DE20210018U1 - Chemical composition for the production of nucleic acid chips - Google Patents

Chemical composition for the production of nucleic acid chips

Info

Publication number
DE20210018U1
DE20210018U1 DE20210018U DE20210018U DE20210018U1 DE 20210018 U1 DE20210018 U1 DE 20210018U1 DE 20210018 U DE20210018 U DE 20210018U DE 20210018 U DE20210018 U DE 20210018U DE 20210018 U1 DE20210018 U1 DE 20210018U1
Authority
DE
Germany
Prior art keywords
chemical composition
composition according
substituted
unsubstituted
condensed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE20210018U
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Konstanz
Original Assignee
Universitaet Konstanz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaet Konstanz filed Critical Universitaet Konstanz
Priority to DE20210018U priority Critical patent/DE20210018U1/en
Priority claimed from DE10209203A external-priority patent/DE10209203A1/en
Publication of DE20210018U1 publication Critical patent/DE20210018U1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00711—Light-directed synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Electroluminescent Light Sources (AREA)

Description

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text was not recorded electronically  

Der Beschreibungstext wurde nicht elektronisch erfaßtThe description text was not recorded electronically

Claims (9)

1. Chemische Zusammensetzung umfassend ein Molekül mit einer labilen funktionellen Gruppe sowie eine chemische Verbindung, deren Triplettzustand energetisch höher oder sehr ähnlich liegt wie der Triplettzustand der labilen funktionellen Gruppe.1. Chemical composition comprising a molecule with an unstable functional Group as well as a chemical compound, the triplet state of which is energetically higher or is very similar to the triplet state of the labile functional group. 2. Chemische Zusammensetzung nach Anspruch 1, dadurch gekennzeichnet, dass die labile funktionelle Gruppe eine photolabile Gruppe ist.2. Chemical composition according to claim 1, characterized in that the labile functional group is a photolabile group. 3. Chemische Zusammensetzung nach Anspruch 2, dadurch gekennzeichnet, dass der Singulettzustand der chemischen Verbindung energetisch gleich hoch oder tiefer liegt als der Singulettzustand der photolabilen Gruppe.3. Chemical composition according to claim 2, characterized in that the The singlet state of the chemical compound is energetically equal to or lower than the singlet state of the photolabile group. 4. Chemische Zusammensetzung nach Anspruch 3, dadurch gekennzeichnet, dass die Triplett-Singulett Energielücke der chemischen Verbindung kleiner ist als die Triplett- Singulett Energielücke der photolabilen Gruppe.4. Chemical composition according to claim 3, characterized in that the Triplet singlet energy gap of the chemical compound is smaller than the triplet Singlet energy gap of the photolabile group. 5. Chemische Zusammensetzung nach Anspruch 1 oder 4, dadurch gekennzeichnet, dass die photolabile Gruppe ausgewählt ist aus der Gruppe bestehend aus NPPOC, MeNPOC, NPES, NPPS, MeNPPOC, DMBOC und deren substituierten Derivaten, substituierten und unsubstituierten, kondensierten und nichtkondensierten 2- (Nitroaryl)ethoxycarbonyl oder -thiocarbonyl-Verbindungen, substituierten und unsubstituierten, kondensierten und nichtkondensierten 2-Nitrobenzyl-, 2- Nitrobenzyloxycarbonyl bzw. thiocarbonyl Verbindungen, substituierten und unsubstituierten, kondensierten und nichtkondensierten 2- (Nitroheterocycloaryl)ethoxycarbonyl, oder -thiocarbonyl Verbindungen, sowie substituierten und unsubstituierten, kondensierten und nichtkondensierten 2- (Nitroheterocycloalkyl)ethoxy-carbonyl/thiocarbonyl Verbindungen, substituierten und unsubstituierten 2-Nitro-N-Methylanilincarbonyl- bzw. thiocarbonylderivaten. 5. Chemical composition according to claim 1 or 4, characterized in that the photolabile group is selected from the group consisting of NPPOC, MeNPOC, NPES, NPPS, MeNPPOC, DMBOC and their substituted derivatives, substituted and unsubstituted, condensed and uncondensed 2- (Nitroaryl) ethoxycarbonyl or thiocarbonyl compounds, substituted and unsubstituted, condensed and uncondensed 2-nitrobenzyl, 2- Nitrobenzyloxycarbonyl or thiocarbonyl compounds, substituted and unsubstituted, condensed and uncondensed 2- (Nitroheterocycloaryl) ethoxycarbonyl, or -thiocarbonyl compounds, as well substituted and unsubstituted, condensed and uncondensed 2- (Nitroheterocycloalkyl) ethoxy-carbonyl / thiocarbonyl compounds, substituted and unsubstituted 2-nitro-N-methylaniline carbonyl or thiocarbonyl derivatives.   6. Chemische Zusammensetzung nach Anspruch 1 oder 4, dadurch gekennzeichnet, dass die chemische Verbindung das Strukturmotiv
aufweist, wobei Y = O, S, N, Se oder Te ist, n = 1 oder 2 bedeutet, C Bestandteil eines aromatischen, heteroaromatischen oder kondensierten aromatischen oder heteroaromatischen Systems ist und wobei im Falle, dass n = 2 ist, das aromatische, heteroaromatische oder kondensierte aromatische oder heteroaromatische System gleich oder verschieden sein kann.6. Chemical composition according to claim 1 or 4, characterized in that the chemical compound has the structural motif
, where Y = O, S, N, Se or Te, n = 1 or 2, C is part of an aromatic, heteroaromatic or condensed aromatic or heteroaromatic system and where, if n = 2, the aromatic, heteroaromatic or fused aromatic or heteroaromatic system may be the same or different. 7. Verwendung einer chemischen Zusammensetzung nach einem der vorhergehenden Ansprüche 1 bis 6 zur Herstellung von DNA-Chips.7. Use of a chemical composition according to one of the preceding Claims 1 to 6 for the production of DNA chips. 8. Kit umfassend eine chemische Zusammensetzung nach einem der Ansprüche 1 bis 6.8. Kit comprising a chemical composition according to any one of claims 1 to 6. 9. Kit, der einen Teil oder alle Reagenzien und/oder Hilfsstoffe und/oder Lösungsmittel und/oder eine Arbeitsanweisung zur Durchführung eines Verfahrens zur Abspaltung labiler funktioneller Gruppen aus Molekülen durch Einwirkung elektromagnetischer Strahlung und/oder zur Herstellung von DNA-Chips enthält.9. Kit containing some or all of the reagents and / or excipients and / or solvents and / or work instructions for performing a spin-off process labile functional groups of molecules by the action of electromagnetic Contains radiation and / or for the production of DNA chips.
DE20210018U 2002-03-04 2002-03-04 Chemical composition for the production of nucleic acid chips Expired - Lifetime DE20210018U1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE20210018U DE20210018U1 (en) 2002-03-04 2002-03-04 Chemical composition for the production of nucleic acid chips

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10209203A DE10209203A1 (en) 2002-03-04 2002-03-04 Composition useful for preparing DNA chips comprises compound with labile functional group and a sensitizer that acts by triplet-triplet energy transfer
DE20210018U DE20210018U1 (en) 2002-03-04 2002-03-04 Chemical composition for the production of nucleic acid chips

Publications (1)

Publication Number Publication Date
DE20210018U1 true DE20210018U1 (en) 2002-11-28

Family

ID=26011046

Family Applications (1)

Application Number Title Priority Date Filing Date
DE20210018U Expired - Lifetime DE20210018U1 (en) 2002-03-04 2002-03-04 Chemical composition for the production of nucleic acid chips

Country Status (1)

Country Link
DE (1) DE20210018U1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10237704A1 (en) * 2002-08-09 2004-03-11 Chemogenix Gmbh Method and device for the intermolecular transfer of activation energy for bond cleavage through space
DE102004019098A1 (en) * 2004-04-20 2005-11-10 Chemogenix Gmbh Photolabile protecting groups

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10237704A1 (en) * 2002-08-09 2004-03-11 Chemogenix Gmbh Method and device for the intermolecular transfer of activation energy for bond cleavage through space
DE102004019098A1 (en) * 2004-04-20 2005-11-10 Chemogenix Gmbh Photolabile protecting groups
US7432368B2 (en) 2004-04-20 2008-10-07 Roche Nimblegen, Inc. Photolabile protecting groups

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Legal Events

Date Code Title Description
R207 Utility model specification

Effective date: 20030109

R150 Term of protection extended to 6 years

Effective date: 20050615

R151 Term of protection extended to 8 years

Effective date: 20080611

R152 Term of protection extended to 10 years

Effective date: 20100609

R071 Expiry of right
R071 Expiry of right