DE2012328A1 - - Google Patents

Description

toothpaste

The invention relates to a toothpaste, in particular a toothpaste to improve oral hygiene by being easy to use even on the sensitive gum parts in the oral cavity «

The gums in humans are often very soft and sensitive, making it difficult or painful to clean them adequately with a conventional toothpaste Contains gums, such as benzyl alcohol, in order to be able to easily clean even the soft, sensitive parts of the oral cavity _. Clove oil and mint oils, such as peppermint oil and frizzy oil, are preferred. However, toothpastes which contain benzyl alcohol in an amount sufficient to deenite gums and the like tend to be

included, in addition to being in a liquid

a

e solid phase to separate.

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The present invention is based on the object of proposing a dental set which contains benzyl alcohol and such a flavoring substance and is nevertheless storable ο

According to the invention, this object is achieved by a toothpaste dissolved, which contains an essentially water-insoluble abrasive, benzyl alcohol and, as a stabilizing agent, zinc oxide, a zinc phosphate or an alkali phosphate with a pK _A in water of 25 ⁰ C of at least 7 or ethyl alcohol and as a flavoring substance when using zinc oxide, zinc phosphate or alkali phosphate clove and / or mint oil and when using ethyl alcohol clove oil

This toothpaste normally has a pH value between 3.5 and 10, preferably between 6 and 9 f and in particular 6.5 ° A buffer system is preferably used to keep the pH value within the limits mentioned and to reduce the effectiveness of the cream to prevent which occurs under more alkaline or more acidic conditions ο

All water-insoluble abrasives can be used for I. Manufacture of dental care products such as toothpastes,

009851/2053

known abrasives or Putsskdrper be powders ,, -eremes and the like .. These abrasives include, for example dicalcium phosphate, tricalcium phosphate, insoluble sodium metaphosphate _9, aluminum magnesium carbonates, calcium carbonates ,, Folymethylmethacrylat _s CaleiiMpyrophosphat, calcium sulfate, etc ₉ bentonite "as well as suitable mixtures derselbenο Preferably, water-insoluble Calciurosalze ₉ such as calcium carbonate, used o In certain embodiments of the products according to the invention, aluminum hydroxide or aluminum hydroxide hydrate are also preferred

The abrasive content in the products of this invention may be different, but it is generally not more than 75 percent "^ ₉ in particular 20-75 GeWnf" of the overall product "

The benzyl alcohol is the Zahnereme for achieving a mild desensitization of the soft tissues in the oral cavity sugesetat.o In general, it is used in amounts of 0 _s 5 to 10 ßewo $ _p is preferably O _s 75 ms 5i, 0 ^ GeWo and 1.0 to insbesonäere 2 wt _o ^ added =

009851/2053 originally inspected

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When using clove oil as Geechmackestoff the presence of benzyl alcohol nonnalerwei "calls already in amounts of 0.5 wt» £ the toothpaste to separate the cream into a liquid and a solid phase hervorο with the use of mint oils as a flavoring agent can be somewhat larger amounts of benzyl alcohol in the generally up au about 2 percent _o? £ be present before the cream separates into a liquid and a solid phase "

According to the present invention, it has been found that zinc oxide, zinc phosphates and alkali phosphates with a pK. stabilize in water at 25 ⁰ C of at least 7 and a Fenzylalkohol mint oils, clove oil or toothpaste containing "These stabilizers are generally used in amounts from 0.15 to 12 wt <, #, preferably 0.5 to 1 wt. ^, added" Effective Stabilizers are specifically zinc oxide, zinc orthophosphate, zinc pyrophosphate, trisodium orthophosphate, disodium orthophosphate, tetrasodium pyrophosphate, tripotassium orthophosphate, dipotassium orthophosphate, tetrapotassium pyrophosphate and the like. The preferred stabilizers are zinc oxide, zinc phosphate and trisodium orthophosphate O

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It was also found that when using ethyl alcohol as a stabilizer, a benzyl alcohol and Toothpaste containing clove oil is stabilized »Ethyl alcohol is generally used in amounts of

0.5 to 3 percent by weight, preferably 1 to 2 percent by weight, in the Toothpaste used ο This is where the benzyl alcohol dissolved in the ethyl alcohol before mixing with the other components of the Zahnoreme

If aluminum oxide hydrate is used as an abrasive in the toothpaste according to the invention, one sets the cream preferably also an astringent one Agents such as zinc sulfate, zinc chloride, aluminum chloride or the like, in proportion the astringent is generally used in amounts of from 0.25 to 3% by weight and preferably from 0.5 to 1GeWo ^ added »Adetringing agents can but also with abrasives other than aluminum oxide hydrate, * · Β. with calcium carbonate together be used"

In addition to benzyl alcohol, other substances with desensibilifiierender effect can the delicate tissues and membranes of the oral cavity augeßen & _θ1η β Bin typiachea example of the invention Zahnorerae.

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OO0S51 / 2O53

Dtr-like substances is "rensocaine (ethyl p-aminobenzoate), which can contain" in amounts of 0.1 to 3 percent by weight, preferably 0 ₉ 19 to 2 percent, in the tooth system.

To produce the toothorems, “ground the liquid and solid components are used in equal proportions to create a creamy mass of the desired. th Xbnstens is obtained. The zabnoremes according to the invention thus obtained are awakened in tubes bottled *

The liquid components used for the toothpaste are mainly water, glycerine and aqueous solutions of sorbitol, propylene glycol and polyethylene glycol or mixtures thereof. In general, it is advisable to use a mixture of water and a humectant or binder such as glycerine or sorbitol. The total liquid content is generally 20 to 75% by weight of the total product. Preferably, the toothpastes are also given a gelling agent such as natural and synthetic Gums, gums, tragacanth, sodium carboxymethyl cellulose, polyvinylpyrrolidone or starch, generally in amounts of up to 10% and preferably between 2 and 5 % of the total product, if one is added

009851/2053

Aesthetic agent is preferably used Iriechroooe ale gelling agent *

Organic surface-active substances can also be added to the toothpaste according to the invention , to increase the prophylactic effect when antimicrobial substances are used, to support the thorough and complete distribution of the dental care product in the oral cavity and to make the toothpaste more cosmetically attractive . These organic surface-active substances can be more anionic be non-ionogenic, ampholytic or cationic in nature; preferably is used as the surfactant, a detergent, which gives the product cleaning and foaming properties _o Suitable on detergents "tien this type are the water-soluble salts of higher Pettsäureinonoglyceridinpnosulfate, ZOB ₀ the Natriuinsalz of roonosulfatierten monoglyceride of hydrogenated coconut oil fatty acids, higher alkyl sulfates _t Z ₀ B ₀ Natriuifllaurylsulfat, alkylarylsulfonates , ZcB _o sodium dodecylbenzenesulfonate, higher alkyl sulfoacetates, higher fatty acid esters of l ₉ 2 ~ dihydroxypropane sulfonate and the largely saturated higher aliphatic Acylaa5.de lower aliphatic aminocarboxylic acid compounds, for example with 12 to 16 carbon

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atoms in the fatty acid, alkyl or acyl group, and the likec AIa examples of the last mentioned Amides can be N-lauroyl sarcosine and the Sodium, potassium and ethanolamine salts of N-lauroyl, N-Myristoyl- and N-Palmitoylearraosinats listed which essentially: should be free of soap or similar higher fatty acid compounds, since these significantly impair the effect of the compounds mentioned. Bit? Putrefaction of the sarcosinates mentioned in the toothpastes according to the invention is particularly beneficial as these compounds promote acid formation in the oral cavity due to carbohydrates persistent and noticeable inhibit and the solubility reduce the enamel in acid solutions »

Other suitable surface-active substances for the toothpastes according to the invention are non-ionic detergents, such as the condensation products of sorbitan monostearate with about 60 moles of ethylene oxide and the condensation products of ethylene oxide with propylene oxide condensates of propylene glycol ("Pluronics ^11" ) »and cationic surface-active germoxy-phenoxy-bacterial compounds such as antibisobutyl-oxy-bacterial compounds. dimethyl-benzyl-ammonium chloride "Benzyldimethyl-stearyl-ammonium chloride, tertiary amines with

BATH

009851/2053

a fatty alkyl group with 12-18 ICo hlenet off atoms and two polyoxyethylene groups on the nitrogen atom, which generally contain a total of 2 to §0 ethenoxy groups per molecule, as well as salts of the same with acids, also compounds of the general formula (CH ₉ CH ₉ Q) ₄ H

( ₂₂ O) H.

RN - CH «CH« CH «fl ¹ Z ^{x 2 Z d x} (CH ₂ CH ₂ O) _y H

wherein R is a fatty alkyl group having 12-18 carbon atoms and x, y and ζ together are a sum of 3 or more, as well as salsa of these compounds with mineral acids or organic acids,

The surface-active substances mentioned are preferably used in amounts of 0.5 to 5% by weight in the inventive Toothpastes used

In addition, various other substances can be added to the toothpastes according to the invention, for example coloring or lightening substances, preservatives, silicones, chlorophyll compounds, ammonium compounds such as urea »MammoLumphosphat and mixtures thereof ₉ as well as other suitable additives» These additives are used in the products according to the invention in quantities,

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009851/2053

which does not adversely affect the desired properties. influence, and selected in type and quantity according to the intended product type *

Furthermore, antibacterial agents may be used, "Suitable agents of this type are, for example, N ^s' (4-chloro ~ benzyl) -N * in the erfindungsgemäöen Zafanereiaes - (2,4-dichlorobenzyl) -biguanide" p-chlorophenyl biguanide ™, 4-Chlorbenzhydrylbiguanid, 4-ChlorbenÄhydrylguanylharnstoff, N-3 ~ I »auroxypropyl-N -p-chlorbenaylbiguanid, 1,6-di-p-chlorphenylbiguaniäohexan, i-fLauryldimethylaBunoniumJ-east-Cp chlorbenzyldiraetliylammonium) -octandichlorid _s 5 ₉ 6-I ) Ilor ~ 2-guanidinobeii5S ~ imidazole, N -p-chlorophenyl-N ^ -laurylbiguanid, U-Ainiao-1,3-bis (2-ethylhexyl) -5-methylhexahydropvriPiidine and their non-toxic acid addition salts »

ψ The antibacterial "means, if erwUnacht, in amounts from 0.01 to 5 wt. $> and preferably above sea _v 05-5 wt. $ augesefczto

In addition to the clove or mint flowers, the eri'iri & ungs · According to toothpastes, if necessary, additional saliva-promoting aromas or saiäatoffe are also added will. Other suitable flavorings or creams

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are oils such as wintergreen, sassafras, ₉ sage, eucalyptus, marjoram, and gesehinaekgende _? Cinnamon ^to _p lemon and orange oil as well as Natriusömethyls & licylato Suitable sweeteners are, for example, sucrose, lactose _s maltose »sorbitol, sodium cyclamate and saccharin» The total amount of salivary substances including clove bait mint oil can amount to 0.5 to 5 $ or more for the dentistry according to the invention.

Zweckinäßig the erfindungsgessäßen Zahncreiaes contain, nor a fluorine compound having beneficial effect on the care and hygiene of the oral cavity, such as reducing the solubility of the 5§ahn ~ enamel in acid and {protect against tooth decay ο Suitable FluorYerbindungen this kind are for example Natriumfluoridj stannous _s potassium fluoride, Kaliurastannofluoriä (SnF ,,. EP), sodium hexafluorostannate ₉ stannous chlorofluoride, sodium fluoroconate and sodium fluorophosphorus These compounds, which dissolve in water or release fluorine-containing ions, are added in effective but non-toxic amounts, generally in the range from 0.01 to 1 wt on water-soluble fluorine »

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The Ej. Finding is made more detailed by the following examples explains "but is not limited to the same" 3Unless otherwise stated, all quantities relate to the weight

example 1

Three toothpastes of the following compositions were prepared

oeil parts parts

Glycerin 22.0 22.0 22.0 Irish moss 1 ₉ 0 1.0 1.0 Sodium benzoate 0.5 0.5 0.5 Sodium saccharinate 0.2 0.2 0.2 Water (distilled) 17.0 19.0 17.5 Zinc sulfate 0.6 0.6 0.6 Sodium auryl sulfate 1.5 1.5 t, 5 Zinc oxide 1.0 0.5 0.5 Aluininiura Oxydhydrate » 52.0 52.0 52 ₉ 0 Benzyl alcohol 3.0 1.5 3.0 CarnationsOl 1.2 1.2 - peppermint oil _ 1.2

To produce these toothpastes, the stabilizer, in this case zinc oxide, was mixed into a gel, which Glycerine, irish moss, sodium benzoate, sodium saccharinate, Contained water, zinc sulfate and sodium lauryl sulfate. This was followed by the abrasive, in this case

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009851/2053

Alumina hydrate, added, whereupon a cremartiga Mass aroseο This mass was made with the benzyl alcohol and the flavored oil added «The creams kept the desired consistency even with one Storage for several months "

The creams could also be used in the oral cavity on the soft, sensitive areas of the gums easy to apply and showed a good cleaning effect on the entire oral cavity including the sensitive gum parts »

Equally good dental cleanses have been obtained if that Zinc oxide after adding the abrasive to the cream was given" .

In comparative experiments, the same creams were produced without the addition of zinc oxide. These creams were produced separated into a liquid and a solid phase within 24 hours /

Example 2

In the same manner as in Example T, toothpastes of the following compositions were prepared

009851/2053

-u-

-JL, JJ C. Parts Parts Parts Glycerin 22.0 22.0 22.0 Irish moss 1.0 "1.0 1.0 Sodium benzoate 0.5 0.5 0.5 Sodium saccharinate 0.2 0.2 0.2 water 18.5 1 « ₉ 5 18.5 Zinc sulfate 0.6 0.6 _ Sodium lauryl sulfate 1.5 1.5 Zinc orthophosphate _ so Zinc oxide 1.0 · ■■ · - Trinatri umo rt hopho sphat - « 1.0 Calcium carbonate 52.0 52.0 52.0 Benzyl alcohol 1.5 », 5 1.5 Clove oil 1.2 1.2 1.2

The creams obtained retained their consistency over a long time while using the same creams without a stabilizer separated into a liquid and a solid phase within a day »

The creams were easy to apply in the oral cavity «, also on the sensitive part of the meat, and caused a good cleansing of the mouth including the sensitive areas.

Example 3

The following dentifrices were made in the same way as in Example II produced the Xthyl-p-amino-

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ben & oai was given after ίί-addition of the abrasive sw, given _o

Parts

Glycerin 22 ₉ O

Irish moss 0.8

Sodium benzoate 0.5

Naiferium saccharinate 0.2

Water 19.4

Zinc Sulphate 0 _t 6 Sodium Lauryl Sulphate. 1.5

Zinc oxide 0.5

Aluminum oxide hydrate §2 _? 0

Ethyl-p-aminobenisost 0.5

Benzj ^ l alcohol 0 _s 8

Clove Oil I ₁ .2

The cream retained the desired consistency long time, while the same cream without zinc oxide quickly turns into a liquid and a solid phase separated "

The cream came off easily; apply in the oral cavity " also on the aarten tissue, and showed a good one Cleansing action in the oral cavity including the sensitive areas of the gums »

Example 4

It became a dental crenia of the following composition manufactured

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009851/2053 BAD OBKäNM *

Parts

Glycerin 22.0

Irish moss 1 "0

Sodium saocharinate 0.2

Sodium benzoate 0.5

Water (distilled) 17.5

Zinc sulfate 0 ₉ 6

Sodium lauryl sulfate 1.5

Aluminum oxide hydrate 52 »0

Benzyl alcohol _$ 1 5

Ethyl alcohol, 95 # ig 2.0

Clove oil 1,2

For the manufacture of this cream, a gel which glycerol, Irischmooa, IJatriumse.ccharinat, TTatriumbenzoat, water was contained _s zinc sulfate UNOE sodium lauryl sulphate, with a solution of benzyl alcohol in 95 # strength ethyl alcohol offset Subsequently, the abrasive (Aluminiumoxydhycirat) was added, followed by cremartige mass o After that, the clove oil was added as a flavoring agent. The finished cream was filled into tubes and remained stable for several months during storage »

The cream was easy to apply in an oral cavity, also on the sensitive areas of the gums; and showed a good cleaning effect in the oral cavity including the delicate tissue parts »

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A comparatively produced denture of the same composition, but without ethyl alcohol, quickly separated into a liquid and a solid phase o

Appendix 5

In the same way as in Example 4, a toothpaste with the following composition was prepared »

Parts

Glycerin 22.0 '.

Iriechmoos 1 ₉ 0

Sodium benzoate 0.5

Sodium saccharinate 0.2

Water . 19.1

Sodium lauryl sulfate 1.5

Calcium carbonate 52 "0

Benzyl alcohol 1.5

Ethyl alcohol 1.0

Clove oil 1,2

This cream retained the desired consistencies2 long time while the same- cream without ethyl alcohol quickly separated into a liquid and a solid phase

The cream was easy to apply in the oral cavity, also on the sensitive parts of the gums, and showed a good cleaning effect in the oral cavity including the sensitive areas of the gums o - 18 -

009851/2053.

Example 6

The following toothpaste was made in the same way as in Example 4 ? the ethyl-p
became after addition of the aluminum oxide hydrate

Parts

Glycerin 22.0

Irish moss 0.8

Sodium benzoate 0.5

ψ Sodium saccharinate 0.2

Water 18.4

Zinc sulfate 0.6

Sodium lauryl sulfate 1.5

Aluminum oxide hydrate 5S, 0

Ethyl-p-aminobes & o & t O ₉ 5

Benzyl alcohol ho1 0.8

Ethyl alcohol, 95 ^f Ag 1.5

Clove oil 1,2

This cream retained the desired Konsistena liber long time ₀ during the same cream without ethyl alcohol "quickly separated a solid phase to a liquid u :: id ·

The cream was easy to apply in the oral cavity, also on the sensitive parts of the gums » and showed a good hindering effect within the room Oral cavity including sensitive areas.

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BATH 0RK31NA :. 009851/2053

Claims (1)

. "fe. g _R characterized U- Zahnc Pure * that it comprises a wasserunlöisliciies in vieeentlichen abrasive Bensylalkohol and as a stabilizing agent zinc "or sin Sinlcphoephat or an alkali phosphate with a * pK ^ in V / aaser of 25 ⁰ C wn at least 7 or ethyl alcohol and as (Jeschinaeksstoff when using γοη zinc oxide, calcium phosphate or alkali phosphate clove and / or mint oil and when using ethyl alcohol contains clove oil “■ 2 α Zahncreiae according to claim I ₁ characterized dadureh that it contains 0.5 10 wt his _o $ Benzylalltoholj as flavoring agent 0.5 bit 5 Gaw.? " Clove oil and as a stabilizing agent 0.15 to 2 wt.9 & zinc oxide or zinc phosphate or Alkaliphoijphat contains. 3ο Zahncreiae according to claims 1 and 2, thereby characterizedί that they use zinc oxide as a stabilizing agent contains » - 20 - 009851/2053 4. Toothpaste naoh claims 1 and 2, thereby marked that all contain zinc phosphate as stable! - • ationic agents 5. Tooths naoh claims 1 and 2, thereby marked * that they are trisodium orthophosphate as 3tabili8ationaumittel contains " 6 · creams according to claim 1, characterized in that they are 0.5 to 10% by weight > benzyl alcohol j Flavor 0.5 to 5 ßew. # Clove oil and as 3 stabilizing agents 0.9 to 3 wt. ^ Ethyl alcohol contains. ι 7t Sahnoreiae naoh claim 1, characterized in that aie 3 to 10 wt. ^ Benzyl alcohol, ale Oesohnaoksetoff 0.5 to 5 ßewo ^ mint oil and ala Stabilieationsmittel 0.15 to 2 wt. £ Zinc oxide P \ or zinc phosphate or alkali phosphate contains. !
j 8. Zahnoreme according to claim 7, characterized in that • that it contains peppermint oil as a flavor * 9 · Toothoreme according to claim 7, characterized in that because it contains zinc oxide as a stabilizing agent. - 21 - ι 009851/2053 ο Zahnoreme according to claims 1 to 9, thereby characterized in that the substantially water-insoluble abrasive is alumina hydrate contains » Toothoreme according to Claims 1 and 3, characterized characterized in that they use alumina hydrate as an abrasive, benzyl alcohol ,, clove oil and Zinc oxide contains »! 12o toothpaste according to claim ti, characterized in that « that it still contains an astringent agent " 13 ° toothpaste according to claim 12, characterized in that; dee zinc sulfate as an astringent j contains "-..---- ', /' I 14 · Toothpaste according to claims t to T3V thereby characterized that they still A'thyl-p-aminobansoat contains ρ IP »method for vciMaoo ^ uug u» «ιιιΐΜΐΜυ ^ 5Χΐΐ (ΐ (ί (characterized in that the oral cavity is treated with a toothpaste g®m & 8 claim 1 W ^ 14"" S B 1/2053 ORIGINAL INÖPECTBD