DE19913719A1 - Sterilizable, skin-compatible adhesive tape soluble in aqueous alkali, useful for adhering covering sheets during operations, comprising carrier sheet and pressure sensitive adhesive both based on acrylates - Google Patents

Abstract

A sterilizable, skin-compatible adhesive tape comprises a polymeric carrier (A) coated on both sides with pressure-sensitive adhesive (B). A sterilizable, skin-compatible adhesive tape comprises a polymeric carrier (A) coated on both sides with pressure-sensitive adhesive (B). (A) (area weight 60-100 g/m<2>) contains 4-12C alkyl (meth)acrylate (65-75 wt. %), vinyl carboxylic acid (10-20 wt. %) and vinyl aromatic compound (5-15 wt. %). (B) (area weight 30-50 g/m<2>) is a mixture of (B1) (50-80 wt. %) and (B2) (20-50 wt. %). (B1) contains 4-12C alkyl (meth)acrylate (73-85 wt. %), vinyl carboxylic acid (5-15 wt. %), methacrylate (4-8 wt. %), di- or triacrylate (0.2-0.5 wt. %) and hydrogenated colophony (2-4 wt. %) based on balsam resin or tall resin. (B2) contains 4-12C alkyl (meth)acrylate (75-85 wt. %), vinyl carboxylic acid (10-20 wt. %), methacrylate (2-6 wt. %) and hydrogenated colophony (0.5-2 wt. %) as in (B1).

Description

The invention relates to a sterilizable, skin-compatible PSA tape with a polymer Backing material and equipped on both sides with a pressure-sensitive PSA, which dissolves completely in an alkaline environment.

Adhesive tapes of the type mentioned are in principle known as redispersible single- or double-sided Splice tapes known.

Self-adhesive tapes for gluing parts of the human body are as plasters, Dressing materials and covering materials such as incision films in medicine widely spread. Under incision foils are transparent foils coated with pressure sensitive adhesives understand that are used in surgery to cover surgical fields to the Microorganisms to fix the skin flora and prevent them from entering the open Surgical wound. The antimicrobial treatment of the surgical field Gluing with incision foils is therefore a very important prophylaxis against wound infections.

Commercial polyurethanes are suitable as backing materials for self-adhesive incision films from terminal hydroxyl-containing aliphatic polyesters and polylactones, the can be linked to aromatic diisocyanates by polyaddition. In the copolymers can, for example, aliphatic diols from hydrocarbons with 4 to 12 carbon atoms be installed as a chain extender. Linear, unbranched, high polymer polyurethanes combine the characteristic features of deformable thermoplastics and rubber-elastic high polymers. They not only show a very good oxidation and Resistance to aging, but also excellent tear resistance and high Permeability to water vapor.

These high molecular weight polyurethanes, which usually contain small amounts of antioxidants, Contain hydrolysis protection agents and lubricants, can be 20 to 80 µm thick, rubber-elastic Extrude foils that can be coated with pressure sensitive adhesives.

To ensure that the incise films are glued to one another in a medically safe manner To ensure human skin, the pressure sensitive adhesive used must be a number of Meet requirements. With slight pressure, it should immediately have intimate contact with the skin produce and adhere so well that after the incision, the film on the expanded  Cut edges of the surgical wound do not detach. In addition to strong adhesion, the Pressure sensitive adhesives also have a high level of cohesion so that it can move throughout the epidermis can understand the operation without splitting. He must also not have any skin irritation cause and should be easily removable from the skin after several hours of surgery with the film without leaving any adhesive residue.

According to the state of the art, only the Hafiklebemasse is water-soluble in the actual sense, while the carrier material is usually undissolved or frayed under mechanical influence (redispersed).

The water solubility of the pressure sensitive adhesive is based on the hydrophilicity of the polymer chain built-in segments. Through a combination of different more or less Water-soluble components will have full solubility in both alkaline water achieved to neutral as well as in the acidic pH range.

The addition of water-soluble alkanolamines lowers the glass transition temperature of the relatively hard polymer and gives it a very good grip. In order to increase the Solubility in water often becomes a neutralization of the carboxyl groups by means of alkalis performed. To increase tack, tackifiers can also be used Resins or water-soluble plasticizers can be added.

Various approaches have been shown in the patent literature to solve these problems. So have been described in EP-0415055 water-soluble, pressure-sensitive skin adhesive. These consist of the salt of an uncrosslinked copolymer of an amino group-containing, monoethylenically unsaturated, free-radically polymerizable monomer and at least one Alkyl esters of acrylic and / or methacrylic acid. The wording is characterized by that they are the salt of at least one higher organic carboxylic acid with 8-20 carbon atoms or a mixture of such a higher carboxylic acid with up to 30 mol% (the anionic Equivalents) of middle carboxylic acids and a portion of the amino group-containing monomer contains in the range of 30-80 wt .-% (based on the weight of the copolymer) and in the Salt form is soluble in water.  

US 3,321,451 describes washable skin pressure sensitive adhesives based on Amino group-containing (meth) acrylate copolymers, the amino groups being partially as a salt of an acid anion.

In US 3 121 021 and DE 12 63 989 skin-compatible acrylate adhesives for tissue and fleece tapes described. DE 19 34 710 is based on water vapor permeable films of polyacrylic acid esters and polyurethanes as pressure-sensitive adhesive tapes for skin bonds. DE 32 11 277 contains pressure sensitive adhesives based on polyisoprene and EPDM terpolymers for Bandages and plasters described. EP 0 130 080 and EP 0 258 753 Emulsion polymerization process for the production of skin-compatible acrylic pressure sensitive adhesives specified. DE 40 01 714 describes a material that adheres well to moist substrates Self-adhesive based on gelatin for medical plasters, labels and adhesive tapes discussed. DE 42 07 657 contains pressure sensitive adhesives based on styrene-isoprene-styrene block copolymers disclosed, in which medical agents are incorporated.

Furthermore, DE 40 07 637 describes aqueous polymer dispersions which are a mixture from an acrylic acid-acrylic acid copolymer with copolymerized monomers, where the alcohol component of the acrylic acid ester can have 2 to 8 carbon atoms and that Copolymer can contain 1 to 5 wt .-% acrylic acid, and a hydrogenated Colophomium resin esters of monohydric alcohols with 1 to 2 carbon atoms in the Alcohol component and also an organic isocyanate as a conventional additive. These polymer dispersions are adhesives for packaging tapes. US 44 13 080 describes copolymers containing carboxyl groups Isooctyl acrylate / butyl acrylate base in a mixture with water-soluble polyoxyethylene derivatives and Tall resin tackifiers. Such copolymers are distinguished by an excellent Solubility in water. During sterilization, however, degradation products are formed, which is the physiological Harmlessness endangered.

Water-soluble PSAs based on 2-ethylhexyacrylate, methacrylic acid and EP 01 47 067 describes hydroxyl-containing (meth) acrylates. These PSAs have excellent water solubility and can be easily sterilized. she  however, have poor skin moisture resistance, which is their Possible uses are severely restricted.

Water-soluble PSAs composed of vinylphosphonic acid, acrylic or methacrylamide, Vinylsulphonic acid and vinylphosphonic acid esters are described in US 45 18 745. they are resistant to skin moisture, can be sterilized perfectly and have good properties Solubility in water. Due to the relatively high concentration of residual monomers, the Skin compatibility and the physiological harmlessness questioned. Water soluble polyvinyl carboxylic acid based pressure sensitive adhesive with at least one hydroxyl-containing plasticizers (molecular mass below 1000), which may be with a DE 38 25 527 describes crosslinkers that are crosslinked. This adhesive material contains as Main components are a copolymer of beta-acryloyloxypropionic acid with other unsaturated Compounds (e.g. methacrylic acid) and a polyoxyalkylene and possibly other components such as crosslinking agents, solvents, colorants, fillers and aging inhibitors.

Water-soluble copolymer of vinyl carboxylic acid, hydroxyl-containing (meth) acrylate, DE 39 01 690 describes (meth) acrylamide derivative and at least one vinyl carboxylic acid salt. The mass is made with a water-soluble plasticizer, for example from the group of Modified polyoxyalkylene.

The corresponding to the prior art according to DE 38 25 527 and DE 39 01 690 "Redispersible" PSA tapes are, for example, preferably suitable for the attachment of Paper webs, but have decisive disadvantages for applications in the hygiene sector, including the temporary fixation of textile fabrics on human skin is understood. So there is an equally high specific adhesion on the skin as well as on the textile fabrics are not given. Resistance to it is particularly weak the skin moisture, which normally leads to a softening of the water-soluble adhesive leads to a break in cohesion. The formulation of conventional water-soluble adhesives was taken into account So far, not even those prescribed by the Federal Health Office, for example Washing conditions that differ considerably from the ratios in a paper pulper differentiate.

This applies in particular to textile fabrics such as drapes for Operations.  

It is particularly disadvantageous that the adhesive tape carrier is only redispersible and is not completely water soluble, causing contamination of the washed textile Fabric comes with fibers that come from the tape carrier.

DE 41 26 230 also describes a sterilizable pressure-sensitive adhesive tape which consists of carboxyl-containing polymers based on acrylate, water-soluble amines, plasticizers Resins, carboxyl-containing, non-acrylate based polymers and Crosslinking agent is produced. It is particularly disadvantageous that the carboxyl group Acrylate copolymer in the usual way by radical polymerization in an organic Solvent is produced. Depending on the monomer composition Acetone or a mixture of acetone / 2-propanol in a ratio of 1: 1 is recommended.

Solvent polymerizations are not very environmentally friendly and require a lot of effort in solvent removal. The polymerization is carried out with a solids content of 50% by weight. carried out, the polymer obtained is with a water-soluble amine, a plasticizing resin, a carboxyl-containing, non-acrylate polymer and a crosslinking agent.

In the case of the water-soluble amine, an alkanolamine such as monoethanolamine, Diethanolamine, triethanolamine, dimethylaminoethanol, diethylaminoethanol, N- Methylethanolamine, monoisopropanolamine, diisopropanolamine, triisopropanolamine are used. The resin softening the adhesive is preferably a hydrogenated rosin ester Methanol, triethylene glycol or glycerin as the alcohol component.

The carboxyl-containing, non-acrylate-based polymers are preferably polyesters, by polycondensation of dicarboxylic acids or their functional derivatives such as Anhydrides and dialcohols such as B. ethylene glycol were made or polymers Polyisoprene base.

Metal chelates, metal acids, epoxy, aziridine or Melamine formaldehyde resins to improve the thermal resistance of water-soluble Adhesives are used.  

A polyacrylate is preferably used as the "backbone" polymer for the PSAs, its water solubility in the alkaline range (pH greater than 8) and at elevated temperature (above 60 ° C) increases disproportionately. Redispersibility of the adhesive tape carrier becomes preferably by using thin, easily friable paper (e.g. tea filter paper, Cigarette paper).

Good solubility in water is achieved if a nonwoven is used as the carrier material, of water-soluble fibers such as calcium alginate fibers or polyvinyl alcohol fibers contains. Another advantageous embodiment of the invention uses water-soluble Polyvinyl alcohol, gelatin or gelatin / glycerin films as carriers.

DE 43 03 616 finally describes a pressure-sensitive, skin-compatible pressure sensitive adhesive which consists of a mixture of the following components:

• A) 30 to 85 wt .-% acrylic ester-acrylic acid copolymer with 2 to 8 carbon atoms in the alcohol component of the acrylic acid ester and based on the copolymer 1 to 10 % By weight acrylic acid,
• B) 0 to 30% by weight of polyvinyl isobutyl ether
• C) 0 to 20% by weight of a hydrogenated rosin ester of polyhydric alcohols with 5 up to 6 carbon atoms in the alcohol component,
• D) 5 to 20 wt .-% of a hydrogenated rosin ester of monohydric alcohols with 1 to 2 carbon atoms in the alcohol component and
• E) 0 to 20% by weight of a terpene phenol resin,

as well as optional additives, with the exception of organic isocyanates.

The pressure sensitive adhesives thus produced are well suited for the production of one or both sides coated, self-adhesive, flat substrates, in particular for the production of self-adhesive incision foils.

For example, rubber-elastic, water vapor-permeable, skin-friendly, 20 to 60 microns thick films, especially coated extruded polyester and polyether polyurethane films  in addition to the usual additives such as hydrolysis inhibitors, lubricants and antioxidants Contains 20% polyamide-based elastomers.

The incision films equipped in this way should be able to absorb sweat, blood or secretions without Loss of adhesive strength. Since these films are disposed of after use, the polyester and / or bothers Polyurethane film, which can still contain up to 20% elastomers based on polyamide, does not. Finally, there are also special, self-adhesive fabrics as surgical tape or surgical drape been proposed, e.g. B. DE 196 28 268, consisting of an air and moisture-permeable, skin-friendly textile material, which is discontinuous in the form of pressure sensitive adhesive segments obtainable by screen printing, gravure printing or flexographic printing on one Page is provided over the entire surface of the textile material.

Of the numerous pressure-sensitive pressure sensitive adhesives for technical tapes, only one is suitable relatively few for skin adhesions. Many adhere too strongly to the skin and cause Rashes or irritation. Other adhesives adhere too weakly and come off after a short time when sweat has formed on the surface.

The known skin-compatible pressure sensitive adhesives have defects with regard to their use, which limit their possible uses, especially with regard to adhesive strength, shear strength, Permeability to water vapor and resistance to the flow of blood and secretions.

Another disadvantage of the known systems is that the adhesive tapes when using Reusable surgical drapes only partially detach in the washing process and the carrier material is either frayed (paper fleece) or does not dissolve (polyester, polyurethane films) and must be removed laboriously.

The present invention was therefore based on the object of a pressure sensitive adhesive tape at the outset to create the type mentioned for special use in the medical field, which is free of the above defects. In particular, the PSA tape is said to be skin-friendly, be physiologically safe and easy to sterilize, high requirements with regard to Adhesion, shear strength, water vapor permeability and resistance to  Skin moisture / sweat, blood and secretion flow and the use of reusable wipes facilitate.

This object is achieved in that the PSA tape consists of a polymeric carrier material (A) which is provided on both sides with a PSA mixture (B). The polymeric carrier material (A) has a weight per unit area of 60-100 g / m ² and contains the following components

• a) 65 to 75% by weight of C ₄ -C ₁₂ alkyl (meth) acrylate,
• b) 10 to 20 wt .-% of a vinyl carboxylic acid and
• c) 5 to 15 wt .-% of a vinyl aromatic

The PSA (B) has a basis weight of 30 to 50 g / m ² and consists of a mixture of 50 to 80% by weight B1 and 20 to 50% by weight B2, the PSA B1 containing the following components:

• a) 73 to 85% by weight of a C ₄ -C ₁₂ alkyl acrylate,
• b) 5 to 15% by weight of a vinyl carboxylic acid,
• c) 4 to 8% by weight of a methacrylate,
• d) 0.2 to 0.5% by weight of a di- or triacrylate and
• e) 2 to 4 wt .-% of a hydrogenated rosin based on balsam resin or tall resin and the PSA B2 contains the following components
• f) 75 to 85% by weight of a C ₄ -C ₁₂ alkyl acrylate,
• g) 10 to 20% by weight of a vinyl carboxylic acid,
• h) 2 to 6 wt .-% of a methacrylate and
• i) 0.5 to 2% by weight of a hydrogenated rosin based on balsam resin or tall resin

According to a preferred feature of the invention, the polymeric carrier material (A) preferably has a basis weight of 70 ± 5 g / m ² and preferably contains the following components.

• a) 65 to 75% by weight of butyl acrylate,
• b) 10 to 20% by weight of methacrylic acid,
• c) 5 to 15 wt .-% styrene and

The PSA B preferably has a weight per unit area of 35 ± 5 g / m ² and preferably consists of a mixture of 75 ± 5% by weight B1 and 25 ± 5% by weight B2. The PSA B1 preferably contains the components

• a) 73 to 85% by weight of butyl acrylate,
• b) 5 to 15 wt .-% acrylic acid
• c) 4 to 8% by weight of methyl methacrylate,
• d) 0.2 to 0.5 wt .-% trimethylolpropane trimethacrylate and
• e) 2 to 4% by weight of a hydrogenated rosin based on balsam resin or tall resin an undetectable abietic acid content and a dehydroabietic acid content of at least 45%.

The PSA B2 preferably contains the components

• a) 75 to 85% by weight of butyl acrylate,
• b) 10 to 20% by weight of acrylic acid,
• c) 2 to 6 wt .-% methyl methacrylate and
• d) 0.5 to 2% by weight of a hydrogenated rosin based on balsam resin or tall resin with an undetectable abietic acid content and a dehydroabietic acid content of at least 45%.

The PSA tape of the invention is produced from aqueous ones Polymer dispersions according to known methods described in the patent literature. The according Claim 1 composite acrylic dispersions are by in aqueous media Emulsion polymerisation is carried out under customary, known conditions, such as that e.g. B. in the book "Methods of Organic Chemistry" by Houben-Weyl, Volume 14/1,  Macromolecular substances, Georg Thieme Verlag, Stuttgart 1972, pages 192 to 208 and in the Patent literature are described.

The PSA tapes according to the invention can advantageously be used wherever there is a Water resistance during use, but complete dissolution after use within specified or existing processing technologies.

Because they are made on a wide variety of substrates, such as textile fabrics Cotton blended fabrics, cotton fabrics, not impregnated or with fluorocarbon resin impregnated, microfilament fabrics or on laminates made of polyester fibers, a high specific Have adhesion and also show high skin tolerance, they are preferred for the temporary fixation of surgical drapes (cloth against cloth and cloth against skin) used. It is particularly advantageous that the PSA tapes according to the invention under usual steam sterilization conditions, can be sterilized during use and is water resistant after use under washing conditions customary for such drapes in an alkaline environment are completely soluble. Another advantage is that these PSA tapes are not a nuisance Have foreign material (paper / polyester film or similar) as a carrier material, solvent-free were produced and can be dissolved without solvents. Since no mercaptans as Regulators were used, they are also sulfur-free.

The PSA tapes of the invention thus contribute to a cost reduction in Clinic area because the use of disposable material in the operating area, its disposal is polluting, expensive and time consuming, can be reduced.

The invention is illustrated by the following examples:

Example 1-4 Manufacture of adhesive tapes

To produce the adhesive tapes according to the invention, a container is first made from a aqueous dispersion of the polymeric carrier material (A) by means of a roller doctor on Silicon paper applied and dried with hot air. The basis weight was balanced.  

From a second container, an aqueous dispersion of an adhesive composition (B), which had previously been mixed from dispersions B1 and B2, was also applied to a silicone paper using a roller doctor knife and dried with hot air. The basis weight was balanced. The polymer films applied to silicone paper were passed through a pair of rollers at 0.5 m / s and a solid bond was produced at a roller temperature of 25 to 50 ° C. and a pressure of 200 N / cm ² .

The adhesive was then applied to the other side of the carrier material the same technology. The PSA tape was finally covered with silicone paper as Liner rolled up. The silicon paper that was required in the meantime for the adhesive films was recycled.

The numbers in Examples 1-4 are given in Table 1.

The following adhesive data were determined and assessed to assess the adhesive behavior:

• - the initial liability ("quick stick") - measured according to FINAT test method No. 9,
• The permanent adhesion or detachability of the PSA tapes on non-pretreated PE Panels - measured according to FINAT test method No. 1, peel strength at 180 ° C and one Clamp speed of 300 mm / min.
• - the shear strength on standard surfaces - measured according to FINAT test method No. 8,
• - Water resistance test:

A 4 cm long surgical tape is applied to the upper left side (rough with Dot marked) of the shorter surgical test sheet glued. Silicone paper is removed and the glued side on the longer piece of surgical sample on the lower right side (smooth with dot marked) glued. Use the Finat pressure roller (2 kg) to apply twice in both directions the glued cloth is rolled to make good contact. After a 2 minute break the sample is prepared lying down with an S-hook and a weight of 200 g. At the time of Immersing the entire sample test bottle in the water (temperature should be 20-22 ° C) the stopwatch is started and the time is measured until the sample drops.  

• - Adhesive behavior on the skin: A 20 cm long strip is placed in a tensile force measuring device clamped. 7 cm of this strip are glued to the forearm of a test subject. The The subject's skin was previously cleaned with isopropanol. The surface temperature of the Skin is measured. The adhesive strip becomes perpendicular to the skin at 300 mm / minute peeled off and the adhesive force measured in N / 25 mm.
• - Adhesion behavior textile / textile: For this experiment the same test arrangement as for used the water resistance test. However, no water is used and instead of 200 g Weights of 1 kg are used.

The results obtained are shown in Table 2.

Example 1-4 Determination of sterilizability

It was the water vapor permeability according to DIN 53122 after 24 hours at 23 ° C and 85% relative humidity determined:

Examples

Example 5-8 Attempts to dissolve in wash water

The PSA tapes, prepared according to Examples 1-4, were made on surgical textile materials (Reusable surgical drapes), such as cotton blended fabrics, cotton fabrics, not impregnated or impregnated with fluorocarbon resin, microfilament fabric or on laminates Glued polyester fibers / -PTFE membranes by laying on 50 mm wide strips and on the side covered with silicone paper with a 2 kg rubber roller (Finat pressure roller) 2 times rolled in both directions over the tape.  

To test the complete detachment / dissolution of the PSA tapes, a simple one Einbad method (comparable to the Laundering test as described in PC-WO95 / 27016 is described) applied. The pre and post wash (rinsing, drying) were not considered. In order to ensure that the items to be washed in the washing process have a good flow and high To enable mechanics, a loading of 60-70% was realized.

The times up to the complete dissolution of the PSA tapes were determined at various Temperatures.

The results are shown in Table 3.

Example 9

The PSA tapes from Examples 1-4 were tested for topical compatibility.

The study was conducted as a randomized study on 36 subjects (male and female Subjects aged 20-65 years) in the intraindividual comparison of four surgical Adhesive tapes and with an assessment of the findings carried out by a blind doctor. Samples (approx. 1.5 × 4.5 cm) all four adhesive tapes were left and right on the Forearms applied, with one of these two skin areas previously disinfected. The Sequence of test samples on the skin was randomized. After 24 hours, the test samples removed from the skin. The order points were immediately followed by a regarding randomized blinded doctor.

The application period of 24 hours was based on safety pharmacological considerations chosen. After 24 hours of contact, the tapes still adhered firmly to the skin.

There were only significant differences between individual tapes in a few test subjects detect. On some areas of the skin a skin tint was visible, which was both as incomplete fading as well as minimal reddening of the otherwise faded skin area  could be interpreted, but was rated as the latter during this test. In The completely faded or minimally reddened skin can be roughly approximated with score values equate between 0 and 5 mm, a slight reddening with 5-10 mm. The normal skin tint, which was not the same for all subjects, corresponds approximately to a score of 10 mm on the visual analog scale.  

Claims (4)

1. Sterilizable, skin-compatible pressure-sensitive adhesive tape with a polymeric carrier material and on both sides with a pressure-sensitive PSA, characterized in that the polymeric carrier material (A) has a weight per unit area of 60 to 100 g / m ² and contains the following components

• a) 65 to 75% by weight of C ₄ -C ₁₂ alkyl (meth) acrylate,
• b) 10 to 20 wt .-% of a vinyl carboxylic acid and
• c) 5 to 15 wt .-% of a vinyl aromatic and

that the PSA (B) has a weight per unit area of 30 to 50 g / m ² and consists of a mixture of 50 to 80% by weight B1 and 20 to 50% by weight B2, the PSA B1 containing the following components:

• a) 73 to 85% by weight of a C ₄ -C ₁₂ alkyl acrylate,
• b) 5 to 15% by weight of a vinyl carboxylic acid,
• c) 4 to 8% by weight of a methacrylate,
• d) 0.2 to 0.5% by weight of a di- or triacrylate and
• e) 2 to 4 wt .-% of a hydrogenated rosin based on balsam resin or tall resin

and the PSA B2 contains the following components

• a) 75 to 85% by weight of a C ₄ -C ₁₂ alkyl acrylate,
• b) 10 to 20% by weight of a vinyl carboxylic acid,
• c) 2 to 6 wt .-% of a methacrylate and
• d) 0.5 to 2% by weight of a hydrogenated rosin based on balsam resin or tall resin

2. Sterilizable skin-compatible pressure-sensitive adhesive tape according to claim 1, characterized in that the polymeric carrier material (A) preferably has a weight per unit area of 70 ± 5 g / m ² and preferably contains the following components

• a) 65 to 75% by weight of butyl acrylate,
• b) 10 to 20% by weight of methacrylic acid,
• c) 5 to 15 wt .-% styrene and

that the pressure-sensitive adhesive (B) preferably has a weight per unit area of 35 ± 5 g / m ² and preferably consists of a mixture of 75 ± 5% by weight B1 and 25 ± 5% by weight B2, the pressure-sensitive adhesive B1 preferably having the following components contains:

• a) 73 to 85% by weight of butyl acrylate,
• b) 5 to 15 wt .-% acrylic acid
• c) 4 to 8% by weight of methyl methacrylate,
• d) 0.2 to 0.5 wt .-% trimethylolpropane trimethacrylate and
• e) 2 to 4% by weight of a hydrogenated rosin based on balsam resin or tall resin with an undetectable abietic acid content and a dehydroabietic acid content of at least 45% and the hafikle composition B2 preferably contains the following component:
  • a) 75 to 85% by weight of butyl acrylate,
  • b) 10 to 20% by weight of acrylic acid,
  • c) 2 to 6 wt .-% methyl methacrylate and
  • d) 0.5 to 2% by weight of a hydrogenated rosin based on balsam resin or tall resin with an undetectable abietic acid content and a dehydroabietic acid content of at least 45%.

3. Sterilizable, skin-compatible pressure-sensitive adhesive tape according to claim 1 and 2, thereby characterized in that it can be dissolved without residue in an aqueous, alkaline medium. 4. Sterilizable, skin-compatible pressure-sensitive adhesive tape according to claim 1 to 3, characterized characterized in that the pressure-sensitive adhesive tape in roll form with silicone paper as a cover is assembled.