DE202020104968U1 - Sprayable composition of a throat spray - Google Patents

Abstract

Composition, characterized in that the composition consists of a polar phase and a non-polar phase, the polar phase containing at least 40% by weight of glycerol and at least 20% by weight of water based on the total weight of the polar phase, the composition per 100 g of the composition contains 0.5 g to 4 g of lecithin, and the non-polar phase contains at least one extract made from an extract from the mint (Mentha arvensis or Mentha x piperita), an extract from the clove tree (Syzygium aromaticum), an extract is selected from ginger (Zingiber officinale) and an extract from real thyme (Thymus vulgaris).

Description

The invention relates to a composition, a spray containing the composition according to the invention, the use of a spray device for distributing a composition according to the invention and a non-medical method for conditioning a section of the human body.

Liquid compositions for use in the oral cavity and throat are known. These compositions are i.a. marketed as a spray under the synonymous names "throat spray", "mouth spray" or "throat spray". These compositions or sprays can either be foodstuffs, food supplements or medical products.

For example, there are various sprays that contain liquid compositions with disinfecting agents, e.g. Cetylpyridinium, dequalinium, hexamidine, and / or local anesthetics, e.g. Lidocaine, and / or non-steroidal anti-inflammatory drugs, e.g. Flurbiprofen. Some compositions in the sprays contain vegetable oils, e.g. Chamomile oil, or other fat-soluble compounds such as cinnamaldehyde or levomenthol. Some compositions in the sprays contain vitamins and / or amino acids and / or minerals.

In addition to the already mentioned sprays for use in the oral cavity and throat, there are also skin sprays that contain similar compositions with active ingredients such as e.g. Contains hydrocortisone.

The known compositions generally have an aqueous base. The use of these compositions therefore requires that the compositions be microbiologically stable, i. that the growth of bacterial or fungal cultures does not occur in the compositions. In order to ensure the microbiological stability of the compositions even after opening, it is generally necessary to add preservatives.

Artificial preservatives, such as e.g. Sorbic acid and derivatives thereof, parabens (derivatives of 4-hydroxybenzoic acid, in particular 4-hydroxybenzoic acid methyl ester and 4-hydroxybenzoic acid propyl ester), sodium edetate and glycerol triacetate are added. Some of these compounds are controversial, among other things because of possible intolerance. Since preservatives are generally lipophilic, in compositions with an aqueous and lipophilic phase these also at least partially convert into the lipophilic phase. So that the concentration of preservative in the aqueous phase is high enough to effect preservation, two-phase systems are therefore usually formulated with a high content of preservatives.

The known compositions mostly contain water-soluble and fat-soluble compounds. Therefore, the addition of solubilizers is usually also necessary, e.g. Ethanol, propylene glycol and derivatives thereof, macrogol and derivatives thereof, cellulose and derivatives thereof (e.g. hypromellose), cyclodextrin and derivatives thereof, anionic, cationic and nonionic surfactants. However, surfactants can impair the effectiveness of the preservatives. A product with ethanol is also not available to everyone, pregnant women, children and people with a history of addiction are excluded. Other solubilizers are also at least controversial, especially when ingested orally, e.g. Propylene glycol and sodium dodecyl sulfate because of skin irritation, macrogolglycerol ricinoleate because of stomach upset, diarrhea and skin and mucous membrane irritation. There is also the problem that two-phase compositions, that is to say mixtures which have an aqueous phase and a lipid phase, are not permanently physically stable and phase separation occurs some time after production.

Some compounds are used because they have both preservative and solubilizing properties, e.g. Tetraalkylammonium compounds such as benzalkonium, benzethonium, cetylalkonium, cetylpyridinium, cetyltrimethylammonium, dequalinium, and the alcohols ethanol and propylene glycol.

Artificial sweeteners, monosaccharides or disaccharides are often added to the compositions to improve the taste.

Concentrated, aqueous solutions of the disaccharide sucrose are also used as the basis for sprays because sucrose in high concentrations is suitable for preservation and as a flavor carrier. It is of course disadvantageous that such a composition is cariogenic and also causes blood sugar peaks, which is particularly disadvantageous for diabetics. Diabetics in particular are particularly exposed to certain risks, so that any product that has nutritional, health or disease-preventive benefits should be suitable for diabetics.

One obstacle to using liquid compositions in sprays is that the Compositions must be sprayable via a spray device. High viscosity compositions, such as oils, or compositions containing solids, are often not sprayable or can at most be applied in the form of a strong jet and without atomization.

Against this background, it is an object of the invention to provide a composition which is suitable for spraying a section of the human body, in particular the oral cavity and the throat, and which has advantages over the compositions of known throat sprays. The composition should be microbiologically stable and both water-soluble and fat-soluble compounds should be included or be soluble or at least dispersible in the composition.

Efforts to achieve this object have resulted in a composition which is characterized in that the composition consists of a polar phase and a non-polar phase, wherein
the polar phase, based on the total weight of the polar phase, contains at least 40% by weight of glycerol and at least 20% by weight of water, the composition contains 0.5 g to 4 g of lecithin per 100 g of the composition, and the non-polar phase or the composition contains at least one extract made from an extract from mint (Mentha arvensis or Mentha x piperita), an extract from the clove tree (Syzygium aromaticum), an extract from ginger (Zingiber officinale) and an extract from real thyme ( Thymus vulgaris) is selected.

The liquid composition consists of a polar, water-containing phase and a non-polar phase, containing non-polar compounds, and yet - at least when observed with the eye - forms a homogeneous mixture. In other words, the composition contains water-soluble and fat-soluble compounds, the compounds being dissolved or at least dispersed. The composition is therefore physically stable. The special base of glycerine, water and lecithin in certain proportions contributes to this. The composition is also microbiologically stable. The glycerol content and the at least one extract contribute in particular to the microbiological stability. The at least one extract can contain essential oil. A microbiologically and physically stable composition that is suitable for oral application is thus only obtained by means of naturally occurring ingredients. As a result, the composition is accepted physiologically and psychologically particularly positively and is particularly well tolerated. The composition has a low risk of intolerance such as allergies. Both water-soluble and fat-soluble compounds dissolve in the composition and can be included without the need for additional solubilizers or surfactants. Thus, the basis of the composition allows hydrophilic and hydrophobic compounds to be incorporated into the composition in order to further modify the properties of the composition or to use the composition as a carrier system for certain compounds. Synthetic or non-naturally occurring additives for preservation or solubilization are not required. The composition has a good taste and smell even without monosaccharides and disaccharides and is therefore not cariogenic and does not cause blood sugar spikes. Above all, the composition is sprayable. Despite the high proportion of relatively viscous glycerine and the oily extract (s), the composition can be applied in the form of a spray. The special basis also enables a long interaction with a sprayed body part and an exchange between the composition and the sprayed body part. In addition to preservation, the at least one extract has a number of positive effects. The ingredients of the extracts can act at the application site, improve the taste, breath odor (bad breath) and mouthfeel and, if necessary, even have an antibacterial and / or antiviral effect.

The extract from the mint can be an extract from the field mint (Mentha arvensis) or from the peppermint (Mentha x piperita). In the context of the invention, an extract from field mint (Mentha arvensis) is preferred.

The extract from field mint (Mentha arvensis) is preferably an extract from the above-ground parts, preferably the flowering, above-ground parts. This can be mint oil according to the European Pharmacopoeia. The extract can e.g. be obtained by steam extraction. The ingredients of the extract can have an antioxidant, possibly antibacterial and / or antiviral effect and impart a fragrant taste and breath.

In another embodiment of the invention, an extract from peppermint (Mentha x piperita) is used instead of the extract from field mint (Mentha arvensis). The extract from the peppermint is preferably an extract from the above-ground parts, preferably the blooming, above-ground parts. This can be peppermint oil according to the European Pharmacopoeia. The extract can be obtained, for example, by steam extraction. The ingredients of the extract can be antioxidant as well possibly have antibacterial and / or antiviral effects and impart a fragrant taste and breath.

The extract from the clove tree (Syzygium aromaticum) is preferably an extract from the cloves, preferably clove oil. The extract is preferably obtained from the flower buds, more preferably the dried flower buds. This can be cloves according to the European Pharmacopoeia. The ingredients of the extract can have antioxidant effects and impart a fragrant taste and breath.

The extract from the ginger (Zingiber officinale) is preferably an extract from the root stocks of the ginger, preferably from the dried root stocks of the ginger. It can be ginger root according to the European Pharmacopoeia. The extract is preferably a CO ₂ distraction extract. The ingredients of the extract can have antioxidant effects.

The extract from the real thyme (Thymus vulgaris) is preferably an extract from the blooming above-ground parts. This can be thyme oil according to the European Pharmacopoeia. The extract can e.g. be obtained by steam extraction. The ingredients of the extract may have antibacterial and antiviral effects.

Lecithin is a preparation that contains phosphatidylcholine as its main ingredient. Phosphatidylcholines are 1,2-diacyl-sn-glycero-3-phosphocholine, phospholipids in which phosphoric acid is esterified with diacylglycerol and choline. According to the Additive Approval Ordinance (ZZulV 1998) under number E 322, lecithin is an additive approved for food in general (with the exception of certain foods).

The composition according to the invention contains 0.5 g to 4 g, more preferably 1 g to 3.5 g, even more preferably 1.5 g to 3.0 g or 2.0 g to 3.0 g of lecithin per 100 g of the composition. The lecithin is mainly present in the border area between polar and non-polar phase. In other words, in addition to the polar phase and the non-polar phase, the composition also consists of a lecithin phase, which consists of the lecithin in the composition. The lecithin has a phosphatidylcholine content of 30% by weight to 100% by weight. In other words, the composition preferably contains 0.2 g to 4 g, more preferably 0.3 g to 3.5 g, even more preferably 0.5 g to 3.0 g or 0.6 g to 3 g per 100 g of the composition , 0 g, phosphatidylcholine. In one embodiment, the composition according to the invention contains 1 g to 3 g, preferably 1 g to 2 g, of phosphatidylcholine per 100 g of the composition. Deoiled lecithin fractions are preferably used as lecithin. This means that the lecithin is preferably essentially free of non-polar lipids such as fatty acids and triglycerides. The content of non-polar lipids such as fatty acids and triglycerides is preferably less than 3% by weight. The lecithin contains a proportion of polar lipids (acetone-insoluble substance) of 90 to 100% by weight. The lecithin can come from a source selected from soy, sunflower, rape, fish, milk and / or eggs, with non-animal sources such as soy, sunflower and rape being particularly preferred. In addition to the main component phosphatidylcholine, lecithin can contain phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, sterols, fats and oils, depending on its origin. For example, a lecithin from soy can contain 40-50% by weight of phosphatidylcholine, about 10% by weight of phosphatidylethanolamine, about 5% by weight of phosphatidylinositol, about 1-2% by weight of phosphatidylserine and also sterols, Contains fats and oils. Lecithin obtained from egg yolks, on the other hand, consists essentially of phosphatidylcholine.

Water and glycerine, possibly also polysaccharides and water-soluble vitamins, are components of the polar phase.

The non-polar phase can consist of fatty acids and their esters, in particular triglycerides (triacylglycerols) and ethyl esters, fat-soluble vitamins and carotenoids, such as e.g. Lutein and zeaxanthin, vitamin A (retinol) and its derivatives retinal, retinyl palmitate and retiny acetate, vitamin E as a collective term for tocopherols and tocotrienols (this includes alpha-, beta-, gamma-, delta-tocopherols and tocotrienols, both as natural mixtures and synthetic in pure form), vitamin E derivatives such as alpha-, beta-, gamma- and delta-tocopherol acetate (both in optically pure form and as a racemate), vitamin D2 (ergocalciferol), vitamin D3 (cholecalciferol), vitamin K1 (phylloquinone ), Vitamin K2 (menaquinone), vitamin K3 (menadione), coenzyme Q 10 H (ubiquinol), ubiquinone-10 and perfluorocarbons. In the present invention, the extract or extracts from mint (Mentha arvensis or Mentha x piperita), in particular mint oil and / or peppermint oil, from the clove tree (Syzygium aromaticum), in particular clove oil, are particularly suitable as a source for the components of the non-polar phase ginger (Zingiber officinale) and real thyme (Thymus vulgaris), especially thyme oil, as well as coconut oil and fat-soluble vitamins.

The composition or the spray is a dietary supplement or a food.

The composition according to the invention is liquid or a liquid at room temperature (25 ° C.).

Embodiments within this document can be combined with one another in any way, unless the subject matter and description of the embodiments clearly indicate otherwise.

The verbs “contain” and “include” and their conjugations also contain the verb “consist of” with its conjugations.

Preferred embodiments are also given in the claims.

The polar phase of the composition according to the invention contains at least 40% by weight of glycerol, based on the total weight of the polar phase. A high content of glycerine supports the microbiological preservation of the composition. The inventors have discovered that by using the extract or extracts, the proportion of preserving glycerol in the polar phase and the composition can be reduced and the proportion of water can be increased. This makes the composition sprayable. For the purposes of the invention, sprayable means that the composition can be delivered in the form of droplets or an atomizing spray jet, e.g. from a spray device customary for throat sprays. In other words, the composition can be atomized with a spray device (atomizer) customary for throat sprays. In the context of the invention, compositions which are not sprayed by conventional spray devices for throat sprays are not sprayable or are released in the form of a strong jet.

Preferably the composition is not only sprayable and suitable for human ingestion, but also suitable for spraying into the human throat.

The non-polar phase (and the composition) preferably contains an extract from mint (Mentha arvensis or Mentha x piperita), an extract from the clove tree (Syzygium aromaticum), an extract from ginger (Zingiber officinale) and an extract from real thyme (Thymus vulgaris). By combining these extracts, the effects described above are used particularly well.

More preferably, the non-polar phase (and the composition) contains an extract from field mint (Mentha arvensis), an extract from the clove tree (Syzygium aromaticum), an extract from ginger (Zingiber officinale) and an extract from real thyme (Thymus vulgaris) . By combining these extracts, the effects described above are used particularly well.

The non-polar phase (and the composition) preferably contains 0.4 g to 10.0 g, preferably 1.5 g to 7.0 g, of the extract or the extracts in total per 100 g of the composition.

The proportion of the non-polar phase in the composition is preferably at most 25% by weight, more preferably at most 20% by weight, even more preferably at most 15% by weight, the polar phase and the lecithin making the difference ad 100% by weight . In a preferred embodiment, the proportion of the non-polar phase in the composition, based on the total weight of the composition, is 0.4% by weight to 10.0% by weight, preferably 1.5% by weight to 7.0% by weight. %, with the polar phase and the lecithin forming the difference to 100% by weight. In a more preferred embodiment, the proportion of the non-polar phase in the composition is 0.9% by weight to 15% by weight, preferably 2.0% by weight to 12.0% by weight, the polar phase and the Lecithin make up the difference to 100% by weight.

The polar phase preferably contains 40% by weight to 78% by weight, more preferably 45% by weight to 75% by weight, even more preferably 50% by weight to 70% by weight, based on the total weight of the polar phase, very particularly preferably 53% by weight to 67% by weight, most preferably 56% by weight to 64% by weight, glycerol.

Preferably, the composition (and the polar phase) contains 0.01 g to 2.0 g of polysaccharides per 100 g of the composition. The inventors have found that polysaccharides in this amount have a positive effect on the stability of the composition and the sprayability. The polysaccharides are preferably β-glucans, particularly preferably (1,3) - (1,6) -beta-D-glucans. β-glucans are polysaccharides made up of β-D-glucose units (β-D-glucopyranose).

The non-polar phase (and the composition) preferably contains 0.1 g to 4.0 g, preferably 1.0 g to 2.5 g, of an extract from field mint (Mentha arvensis) per 100 g of the composition.

Preferably, the non-polar phase (and the composition) contains per 100 g of Composition 0.1 g to 2.0 g, preferably 0.2 g to 1.2 g, of an extract from the clove tree (Syzygium aromaticum).

The non-polar phase (and the composition) preferably contains 0.1 g to 2.0 g, preferably 0.2 g to 0.8 g, of an extract from ginger (Zingiber officinale) per 100 g of the composition.

The non-polar phase (and the composition) preferably contains 0.1 g to 2.0 g, preferably 0.4 g to 1.5 g, of an extract from real thyme (Thymus vulgaris) per 100 g of the composition.

The non-polar phase (and the composition) particularly preferably contains 0.1 g to 4.0 g, preferably 1.0 g to 2.5 g, of an extract from field mint (Mentha arvensis), 0.1 g per 100 g of the composition g to 2.0 g, preferably 0.2 g to 1.2 g, of an extract from the clove tree (Syzygium aromaticum), 0.1 g to 2.0 g, preferably 0.2 g to 0.8 g, one Extract from ginger (Zingiber officinale) and 0.1 g to 2.0 g, preferably 0.4 g to 1.5 g, of an extract from real thyme (Thymus vulgaris).

The benefits of these extracts are described above. The extracts are particularly useful in these concentrations.

The composition preferably contains 0.05 g to 2.0 g, preferably 0.1 g to 0.8 g, of an extract from grapes (Vitis vinifera), preferably from grape seeds, per 100 g of the composition. Such an extract contains tannins. Tannins are polyphenols that can have antioxidant, astringent and enzyme-inhibiting properties. Tannins can also give a special mouthfeel. Certain tannins have been reported to prevent a virus from docking on its host cell, which may reduce the risk of infection by pathogens that cause local or general disturbance of the organism. The composition according to the invention can therefore possibly support the defense against pathogens. Due to the formulation of the composition, the composition adheres to the application site for a relatively long time and can act. In the formulation as a spray, the composition can be applied directly and finely divided.

The non-polar phase (and the composition) preferably contains 0.5 g to 5.0 g, preferably 1 g to 3.0 g, triacyl glycerols per 100 g of the composition in addition to any triacylglycerols contained in the extract (s). Preferably they are medium chain triacylglycerols, e.g. from coconut oil. Triacylglycerols can serve as carriers for lipophilic active ingredients and essential oils. Their use can stabilize the formulation. Furthermore, the spray behavior of the composition can be influenced in a positive way. Furthermore, the triacylglycerols form an oil film that adheres to the sprayed part of the body (e.g. throat) over a longer period of time, through which lipophilic compounds can diffuse and act.

The composition preferably contains at least one vitamin per 100 g of the composition, selected from vitamin B2, vitamin B7 (biotin), vitamin B12, vitamin D3 and derivatives thereof, vitamin A and derivatives thereof and vitamin E and derivatives thereof. More preferably, the composition contains vitamin B2, vitamin B7 (biotin), vitamin B12, vitamin D3 or a derivative thereof, vitamin A or a derivative thereof and vitamin E or a derivative thereof. In an even more preferred embodiment, the composition contains 0.1 g to 0.3 g vitamin B2, 0.004 g to 0.01 g vitamin B7 (biotin), 0.0002 g to 0.0006 g vitamin B12 per 100 g of the composition, 10,000 IU to 50,000 IU vitamin D3, 0.05 g to 0.2 g retinyl palmitate and 1 g to 3 g vitamin E acetate. Vitamin A, vitamin D3 and vitamin B12 can contribute to the normal function of the immune system. Vitamin B2, vitamin B7 (biotin) and vitamin A can help maintain normal mucous membranes. Vitamin E can help protect cells from oxidative stress. These vitamins promote general health, in particular the health of the cells of the mouth and throat. These vitamins are partly water-soluble, partly fat-soluble. Thanks to the special formulation, these vitamins can be applied simultaneously directly to the mucous membranes of the throat.

• 0,5 g bis 4 g, bevorzugter 1 g bis 3,5 g, noch bevorzugter 1,5 g bis 3,0 g oder 2,0 g bis 3,0 g, Lecithin (0,2 g bis 4 g, bevorzugter 0,3 g bis 3,5 g, noch bevorzugter 0,5 g bis 3,0 g oder 0,6 g bis 3,0 g, Phosphatidylcholin oder 1 g bis 3 g, bevorzugt 1 g bis 2 g, Phosphatidylcholin),
  • - 0,1 g bis 4,0 g, bevorzugt 1,0 g bis 2,5 g, eines Extraktes aus der Ackerminze (Mentha arvensis),
  • - 0,1 g bis 2,0 g, bevorzugt 0,2 g bis 1,2 g, eines Extraktes aus dem Gewürznelkenbaum (Syzygium aromaticum),
  • - 0,1 g bis 2,0 g, bevorzugt 0,2 g bis 0,8 g, eines Extraktes aus dem Ingwer (Zingiber officinale),
  • - 0,1 g bis 2 g, bevorzugt 0,4 g bis 1,5 g, eines Extraktes aus dem Echten Thymian (Thymus vulgaris),
  • - 0,5 g bis 5,0 g, bevorzugt 1,0 g bis 3,0 g, Triacylglycerole, vorzugsweise mittelkettige Triacylglycerole,
  • - 0,01 g bis 2,0 g Polysaccharide, bevorzugt β-Glucane, besonders bevorzugt (1,3)-(1,6)-Beta-D-Glucane,
  • - 0,05 g bis 2,0 g, bevorzugt 0,1 g bis 0,8 g, eines Extraktes aus Weintrauben (Vitis vinifera), vorzugsweise aus Weintraubenkernen,
  • - Vitamin B2, vorzugsweise 0,1 g bis 0,3 g Vitamin B2,
  • - Vitamin B7 (Biotin), vorzugsweise 0,004 g bis 0,01 g Vitamin B7 (Biotin),
  • - Vitamin B12, vorzugsweise 0,0002 g bis 0,0006 g Vitamin B12,
  • - Vitamin D3, vorzugsweise 10000 IE bis 50000 IE Vitamin D3,
  • - Retinylpalmitat, vorzugsweise 0,05 g bis 0,2 g Retinylpalmitat, und
  • - Vitamin E-Acetat, vorzugsweise 1 g bis 3 g, Vitamin E-Acetat.

In a particularly preferred embodiment, the composition consists of a polar phase and a non-polar phase,
the polar phase containing at least 20% by weight of water based on the total weight of the polar phase,
wherein the polar phase, based on the total weight of the polar phase, is 40% by weight to 78% by weight, more preferably 45% by weight to 75% by weight, even more preferably 50% by weight to 70% by weight, very particularly preferably 53% by weight to 67% by weight, most preferably 56% by weight to 64% by weight, contains glycerol,
wherein the composition contains, in addition to water and glycerin per 100 g of the composition:

• 0.5 g to 4 g, more preferably 1 g to 3.5 g, even more preferably 1.5 g to 3.0 g or 2.0 g to 3.0 g, lecithin (0.2 g to 4 g, more preferably 0.3 g to 3.5 g, more preferably 0.5 g to 3.0 g or 0.6 g to 3.0 g, phosphatidylcholine or 1 g to 3 g, preferably 1 g to 2 g, phosphatidylcholine),
  • - 0.1 g to 4.0 g, preferably 1.0 g to 2.5 g, of an extract from field mint (Mentha arvensis),
  • - 0.1 g to 2.0 g, preferably 0.2 g to 1.2 g, of an extract from the clove tree (Syzygium aromaticum),
  • - 0.1 g to 2.0 g, preferably 0.2 g to 0.8 g, of an extract from ginger (Zingiber officinale),
  • - 0.1 g to 2 g, preferably 0.4 g to 1.5 g, of an extract from real thyme (Thymus vulgaris),
  • - 0.5 g to 5.0 g, preferably 1.0 g to 3.0 g, triacylglycerols, preferably medium-chain triacylglycerols,
  • - 0.01 g to 2.0 g of polysaccharides, preferably β-glucans, particularly preferably (1,3) - (1,6) -beta-D-glucans,
  • - 0.05 g to 2.0 g, preferably 0.1 g to 0.8 g, of an extract from grapes (Vitis vinifera), preferably from grape seeds,
  • - vitamin B2, preferably 0.1 g to 0.3 g vitamin B2,
  • - Vitamin B7 (biotin), preferably 0.004 g to 0.01 g vitamin B7 (biotin),
  • - Vitamin B12, preferably 0.0002 g to 0.0006 g vitamin B12,
  • - Vitamin D3, preferably 10,000 IU to 50,000 IU vitamin D3,
  • Retinyl palmitate, preferably 0.05 g to 0.2 g retinyl palmitate, and
  • - Vitamin E acetate, preferably 1 g to 3 g, vitamin E acetate.

In a particularly preferred embodiment, the composition consists of these constituents, water and glycerol forming the difference to 100 g of the composition.

• - 25 g bis 35 g Wasser,
• - 0,5 g bis 4 g Lecithin,
• - 1 g bis 2,5 g Minzöl (Mentha arvensis),
• - 0,2 g bis 1,2 g Gewürznelkenöl (Syzygium aromaticum),
• - 0,2 g bis 0,8 g Ingwerwurzelstock-CO₂-Destraktionsextrakt (Zingiber officinale),
• - 0,4 g bis 1,5 g Thymianöl (Thymus vulgaris) und

mindestens 50 g Glycerin. Die Zusammensetzung kann gemäß der Offenbarung dieser Schrift modifiziert werden.In a preferred embodiment, the basis of a composition according to the invention is formed from a composition which contains per 100 g of the composition:

• - 25 g to 35 g water,
• - 0.5 g to 4 g of lecithin,
• - 1 g to 2.5 g of mint oil (Mentha arvensis),
• - 0.2 g to 1.2 g clove oil (Syzygium aromaticum),
• - 0.2 g to 0.8 g of ginger root CO ₂ -destraction extract (Zingiber officinale),
• - 0.4 g to 1.5 g of thyme oil (Thymus vulgaris) and

at least 50 g of glycerine. The composition can be modified according to the disclosure of this document.

• - 33 g Wasser,
• - 2 g Lecithin (1,5 g Phosphatidylcholin),
• - 1,6 g Minzöl (Mentha arvensis),
• - 0,4 g Gewürznelkenöl (Syzygium aromaticum),
• - 0,4 g Ingwerwurzelstock-CO₂-Destraktionsextrakt (Zingiber officinale),
• - 0,8 g Thymianöl (Thymus vulgaris),
• - 2 g mittelkettigen Triacylglycerolen,
• - 0,05 g (1,3)-(1,6)-Beta-D-Glucanen,
• - 0,16 g eines Extraktes aus Weintraubenkernen (Vitis vinifera),
• - 0,2 g Vitamin B2,
• - 0,007 g Vitamin B7 (Biotin),
• - 0,0004 g Vitamin B12,
• - 10000 IE bis 50000 IE Vitamin D3,
• - 0,13 g Retinylpalmitat,
• - Vitamin E-Acetat, vorzugsweise 2 g Vitamin E-Acetat, und
• - Glycerin ad 100 g.

In a very particularly preferred embodiment, the composition consists of per 100 g of the composition

• - 33 g water,
• - 2 g lecithin (1.5 g phosphatidylcholine),
• - 1.6 g of mint oil (Mentha arvensis),
• - 0.4 g clove oil (Syzygium aromaticum),
• - 0.4 g ginger root CO ₂ -destraction extract (Zingiber officinale),
• - 0.8 g of thyme oil (Thymus vulgaris),
• - 2 g medium-chain triacylglycerols,
• - 0.05 g (1.3) - (1.6) -Beta-D-glucans,
• - 0.16 g of an extract from grape seeds (Vitis vinifera),
• - 0.2 g of vitamin B2,
• - 0.007 g vitamin B7 (biotin),
• - 0.0004 g vitamin B12,
• - 10,000 IU to 50,000 IU vitamin D3,
• - 0.13 g retinyl palmitate,
• - Vitamin E acetate, preferably 2 g of vitamin E acetate, and
• - glycerine ad 100 g.

In a preferred embodiment, the composition does not contain any monosaccharide or disaccharide. In a preferred embodiment, the composition contains a maximum of 1 g of monosaccharides and disaccharides per 100 g of the composition. A monosaccharide in the context of this document is e.g. Glucose or fructose. A disaccharide in the context of this document is e.g. Sucrose.

In a preferred embodiment, the composition does not contain a monohydric alcohol. In a preferred embodiment, the composition contains a maximum of 1 g of monohydric alcohols per 100 g of the composition. Monohydric alcohol within the meaning of this document are e.g. Ethanol and propanol.

In a preferred embodiment, the composition does not contain any dihydric alcohol. In a preferred embodiment, the composition contains a maximum of 1 g of dihydric alcohols per 100 g of the composition. For the purposes of this document, a dihydric alcohol is, for example, propylene glycol.

In a preferred embodiment, the composition does not contain a synthetic surfactant. The term “none” is to be understood to mean that the concentration of the compound is so low that no significant effect is to be expected. In other words, the concentration is out of the range at which the compound is normally used. Synthetic surfactants for the purposes of the invention include ethoxylated surfactants, macrogol and derivatives thereof (for example macrogol glycerol fatty acid esters such as macrogol glycerol ricinoleate, macrogol fatty acid esters such as macrogololeate, macrogol fatty alcohol ethers such as polyoxyethylene cetyl ether), propylene glycol and derivatives thereof (cellular ethylene glycol and derivatives thereof, polyoxypropylene, for example hypromellose), benzalkonium, benzethonium, Cetylalkonium, cetylpyridinium, cetyltrimethylammonium, dequalinium, sodium dodecyl sulfate, sodium cetyl sulfate, sodium stearyl sulfate, ethylene glycol monostearate, partial esters of sorbitan (such as sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan tristearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate, polysorbates (polyoxyethylene) fatty acid ester of sucrose , Fatty acid esters of polyglycerol and D-α-tocopheryl-1000-succinate.

In a preferred embodiment, the composition does not contain any artificial preservative. The term “none” is to be understood to mean that the concentration of the compound is so low that no significant effect is to be expected. In other words, the concentration is out of the range at which the compound is normally used. Artificial preservatives in the context of the invention are 4-hydroxybenzoic acid esters (e.g. 4-hydroxybenzoic acid methyl ester and 4-hydroxybenzoic acid propyl ester), chlorocresol, chlorobutanol, sorbic acid (E 200), potassium sorbate (E 202), calcium sorbate (E 203), sodium edetate, glycerol triacetate, Benzethonium, cetylalkonium, cetylpyridinium, cetyltrimethylammonium, cetrimonium, chlorhexidine, dequalinium, organic mercury compounds.

In a preferred embodiment, the composition does not contain any artificial sweetener. The term “none” is to be understood to mean that the concentration of the compound is so low that no significant effect is to be expected. In other words, the concentration is out of the range at which the compound is normally used. Artificial sweeteners within the meaning of the invention are acesulfame (E 950), advan tame (E 969), aspartame (E 951), aspartame acesulfame salt (E 962), cyclamate (E 952), neohesperidin (E 959), neotame ( E 961), saccharin (E 954) and sucralose (E 955). Steviol glycosides, e.g. Stevioside (E 960) are not considered artificial sweeteners within the meaning of the invention.

In a preferred embodiment, the composition is sugar-free within the meaning of Regulation (EC) No. 1924/2006 of the European Parliament and of the Council of December 20, 2006 on nutrition and health claims made about foods. In other words, in a preferred embodiment, the composition does not contain more than 0.5 g of sugars (monosaccharides and disaccharides) per 100 g of the composition.

In a certain embodiment, the composition does not contain any ingredients of animal origin. In other words, the composition is suitable for a vegetarian and / or vegan lifestyle.
The efforts to achieve the object mentioned in the introduction also result in a spray comprising a spray device and a storage chamber, the storage chamber containing a composition according to the invention. The spray device has means to guide the composition according to the invention from the storage chamber and to deliver it to the environment in the form of fine droplets or an atomizing jet. Suitable sprays, comprising a spray device and a storage chamber, are known to the person skilled in the art and to the user of, for example, mouth, throat and throat sprays from the pharmacy or drugstore. By actuating, preferably manually pressing down, a trigger on the spray device (atomizer), the user can release a spray of a liquid with a usually aqueous or ethanolic base from the storage chamber in the form of fine droplets or an atomizing jet to the environment. A spray according to the invention comprises a composition according to the invention in such a commercially available device with a spray device and storage chamber.

The efforts to achieve the object mentioned in the introduction have resulted in the use of a spray device for distributing a composition according to the invention.

Preferably the spreading is spraying.

The use according to the invention is preferably a non-medical use.

The efforts to solve the problem mentioned in the introduction also result in a non-medical method for conditioning a section of the human body to achieve at least one effect selected from i) supporting the maintenance of the function of the mucous membrane, ii) supporting the function of the immune system, iii) supporting the protection of cells from oxidative stress, iv) improving breath odor (bad breath), v) improving the taste, vi) improving the mouthfeel and vii) supporting the defense against pathogens selected from viruses and bacteria, the method being the Comprising applying a composition of the invention to the portion of the human body.

The application is preferably spraying on, preferably by means of a spray device (a spray).

The section of the human body is preferably selected from the oral cavity and the throat.

The invention is further illustrated below using an example.

• - 33 g Wasser,
• - 2 g Lecithin (1,5 g Phosphatidylcholin),
• - 1,6 g Minzöl (Mentha arvensis),
• - 0,4 g Gewürznelkenöl (Syzygium aromaticum),
• - 0,4 g Ingwerwurzelstock-CO₂-Destraktionsextrakt (Zingiber officinale),
• - 0,8 g Thymianöl (Thymus vulgaris),
• - 2 g mittelkettige Triacylglycerole,
• - 0,05 g (1,3)-(1,6)-Beta-D-Glucane,
• - 0,16 g eines Extraktes aus Weintraubenkernen (Vitis vinifera),
• - 0,2 g Vitamin B2,
• - 0,007 g Vitamin B7 (Biotin),
• - 0,0004 g Vitamin B12,
• - 10000 IE bis 50000 IE Vitamin D3,
• - 0,13 g Retinylpalmitat,
• - 2 g Vitamin E-Acetat und
• - Glycerin ad 100 g.

An exemplary composition according to the invention contains per 100 g of the composition

• - 33 g water,
• - 2 g lecithin (1.5 g phosphatidylcholine),
• - 1.6 g of mint oil (Mentha arvensis),
• - 0.4 g clove oil (Syzygium aromaticum),
• - 0.4 g ginger root CO ₂ -destraction extract (Zingiber officinale),
• - 0.8 g of thyme oil (Thymus vulgaris),
• - 2 g medium-chain triacylglycerols,
• - 0.05 g (1.3) - (1.6) -Beta-D-glucans,
• - 0.16 g of an extract from grape seeds (Vitis vinifera),
• - 0.2 g of vitamin B2,
• - 0.007 g vitamin B7 (biotin),
• - 0.0004 g vitamin B12,
• - 10,000 IU to 50,000 IU vitamin D3,
• - 0.13 g retinyl palmitate,
• - 2 g of vitamin E acetate and
• - glycerine ad 100 g.

The composition is liquid or a liquid at room temperature (25 ° C). All ingredients occur naturally. The composition does not contain substantial amounts of monosaccharide, disaccharide, mono- or dihydric alcohol, synthetic surfactant, artificial preservative or artificial sweetener. Ingredients of animal origin are not required. The composition has a low risk of intolerance such as allergies. The composition has a good taste and smell, is non-cariogenic and does not cause blood sugar spikes. The composition is sugar-free within the meaning of Regulation (EC) No. 1924/2006 of the European Parliament and of the Council of December 20, 2006 on nutrition and health claims made on foods. In other words, the composition contains no more than 0.5 g of sugars (monosaccharides and disaccharides) per 100 g of the composition.

At the same time, the composition is microbiologically and physically stable. When used in a spray, the composition can be sprayed into the human throat via a conventional spray device and is suitable for being swallowed without concern. The special basis of glycerine, water, medium-chain triacylglycerols and lecithin in certain proportions enables it to stick to the throat and a long interaction and exchange between the composition and the sprayed body part.

The vitamins promote general health, in particular the health of the cells of the oropharynx. Thanks to the special formulation, the water- and fat-soluble vitamins can be applied directly to the mucous membranes with one spray, which supports the mucous membranes and the immune system.

By using the extract or the extracts, the proportion of preserving glycerine in the composition can be reduced and thus the proportion of water can be increased. U.a. this makes the composition sprayable. In addition to the preservative effect, ingredients of the extract (s) have antioxidant and possibly antiviral and / or antibacterial effects. In addition, the composition improves taste, breath odor (bad breath) and mouthfeel. The person skilled in the art will recognize that the individual components of the composition interact in a special way in order to form the product according to the invention with all of its advantageous properties.

Claims (14)

Composition, characterized in that the composition consists of a polar phase and a non-polar phase, the polar phase containing at least 40% by weight of glycerol and at least 20% by weight of water based on the total weight of the polar phase, the composition per 100 g of the composition contains 0.5 g to 4 g of lecithin, and the non-polar phase Contains at least one extract made from an extract from mint (Mentha arvensis or Mentha x piperita), an extract from the clove tree (Syzygium aromaticum), an extract from ginger (Zingiber officinale) and an extract from real thyme (Thymus vulgaris ) is selected. Composition at least after Claim 1 , characterized in that the non-polar phase consists of an extract from mint (Mentha arvensis or Mentha x piperita), an extract from the clove tree (Syzygium aromaticum), an extract from ginger (Zingiber officinale) and an extract from real thyme (Thymus vulgaris). Composition according to at least one of the Claims 1 to 2 , characterized in that the non-polar phase contains an extract from the field mint (Mentha arvensis), an extract from the clove tree (Syzygium aromaticum), an extract from the ginger (Zingiber officinale) and an extract from the real thyme (Thymus vulgaris). Composition according to at least one of the Claims 1 to 3 , characterized in that the polar phase, based on the total weight of the polar phase, is 40% by weight to 78% by weight, more preferably 45% by weight to 75% by weight, even more preferably 50% by weight to 70% by weight %, very particularly preferably 53% by weight to 67% by weight, most preferably 56% by weight to 64% by weight, contains glycerol and the non-polar phase per 100 g of the composition contains 0.4 g to 10% , 0 g, preferably 1.5 g to 7.0 g, of the extract or the extracts in total. Composition according to at least one of the Claims 1 to 4th , characterized in that the composition contains 0.01 g to 2.0 g of polysaccharides, preferably β-glucans, particularly preferably (1,3) - (1,6) -beta-D-glucans, per 100 g of the composition. Composition according to at least one of the Claims 1 to 5 , characterized in that the non-polar phase contains 0.1 g to 4.0 g of an extract from field mint (Mentha arvensis) per 100 g of the composition. Composition according to at least one of the Claims 1 to 6th , characterized in that the non-polar phase contains 0.1 g to 2.0 g of an extract from the clove tree (Syzygium aromaticum) per 100 g of the composition. Composition according to at least one of the Claims 1 to 7th , characterized in that the non-polar phase contains 0.1 g to 2.0 g of an extract, preferably a CO ₂ -destraction extract, from ginger (Zingiber officinale) per 100 g of the composition. Composition according to at least one of the Claims 1 to 8th , characterized in that the non-polar phase contains 0.1 g to 2.0 g of an extract from real thyme (Thymus vulgaris) per 100 g of the composition. Composition according to at least one of the Claims 1 to 9 , characterized in that the composition contains 0.05 g to 2.0 g of an extract from grapes (Vitis vinifera), preferably from grape seeds, per 100 g of the composition. Composition according to at least one of the Claims 1 to 10 , characterized in that the non-polar phase contains 0.5 g to 5.0 g of triacylglycerols, preferably medium-chain triacylglycerols, per 100 g of the composition in addition to the triacylglycerols contained in the extract / extracts. Composition according to at least one of the Claims 1 to 11 , characterized in that the composition contains at least one vitamin selected from vitamin B2, vitamin B7 (biotin), vitamin B12, vitamin D3 and derivatives thereof, vitamin A and derivatives thereof and vitamin E and derivatives thereof. Composition, characterized in that the composition contains per 100 g of the composition: - 25 g to 35 g of water, - 0.5 g to 4 g of lecithin, - 1 g to 2.5 g of mint oil (Mentha arvensis), - 0, 2 g to 1.2 g of clove oil (Syzygium aromaticum), - 0.2 g to 0.8 g of ginger root CO ₂ -destraction extract (Zingiber officinale), - 0.4 g to 1.5 g of thyme oil (Thymus vulgaris) and at least 50 g of glycerine. Spray comprising a spray device and a storage chamber, the storage chamber having a composition according to at least one of Claims 1 to 13 contains.