DE19503934C2 - Use of unsaturated flavors to prevent ozone damage - Google Patents

Description

Due to the decrease in the ozone layer in the stratosphere and the increasing NO _x and hydrocarbon emissions near the ground, the ozone concentration rises steadily with intensive solar radiation in the biosphere.

Both about the meaning of the "ozone hole", the Luftver pollution including polluter and geographical chemical and biological conditions for the increase ground-level ozone concentration and its effects innumerable publications exist on living things. In plants, ozone primarily affects chloroplasts on; in humans and animals are primarily the mucous membranes affected. It has a mucociliary depressive effect on the respiratory tract siv.

Extensive studies report medical symptoms ozone pollution such as reddened and / or watery eyes Syndrome of the "dry eye", "scratching" in the throat possibly with Cough, head pressure and / or pain, tiredness, increased susceptibility to infection and allergy, however also psychological effects in the sense of a toxicopy. (M. WAGNER: "Ozone - somatic and psychological effects", Munich. med. Wschr. 135 (1993) 367-370).

The currently only possible prophylaxis is medics and Environmental toxicologists on maternity leave, d. H. with increased ozone concentrations trations ("summer smog", ozone warnings in summer 1994) should children and the elderly, sensitive or respiratory People stay in enclosed spaces; the success is on However, due to the gas exchange questionable. Furthermore is recommended for healthy people with increased ozone levels between 11:00 and 17:00 (depending on the specific Conditions fluctuate the times) outdoors no licensed to do physically difficult work or physically demanding to end sports.  

To reduce the ozone concentration in rooms with limited Gas exchange becomes a catalytically ozone-depleting art fabric (NOXON from Hoechst AG) or C = C double bonds Retaining fragrance / aroma substances (R. GREIFF, Offenlegungsschrift DE 44 25 775 A1 dated 26.01.95).

If mucous membranes are stimulated to overproduction by ozone ("runny" nose ...), sympathomimetics (decongestant nose drops) can bring temporary relief. An undesirable side effect is the risk of vasoconstriction (drying of the nasal mucosa). If the nasal mucosa reacts with barking and dryness (especially in small children), oily or panthenol-containing ointments help for a short time. Accidental aspiration, however, threatens lipid pneumonia (M. CLASSEN, V. DIEHL, K. KOCHSIEK (ed.): "Internal Medicine", Urban &Schwarzenberg; Munich-Vienna-Baltimore, 1991, p. 1097). In order to maintain the lively regeneration metabolism of the mucous membranes even when exposed to ozone (oxidative stress), an adequate supply of vitamins and radical scavengers A, B ₂ , B ₆ , C, E, Se, Zn ... is recommended (adj. GREIFF, unpublished results).

At the same time there are reflex irritations like facial castings, Nose tamponade according to GOTTSTEIN, touching with a soft Rubber catheter or the use of a HARKE irrigation bulb helpful (H. KRAUSZ: "breath therapy", VEB Verlag Volk and Gesundheit, Berlin, 1980, pp. 145-150).

Animal experiments were carried out for drug ozone protection Deferoxamine (DFO) performed (S. LOUIE, M.A. ARATA, S. D. OFFERDAHL et al .: "Effect of tracheal insufflation of deferoxamine on acute ozone toxicity in rats ", J. Lab. Clin. Med., 121 (1993) 502-509). However, leave the identified side effects such as complexation of Iron and thus initiation of iron deficiency anemia ask it Lich whether this drug for the indications position ozone protection can be used at all.  

The secretion that protects and cleanses the mucous membranes (Slime) - consisting of approx. 95% water, 1% inorganic Salts, 2% glyco- / mucoproteins (fuco-, sial-, sulfomucine ...) and 2% lipids - probably occurs in layers piling of usually 5-10 µm thick (H. EDEL, K. KNAUTH: "Basics of respiratory therapy", VEB Verlag Volk und Gesundheit, Berlin, 1986, pp. 52-53).

To protect against the irritant gas ozone, the sensitive Mucous membranes (lining of the respiratory tract, conjunctiva of the Eyelids) should be covered with secretions if possible, which is a secretion requires promotion and liquefaction, and an im Active ingredient containing secretions should make the ozone ineffective do.

The present invention presents the use of unsaturated flavors, which is the task of to ensure efficient ozone protection, simple, economical and solve without stressful side effects.

The basis for this is the ozone bond through C = C double bonds Containing substances that also stimulate secretion and have a secretolytic effect.

The method according to the invention for the production of orally administrable active ingredients for preventing ozone damage uses unsaturated aroma substances such as

• Limonene (4-isopropenyl-1-methyl-1-cyclohexene),
• Citronellol (3,7-dimethyl-6-octen-1-ol),
• - citral (3,7-dimethyl-2,6-octadienal),
• - carvone ((+) - p-mentha-6,8-dien-2-one),
• Geraniol (3,7-dimethyl-2,6-octadien-1-ol),
  which are absorbed in effective doses in the digestive tract (small intestine).

Saturated flavors such as menthol ((1S, 2R, 5S) - (±) -p-menthan- 3-ol) or cineol (1,8-epoxy-p-menthan) have a secreto effect lytic and expectorant, but do not protect against ozone effects; on the contrary, the ozone stimulus can be increased.  

Because most of these are unsaturated natural or natural identical synthetic compounds the mucous membranes of the Digestive tract when swallowing depending on the individual can irritate differently, they are mixed with oils. Emulsifiers are used for better absorption. Although the Ver the juices of the stomach do not contain the oily active ingredient mixtures attack, it is for the taste sensation and for a quick passage of the stomach is more useful if the active ingredients in small intestine-soluble gelatin capsules are used. The blood transports the effects absorbed in the small intestine substances to the lungs, where they are evaporated in the alveoli and develop their protective effect. But also the mucous membrane secretions from unicellular (goblet cells) and multicellular intraepithelial glands such as nasal and pharyngeal glands, -tracheales, -bronchiales and -conjunctivales included the ozone protection agents.

Examples:

• 1. 100 mg of lime are mixed with 200 mg of olive oil and 20 mg of soy lecithin mixed; this mix represents an adult dose.
• 2. 100 mg geraniol, 200 mg safflower oil and 50 mg methylhydroxy After pasting, cellulose is for an adult ready for application.

Claims (3)

1. Use of unsaturated flavorings with oils and / or emulsifiers mixed as a suspension or in the small intestine Capsules enclosed to prevent ozone damage gung. 2. Use according to claim 1, characterized, that the mixture of active ingredients promoting absorption, bind Tissue-strengthening and secretion-stimulating components be added. 3. Use according to claim 1, characterized, that components are added to the active ingredient mixture, that reduce oxidative stress and free radicals make harmless, which as side effects at Ozone exposure can occur.