DE19825512A1 - 3-,8-subsituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik - Google Patents

3-,8-subsituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik

Info

Publication number
DE19825512A1
DE19825512A1 DE1998125512 DE19825512A DE19825512A1 DE 19825512 A1 DE19825512 A1 DE 19825512A1 DE 1998125512 DE1998125512 DE 1998125512 DE 19825512 A DE19825512 A DE 19825512A DE 19825512 A1 DE19825512 A1 DE 19825512A1
Authority
DE
Germany
Prior art keywords
group
hydrogen atom
diethyl
mmol
tetramethylporphyrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE1998125512
Other languages
German (de)
English (en)
Inventor
Johannes Platzek
Ulrich Niedballa
Bernd Raduechel
Wolfgang Ebert
Hanns-Joachim Weinmann
Thomas Frenzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE1998125512 priority Critical patent/DE19825512A1/de
Priority to PCT/EP1999/003514 priority patent/WO1999062512A1/fr
Priority to AU43653/99A priority patent/AU4365399A/en
Priority to US09/323,996 priority patent/US6136841A/en
Publication of DE19825512A1 publication Critical patent/DE19825512A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1998125512 1998-06-02 1998-06-02 3-,8-subsituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik Withdrawn DE19825512A1 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE1998125512 DE19825512A1 (de) 1998-06-02 1998-06-02 3-,8-subsituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik
PCT/EP1999/003514 WO1999062512A1 (fr) 1998-06-02 1999-05-25 Derives de deuteroporphyrine substitues en position 3 et 8, substances pharmaceutiques les contenant, procede pour les preparer et leur utilisation dans la therapie photodynamique et le diagnostic par irm
AU43653/99A AU4365399A (en) 1998-06-02 1999-05-25 3-, 8-substituted deuteroporphyrin derivatives, pharmaceutical substances containing the same, method for the production and use thereof in photodynamic therapyand mri diagnosis
US09/323,996 US6136841A (en) 1998-06-02 1999-06-02 3-, 8-substituted deuteroporphyrin derivatives, pharmaceutical agents that contain the latter, process for their production and their use in photodynamic therapy and MRI diagnosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1998125512 DE19825512A1 (de) 1998-06-02 1998-06-02 3-,8-subsituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik

Publications (1)

Publication Number Publication Date
DE19825512A1 true DE19825512A1 (de) 1999-12-09

Family

ID=7870254

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1998125512 Withdrawn DE19825512A1 (de) 1998-06-02 1998-06-02 3-,8-subsituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung in der photodynamischen Therapie und MRI-Diagnostik

Country Status (3)

Country Link
AU (1) AU4365399A (fr)
DE (1) DE19825512A1 (fr)
WO (1) WO1999062512A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
EP1148057A4 (fr) * 1999-11-30 2002-05-29 Photochemical Co Ltd Complexe porphyrine servant de support a un nitroimidazole
EP1401430A4 (fr) * 2001-05-31 2005-10-19 Miravant Pharm Inc Derives porphyrine et azaporphyrine substitues et utilisation en therapie photodynamique, radioimagerie, et diagnostic par irm
DE10240343A1 (de) * 2002-08-27 2004-03-11 Schering Ag Peroxynitrit-Umlagerungskatalysatoren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3827940A1 (de) * 1988-08-13 1990-03-01 Schering Ag 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4232925A1 (de) * 1992-09-28 1994-03-31 Diagnostikforschung Inst 3-,8-substituierte Deuteroporphyrinderivate, diese enthaltende pharmazeutische Mittel und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
WO1999062512A1 (fr) 1999-12-09
WO1999062512A9 (fr) 2000-03-23
AU4365399A (en) 1999-12-20

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