DE19716913A1 - Modular storage device for cryogenic storage of flat plastic bags filled with frozen cell suspension - Google Patents

Modular storage device for cryogenic storage of flat plastic bags filled with frozen cell suspension

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Publication number
DE19716913A1
DE19716913A1 DE19716913A DE19716913A DE19716913A1 DE 19716913 A1 DE19716913 A1 DE 19716913A1 DE 19716913 A DE19716913 A DE 19716913A DE 19716913 A DE19716913 A DE 19716913A DE 19716913 A1 DE19716913 A1 DE 19716913A1
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Germany
Prior art keywords
storage
storage device
refrigerated
containers
modules
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DE19716913A
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German (de)
Inventor
Bernd Mingers
Andreas Sputtek
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Individual
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Individual
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Priority to DE19716913A priority Critical patent/DE19716913A1/en
Priority to AU82064/98A priority patent/AU8206498A/en
Priority to PCT/DE1998/001114 priority patent/WO1998047357A2/en
Priority to ZA983445A priority patent/ZA983445B/en
Publication of DE19716913A1 publication Critical patent/DE19716913A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
    • A01N1/0257—Stationary or portable vessels generating cryogenic temperatures
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D25/00—Charging, supporting, and discharging the articles to be cooled
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
    • F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
    • F25D3/105—Movable containers
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D9/00—Devices not associated with refrigerating machinery and not covered by groups F25D1/00 - F25D7/00; Combinations of devices covered by two or more of the groups F25D1/00 - F25D7/00

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  • Engineering & Computer Science (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Combustion & Propulsion (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Warehouses Or Storage Devices (AREA)
  • Devices That Are Associated With Refrigeration Equipment (AREA)

Abstract

The invention relates to a device and method for storing suspensions of living cells at cryogenic temperatures in a large number of packs, for example in a large blood bank. It is especially important to ensure that the preparations being stored can be accessed and administered automatically, especially given the working conditions in a deep-cooled storage room. Self-sufficient operation over a limited period of time, for example during transportation is also desirable from the point of view of use in a disaster or a national defence situation. The inventive storage device (1) provides for structured storage of deep-frozen cell suspensions in flat bags (13) at cryogenic storage temperatures, in storage boxes (14), storage clusters (15) and refrigerated storage modules (2). According to the invention, storage and removal from storage takes place by means of an integrated storage control unit (16) and a refrigerated shuttle system (29). The refrigerated storage modules (2) configured with a container assembly can remain self-sufficient for a limited period of time by virtue of integrated energy carriers and data storage devices (6, 7), and can therefore be transported without this restricting operation in any way. The container structure of the refrigerated storage modules (2) means that any number of said modules can be linked to an automated larger storage facility. It is also possible to extend the device by adding further refrigerated storage modules without interrupting operation.

Description

Das Tiefgefrieren ermöglicht das Haltbarmachen biologischer Sub­ stanzen wie z. B. Blutplasma oder lebender Zellen für praktisch unbegrenzte Zeit. So wird beispielsweise vor zeitlich planbaren, blutverlustreichen chirurgischen Eingriffen dem Patienten Blut entnommen, aufbereitet und anschließend tiefgefroren und gela­ gert. Auf diese Weise wird es möglich, ein ausreichendes Depot mit Eigenblut des Patienten anzulegen, so daß dieser während der Operation und danach mit Eigenblut versorgt werden kann. Dadurch wird eine Infektion des Patienten mit im Blut von fremden Spen­ dern möglicherweise enthaltenen und aufgrund des "diagnostischen Fensters" nicht nachweisbaren Hepatitiden und HI-Viren zuverläs­ sig verhindert. Desweiteren ermöglicht das allgemein als Kryo­ konservierung bezeichnete Verfahren die Herstellung von soge­ nannten "Quarantänepräparaten" aus Fremdblutspenden, die Über­ brückung temporärer Versorgungsengpässe und die Bevorratung sei­ tener Blutgruppen.Freezing enables the biological sub to be preserved punch like B. blood plasma or living cells for practical unlimited time. For example, before blood loss-rich surgical procedures the patient's blood removed, processed and then frozen and gela device. This way it becomes possible to have a sufficient deposit with the patient's own blood, so that the patient during the Surgery and then can be supplied with your own blood. Thereby becomes an infection of the patient with in the blood of foreign spen possibly contained and due to the "diagnostic Window "undetectable hepatitis and HI viruses prevented sig. Furthermore, this enables generally as a cryo Preservation methods called the production of so-called called "quarantine preparations" from foreign blood donations, the About bridging temporary supply bottlenecks and stockpiling tener blood groups.

Blut und andere Zellpräparate werden für diesen Zweck in beson­ derer Weise aufbereitet und anschließend in flächigen Kunst­ stoffbeuteln schockgefroren. Hiernach erfolgt die Lagerung der Beutel bei Temperaturen unterhalb der Glasübergangstemperatur von Wasser (ca. -130°C), da bei derartigen Temperaturen weder physikalische noch physiologische Veränderungen der so genannten "Kryokonserve" beobachtet werden.Blood and other cell preparations are especially used for this purpose prepared and then in flat art snap-frozen fabric bags. This is followed by the storage of the Bags at temperatures below the glass transition temperature of water (approx. -130 ° C), because at such temperatures neither physical or physiological changes of the so-called "Cryopreserve" can be observed.

Bislang erfolgt die Lagerung von jeweils in der Größenordnung von ca. 100 Blutbeuteln in großvolumigen, runden, vakuumisolier­ ten Vorratsbehältern, in der Gasphase über flüssigem Stickstoff. Eine sinnvolle Automatisierung der Einlagerung und Entnahme ist jedoch unter diesen Umständen nicht möglich, da die Beutel in komplizierter geometrischer Anordnung im Behälter angeordnet sind. Beschickung der Behälter und Entnahme der Beutel erfolgen manuell. Durch die natürliche Verdampfung des Stickstoff entwei­ chen laufend größere Gasmengen aus den Behältern, die zu einer Stickstoffanreicherung der Lagerraumluft führen und entsprechen­ de Überwachungs- und Klimatisierungsmaßnahmen zum Schutz des Be­ dienpersonals notwendig machen. Darüber hinaus ist aufgrund der ungünstigen Geometrie der Lagerbehälter ein sehr großes Lager­ raumvolumen erforderlich, um größere Beutelstückzahlen - etwa für eine Blutbank - einzulagern. Der gleichzeitige Transport ei­ ner größeren Anzahl an Blutbeuteln in Ihrem Lagerbehälter - wie beispielsweise im Katastrophenfall wünschenswert - ist aufgrund der Behälterkonstruktion nicht möglich.So far, the storage has been of the order of magnitude of approx. 100 blood bags in large, round, vacuum-insulated ten storage containers, in the gas phase over liquid nitrogen. A sensible automation of storage and removal is however, not possible in these circumstances because the bags are in complicated geometric arrangement arranged in the container  are. The containers are loaded and the bags are removed manually. Escape through the natural evaporation of nitrogen continuously larger quantities of gas from the containers leading to a Lead and comply with nitrogen enrichment of the storage room air de Monitoring and air conditioning measures to protect Be make service personnel necessary. In addition, due to the unfavorable geometry of the storage container a very large warehouse space required to accommodate larger numbers of bags - for example for a blood bank - store. The simultaneous transport egg a larger number of blood bags in your storage container - like desirable in the event of a disaster, for example the container construction is not possible.

Aufgabe der vorliegenden Erfindung war es daher, ein modular er­ weiterbares, automatisierbares Lagerungskonzept zu bereitzustel­ len, das wenig Bauraum benötigt und im Bedarfsfall bei uneinge­ schränkter Funktionsfähigkeit transportabel ist.The object of the present invention was therefore a modular he to provide an expandable, automatable storage concept len, which requires little space and if necessary with uneinge limited functionality is portable.

Gelöst wird diese Aufgabe durch Integration eines in Einzelge­ binde, Depots und Cluster gegliederten Lagersystems für die La­ gerung von gefrorenen Zellpräparaten in flächigen Kunststoffbeu­ teln bei tiefkalten Temperaturen in einen hoch isolierten Trans­ portcontainer, der ein vorübergehend autarkes Kälte- und Ener­ gieversorgungssystem sowie eine automatische Ein- und Auslage­ rungsvorrichtung beinhaltet, die eine manuelle Handhabung des Gefrierguts überflüssig macht.This task is solved by integrating one in single binding, depots and clusters of structured storage systems for the La storage of frozen cell preparations in flat plastic bags at low temperatures in a highly insulated trans port container, which is a temporarily self-sufficient refrigeration and ener power supply system and an automatic loading and unloading Rungsvorrichtung includes manual handling of the Makes frozen goods superfluous.

Das nachfolgend beschriebene Lagersystem zeichnet sich durch ei­ nen modularen Aufbau aus, der eine bedarfsabhängige Erweiteung der Lagerkapazität erlaubt. Da es sich um eine automatisch be­ triebene Lagervorrichtung handelt, deren tiefkalter Lagerbereich zur normalen Bedienung nicht begangen wird, ist eine Gefährdung von Bedienpersonal durch Stickstoffanreicherung in der Atemluft ausgeschlossen. Der modulare Aufbau gewährt zusätzlich die Mög­ lichkeit des Transportes autark gekühlter und mit Strom versorg­ ter Lagereinheiten, etwa zur Blutversorgung im Katastrophen- oder Verteidigungsfall, ohne daß ein Auftauen der Konserven er­ forderlich wäre.The storage system described below is characterized by egg NEN modular structure, which is a needs-based expansion the storage capacity allowed. Since it is an automatic driven storage device, the cryogenic storage area is not committed for normal operation is a hazard by operating personnel through nitrogen enrichment in the breathing air locked out. The modular structure also provides the possibility possibility of transport self-sufficient cooling and supplied with electricity  storage units, for example for blood supply in disaster or case of defense without thawing the canned food would be required.

Die Erfindung wird im folgenden anhand der Fig. 1 und 2 wei­ ter erläutert.The invention is explained below with reference to FIGS. 1 and 2 ter.

Fig. 1 Schematische räumliche Übersichtsdarstellung des Lager­ systems im Teilschnitt, Fig. 1 Schematic representation of spatial overview of the storage system in partial section,

Fig. 2 Detaildarstellung von Haltevorrichtung und Depotboxen mit automatischer mechanischer Einlagerungsvorrichtung. Fig. 2 detailed view of the holding device and depot boxes with automatic mechanical storage device.

Wesentlicher Bestandteil und äußere Hülle der Lagervorrichtung ist ein Raumcontainer (1), dessen Abmessungen vorteilhafterweise für den Straßentransport geeignet sind. Geeignete Ladevorrich­ tungen (2) ermöglichen eine Verladung auf straßen- oder schie­ nengebundene Fahrzeuge, Schiff oder ggf. Flugzeug. Im Inneren des Containers ist ein durch eine Türe (3) von außen zugängli­ cher Versorgungsraum (4) abgeteilt, der die erforderliche Ver­ sorgungstechnik mit Kälteerzeugung (5), Energieträgerlagerung mit Kältemittel-Speicherbehälter (6) und Kraftstoffversorgung (7), Stromversorgung (8) (Akkumulator oder Generator) sowie Meß­ und Regeltechnik und Nebenaggregate (9) aufnimmt.An essential component and outer shell of the storage device is a space container ( 1 ), the dimensions of which are advantageously suitable for road transport. Suitable loading devices ( 2 ) enable loading onto road or rail-bound vehicles, ships or possibly aircraft. Inside the container is a supply room ( 4 ) accessible from the outside through a door ( 3 ), which contains the necessary supply technology with refrigeration ( 5 ), energy storage with refrigerant storage tank ( 6 ) and fuel supply ( 7 ), power supply ( 8 ) (Accumulator or generator) as well as measurement and control technology and auxiliary units ( 9 ).

Eine gasdicht verschließbare, thermisch isolierte Servicetüre (10) trennt den Versorgungsraum vom eigentlichen Lagerraum, des­ sen gasdichte Außenwände (11) thermisch hoch isoliert und derart gasdicht miteinander verbunden sind, daß der gesamte Lagerraum hermetisch abgeschlossen ist.A gas-tight lockable, thermally insulated service door ( 10 ) separates the supply room from the actual storage room, the gas-tight outer walls ( 11 ) of which are thermally highly insulated and gas-tightly connected to one another in such a way that the entire storage room is hermetically sealed.

In den Lagerraum fest eingebaut sind Befestigungsvorrichtungen (12), die zur Fixierung von Halterahmen dienen. Die Halterahmen fassen mehrere separate Lager- oder Depotboxen (14) zu einem La­ gercluster (15) zusammen. Die Depotboxen nehmen jeweils einen oder mehrere Kryokonservenbeutel (13) auf. Die regelmäßige An­ ordnung der Halterahmen wird derart gestaltet, daß jede Depotbox zur Einlagerung und Entnahme von Kryokonservenbeuteln (13) frei zugänglich ist. Vorteilhafter Weise können die Depotboxen (14) hierfür als Schubladen ausgebildet werden, die im geschlossenen Zustand eine oder mehrere regelmäßige Wandflächen im Lagerraum bilden. Die Gestaltung der Depotboxen (14) erlaubt eine Automa­ tisierung des Einlagerungs- und Entnahmevorgangs durch eine ge­ eignete mechanische Handlingvorrichtung (16), die von außen ge­ steuert werden kann. Alle Depotboxen und Lagerbeutel sind durch ein maschinenlesbares Kennzeichnungssystem individuell markiert.Fastening devices ( 12 ), which serve to fix the holding frame, are permanently installed in the storage room. The holding frames combine several separate storage or depot boxes ( 14 ) to form a storage cluster ( 15 ). The depot boxes each hold one or more cryopreserved bags ( 13 ). The regular arrangement of the holding frame is designed such that each depot box for storing and removing cryopreserved bags ( 13 ) is freely accessible. For this purpose, the depot boxes ( 14 ) can advantageously be designed as drawers which, when closed, form one or more regular wall surfaces in the storage room. The design of the depot boxes ( 14 ) allows automation of the storage and removal process by a suitable mechanical handling device ( 16 ) which can be controlled from the outside. All depot boxes and storage bags are individually marked by a machine-readable labeling system.

Die Übergabe der Beutel an die automatische Einlagerungsvorrich­ tung, bzw. die Entnahme der Beutel aus dem Lagerraum erfolgt durch eine gasdicht verschließbare Schleuse (17).The transfer of the bags to the automatic storage device, or the removal of the bags from the storage space, is carried out by a gas-tight lock ( 17 ).

Die Schleuse ist so gestaltet, daß sowohl Einzelbeutel als auch - wie hier dargestellt - Depotboxen (14) übergeben werden kön­ nen. Für Wartungszwecke ist darüber hinaus eine hier nicht dar­ gestellte weitere gasdicht verschließbare, thermisch isolierte Öffnung vorgesehen, die die Umlagerung von Depotboxenclustern mit der zugehörigen Haltevorrichtung in ein geeignetes Stand-by-Lager erlaubt.The lock is designed so that both individual bags and - as shown here - deposit boxes ( 14 ) can be handed over. For maintenance purposes, a further gas-tight, thermally insulated opening, not shown here, is also provided, which allows the relocation of depot box clusters with the associated holding device to a suitable stand-by warehouse.

Die automatische mechanische Entnahmevorrichtung verfügt über eine hier ebenfalls nicht dargestellte Lesevorrichtung zur Iden­ tifizierung der Kennzeichnung von Depotboxen und erforderlichen­ falls Einzelbeuteln, so daß eine Kopplung der Entnahmevorrich­ tung an ein ebenfalls in die Lagervorrichtung integriertes elek­ tronisches Datenverarbeitungssystem eine vollautomatische Lager­ verwaltung ermöglicht.The automatic mechanical removal device has a reading device for identification, also not shown here Certification of the labeling of depot boxes and necessary if single bags, so that a coupling of the removal device device on an electrical system also integrated in the bearing device tronic data processing system a fully automatic warehouse management enables.

Die Temperaturregelung bzw. Kühlung des Lagerraums erfolgt ent­ weder durch ein offenes Kühlsystem, das dem Baum direkt ein tiefkaltes flüssiges Medium zur Kühlung zuführt, oder aber - wie hier dargestellt - durch eine indirekte Kühlung durch Wärmetau­ scher (19), die von einem geeigneten Kältemittel - i.allg. flüs­ siger Stickstoff - durchströmt werden. Zur Verbesserung der Tem­ peraturgleichmäßigkeit innerhalb des Lagerraumes kann zusätzlich ein nicht dargestelltes internes Luftumwälzsystem - vorteilhaf­ ter Weise durch tieftemperaturtaugliche Umwälzventilatoren - vorgesehen werden.The temperature control or cooling of the storage room is carried out either by an open cooling system that supplies the tree with a cryogenic liquid medium for cooling, or - as shown here - by indirect cooling by heat exchangers ( 19 ) by a suitable refrigerant - generally liquid nitrogen - are flowed through. To improve the temperature uniformity within the storage room, an internal air circulation system, not shown, can be additionally provided, advantageously by means of circulation fans suitable for low temperatures.

Die Zufuhr des Kühlmediums sowie die Versorgung mit elektrischer Energie für Lagervorrichtung und Hilfsaggregate erfolgt durch entsprechende Versorgungsleitungen (19, 20) aus dem Versorgungs­ raum.The supply of the cooling medium and the supply of electrical energy for the storage device and auxiliary units takes place through corresponding supply lines ( 19 , 20 ) from the supply room.

Während des ortsfesten Betriebs der Containereinheit werden die lokalen Energie- und Datenverarbeitungssysteme des Versorgungs­ raums über Schnittstellen (21, 22, 23) mit einem zentralen Da­ tenverarbeitungssystem, einem stationären Leitungssystem aus ge­ eigneten ortsfest installierten Energie(träger)lager- oder -erzeugungseinheiten und einer zentralen Stromversorgung verbun­ den, welche ihrerseits zur Versorgung mehrerer gleichzeitig an­ geschlossener Lagercontainer geeignet sind.During the stationary operation of the container unit, the local energy and data processing systems of the supply room are interfaced with interfaces ( 21 , 22 , 23 ) with a central data processing system, a stationary line system made of suitable stationary installed energy (carriers) storage or generation units and one central power supply connected, which in turn are suitable for supplying several storage containers closed at the same time.

Bei transportablen Lagereinheiten sind die Speichereinrichtungen des Versorgungsraumes jedoch so bemessen, daß während eines Transportes über einen festgelegten Zeitraum die Kühlung und Temperaturregelung aufrecht erhalten werden und die vor Ort zu speichernden Lagergutdaten erhalten bleiben.In the case of transportable storage units, the storage devices are of the supply room, however, such that during a Cooling and transport over a fixed period of time Temperature control is maintained and on-site too stored inventory data are retained.

Eine vorteilhafte Variante des Lagersystems sieht vor, daß die Container auf einander gestapelt werden können. Bei geeigneter Ausführung von Schnittstellen der Versorgungssysteme könne in diesem Fall zwei oder mehr Container mit einem gemeinsamen Kühl- bzw. Energieversorgungssystem arbeiten.An advantageous variant of the storage system provides that the Containers can be stacked on top of each other. With more suitable Execution of interfaces of the supply systems can in in this case two or more containers with a common cooling or energy supply system work.

Claims (8)

1. Lagervorrichtung (1) für die Aufbewahrung tiefgefrorener Zel­ len oder Gewebsteile insbesondere in flachen elastischen Kunststoffbeuteln (13), dadurch gekennzeichnet, daß eine große Anzahl von Einzelgebinden - i.allg. einige Tausend Stück - ge­ meinsam in einem thermisch hoch isolierten Lagerraum bei kryo­ genen Temperaturen unter -80°C gelagert werden.1. Storage device ( 1 ) for storing deep-frozen cells or tissue parts, in particular in flat elastic plastic bags ( 13 ), characterized in that a large number of individual containers - i.allg. several thousand pieces - stored together in a thermally highly insulated storage room at cryogenic temperatures below -80 ° C. 2. Lagervorrichtung nach Anspruch 1, dadurch gekennzeichnet, daß in der Lagervorrichtung Speichereinrichtungen (6, 7) für die Energieträgerbevorratung installiert sind, die über einen be­ grenzten Zeitraum eine autarke Energie- und Kälteversorgung zur Aufrechterhaltung der Kühl- und Lagerfunktion ermöglichen.2. Storage device according to claim 1, characterized in that in the storage device storage devices ( 6 , 7 ) for the energy storage are installed, which allow a self-sufficient energy and cooling supply to maintain the cooling and storage function over a limited period of time. 3. Lagervorrichtung nach Anspruch 1 oder 2, dadurch gekennzeich­ net, daß die Lagervorrichtung ohne Einschränkung der Kühl- und Lagerfunktion transportiert werden kann.3. Storage device according to claim 1 or 2, characterized net that the storage device without restriction of the cooling and Warehouse function can be transported. 4. Lagervorrichtung nach einem der vorausgehenden Ansprüche, da­ durch gekennzeichnet, daß das Gefriergut unter Zusammenfassung mehrerer Einzelgebinde in entnehmbaren Depotbehältern (34) und mehrerer Depotbehälter in entnehmbaren Depotclustern (15) in einem modular strukturierten Aufbewahrungssystem gelagert wird.4. Storage device according to one of the preceding claims, characterized in that the frozen goods are stored in a modular structured storage system by combining several individual containers in removable storage containers ( 34 ) and several storage containers in removable storage clusters ( 15 ). 5. Lagervorrichtung nach einem der vorausgehenden Ansprüche, da­ durch gekennzeichnet, daß die Ein- und Auslagerung des Ge­ frierguts in Einzelgebinden (13), Depotbehältern (14) oder De­ potclustern (15) durch ein in die Lagervorrichtung integrier­ tes, bei der tiefen Betriebstemperatur im Inneren des Lagers arbeitendes, automatisches Handlingsystem (16) erfolgt.5. Storage device according to one of the preceding claims, characterized in that the storage and retrieval of Ge frozen goods in individual containers ( 13 ), storage containers ( 14 ) or de pot clusters ( 15 ) by an integrated in the storage device, at low operating temperature automatic handling system ( 16 ) working inside the bearing. 6. Lagervorrichtung nach einem der vorausgehenden Ansprüche, da­ durch gekennzeichnet, daß die Erfassung und Verwaltung der das gelagerte Gefriergut betreffenden Daten durch ein in die La­ gervorrichtung integriertes lokales Datenverarbeitungssystem erfolgt.6. Storage device according to one of the preceding claims, there characterized in that the registration and management of the stored frozen goods data by a in the La  Integrated local data processing system he follows. 7. Lagervorrichtung nach einem der vorausgehenden Ansprüche, da­ durch gekennzeichnet, daß zwei oder mehr im Betrieb befindli­ che Lagereinrichtungen aufeinander gestapelt werden können.7. Storage device according to one of the preceding claims, there characterized in that two or more are in operation che storage facilities can be stacked on top of each other. 8. Lagervorrichtung nach einem der vorausgehenden Ansprüche, da­ durch gekennzeichnet, daß die Lagervorrichtung Schnittstellen (21, 22, 23) besitzt, über die eine beliebige Anzahl von Lage­ reinrichtungen durch ein gemeinsames Energie- und Datenversor­ gungsnetz zu einem Großlager verbunden werden kann.8. Storage device according to one of the preceding claims, characterized in that the storage device has interfaces ( 21 , 22 , 23 ) through which any number of location devices can be connected to a large warehouse by a common energy and data supply network.
DE19716913A 1997-04-23 1997-04-23 Modular storage device for cryogenic storage of flat plastic bags filled with frozen cell suspension Ceased DE19716913A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE19716913A DE19716913A1 (en) 1997-04-23 1997-04-23 Modular storage device for cryogenic storage of flat plastic bags filled with frozen cell suspension
AU82064/98A AU8206498A (en) 1997-04-23 1998-04-21 Device and method for deep-freeze storing of biological preparations
PCT/DE1998/001114 WO1998047357A2 (en) 1997-04-23 1998-04-21 Device and method for deep-freeze storing of biological preparations
ZA983445A ZA983445B (en) 1997-04-23 1998-04-23 Apparatus and process for the low-temperature storage of biological preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19716913A DE19716913A1 (en) 1997-04-23 1997-04-23 Modular storage device for cryogenic storage of flat plastic bags filled with frozen cell suspension

Publications (1)

Publication Number Publication Date
DE19716913A1 true DE19716913A1 (en) 1998-11-05

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EP1634496A1 (en) * 2004-09-14 2006-03-15 The Automation Partnership (Cambridge) Limited Ultra-low temperature storage system
EP1639892A1 (en) 2004-09-14 2006-03-29 The Automation Partnership (Cambridge) Limited Ultra-low temperature storage system
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EP1939561A3 (en) * 2006-12-07 2008-07-23 Tecan Trading AG Compact bearing element and its use
EP2051810A2 (en) * 2006-01-23 2009-04-29 Nexus Biosystems, Inc., Automated system for storing, retreiving and managing samples
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US7765829B2 (en) 2004-02-09 2010-08-03 Angelantoni Industrie Spa Apparatus for receiving, storing and providing bags of blood
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US6646238B1 (en) 1999-05-07 2003-11-11 Evotec Oai Ag Method and device for a accomodating samples on cryosubstrates
WO2000068663A1 (en) * 1999-05-07 2000-11-16 Evotec Biosystems Ag Method and device for accommodating samples on cryrosubstrates
DE10060889A1 (en) * 2000-12-07 2002-06-27 Fraunhofer Ges Forschung Cryopreservation method for cells and cell components comprises applying samples to e.g. a CD as a storage substrate and burning position-specific data on to disk.
US6931864B2 (en) 2000-12-07 2005-08-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Cryostorage method and device
DE10144925A1 (en) * 2001-09-12 2003-03-27 Fraunhofer Ges Forschung Cryopreservation method for cells and cell components comprises applying samples to e.g. a CD as a storage substrate and burning position-specific data on to disk.
DE10146371A1 (en) * 2001-09-20 2003-04-17 Georg S Wengler Mobile unit, for harvesting human or animal stem cells, comprises a container divided into sections for the extraction, preservation and storage of stem cells from donor materials
US7765829B2 (en) 2004-02-09 2010-08-03 Angelantoni Industrie Spa Apparatus for receiving, storing and providing bags of blood
DE102004014937A1 (en) * 2004-03-26 2005-10-20 Asys Prozess Und Reinraumtechn Storage arrangement has air treatment facility adjacent to storage space and draws air from storage space, processes it, and then blows cleaned and/or climatized air into storage space
EP1639892A1 (en) 2004-09-14 2006-03-29 The Automation Partnership (Cambridge) Limited Ultra-low temperature storage system
EP1634496A1 (en) * 2004-09-14 2006-03-15 The Automation Partnership (Cambridge) Limited Ultra-low temperature storage system
WO2006035465A1 (en) * 2004-09-29 2006-04-06 Angelantoni Industrie Spa Apparatus and method for receiving, storing and distributing blood bags
US8113007B2 (en) 2004-09-29 2012-02-14 Angelantoni Industrie Spa Apparatus and method for receiving, storing and distributing blood bags
CN100551237C (en) * 2004-09-29 2009-10-21 安吉尔安东尼工业股份公司 Be used to receive, store and divide the equipment and the method for match bag
US7648321B2 (en) 2006-01-23 2010-01-19 Nexus Biosystems, Inc. System and method for partitioning a temperature controlled compartment
US8252232B2 (en) 2006-01-23 2012-08-28 Brooks Automation, Inc. Automated system for storing, retrieving and managing sample
EP2051810A2 (en) * 2006-01-23 2009-04-29 Nexus Biosystems, Inc., Automated system for storing, retreiving and managing samples
US7635246B2 (en) 2006-01-23 2009-12-22 Nexus Biosystems, Inc. Device and method for retrieving or replacing a tray within a storage compartment
US11175298B2 (en) 2006-01-23 2021-11-16 Brooks Automation, Inc. Automated system for storing, retrieving and managing samples
US10168344B2 (en) 2006-01-23 2019-01-01 Brooks Automation, Inc. Drive assembly for robotic conveyor system
US9702887B2 (en) 2006-01-23 2017-07-11 Brooks Automation, Inc. Automated system for storing, retrieving and managing samples
US7793842B2 (en) 2006-01-23 2010-09-14 Nexus Biosystems, Inc. Device and method for reading bar codes on an object
EP2051810A4 (en) * 2006-01-23 2011-02-09 Nexus Biosystems Inc Automated system for storing, retreiving and managing samples
US8083994B2 (en) 2006-01-23 2011-12-27 Brooks Automation, Inc. System and method for selectively extracting individual vials from an array of vials within a rack
EP2682189A1 (en) * 2006-01-23 2014-01-08 Nexus Biosystems, Inc., Automated system for storing, retrieving and managing samples
FR2900913A1 (en) * 2006-05-15 2007-11-16 Efs Nord De France Etablisseme Blood/derivative product pocket distributing equipment for output expedition and stocking shop, has automate with circuits controlling conveyor and distributing assembly that distributes pocket towards zone based on data of product type
EP2075205A1 (en) * 2006-05-15 2009-07-01 EFS Nord de France Equipment and method for distributing pouches of blood
EP1857380A1 (en) * 2006-05-15 2007-11-21 EFS Nord de France Equipment and method for distributing pouches of blood
EP1939561A3 (en) * 2006-12-07 2008-07-23 Tecan Trading AG Compact bearing element and its use
EP2146163A3 (en) * 2008-07-10 2011-12-28 DOMETIC S.a.r.l. Blood storage device, blood bank storage system and method for operating a blood bank storage system
DE102008032407A1 (en) * 2008-07-10 2010-01-14 Dometic S.A.R.L. Blood refrigerator, blood bank storage system and method of operating a blood bank storage system
WO2012104079A3 (en) * 2011-02-02 2012-10-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Cooling system, especially for cryopreserving biological samples, comprising devices for use in case of an emergency
CN103369959A (en) * 2011-02-02 2013-10-23 弗劳恩霍弗应用技术研究院 Cooling system, especially for cryopreserving biological samples, comprising devices for use in case of an emergency
JP2014504617A (en) * 2011-02-02 2014-02-24 フラウンホーファーゲゼルシャフト ツール フォルデルング デル アンゲヴァンテン フォルシユング エー．フアー． Cooling system with equipment used in an emergency and mainly used for cryopreservation of biological samples
CN103369959B (en) * 2011-02-02 2015-11-25 弗劳恩霍弗应用技术研究院 Comprise the device for emergency situation and be particularly useful for the cooling system of the low temperature storage of biological specimen
US9310119B2 (en) 2011-02-02 2016-04-12 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Cooling system, especially for cryopreserving biological samples, comprising devices for use in case of an emergency
EP3415005B1 (en) * 2017-06-16 2022-08-03 Liconic Ag Automatic blood bank

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AU8206498A (en) 1998-11-13
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WO1998047357A3 (en) 1999-01-28

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