DE184774C - - Google Patents
Info
- Publication number
- DE184774C DE184774C DENDAT184774D DE184774DA DE184774C DE 184774 C DE184774 C DE 184774C DE NDAT184774 D DENDAT184774 D DE NDAT184774D DE 184774D A DE184774D A DE 184774DA DE 184774 C DE184774 C DE 184774C
- Authority
- DE
- Germany
- Prior art keywords
- substances
- isin
- tablets
- substance
- concentrated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000126 substance Substances 0.000 claims description 11
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 235000015097 nutrients Nutrition 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000000968 intestinal Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 210000004051 Gastric Juice Anatomy 0.000 description 2
- ZQBAKBUEJOMQEX-UHFFFAOYSA-N Phenyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OC1=CC=CC=C1 ZQBAKBUEJOMQEX-UHFFFAOYSA-N 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 241000031711 Cytophagaceae Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 210000000936 Intestines Anatomy 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 241000272168 Laridae Species 0.000 description 1
- 229920001800 Shellac Polymers 0.000 description 1
- 210000002784 Stomach Anatomy 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000002378 acidificating Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000001264 neutralization Effects 0.000 description 1
- 229960000969 phenyl salicylate Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
- JVl 184774 -KLASSE 30 h. GRUPPE - JVl 184774 - CLASS 30 h. GROUP
EUGENE DONARD und HENRI LABBE in PARIS.EUGENE DONARD and HENRI LABBE in PARIS.
Substanzen oder Nährstoffen.Substances or nutrients.
Patentiert im Deutschen Reiche vom 25. Januar 1906 ab.Patented in the German Empire on January 25, 1906.
Die Erfindung bezieht sich auf ein Verfahren zur Isolierung von luft- und feuchtigkeitsempfindlichen medizinischen oder anderen Substanzen durch Umhüllung mit dem im Handel unter der Bezeichnung »Ma'isin« erhältlichen Eiweißstoffe.The invention relates to a method for the insulation of air and moisture sensitive medicinal or other substances by coating with the commercially available under the name "Ma'isin" available proteins.
Dieser nach dem in der Patentschrift 14421753 beschriebenen Verfahren aus Mais gewonnene Eiweißstoff weist Eigenschaften auf, die ihn zu einem hervorragenden Einhüllungsmittel machen, insbesondere für solche Stoffe, Welche im Darm zur Einwirkung kommen sollen und durch den Magen dahin gelangen. Maiisin widersteht dem sauren Magensaft, löst sich dagegen leicht im alkalischen Darmsaft und wird infolge seiner Proteidnatur durch Assimilation verwertet. Es ist vollkommen neutral, unlöslich in Wasser, daher unempfindlich gegen einen Wassergehalt der eingehüllten Substanz und gegen die Luftfeuchtigkeit, auch unempfindlich gegen Sonnenlicht.This protein obtained from maize according to the method described in patent specification 144 217 53 has properties that make it an excellent enveloping agent, especially for those substances that are supposed to act in the intestine and get there through the stomach. Maiisin resists acidic gastric juice, but dissolves easily in the alkaline intestinal juice and, due to its protein nature, is utilized by assimilation. It is completely neutral, insoluble in water, therefore insensitive to the water content of the enveloped substance and to air humidity, also insensitive to sunlight.
Es gibt mit Alkohol eine konzentrierte, viskose Lösung, wodurch die Bildung selbstThere is a concentrated, viscous solution with alcohol, which causes the formation itself
häutchenfeiner Überzüge bei größter Gleichmäßigkeit ermöglicht wird. Die Überzüge sind schmiegsam und nicht zur Brüchigkeit geneigt.skin-fine coatings is made possible with the greatest uniformity. The coatings are pliable and not prone to breakage.
Dazu gesellt sich ein geringer Preis.In addition, there is a low price.
Durch diese Eigenschaften unterscheidet sich Ma'isin ganz wesentlich von den üblichen Umhüllungsstoffen. So ist die Gelatine magenlöslich und kann nicht dazu dienen, Stoffe in den Darmtraktus zu bringen. Keratin, welches ebenfalls nur im Darmsaft löslich ist, gibt einen spröden und wasserempfindlichen Überzug, der einer wasserundurchlässigen Unterlage bedarf und außerdem schwierig herzustellen ist. Salol (Salicylsäurephenylester) läßt wegen seiner chemischen Beschaffenheit nur eine beschränkte Anwendung zu und ist zudem nicht ganz unempfindlich gegen Magensaft; es ist keine indifferente Substanz und muß kühl und vor der Sonne geschützt aufbewahrt werden. Schellack kann nur als äußerster Notbehelf erachtet werden.These properties make ma'isin very different from the usual Wrapping materials. So the gelatin is stomach-soluble and cannot be used to put substances in to bring the intestinal tract. Keratin, which is also only soluble in the intestinal juice, gives a brittle and water-sensitive coating, that of a water-impermeable one Requires pad and is also difficult to manufacture. Salol (salicylic acid phenyl ester) Due to its chemical nature, it can only be used to a limited extent and is also not completely insensitive to gastric juice; it is not an indifferent substance and must be kept cool and protected from the sun. Shellac can only be used as extreme makeshift.
Die Benutzung des Ma'isins für den vorliegenden Zweck erfolgt in der üblichen Weise, d. h. man kann die zu schützende Substanz in Form eines Pulvers von beliebiger Korngröße mit einer konzentrierten Maisinlösung mischen, wobei diese zugleich als BindemittelThe ma'isin is used for the present purpose in the usual way, d. H. the substance to be protected can be in the form of a powder of any grain size Mix with a concentrated maisin solution, using this as a binding agent
Claims (1)
Verfahren zum Isolieren von luft- und feuchtigkeitsempfindlichen medizinischen Substanzen oder Nährstoffen, gekennzeichnet durch die Verwendung des unter dem Namen Ma'isin bekannten Eiweißstoffes.Patent-A ν SPRU ch:
Method for isolating air- and moisture-sensitive medical substances or nutrients, characterized by the use of the protein known under the name Ma'isin.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE184774C true DE184774C (en) |
Family
ID=448678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT184774D Active DE184774C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE184774C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2361915A1 (en) * | 1976-08-20 | 1978-03-17 | Ciba Geigy Ag | LONG-TERM PHARMACEUTICAL DOSAGE FORMS |
| EP0158277A2 (en) * | 1984-04-11 | 1985-10-16 | Hoechst Aktiengesellschaft | Implantable controlled-release preparations of regulatory peptides, and process for their preparation |
-
0
- DE DENDAT184774D patent/DE184774C/de active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2361915A1 (en) * | 1976-08-20 | 1978-03-17 | Ciba Geigy Ag | LONG-TERM PHARMACEUTICAL DOSAGE FORMS |
| EP0158277A2 (en) * | 1984-04-11 | 1985-10-16 | Hoechst Aktiengesellschaft | Implantable controlled-release preparations of regulatory peptides, and process for their preparation |
| EP0158277A3 (en) * | 1984-04-11 | 1987-04-29 | Hoechst Aktiengesellschaft | Implantable controlled-release preparations of regulatory peptides, and process for their preparation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3786316T2 (en) | Cover membrane and means made therewith. | |
| DE69127456T2 (en) | GELATIN CAPSULES SUBSTITUTED BY STRENGTH WITH A HIGH AMYLOSE CONTENT | |
| DE69829254T2 (en) | Drug preparation with controlled drug release rate | |
| DE3011044C2 (en) | ||
| DE184774C (en) | ||
| DE2647722A1 (en) | RODENTICIDAL AGENTS AND METHOD FOR THEIR PRODUCTION | |
| EP0225843B1 (en) | Hardenable silicone-based mould material which, upon mixing, permits an optical control of the sufficiency of the mixing process | |
| DE874553C (en) | Process for the production of storable fodder lime preparations containing vitamins | |
| DE1165392B (en) | Substances containing vitamins as admixture to animal feed | |
| DE964924C (en) | Process for the production of multilayer material from hydrophilic and hydrophobic layers | |
| DE12416C (en) | Improvements in the manufacture of photographic emulsions | |
| DE2621838C3 (en) | ||
| DE1147844B (en) | Coating layer for photographic print-out halogen silver emulsions | |
| DE1291997B (en) | Process for the production of stable dispersions of silver precipitating, metal sulfide or metal selenide containing germs for the silver salt diffusion process | |
| DE2655326C2 (en) | Process for improving the solubility and stability of basic medicinal products in mono- and diglycerides of medium-chain fatty acids (C 6 -C 1 2) for the purpose of oral administration | |
| DE1792713C3 (en) | Sodium Chloride Mixture as Complementary Feed Excretion from 1792392 | |
| DE624340C (en) | Process for the preparation of durable, dry hormone preparations in solid form | |
| DE936007C (en) | Process for the production of light-insensitive auxiliary layers in photographic materials | |
| DE710994C (en) | Process for the preparation of a blood substitute fluid | |
| DE973974C (en) | Process for the production of impression materials for dental purposes | |
| DE637865C (en) | Binders for photographic emulsions | |
| DE620300C (en) | Process for the production of acetone-soluble, highly viscous cellulose esters of lower fatty acids by treatment with halogen-containing phosphorus compounds | |
| DE468810C (en) | Process for the manufacture of a hormone-containing substance of plant origin | |
| DE96495C (en) | ||
| DE341831C (en) | Process for the production of a durable binding agent from casein, which can be made usable by simply mixing it with water |