DE202004001072U1 - Antimold preservative system used for buildings for protecting wood, masonry and plaster, comprises four aqueous isopropanolic preparations with cleaning, fungicidal and mold preventing actions - Google Patents

Abstract

Chemical antimold preservative system (I) comprises four separate aqueous isopropanolic preparations (1)-(4) having cleaning, acute fungicidal, potent fungicidal and mold-preventing action, respectively. Chemical antimold preservative system (I) comprises four separate preparations comprising: (1) Fungo cleancomprising 70% water, 22% isopropanol, 2.5% sodium dodecyl sulfate, 2.5% polyoxyethylene sorbitan monostearate, 2.5% polyoxyethylene sorbitan monooleate and 0.5% propyl paraben; (2) Fungo-EX-rapidcomprising 75% isopropanol, 24% water, 0.2% benzalkonium chloride, 0.1% sodium salicylate, 0.1% 2-phenylphenol, 0.45% propyl paraben and 0.15% thiabendazole; (3) Fungo-EX-fortecomprising 78% isopropanol, 20% water, 1.35% 2-phenoxyethanol, 0.2% benzalkonium chloride, 0.05% sodium salicylate, 0.1% 2-phenylphenol, 0.1% propyl paraben, 0.15% thiabendazole and 0.05% chloroxylenol, and (4) Fungo-Preventcomprising 58% water, 40% isopropanol, 1.2% 2-phenoxyethanol, 0.15% sodium salicylate, 0.15% 2-phenylphenol and 0.5% propyl paraben. ACTIVITY : Fungicide. MECHANISM OF ACTION : Carotenoid synthesis inhibitor; Respiration chain inhibitor.

Description

1 .: problem

1.1 General introduction and basic concepts

All In addition to the inorganic substance, building materials also contain organic substances in more or less high proportions. Wood is an example of a high proportion of organic substances, reinforced concrete or grid stones however an example of a small proportion of these substances.

Fungi, especially molds, represent heterotrophic organisms. This means that organic Substance implemented for the purpose of cell metabolism and growth becomes. Because of this, it is possible that practical any form of building substance through the location of a microbial infestation Can represent molds.

Under certain conditions (temperatures in the range of 10 ° C up to 20 ° C and humidity over 80% rel. Moisture, or the presence of condensing moisture in the If the temperature falls below the dew point), it is possible that ubiquitous spores different types of fungi can infect the building substance.

This leads to being mitotic Proliferation, starting from the spores, a fungal mycelium consisting from thread-like strands (Hyphae) of the fungal cells in the building structure.

1.2 Effects on the fabric of the building and room hygiene

The mushroom mycelium causes a loss in terms the parameters tensile strength and bending coefficient. Wooden parts unusable, loosen glue connections themselves, wallpapers lose their grip on the plaster, stucco decorations can break.

Since only the spore levels (conidiophores) of the fungal attack as greasy, white Substance (yeast) or as a fur-like gray structure (mold) are visible while not to macroscopically identify the actual fungal mycelium is often a much larger part when individual "gray deposits" appear of the building fabric.

Set the spore stands as termini of the mycelial strands permanent spores free, leading to immediate allergic reactions or lead to contact allergies can, especially in children, the elderly People and weakened defenses People.

First is a change the ambient conditions required (surge ventilation, correction of air humidity and heating habits, etc.); at the same time, however, is also one fungicidal treatment necessary because of a sole change a manifestation of mold in the ambient conditions cannot eradicate.

2. Previous fungicidal treatment

Typically the fungicide Treatment so far with various polycyclic, aromatic hydrocarbons, polyhalogenated aromatic hydrocarbons, organophosphates, organometallic compounds, heavy metal salts or through radical formers, such as hydrogen peroxide and sodium hypochlorite.

The disadvantage of polycyclic, Aromatic hydrocarbons are carcinogenic due to the fact that in the human body from these substances unstable epoxides are formed; as a result there are bonds between these epoxides and bases of DNA (mutagenic and carcinogenic Effect) and between epoxides and proteins (loss of function of the Proteins). The polycyclic aromatic hydrocarbons also act due to their high lipophilicity, cumulative in adipose tissue the chronological "controllability" of the effect is lost.

Similar The polyhalogenated aromatic hydrocarbons have disadvantages on; As part of the metabolism, halogen radicals (e.g. Cl) occur, moreover there are cumulative effects.

Organophosphates are human toxicological considered inhibitors of the action of certain enzymes that the Mediate interaction between nerve cells. It is therefore neurotoxic substances that are also disadvantageous.

Organometallic compounds and heavy metal salts are also disadvantageous active substances, since these are enzyme inhibitors in human metabolism. The cumulative effect should be mentioned especially with regard to the organometallic compounds. Radical formers (such as hydrogen peroxide or sodium hypochlorite) have the disadvantage that their use in fungicides can lead to changes in the building structure. Furthermore, due to their hydrophilic properties, the substances mentioned only act on the surface and inside often do not reach the actual mushroom mycelium.

This led to the fight against fungi in in the past often only with great risks or too little Efficiency.

3. Innovation

A system was newly developed from four different preparations. By using this system you can practically all aspects of mold eradication to be covered:

• - Current Infestation present, infestation moderate to moderate and / or none visible signs of infestation (e.g. gray, fluffy spots) - preparation 1 + Preparation 2 according to instructions for use.
• - Current Infestation present, infestation to a high degree, visible signs of infestation are present. - preparation 1 + Preparation 3 according to instructions for use.
• - None Current infestation is present, however, there is a risk of fungal infection favorable Environmental factors: - preparation 4 according to instructions for use.

3.1 Description of the preparations

3.1.1 Preparation 1 Fungo-Clean

This combination of substances is for Pre-cleaning of surfaces suitable to be subjected to fungicidal treatment. It consists of one anionic (sodium dodecyl sulfate) and two nonionic surfactants (polyoxyethylene sorbitan monostearate and polyoxyethylene sorbitan monooleate), the nonionic surfactants were chosen so that from the chain length the hydrophobic content of these surfactants is particularly good for mushroom cells and spores results. The preparation is proportionate before application diluted with water from 1:20 to 1:50.

Composition of preparation 1

3.1.2 Preparation 2 (Fungo-EX-rapid

It is a fungicide for Eradication of a current mild to moderate mold infestation (up to approx. 10000 CFU / g). At the same time, a remanence effect is required i.e. after eradication, there is a renewed infestation by ubiquitous approach pores avoided.

Composition of preparation 2

3.1.3 Preparation 3 (Fungo-EX-forte

Like preparation 2, preparation 3 is a fungicide. In contrast to preparation 2 it is a highly potent broad spectrum fungicide that is specifically designed for to a high degree of infestation (places where there are visible signs of infestation (e.g. fluffy, gray toppings, etc.) are available; also> 10000 CFU / g) can be used. The residual effect remaining after eradication is extremely strong pronounced.

Composition of preparation 3

3.1.4 Specimen 4 (Fungo Prevent)

This is not about a fungicide to be used directly, but rather a preparation, its application one possible Prevention of mold infestation of still mold-free building parts. This is useful if the corresponding objects are in an environment be spent, which favors a mold infestation.

Composition of preparation 4

Preparation 1 is part of a aqueous mechanical cleaning used, preparations 2,3 and 4 are by means of a soft hair brush applied by brushing.

3.2 Effects of the ingredients

3.2.1 Destinations of the fungicidal effect

• - cell wall: Inhibition of chitin synthesis, loss of cell pressure, "withering" of the cells.
• - Continuity of the bio membrane the cell: perforation induction, in and out diffusion are facilitated, “cell runs out".
• - new synthesis the biomembrane of the cell: by inhibiting certain key enzymes (e.g. lanosterol demethylase) the synthesis can be more mushroom-specific Membrane determinants are prevented (such as Ergosterol).
• - Carotenoid synthesis: The synthesis of endogenous radical scavengers (carotenoids) is interrupted, this makes the fungal cell more unstable to radical attacks.
• - Breathing chain: By inhibiting certain specific enzymes, the production of the cell's own energy substance "ATP" is prevented.
• - intercalation with proteins and DNA: This occurs in the context of radical Reactions to proteins as structural determinants and enzymes as Biocatalysts to polymerize these structures to afunctional ones Macromolecules; intercalation with the DNA induces strand crosslinks and strand breaks, replication as part of cell division is no longer possible.
• - Germination inhibition: Differentiation and proliferation of approach spores to a mycelium is prevented (an essential part of the remanence effect!).

By another innovation, in the frame of which several active ingredients are used in parallel, on different Interfering with the metabolism of the fungal cells, is caused to one is the absolute concentration of the active ingredients in the preparations can be kept low, on the other hand, by this principle too the occurrence of resistance is counteracted.

Overview of the effects

3.2.2 Details of the effect

Active substances for eradication (at the same time Disinfectant)

• - Isopropanol: a typical technical alcohol. This alcohol penetrates through the chitin layer of the cell wall and perforates the biomembrane of the fungal cell. This makes the cell accessible to other substances. At the same time, membrane damage leads to cell damage, and proteins are irreversibly denatured. The isopropanol also serves as a solvent for the other active ingredients.
• - Benzalkonium chloride: This substance is a cationic surfactant, which by intercalation with the biomembrane of the fungal cells due to the emulsifying effect leads to membrane perforation (analogous to isopropanol). Of proteins are also irreversibly denatured.

Active ingredients to build a remanence effect:

• - sodium salicylate: It is the sodium salt of a natural product (salicylic acid), the e.g. occurs in the willow bark or in the Spier perennial. Caused is an inhibition of cell enzymes that oxidize certain fatty substances. This can limit the control of cell metabolism. simultaneously the sodium salicylate inhibits spore germination.
• - 2-phenyphenol: This substance inhibits carotenoid synthesis Enzyme inhibition (carotenoids are cell protectors = "radical scavengers"), an inhibition of Cell wall stability through interventions in chitin synthesis and an inhibitory intervention into the so-called "respiratory chain", by means of which the cell's own energy ATP is produced.
• - thiabendazole: These active substances inhibit the re-synthesis of the cell membranes the fungal cells, which prevents cell growth. This is by chelating inhibition of key enzymes in ergosterol synthesis (Lanosterol demethylase) reached. - An inhibitory intervention in the respiratory chain is also present.
• - 2-phenoxyethanol: The substance represents an ether, which is intermediate, radical Reactions within the fungal cells to alkylation and thereby Polymerization of various cell structures (usually proteins and DNS) leads (so-called "intercalation").
• - chlorxylenol: It is an active ingredient that decouples the "respiratory chain" and thus one Failure to produce the cell's own energy ATP leads.
• - propyl hydroxybenzoate: The active ingredient causes long-term damage to the surface activity continuity the biomembrane, the substance also has a polymerizing effect on proteins and also inhibits the cell metabolism by binding to different coenzymes.

3.3. Further information:

The substances mentioned are after Recipe first measured exactly (the required quantities are expressed as a ratio of the desired Volume determined for the guideline recipe). After that, for each preparation the hydrophobic components in the isopropanol fraction, the hydrophilic Components in the aqueous Fraction solved. Once this has been done, the two fractions are mixed together.

The simultaneous use of Has oxidizing agents such as hydrogen peroxide or sodium hypochlorite to be avoided, as these substances are incompatible with the above-mentioned preparations are.

Since preparations 2 and 3 are highly flammable, are all Extinguish flames and exclude all spark sources.

While use should follow basic hygiene rules should not be eaten, drunk or smoked, furthermore is for good ventilation to care.

Identification of the substances of preparations 1–4 based on the CAS numbers

Claims (2)

Building protection - chemical, preservative system, consisting of four newly developed preparations to combat mold infestation of the organic (wood) and inorganic (masonry, plaster) building substance, characterized in that, in addition to an acute effect in the form of eradication of the current fungal attack, there is a remanent effect which a prolonged, fungicidal and fungistatic effect. In this way, a current fungal infection is eradicated and at the same time a new manifestation of mold is reliably prevented. Preparation 1 (fungo clean) is characterized in that the use of anionic surfactants in combination with nonionic surfactants of a certain structure achieves a high emulsifying cleaning action due to the affinity of the surfactant structure for the cell wall of the fungal cell and fungal spores. Preparation 1 according to protection claim 1 is further characterized in that the preparation is composed of 70% water, 22% isopropanol, 2.5% sodium dodecyl sulfate, 2.5% polyoxyethylene sorbitan monostearate, 2.5% polyoxyethylene sorbitan monooleate and 0.5% propylhydroxybenzoate. Preparation 2 (Fungo-EX-rapid) is characterized in that, in addition to an acute fungicidal action, a remanent action is also required as part of the application of the preparation. The preparation 2 is further characterized in that it consists of 75% isopropanol, 24% water, 0.2% benzalkonium chloride, 0.1% sodium salicylate, 0.1% 2-phenylphenol, 0.45% propylhydroxybenzoate and 0.15% thiabendazole consists. Preparation 3 (Fungo-EX-forte) is characterized by the fact that there is a particularly potent acute fungicidal broad-spectrum effect, which is supplemented by a remanent effect which is present at the same time. Preparation 3 is further characterized in that 78% isopropanol, 20% water, 1.35% 2-phenoxyethanol, 0.2% benzalkonium chloride, 0.05% sodium salicylate, 0.1% 2-phenylphenol, 0.1% propylhydroxybenzoate, 0 , 15% thiabendazole and 0.05% chlorxylenol are included. Preparation 4 (Fungo-Prevent) is characterized in that mold application is prevented with prospective application with a view to prevention. Preparation 4 is further characterized in that the desired effect is achieved by 58% water, 40% isopropanol, 1.2% 2-phenoxyethanol, 0.15% sodium salicylate, 0.15% 2-phenylphenol and 0.5% propylhydroxybenzoate. The system of four preparations according to protection claims 1 is characterized as a further feature that a low chronic human toxicity due to the lack of cumulative, also missing teratogenic, carcinogenic and mutagenic effects by dispensing with content and Active ingredients with high chronic human toxicity (polyhalogenated aromatics, polycyclic aromatic hydrocarbons, organometallic compounds and heavy metal salts).