DE218910C - - Google Patents

Description

(Stncjuflicjt bcz c &viiviM.l'inui |

IMPERIAL

PATENT OFFICE.

PATENT LETTERING

- JVi 218910 CLASS Up. GROUP

Dr. DEGEN & KUTH in DÜREN, Rhld.

The invention relates to a process for the production of iron-mannitol-vitelline compounds, which are water-soluble and, precipitated from their solutions by acids or alcohol, if small amounts of alkali are added, they dissolve again in water.

The method consists in that you first of all contained in the egg yolk Nucleoalbu-. . min, the vitelline, by the action of inorganic iron salts in the presence of Alkali solution converted into an insoluble iron compound, this then with further addition treated by alkali with mannitol and the resulting solution either evaporated to dryness or the iron-mannitol-Vitellm compounds by alcohol or dilute acids fails.

The compounds are intended to be used dry or in solutions as medicaments.

Due to their mannitol content, any nuisance to the gastrointestinal canal is excluded; Constipations, especially with the well-known organic and inorganic iron preparations make themselves uncomfortable in convalescents, come with use of the above connections.

Compounds of iron and casein with organomineral acids are already known (French 379693), e.g. B. glycerol-arsenic acid / mannitol-phosphoric acid, especially but glycerol-phosphoric acid; but these are combinations of polyatomic mineral acids with polyatomic alcohols. The use of polyatomic alcohols alone is unknown.

The use of vitellin is also unknown, the main physiological component of which is the Paranuclein, is quite different from the corresponding, des Caseins (cf. L. Hugounang, Chem. Centn Bl. 1906, I, p. 572). This diversity of Paranucleine also corresponds to the various, long-known nutritional values of the egg yolk compared to the casein, which makes iron-vitelline compounds necessarily the iron-casein compounds are preferable. That vitelline is dissolved in saline, but casein is not, should only be mentioned in passing.

Of the known iron-protein compounds (German Pharmacopoeia IV - Pbarmak. Helvetica - Regulations of the German Pharmacists' Association, Dietrich's Manual, patent specifications 173013 and 195120 of class 30 h) the iron-egg yolk compounds produced by the present process differ advantageous due to their high phosphorus content, which they only add to the natural, is known to owe very easily assimilable phosphorus content of the egg yolk.

Connections of this kind have not yet become known. ..

Example.

100 g egg yolks are defatted with ether in a known manner. The defatted egg yolk is then dissolved in saline water and the colloidal solution in 5 liters of water poured. The excreted vitelline is separated from the liquid by centrifugation and further purified by frequent redissolving in table salt and reprecipitation, finally by dialysis from table salt

Claims (1)

freed. The pulpy vitelline, made up to about 100 g, is now mixed with 30 g of ferric chloride solution and 10% sodium hydroxide solution is added to the mixture drop by drop with constant stirring until an alkaline reaction is achieved. The precipitated Eisenvitellinat is then washed, vacuumed and still moist triturated 0 H with 60 g mannitol, with the addition of 6 g of sodium hydroxide solution of 15 percent Na. After standing for a while, the mass becomes thinner; eventually complete solution occurs. The dissolution can be accelerated by heating the mixture. However, the temperature should not exceed 40 ° here. The solution may be evaporated to dryness, as such, more or less diluted or used in a vacuum at a 40 ⁰ temperature not exceeding. If the solution is poured into twice the amount of absolute alcohol in a thin stream with constant stirring, then after suctioning off, drying and rubbing in, one gets an Product richer in iron, phosphorus and nitrogen, poorer in mannitol and alkali, which only dissolves again after the addition of alkali. A similarly composed preparation is obtained if the solution is carefully acidified, the precipitate formed is filtered off with suction and dries. Sponsorship τ claim: Process for the production of water-soluble iron-mannitol-vitelline compounds, characterized in that freshly precipitated iron vitellinate is mixed with mannitol with the addition of small amounts of alkali and the solution obtained either, expediently in vacuo and at temperatures not exceeding 40 °, to dryness evaporated or the iron-mannitol-vitelline compounds from the alkaline solution precipitates from alcohol or dilute acids.