DE2009964A1 - Rodent killers - Google Patents

Description

PATENTAt-J WXLTE

DR.-1 N GH FINCKE DIPL.-ING. H. BOHR DIPL.-INQ. S. STAEGER

f ir η r υ f: '26 60 60

3 MUNICH S ₁

MOUmtraG « Vi

»March 3, 1970

Folder 222ιΛ - Lr.K, C 5?

Bllllton - KScT Chömiaciie Xaö.Ue't; "« * ie S, 7. The Hague / Niedeilande

Air inflator for hagetians

Priority: 3- Harz 1969 ■ - V.St.A.

The invention relates to toxic compositions and, more particularly, to the use of certain «! ¹ Silatran compounds ale poisons and especially as rodent poisons «

Beasts such as Mauae ' _t Hatten, rabbits and squirrels, bring huge financial losses every year. The rodents attack trees, neu® plantings and various food plants.

"■ ;; 009838/224?

The aim of the invention is to provide an improved Procedure for extermination of haggs. Another object of the invention is to provide an effective "rapid and poisons for hats, mice and other rodents in a single dose. Another object of the invention is the creation of a primary poison that has no secondary shows toxicity. Another object of the invention is to provide a rodent killer which leaves no permanent toxic residues. Another one The aim of the invention is to provide a rodent killer which can be used in a wide variety of approaches can be.

Las problem of rodent harm has been very serious for many years. For example, consume and pollute Hats and mice had large amounts of grain and other foods, spread rubbish and disease, and killed chicks and the like. The United States government estimates that rodents damage hundreds of millions of dollars annually cause and that each rodent destroys much very much than it eats. It is only when you realize that this is only a small fraction of the total damage that the size of the problem becomes clear. For this reason it is natural that any improvement in compositions for the extermination of rats and mice would make a welcome contribution to technology represents. Some rodents not only cause harm, Destruction or contamination of valuable goods, but are also the usual carriers of some human Diseases such as bubonic plague, acari rickettsiosis and possibly mouse typhoid.

According to the invention, a rodent poison is proposed which consists of a carrier and an effective amount of an organic Compound consists of at least one silicon atom and contains at least one nitrogen atom.

009838/2247

According to the invention, a rodent poison is also proposed, which consists of a carrier and an effective amount of a silatran compound of the formula

, 0 - CH ■■ - ■

O -

R, CH

0 - .CH - CE

consists, where R ^, Rg, H, - or hydrogen "mean.

and R * hydrocarbon groups

In this compound, R ^, Rg, R * and R ^ can be hydrocarbon radicals selected from ana alkyl, alkenyl, cycloalkyl, aralkyl, aryl, alkaryl and such inertly substituted radicals. If R ^, Ro »Rz or R ^ is alkyl, then it can typically be straight-chain or branched-chain alkyl, such as methyl, ethyl, n-propyl, isopropyl, η-butyl, isobutyl, sec-butyl, tert- Butyl, n-amyl, neopentyl, isoamyl, n-hexyl, isohexyl, heptyl, octyl, decyl, dodecyl, tetradecyl, octadecyl etc. Octyl and lower groups If R ^, R ^ z and R ^ are alkeny! Groups, then they can typically be vinyl, allyl, 1-propenyl, ilethallyl, buten-1-yl, buten-2-yl, butene -3-yl, penten-1-yl, hexenyl, heptenyl, octenyl, decenyl, dodecenyl, tetradecenyl, octadecenyl, etc. be. When R ₁ , Rg »R ^ and R ^, are cycloallryl groups, then they typically can

0Q9 $ 38 / 22A7

200996A

Cyclopentyl, cyclohexyl, cycloheptyl ,, Cycloocty.l etc. be * If R ^, R ₂ , R * and R ^ are aralkyl groups, then they can typically be benzyl, ß-ifcenylethyl, "Y ^ phenylpropyl, ß -Phenylpropyl, etc. If ILp R ₂ * ^E 3 ^ ^{1110 S} 4 are aryl groups, then typically they can be phenyl, capthyl, etc. If R ^ j, Rg ' ^R 3 ^or % are alkaryl groups then they can typically tolyl, xyIyI, p-ethylphenyl, p ~ nonylphenyl, etc. ILp R2 * ^ 3 ¹ ^ % can be inertly substituted, for example they can carry non-reactive substituents, such as alkyl, aryl, cycloalkyl, aralkyl, Alkaryl, alkenyl, ether, halogen, nitro, sster, etc. Typical substituted alkyls are 3-chloropropyl, 2- ethoxyethyl, carbethoxymethyl etc. Substituted alkenyls are 2.B * 4-chlorobutyl, γ-phenylpropenyl, chloroallyl and the like Cycloalkyl are eg 4-Kethylcyclohea ^ l, ^ -Chlorooyclo «hexyl etc. Inert substituted aryls are, for example, chlorophenyl, anisyl, biphenyl etc. Inert substit Uated aralkyls are, for example, chlorobenzyl, p-ehenylbenzyl, p-methylbenayl, etc. Inert substituted alkaryls are, for example, 3-chloro-5-detliylphenyl, 2, e-di-t-butyl - ^ - chlorophenyl, etc.

Examples of particularly preferred compounds of the formula

CH

CH

CH

are those In which one of the symbols R ^ represents phenyl.

, R ₂ * Rx and

009838/2247

_ 5 -

Examples of specific siiatran cage poisons according to the invention are: 5-p-chlorophenylsilatran, 5-phenylsilatran, ^ -p-chlorophenyl-J-methylsilatran, 5-p-chlorophenyl-3, 7-dimethylsilatran, 5-p-shlorophenyl-3 , 7,10-trimethylsilatran, 5-o ^ -Haphthoxy - Bllatran _> 5 - Ö "tfaphthoxysilatran _t 5-Phenoxysilatran, 5-Benzylsilatran and Phenyläthylsilatran.

According to the invention, a rodent venom in 3? Orm proposed an aqueous composition consisting of an aqueous solution containing a compound of the formula

O - CE - GH ₂

K ₁ Si O - CH CH ₂

O - CH - CH ₂

contains, wherein R ^, R ₂ , R ₃ , and R ^ are hydrocarbon groups or hydrogen.

The hag poisons according to the invention act quickly in one single dose by affecting the central nervous system. Therefore, they are not subject to a build-up of resistance.

The rodent poison according to the invention show little or no toxicity to the skin and eyes and leave behind after death or after 7 days no residues and do not cause secondary poisoning as the detoxification takes place in the first animal. Another feature of the invention is that it has a wide range of rodents

009838/2247

the lethal effects of the rodent venom of the invention subject.

The dermatological toxicity of 5-p-chlorophenylsilatran is

very low 25OO mg / kg.

very low. The dermisehe Lj., - Q value is greater than

The invention provides a composition with improved taste and attractiveness to rodents and thus increases the desire of the rodents to harm the bait.As a result, the uptake of rodent venom by hats and mice is increased and therefore a relatively quick and effective kill obtain. The active components according to the invention, unlike most fast-acting rodent poisons which result in instant death of the rodents, do not create suspicion of the bait. One suspicion of the bait is the aversion rodents show towards the bait after seeing the death of some rodents using the. Had taken bait.

The bait containing dao rodent venom can be any of the be commonly used solid or aqueous baits, as they have been used up to now. Most used as bait Solid foods are cereal grains. The grains can be whole grains, such as ifais, wheat, Rye, rice, barley, malt, oats, groats, peanut kernels or the like (individually or in a mixture) to break up fragments of these grains or pellets made from these grains.

The carrier for the dllatrannage animal poisons according to the invention can also be any inorganic or mineral material such as sand. The solid supports are preferred not hygroscopic, primarily condern material

0098 3 8/2247

IAD ORIGINAL

lien that result in a permanently dry and free-flowing composition. Suitable solid supports are e.g. Clays, such as bentonites and attapulgites, other minerals in their natural state, e.g. talc, diatomaceous earth, chalk, kaolin, volcanic ash, salt and sulfur, as well as powdered cork, powdered wood, etc.

Other baits are e.g .: shredded meat, dozed off Dog food, dried dog food, canned fish, Cat food, cakes, donuts, breadcrumbs and peanut butter

The admixture of the poison can be done by any known method such as coating, impregnation, spraying or similar treatment of the solid bait with the poison. Aqueous baits consist of the usual water, which is a dissolved Contains water-soluble rodent venom.

The amount of poison that is normally incorporated into the bait depends on the bait, the type of bait (solid or watery) and the toxicity level of the rodent poison towards people and pets. Usually amounts to the amount of rodent venom is about 0.005-10% by weight.

Additives can be used with the rodent poisons according to the invention to enhance the palatability and intake of the Rodent venom increase and thus a fatal uptake of the poison by the rodents. The rodent poison composition of the present invention has one special advantage in killing mice. Mice often bring a specific problem with them because they are different as rats, chew on their food and suddenly ingest relatively little. Mice are "nibblers". she eat 18-25 times in 24 hours and therefore usually do not consume a lethal amount of the rodent venom when it does is not of a particularly vigorous kind. The inven-

009838/2247

Rodent poisons are particularly powerful Poisons,

A particular advantage of the rodent poisons according to the invention is their partial solubility in water. Most known rodent poisons are insoluble in water and must therefore be offered in the form of trcoVenes baits, which by mixing the β Kk get ItVT ⁴ KJ ft »mi ν of a food for öin rodent .hfrgcrt» - 11 «» rdes. Au stables where natural %

";:; \ y ^!, .s! Λ-ez. Ksgatl

Alls dl * «?«? \ -:, \ ^ ν. ^. .V. a-,,: .- ■: Ι..Μ edible ywi / j; # 4 ^ ,. y; _; ; '.,. ,, ^ * .Xc'ixT si .: ■; ■

Cereal and other Naiir-uiigfiEitt-.l ^ -i ' ¹ · - reduced, where ge / jügöiid cereals vaji. aaders Mb'uti: »i see disposition and where Wassercjue Umu for des

009838/2247

BATH ORIGINAL

are not easily accessible.

If these watery baits are offered to the rodent, then drink these baits while eating. Farther The aqueous rodent baits are much more effective than dry baits, mainly because of the rapid absorption of the solute Hage ti er gifts. The silatran rodent poisons according to the invention are particularly soluble in water and, as a result, is it is possible to prepare aqueous poisonous rodent baits containing these compounds.

The aqueous baits can be made with distilled water. Rainwater, concentrated water, water softened with zenolite (but not water softened with alum) are stable, but give the baits a strange taste for rodents. As a result, such aqueous baits are less favorable than those baits which are made with a water with which the hagfish are known. Waters of this kind are also not always readily available. It is a feature of the invention that the water hardness or water quality has no harmful influence on the effectiveness of the rodent poison according to the invention. in 3 »6 1 water and mixes carefully. A sufficient amount of sugar can be added to the aqueous bait to improve the taste and attractiveness of the aqueous bait. The amount of sugar can be up to 20% based on the total weight of the composition. The amount can vary between 0.1 and 20 wt .- $> * The sugar additives may be mixed into the composition in any conventional catfish _9, for example by simple mixing of the poison with Waseer and dissolving sugar in the composition. The incorporation of the sugar can be carried out before the incorporation of the oil poison, or after incorporation of the oil oil poison or at the same time. That

ic -

moderate rodent venom can be tabletted for the riarkt, whereby every packet or tablet has a sufficient kenge Contains material to produce the rodent poison according to the invention, when dissolved in an appropriate volume of water. A better method is to make one liquid concentrate with a certain volume, welghee is added to a certain volume of water in order to prepare the novel rodent killing agent according to the invention. So you can, for example, with 28 g of rodent venom according to the invention Make 3.8 1 poisoned water bait.

The addition of sugar to the aqueous bait is preferred, however other materials can also be used such as glycerin, sorbitol, mannitol, saccharin, and that known as 3ucaryl Sweeteners. Salt (NaCl) up to about 0.055% can also be added to the rodent killing composition of the invention be admitted. Suitable colors can also be added to the water of the finished bait * or to color the rodents. . '. For example, you can use the color in the composition according to the invention work in that the color of the silatran solution is etched into the (carrier or that before applying the Sllatranlöaung color Kuaetftt. Venn Color is used, then noil ele worldly geech & acke · » and odorless «one and with the pH leveler used» the Solutions stable »on *

The venom poison according to the invention

Rescue teams require the services of professionally licensed personnel Vermin fighters. The invention. Silatran compounds Other than certain poisons, such as phosphorus compounds, do not produce any repellent decomposition products. the Activity of the Üilatranna animal poisons is sufficiently rapid, fc that the rodents that ingested the poison had no chance have to warn the rodent colonia from danger.

Although the invention was made exclusively in connection with; the extermination of hagstones, but the JflrfLnduag

UU9 * 3ö / 2247

BAD ORiQINAL

is not limited to this. Rats are the most difficult haggots to destroy, and therefore they were selected to illustrate the effectiveness of the aqueous baits and solid baits of the present invention. However, these hag poison compositions are generally extremely effective. against various rodents, such as mouse © croissants, rabbits, Prarieb.ua.de «) beaver imä,

When making it? active

Israelit * w © she © © S'gJTältig

Bio

© Isq ©

_δ Ibis oitsto "b © - & ä ^ o dos?

® ^ © iaa Liquid

:! ^ 7Γ; · ΐ: ^: ^ ait-

with

Di © hl © rob @ ns © l imd ffeigaesiea tante-s »

as Lösnassmit% @ l by "? di © usual Grigaardhergestellt" .Üthyl © ndibs omid "is the initiator verv / eadet" The Grignard Eeagene / elsfe produced in this V can then at Einei ¹ × solution of TetraäthoxysilaMs ^ΐπ: I * ö1uo1

to * 9% $ fXk1

BATH ORIGINAL

can be added. A reverse addition and excess of tetraethoxyeilane is used to prevent the formation of to avoid higher arylated products. The by-product, Magnesium chloroethoxide, is filtered off and washed carefully with solvent, and the organic phase is then distilled. After the solvents have been separated off and recovered, the p-chlorophenyltriethoxysilane has to be distilled are »to separate it from higher-boiling alkylated products.

p-Chlorophenyltriäthoxysilan is then with triethanolaain reacted using xylene as a solvent, and the reaction mixture is prepared using an action column heated to reflux «The theoretical amount of the by-product ethanol is first collected, and then are about 3/4 of the xylenes distilled off. On cooling, 5-p-chlorophenylsilatran crystallizes out. It can be done by crystallization can be purified from ethanol.

That. recrystallized product is 5-P-chlorophenyl latran a white crystalline solid that has a melting point from 233 ~ 235 ° C. This connection contains a strong one coordinative Sticketoff-SiliciuB-Biadung. The product iefc in most organic Lueu & ganltteln iöalioh, like ».B. Benzene, chloroform, ethanol, tetrahydrofuran and acetone. can be recrystallized from benzene, toluene or ethanol Ee is odorless and non-flammable * The product is almost non-flammable restricts stable when stored at tree temperature.

The above synthesis of 5-p-chlorophenyleilatran can be carried out by the following equation can be represented:

009838/2247

^ß AD ORIGINAL

Cl- ^ y-Si (OCpHc), + UCCHpCHpOH),

I ² I ² σ ~ c

.p-o-o

\> - si ^ -— ο - σ - ο — i>

• ο - ο σ

The invention is further illustrated by the following examples explained.

example 1

A dry comparative bait mix made from the following components:

Table I. Weight "% component 90 * Corn oil
sugar
oatmeal

An identical poisonous bait, but containing 0.25% 5-p-chlorophenylsilatran (4,6,11 ~ Trioxa-1-aza-5-sila-5-P "chlorophenyltricycloC3,3» 3 »0 ^ undecane) was produced * Admission tests were carried out with laboratory rats, who had a free choice under identical conditions. The animals fell awake before the experiment. Among the loading

009638/2247 bad ordinal

dinguages of a free choice ate the hats more of the deadly £ worse than the comparison bait. The following table shows the results of the bait intake tests.

Q09838 / 22V7

“AD ORIGINAL

the

Table II

Bait on take attempt
fasted overnight before attempting

More active
Fabric in
poisonous
bait

2 _t 5 mg / g
2.5 mg / S
2.5 ms / g

2.5 mg / g

tPier »blows

o, aoe

0.168 0.173 0.150 0.192

Amount of available? ten bait in e

gif tip ·. Comparison.. Amount eaten overnight in g

10 10 10 10 10

10, 10

10

Verpleich result I. 0.5 dead VJl 0.0 dead I. 0.5 dead 10.0 dead 0.5 dead

Table III

ο ο <ο

Animal-
weight
*G Attempt to pick up the bait to the
frame
in g
comparison Hours ago trying result 0.189 Animals fasted four 10 over night
Amount in g eaten
comparison dead More active
Fabric in
poisonous
bait 0.183 Amount of
disposal
ten bait 10 2.75 1.50 dead 2.5 mg / g 0.206 10 10 3 * 50 1.25 dead 2.5 mg / g 0.156 10 10 3.25 1.00 dead 2.5 mg / g 0.177 10 10 2.25 1.50 dead 2.5 mg / g 0.202 10 10 2.75 0.0 survived 2.5 mg / g 0.191 10 10 1.00 1.75 survived 2.5 mg / g 0.167 10 10 0.75 7.0 dead 2.5 mg / g 0.17s 10 10 1.25 0.75 dead 2.5 mg / g 10 2.0 1.75 2.5 mg / g 10

O CD CO CO

Example 2

A high protein bait was made by mixing the the following components:

Table IV
Component , composition (weight)

white cornmeal 65 parts

Fish meal 20 parts

Hog protein supplement * 5 parts

Flat block ·· 5 parts

Corn oil 5 parts

5-p-chlorophenylsilatran 0.25-0.75 parts

The Hog protein supplement, by analysis, contained:

Protein analysis 36%

raw fat 2%

raw fiber 10%

Calcium (maximum) 5.5%

(minimal) A -,%

Phosphorus (minimum) 2.5%

Iodine (minimum) 0.001% Salt (NaCl) (maximum) 2.0%

The Hog Protein Supplement contained: Söyabeans, Flei.sch- and bone meal, dehydrated Lusern meal, cottonseed meal, dried soluble substances from corn fermentation, dried solubles of corn distillates, Fish meal, irradiated dried yeast (vitamin D-2), vitamin A palmitate, vitamin B-12 supplement, riboflavin, Calcium pantathenate, niacin, chloride, defluorinated tea Phosphate rock - 6% and salt - 2%.

** Fish block consists essentially of the following: cottonseed meal, soybean meal, fish meal, soft and bone meal, hydrolysed poultry feathers, dehydrated alfalfa, granulated sorghum flour, cracked bran ₉ dark wheat flour, dried whey, dried soluble substances from corn stalks,

BATH ORIGINAL

Sugar cane molas, iron oxide, salt, calcium carbonate, Dicalcium phosphate, ri £ mgan (II) -O3cya, 2i8en (II) -carbonat, Copper oxide, cobalt carbonate, oalciumjouid, choline chloride, d-pantothenic acid, riboflavin supplement, niacin, Kenadione / sodium bisulfite complex (source of vitamin K activity), vitamin Ε supplement, vitamin A palmitate (improved stability), vitamin B 12 supplement, O-activated animal sterol (source of vitamin D-3), BHA and BHT and ethoxyquin (protective agent) and Anisole.

The above components were carefully mixed with 0.5 wt. 5-p-chlorophenylslatran mixed.

Rolls of paper containing the poisoned bait for the rodents were found in 16 locations in Louisiana State Penitentiary for Women, Iberville Parish, St. Gabriel, Louisiana. The trial area in the State Penitentiary for V / omen comprised a house for convicts, an adjoining corn mill and a large building for storage used by corn. The rodent poison was placed in different places in each of the buildings. The rats consumed quantities of the rodent poison bait and died within 50 minutes of the bait being laid. Within A total of 16 rats were killed by ingestion of the bait for 2 days.

Example 3

A high protein bait composition was made made the following:

Table V Component Composition (weight )

white cornmeal 65 parts

Fish meal 20 parts Hog Protein Supplement 5 Part " Flat block 5 part Kora oil 009938/2247 5 part BATH ORIQINAL

The above composition was made by that the dry components were carefully mixed and then the corn oil was added. To "certain amounts of the above Bait composition were 0.25% ^ -p-chlorophenylsilatran, 0.% 5-p-chlorophenylsilatran and 0.75% 5-pvchlorophenyl- ^ admitted.

Samples of the above toxic compositions were given in random selected spots in the vicinity of the debris dump Ibervllle Parish, Plaquemine, Louisiana, auege lays. It was observed that four had within 24 hours who had been killed.

Example 4-

A watery, poisoned bait mix would follow manufactured;

Table Vl Weight percent component 79.799 water 20.0 Sugar - 0.001 liween SO

5-p * chlorophenylsilatran

(^, 6,11-Trioxa-1-aza - ^ - silaSp

chlorophenyl ^{tricyclol 3,3,3,0 1} P jundecane) 0.01

Bowls with the above aqueous poisoned bait were aa urban dump of Plaquemine, Iberville Parish, Louisiana, laid out. The samples were monitored for 17 hours. Six had been observed taking the poisoned bait soak. The six rats died and their bodies were collected. Then the bait was taken away and disposed of

009838/220

Example 5

The absence of secondary poisoning by the rodent poisons of the present invention was determined by giving mice massive oral doses (3.125 mg) of 5-p-chlorophenylsilatrane (4,6,11-trioxa-1-aza-üjj-sila- ^ p-chlorophenyltricycloC3 "3" 3to ^'1' ^ Uundecan) were added, after which the mice died immediately afterwards the dead mice with white laboratory rats Busammengebracht (average weight 300 g). Within the next 43 hours no symptoms of poisoning were observed in the white laboratory rats.

Example 6

Oral toxicity (minimum lethal dose that accounts for 50% of experimental animals is fatal) of three silatrans was determined by inserting the compounds through gastric tubes in the test animals (white batteries) were introduced. the The results are given in Table VII below.

Table VII Oral toxicity of silatrans (white rats)

Silatran ^ D50

5-fhenylsilatran 0.4

5-ß-Hienyläthyleilatran 5-10

5-p-chlorophenylsilatran 5-10

Example 7

A dry poisonous SödersuMmoenaetsuiig was made from the following components:

009838/224?

Table VIII. component Weight percent Corn oil 5. oatmeal 44.85 Cornmeal 44.90 sugar 5.0

5-p-chlorophenylsilatran

(4,6,11-trioxa-1 ~ aza-5-8ila »5-p-

chlorophenyltricycloU 3 »3» 3 »O," * 5I1-

undecane) 0.25

A comparative bait similar to the above but containing no rodent venom was also made. Weighed servings of the poisonous bait composition were made placed in a cage containing three previously weighed catfish male laboratory mice weighing in the range of 22-23 g lay · Furthermore, weighed amounts of the comparison bait, which did not contain 5-p-chlorophenylsilatran, were added in introduced another cage, which also contains three catfish Contained laboratory mice. The mice touched the poisoned bait within 7 minutes of having access to the bait. Two mice died within 4 minutes the first contact with the poisoned bait. The surviving mouse that ate the rodent venom suffered muscle spasms and twitches.

You mice in the cage that contained the comparison bait, which one exhibited no poison, touched the comparison bait inside 5 minutes. None of the animals that took the samples tended to have any effects.

Example B.

The minimum lethal concentration of 5-p-chlorophenylsilatran was determined by mixing bait, ie % corn oil, 45% oatmeal, 45% cornmeal and various

BATH ORIGINAL

dene amounts of 5-p-chlorophenylsilatran would contain ι. The quantities the lift in the individual samples was 0.5 '»0.25%, 0.1 £ 5%, 0.0625%, and 0.03125 $ 5-p-chlorophenylsilatrane. Samples with the different poison concentrations were each placed in one of different cages, which contained previously weighed homes that had fasted for 24 hours. It was found that the critical concentration of 5-p-chlorophenylsilatran was 0.125% when it was was introduced into a grain bait. The good absorption of the poison was shown by the fact that the time, which Allowed the mice to elapse until they touched the poisoned bait, and the time it took the mice to touch the non-poisoned bait passed was essentially the same.

Example 9

The concentration of various rodent poisons and the amount necessary to kill 50% of the test rats was given in a test similar to that in Example 8. The results are summarized in Table IX below.

Table IX % recording Rodent poison L _D c ₀ (rats) Poison DOS
Bait mgAg 0.25 Well 5-p-Chlorophtnyl eil * tear 0.8-5 5.0 bad 5-phenylailatran 3-5 2.5 bad 5-p ~ Chlorophtnjl-3 »7-
dimethylailatrsn 42 5-p-0hloroph «ny1-3» 7 »10- 2.5 Well trimtthjlailatran 301 5 gat 5 «oC Waphthoa ^ ailatran 100 5 Well 5-α-Kaphthoarya atran 100-200 1 . gat 5-B «naylailatra & 66

009838/2247

Example 10

A water-based hag poison was prepared by dissolving 3% of 5-p-chlorophenylsilatran in a sugar water to make a solution containing 100 ppm of 5-p-chlorophenylsilatran in water. The poisoned solution was offered as drinking water to three white mice, which had weights of 20-24 g. I) Three houses died after they had drunk the poisoned water.

Example 11

To the . Achieving a full spectrum of toxicity hazards of silatran compounds have been dermal teacicity studies executed. The procedure consisted in "removing the bodies of rabbits (white rabbits from Heuseeland weighing 2-3 kg) and shaved the exposed areas with a hypodermic needle, without drawing blood, epidermal were rubbed. The test compounds were applied to approximately 10% of the exposed area, and the The body was then wrapped in a polyethylene wrap and fastened at both ends. Different doses were made checked. The results of these studies are shown in Table X.

Table X Connection . dermic tcocicity PSienylsilatran> ^ mo ^ ⁰⁰

ß-rhenylethyleilatran> LyjeQ 300

5-p-Ghloroph «nyleilatran 3,5-dichlorophynylilatrn

009838/2247

Example 12

To the lack of secondary poisoning in the invention show, 5-p-chlorophenylsilatran was administered to laboratory mice, thereby killing them. These dead mice were again used as control baits to check their toxic Determine effects. The time between the death of each mouse and the administration of the mouse to a rat was between 5 and 10 minutes with the rats fasting overnight. The results are shown in Table XI below summarized and show that no secondary poisoning occurs when using the rodent poisons according to the invention.

009838/2247

" weight
• iner
every
rat recording Tabel active Be
component of
by äeae
Rat eaten
had been mg / kU Death
cases toxic
Reaction
nen G Weight / κ 27.9
14.4
20.5
O 291.0
502.0
291.0
311.0 Amount of
Hay · that
through the
Rat
fairies
became 8.125
4,360
5,970
O ο ο ο ο no
no
no
no O
O '' weight
one
every
Ma.ua Weight / κ ¥> of poisoned mice «P. ' K 18.2 100.0
13.1 53.7
15.0 73.5
22.9 100.0 white laboratory rats OS
09
** ■ " 18.2
24.4
20.4
22.9 more active
Component,
the through
the mouse
eaten
had been - 8.125
6.125
8.125
O

$ ■

ο S.

Z,

ο ο CO OD σ>

Example 15

A poisonous bait composition was made from the following components:

Table XII Weight p component 5.0 sugar • 5.0 Corn oil 43.75 oatmeal 43.75 Cornmeal

5-p-chlorophenyl-

3.7 »10-trimethylsilatrane 2» 5

Mash white male mice were weighed and 24 hours starved, whereupon the above poisoned bait was made available to the three mice. The mice touched the Bait within 2 minutes and died between 74 and Hours later. The delayed toxicity exhibited by this special poison allows the use of an antidote in the event accidental recording.

009838/2247

Claims (1)

Claims 1. Rodent venom composition, marked thereby net that it consists of a carrier and an effective amount an organic compound consists of at least one Contains silicon atom and at least one nitrogen atom. 2. Composition according to claim 1, characterized in that it is an effective component as the active component Amount of a compound of the formula R ₁ Si - I: contains, wherein R ₁ -, R2, R * and represent hydrogen atoms. Hydrocarbon groups or 3. Composition according to claim 2, characterized in that it is in the form of a solid bait. 4-. Composition according to Claim 2, characterized in that it is in the form of an aqueous bait having. 009838/22 4 7 - 26 - 5. Composition according to claim 2, characterized in that. that R ^ is phenyl. 6. Composition according to claim 2, characterized in that the compound consists of 4,6,11-trio: xa-1-aza-5-8ila-5-p-chloTophenyltricycloC3,3 »3» 0 * \ jundecane. 7. Composition according to claim 2, characterized in that the compound of 3 »7» ' ¹ O-trimethyl-4,6,11-trioxa-1-aza-5-p-chlorophenyltricyclo C3 »3» 310 ¹ ^] - undecan exists. 009838/2247