyde - 11) glyoxal 2h 12) formaldehyde + DMB *) lh ! 3) Glutaraldehyde -s- DMB *) - 14) Glyoxal + DMB *) lh 15) 2-phenylphenol lh ίό) 4-chloro-3-methylphenoi

Il

i'continuation

Area infection paint 2% paint. E. Coli paint. Desoldering time in hours wood Staph. Fetch / PVC wood 1% PVC Staph. H. CoIi PVC lacquer. PVC wood

17) 2.6-I) inroin-4-methylphenol

18) 1-Un> m-2.6- ^{dimethyl phenol I 1} M Hlimlwerl (without active ingredients)

Tego 51
* ||) MH · Ι- »ηιιιι-2. () - ιΙιηκ · ΙΙι>! Phenol

> 6h> 6h> 6h 6h> 6h> 6h 6h 4h

■■ 6 h -6 h 6 h 4 h> 6h -6 h 2 h lh

up to 5 "- everything> 6h ·

• (, h -6 h 6 h 6 h > 6h -6h 4h lh

Further experiments were carried out with the following milled phenols 2.6-dibromo-4-methylphenol 2.4.6-tri-methyl phenol 2,4, b-T nod.ylphenol 4-chloro-2.b-dimethylphenol 4-chloro-2, b-dioctylphenol 4-bromo-2,6-diol'tylphenol 2,6-dibromo-4-ethylphenol 2,6-dibromo-4-octylphenol

4- bromo-2,6-diethy! Phenol carried out.

The formulations prepared with these phenols are in Table 10, those with the formulations

l'ahelle 10

Results obtained in the suspension test in Table 11 and the results obtained in the area test

»° compiled in Table 1 2.

As mentioned above, they show that the trisubstituted phenols meet the requirements of the suspension test, but not meet those of the area test. However, the effect in the area test is surprising

»5 ways improved when you get the tri-substituted Phenols also add formaldehyde, glutaraldehyde or glyoxal. The corresponding formulations are in Table 13, those with them in the suspension test results obtained in Table 14 and the im

Area test results obtained in Table 15 listed.

: a

2.6-1) ibroiii-4-melh> I phenol 2.4.h-trimethylphenol 2.4.6-Trioct> ! phenol 4-C chloro-2.6-dimethyl phenol 4-chloro-2,6-dioctylphenol 4-Hrom-2.6-ili oc tyl phenol 2.6-dibromo-4-; ith \! Phenol 2.6-dibromo-4-OLt>! Phenol 4-Hrom-2.6-di; ith> Iphenc ;!

l'ropanol-2

.Mk \ lar \ Ipohgh koliilhersulfat (Na-SaIz) Disodium lauryl alcohol polyglycol ether sulfosuccinate Triethanolamine lauryl sulfate permuted water

Table 11

20th

20th

20th

20th

20th

20th 20th 20th 20th 20th 20th 20th 20th 20th 20th 20th 20th 20th 20th 20th 20th 20th 20th 8th 8th 8th 8th 8th 8th 8th 20th 8th 2 2 2
-ad 100 2 2 8th 1 2

Form- Sir Ph r.coii Ps.aer. Per;. ! iorung = ρ · -ΐ "0 15th 15 5 nsions' 3'j 15th 30 30 .ersu; h ^; 0 30th > 30 30 20th Killing time in minutes 2i 0.1 S ta ; >.

0.2 '; 0.5% ins

Staph. K.coü Ps.aer. l'rot. Slaph F.coli Ps.aer. Prot. Staph. E. coli Ps 3cr. Proi

15th

2.5

5 15 2.5

1 <

2.5
2.5

/ 3

• ■ '(trtstM / imi!

Corniu lation

Suspension attempt, kill time in minutes

O.I '/. Prot. 1 i paint. 0.2 % E. coli P.;. Aei \ r l-'ormuli ^ runi! .- (I 31 Prot. 5 0.5 "/. I .. coli ■ ' ⁴ Ps.aer. Prot , 5 IO ¹ . . E.coh P ' I. Staph. F: .coli Ps.aer. 5 around:., _ ■■ ■, ·,
Payment time in hours Fetch / Staph. 2.5 2.5 : » 2. 5 Staph. 2.5 2 2 Suph 23 15 5 15 5 0.2% Xih 2.5 S. ς 10 10 2. 2.5 2.5 2 2 5 24 30 15 15 5 Staph.aur. l ·. col - 15th 5 5 10 2 5 2.5 2.5 10 ■) 2 , 5 25 30 15 15 5 PVC lacquer. PW - 15th 2.5 2.5 10 10 2. 2.5 2.5 2 2 26 30 15 15 15th Fetch / 5 5 15th 10 5 S. 2.5 2.5 2 2 S. 27> 30 15 30 5 20> 6h> 6h Xih - 30th 2.5 2.5 2, S. 2> 2 28 15 5 15 21 - 5 2 5 10 ■ 30 Blank value 22 - _ '30 (without 2. ', - IH f »'ΪΓΚλΪΓϊι iC / 24 Tahcllc 12 75 - - - I omul-! '' Liichcnilcsinlcktim 26 - 27 - ■) yi "_ _ d.5 ".. aur. I. coli lk I. .ΙΙΙΓ I. ick. .ΙΙΙΓ I. Ulindwerl «- - - - Staph. paint. pvc la oil/ Slaph. l.i '.- k. P. I. lot / Sl.iph paint I " (without PVC Fetch / ^11th Wed P \ ( Fetch / I. Wed P \ C 1 (1 Fetch / Active ingredients) •> hh XiIi -Mi Mi II ■ ie Table 13 > 6h - -th Xih -th -th ■ ie > (ι Il > 6h Xih 4 h ■ • ie Mi h Xih XiIi - > 6h X.h ie ■ ie • ie [• 'Ormaldehyde > 6h Xih XiIi Xih X) II /, I ₁ • ie ■ ie Glutaraldehyde > 6h - * (\ - ■ Λ Ii Xih ie Mill Glyoxal - ^ ( ι Xih O Il
Xih -> /. I ₁ - () II Wed ^ f, h ■ (<"Ί 2,6-dibromo-4-methy I phenol > 6h > 6h Xih > Wed Xih ^ h ■ ie 2.4.6-trimethylphenol > 6h ) i- Xih 2.4.6-trioctyl phenol everything oh 4-chloro-2,6-dimethylphenol 4-chloro-2,6-diocty I phenol 4-bromo-2,6-dioctylphenol 2.6-dibromo-i-eth \! Phenol . '■ (> 2.6-dibromo-4-ociylpric-noi 33 ; u 4-bromo-2,6-diethylphenol 10 10 in ! ι ¹ 10 10 lo • 6h ic . /. I ₁ .5 (* Ii
Wed , 5 ι the prot. • ie _5 S. . s ■ 5 30-30 -. ^ IO . coil 10 W. coli M) Il W Uk Mi h Fetch / Wed Il (i h 4 h Wed (i h d h ie ie -dh : ii ih M'h 4 h 2 ii Mi h 4 Ji ₁ ι j-. r-h 4 h ('h 4 h Λ Ii ^ Ii 10 id 10

15th 23 1 Suspension attempt 1 Fl.coli Ps.acr . Prol. aur. ■ il in hours tack. 2 30 31 1 666 5 paint. 33 1". the founding 34 ac 35 16 36 i paint. 37 38 2.5 ψ 40 2.5 F. coli paint Storage carried out Kill rate in minutes 30th > 30 15th paint. Fetch / 20 20 5 Fetch / 20th Slaph olgendc values: 20th 20th 20th Fetch / 20th 20th 2.5 20th 2.5 PVC Hol | ^; cirl> cl / wng 0.1% 15th > 30 5 Fetch / 20 20 15th 6 h 20th PVC 20th 20th 20th 4 h 20th 20th 2.5 20th 2.5 lh formulation Staph. 30th > 30 30th " F. coli - 8 8 30th 4 h 8th 8th 8th 8th lh 8th 8th 2.5 8th 2.5 lh lh 29 > 30 > 30 > 30 > 30 - PVC 4 h 32 30th 2h 6 h l.coli lh 5 39 2.5 lh - Propanol-2 Alkyl aryl polyglycol ether sulfate 20th 30th > 30 > 30 > 30 6 h 4 h 0.2% 2 2 20th 15th 2 h 2 2 h 2 2.5 2 2 lh 2 2 2.5 20th 2 2.5 - - (Na-SaIz) 20 > 30 30th > 30 30th 6 h _. 6 h Staph. 20th 30th 2 h lh 2.5 ι inn lh 2.5 20th 2.5 - Disodium lauryl alcohol polyglycolide 8 > 30 > 30 > 30 > 30 6 h - 4 h 30th 8th 30th 2 h lh 2.5 i IUU - lh 5 8th 2.5 - - sulfosuccinate > 30 > 30 > 30 > 30 6 h 6 h 4 h 15th 30th 2 h lh 5 lh 2.5 2.5 - - > 30 30th > 30 > 30 6 h 6 h 4 h 30th 2 30th 2 h lh 5 lh 2.5 2 2.5 - - > 30 > 30 > 30 > 30 6 h 6 h 4 h 30th 30th : i \ 0.5 "» lh 2.5 I h ]% 2.5 2.5 - > 30 > 30 > 30 > W 6 h 6 h 4 h > 30 2 h Slaph. I. lh 5 Ps.aer. ProL I h Staph. E.col Ps.aer. Prol Triethanolamine lauryl sulfate > 30 6 h 6 h Century 30th : ii 2.5 I h 5 2.5 2.5 I h 2.5 2.5 Water permutes > 30 cnilcsinleklion Wed 6 h > 30 2.5 I h 2.5 2.5 2.5 2.5 2.5 .inch very resistant. Regarding ( Table 14 > 30 Abortion / i 4 h > 30 15th I h 5 5 2.5 2.5 2.5 cli I-year-old Formu 0.2 "» 4 h > 30 n.coli Ps.aer.Prol. ili 15th The inventive disinfectants and preservatives 2.5 30th 15th S. . aur. 5 lation Flat Slaph 6 h > 30 15 15 30 I. Storage stability with > 30 15th 15th paint. 15th pvc > 30 5 15 15th Tests have shown I. S. 2.5 2.5 HnI / 2.5 15 30 30th 30th 15th 5 4 h 5 29 _ 15> 30 30th 15th 15th 2.5 lh 5 30th - 30> 30 15th . aur. 5 2.5 2.5 - 2.5 31 4 h (1.5 ". 15 30 30th paint. 15th 15th 5 - 5 32 6 h Slaph 30> 30 15th Fetch / S. 5 5 - 2.5 }} 6 h PVC 30 >? 0 6 h 34 4 h 15 30 4 h - 35 6 h > 6h 30> 30 - 36 6 h > 6h 15 30 2 "■ 37 4 h 2h I co Staph 38 6 h 2h pvc PVC 39 6 h 4 h Table 15 2 h 4 h 4 h Formu 4 h . aur. F. c lh lh lation 4 h paint. PVC lh - . ¹ ii Fetch / lh 4 h > 6h 6h H lh - lh > 6h 6h I) lh - 2 h 2 h H lh - 29 2 h 2 h H lh - 30th 2 h 2 h H I h 31 2 h 2 h H I h 32 2 h 2 h H I h 33 2h 2h H 34 2 h 2 h H 35 2Ii 2 h are 36 2 h 2Ii Formulation I immediately and n; } - 3 pp 3 ¹ '

23 Π 666

17 18

Flüchendes Inleklion suspension test

Staphylococci paint. Moles / i · :. com luck. UoU 5 Immediately Siaph. E. . coli Ps. Aeru- Proieus PVC PVC 0.5% ginosa vulgaris Immediately lh I h 1% 1% 1 h lh lh lh ¹⁰ After 1 year 2 72 ' 2 72 ' 30 ' 2 72 ' 2% lh lh 0.5% 2 72 ' 2 72 ' 272 ' 2 72 ' After 1 year lh lh 1% 1% lh lh lh lh 2 7: ' 5 ' 15 ' 2 72 ' 2% lh lh 2 72 ' 2 72 ' 272 ' 272 '

They show that the effectiveness is retained even after prolonged storage

Claims (1)

Patent claims: 23 Π 666 I. Disinfectants and preservatives based on aldehydes or aldehydes splitting off substances and phenols, characterized in that they are phenols of the general formula OH