DE1768020A1 - Alkene derivatives and processes for their preparation - Google Patents

Alkene derivatives and processes for their preparation

Info

Publication number
DE1768020A1
DE1768020A1 DE19681768020 DE1768020A DE1768020A1 DE 1768020 A1 DE1768020 A1 DE 1768020A1 DE 19681768020 DE19681768020 DE 19681768020 DE 1768020 A DE1768020 A DE 1768020A DE 1768020 A1 DE1768020 A1 DE 1768020A1
Authority
DE
Germany
Prior art keywords
radical
hydrogen
trans
replaced
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19681768020
Other languages
German (de)
Inventor
Richardson Dora Nellie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB34989/62A external-priority patent/GB1013907A/en
Priority claimed from GB30755/65A external-priority patent/GB1064629A/en
Priority claimed from GB18491/67A external-priority patent/GB1146405A/en
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of DE1768020A1 publication Critical patent/DE1768020A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms

Claims (9)

Vom Deutschen Patentamt ohne jede Gewähr h&afgesteilte Abschrift von^ffnterlagen, die zur fp^tfioechanischen Wiederga>Tnicht geeignet sind^^"^ T768020 Patent an s ρ r ü c h eCopies of documents which are not suitable for fp ^ tfioechanical playback ^^ "^ T768020 Patent to s ρ r ü c h e are made by the German Patent Office without any guarantee 1. Gis- oder trans-Isomer eines Alkenderivats der !Formel:1. Gis or trans isomer of an alkene derivative of the formula: R1NH·R 1 NH und die Säureadditionssalze davon, dadurch gekennzeichnet, daß R das Äthylradikal darstellt, R und R4 Phenylradikale darstellen und R^ das Methyl- oder Äthylradikal dar- Λ stellt.and the acid addition salts thereof, characterized in that R represents the ethyl radical, R and R 4 being phenyl radicals and R represents the methyl or ethyl radical DAR Λ. 2. Die Alkenderivate: 1-(p-ß-Äthylaminoäthoxyphenyl)-1,2-trans-diphenylprop-1-en und i-(p-ß-Äthylaminoäthoxyphenyl) -1,2-trans-diphenylbut-1-en und die Säureadditionssalze davon.2. The alkene derivatives: 1- (p-ß-ethylaminoethoxyphenyl) -1,2-trans-diphenylprop-1-en and i- (p-ß-ethylaminoethoxyphenyl) -1,2-trans-diphenylbut-1-ene and the acid addition salts of that. 3. Salz nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß es ein Salz mit Salz-, Schwefel-, Phoephor-, Essig-, Wein-, Oxal- oder Citronensäure ist.3. Salt according to claim 1 or 2, characterized in that it is a salt with salt, sulfur, Phoephor-, vinegar, wine, Is oxalic or citric acid. 4. Verfahren zur Herstellung eines eis- oder trans-Isomers4. Process for the preparation of a cis or trans isomer eines Alkenderivats nach Anspruch 1, dadurch gekennzeichnet, f daß eine Schützgruppe (P) in einer Verbindung der Formel:of an alkene derivative according to claim 1, characterized in that f that a protecting group (P) in a compound of the formula: R1N-(CH2)20- P \ -CR3=CR4RR 1 N- (CH 2 ) 2 0- P \ -CR 3 = CR 4 R diethe 209846/1224209846/1224 wobei R , R , R und Br die in Anspruch. 1 angegebenen Bedeutungen haben und P ein Alkoxycarbonyl- oder Arylsulfonylradikal darstellt, durch Wasserstoff ersetzt wird, worauf die so erhaltene Isomermischung gegebenenfalls getrennt wird.where R, R, R and Br are those in claim. 1 have given meanings and P represents an alkoxycarbonyl or arylsulfonyl radical, is replaced by hydrogen, whereupon the isomer mixture thus obtained is optionally separated. 5. Verfahren nach Anspruch 4, dadurch gekennzeichnet, daß P das Ithoxycarbonylradikal darstellt.5. The method according to claim 4, characterized in that P represents the ithoxycarbonyl radical. 6. Verfahren nach Anspruch 4 oder 5, dadurch gekennzeichnet, daß die Schützgruppe P mittels einer alkalischen Hydrolyse durch Wasserstoff ersetzt wird.6. The method according to claim 4 or 5, characterized in that that the protecting group P is replaced by hydrogen by means of an alkaline hydrolysis. 7. Verfahren nach Anspruch 4, dadurch gekennzeichnet, daß P das p-Ioluolsulfonylradikal darstellt.7. The method according to claim 4, characterized in that P represents the p-ioluenesulfonyl radical. 8. Verfahren nach Anspruch 4 oder 7, dadurch gekennzeichnet, daß die Schützgruppe P mittels einer konzentrierten Lösung von Bromwasserstoff in einer niedrigeren aliphatischen Säure in Gegenwart von einer Verbindung, die mit Brom rasch reaktionsfähig ist, durch Wasserstoff ersetzt wird.8. The method according to claim 4 or 7, characterized in that the contactor group P by means of a concentrated Solution of hydrogen bromide in a lower aliphatic acid in the presence of a compound that works with Bromine is rapidly reactive, is replaced by hydrogen. 9. Pharmazeutische oder Veterinäre Masse, dadurch gekennzeichnet, daß sie ein eis- oder trans-Isomer nach Anspruch 1 in Mischung mit einem pharmazeutisch zulässigen Verdünnungsmittel oder Träger enthält.9. Pharmaceutical or veterinary mass, characterized in that that they contain a cis or trans isomer according to claim 1 in admixture with a pharmaceutically acceptable one Contains diluents or carriers. Vom Deutschen Patentamt ohne jede
Gewähr hergestellte Abschrift von
Unterlagen, die zur fotoaeciianisdno.
Wiedergabe nicht geeignet sind.From the German Patent Office without any
Guaranteed copy of
Documents related to fotoaeciianisdno.
Playback are not suitable. 209846/1224209846/1224
DE19681768020 1962-09-13 1968-05-21 Alkene derivatives and processes for their preparation Pending DE1768020A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB34989/62A GB1013907A (en) 1962-09-13 1962-09-13 Alkene derivatives
GB30755/65A GB1064629A (en) 1962-09-13 1965-07-20 Alkene derivatives
GB18491/67A GB1146405A (en) 1962-09-13 1967-04-21 Alkene derivatives

Publications (1)

Publication Number Publication Date
DE1768020A1 true DE1768020A1 (en) 1972-11-09

Family

ID=40342705

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19681768020 Pending DE1768020A1 (en) 1962-09-13 1968-05-21 Alkene derivatives and processes for their preparation

Country Status (3)

Country Link
CH (1) CH500165A (en)
DE (1) DE1768020A1 (en)
FR (2) FR95156E (en)

Also Published As

Publication number Publication date
FR95156E (en) 1970-07-31
FR318F (en) 1970-06-22
CH500165A (en) 1970-12-15

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