DE1767852A1 - Stabilized antibiotic preparations for feeding animals and processes for their manufacture - Google Patents

Description

Patent attorneys Dipl.-Ing. F. Weickmann, Dr. Ing. A. We ic km to N

Dipping. H.Weickmann, Dipl-Phys. Dx. K. Fincke Dipl.-Ing. F. A. Weickmann, Dipl.-Chem. B. Hum

I MONK 27 DEN MDHLSTRASSE 22, CALL NUMBER 413921/22

See / Gl

3.I.T. Recherche et Industrie Sherapeutiques, Gronval, Belgium

Stabilized antibiotic preparations for feeding. Siere and procedures au their Heratellurg

The present invention relates to stabilized antibiotic preparations which are suitable for feeding animals, as well as processes for producing these additives.

The nutritional supplements are usually fortified by substances which have specific physiological effects and are subsequently added as "biologically active substances". Such biologically active substances, where B «i ~

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Games for such substances are antibiotics normally added to the basic feed in the form of a premix on a carrier, the carrier being either is inert or has nutritional value.

The instability of the antibiotics in the premixes as well as in the fortified feed that may be nor by the adverse effect of some components d, he feed (for example, water that is contained in caves and amines present in fishmeal) has long been recognized as the main problem facing the Confront manufacturers and buyers of feed and feed concentrates.

Sampling is therefore of great importance because on the one hand the quantities of antibiotics should generally be kept limited for economic reasons, and on the other hand their effect is considerably reduced or even completely switched off if the feed is stored for a long time and / or unfavorable conditions, such as present, for example, relatively high temperatures and / or humidity, so that the amount of antibiotics below a minimum critical value is lowered, the door of each servant antibiotics let more or less characteristic.

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The aim of the present invention is to create new preparations for animal feed containing at least one antibiotic that is exposed to the adverse conditions mentioned has been made permanent. The present invention provides stable preparations are available, which are fully effective and provide the active ingredient in a simple manner.

It turned out in a surprising way that the Stability of antibiotics in preparations for animal feed considerable compared to the destructive factors, such as prolonged storage, humidity, temperature and chemical gowns, can be increased when using the biologically active ingredients in the form of granulated products at least one compatible chemical compound, which consists of an oxide or a mineral salt and specific Has physicochemical properties, are present, the granulation in the presence of a binder and preferably a disintegrating agent is performed.

The term "compatible" means the fact, that no physical or chemical adverse effect is exerted on the antibiotic.

According to the invention, antiblotic preparations for animal

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Feed made available in which the antibiotics is in the form of a granulated product with a compatible mineral compound, the mineral Compound of silicon oxide or the oxides of aluminum, calcium or magnesium or the carbonates and silicates of these elements. The mineral compound has a specific total surface area of at least 5 and preferably

2
assigned at least 50 m per gram, a water absorbency of at least half of its own weight and a solubility in water below 1/500 (w / w). The antibiotic and the mineral compound are compacted by a binder, preferred binders being the cellulose esters (in particular sodium carboxymethyl cellulose, methyl cellulose or ethyl cellulose), gelatin, polyvinylpyrrolidone, agar-agar or lactose. The grains of the granulated product have a diameter of at least 0.05 mm and preferably of at least 0.10 mm (the diameter being in particular between 0.1 and 0.5 mm). They contain from 0.1 to 70 # of the antibiotic 20-70 i "of the mineral compound, and 1-50 i" of the binder, wherein the weight percentages are on a weight-Baais /.

According to a preferred embodiment of the present invention is a disintegrating agent (e.g. starch) in an amount of up to 30 # based on the

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granulated product, before. The "granulated product", the "premix" and the "reinforced feed" are examples of "preparations" as understood according to the invention should.

It is clear that the relative amounts of the binding agent and the disintegrating agent also depend on specific factors, for example the type of biologically active substance and the desired rate of decomposition in the gastrointestinal tract of the animal.

Similarly, the amount of the biologically active substance may be in the grains up to the sweckmässigsten range, for example to a range from 0.1 to 70 $> be adjusted, to facilitate the distribution of the substance in the dor Nahrungsmitttl.

To produce the preparations defined above, the antibiotic is mixed with the mineral compound and the binder and agglomerated, whereupon the agglomerate is granulated and standardized to obtain the granules defined above.

The preparation (grains) obtained can then be easily put into any suitable feed or JLa.

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a priming substrate. According to one preferred In the embodiment, the grains are mixed directly turns.

Wet or dry granulation or compaction processes can be used to produce the granulated product defined above.

If a wet granulation process is used, it will Antibiotic thoroughly in the specified amounts with the oxide or salt, binder and a suitable solvent mixed, whereupon the agglomerate (paste) obtained is granulated, dried and then classified into appropriate catfish will. It is of course a prerequisite that the process conditions are consistent with the stability of the antibiotic stand. Examples of suitable solvents are water, chloroform, alcohols, ketones or other known solvents, how they are used for wet granulation processes.

Optionally, the granulated product defined above can also be produced by dry compaction of the antibiotic / oxide or Antibiotic / salt mixture in the specified amounts, after which the compaction is followed by grinding to obtain the granulated Product attached.

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The term "granulate" is intended to include any known granule erunge process en be understood that for the production τοη Granules consisting of powdery components physically mixed with one another can be used, "whereby these components are held together by means of an adhesive or binding agent, so that the hardness is increased and the surface area of the biologically active substance exposed to unfavorable conditions is considerably reduced. In other words, this means that the apparent density is markedly increased as a result of the distribution of the biologically active substance in the bound hate.

Various biologically active ingredients and / or the above-mentioned oxides and salts and / or binders can be used can be used at the same time to carry out the method described. Moreover, although thee a lubricant is not required with no adverse effects can be added. Possible lubricants are magnesium stearate, Polyethylene glycol stearate, talc, starch or the like.

It should be noted that to achieve the invention the set goal is not a simple mixture of the oxide or sale and the biologically active constituents

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part is sufficient, but rather there must be intimate contact between the oxide or salt and the biologically active one Component as a consequence of the G-renulation.

The present invention is particularly suitable for stabilizing antibiotics, preferred examples being for Antibiotics the macrolide-like antibiotics such as oleandomycin and erythromycin, the peptide-like antibiotics, such as bacitracin or derivatives thereof, the components of the vernamycin-like antibiotic compounds, i.e. mixtures of the components vemamycin, streptogramin, Synergistin, Ostreogrycin, Prietinamycin, Mikamycin and Virginiamyoin, the tetracydine type antibiotics such as ! Tetracycline, Ohlortetracycline and Oxytetraeycline, aminoglycosldisohe antibiotics such as streptomycin, as well as the penicillin-like antibiotics, namely the natural or semi-synthetic antibiotics.

The following examples explain the preparation of the compounds according to the invention Preparations.

example 1

525 g of chlorotetracyoline hydrochloride and 175 g of methyl cellulose are thoroughly mixed with 300 g of Calflo E (a synthetic GaI-oiumeilikat with a specific surface of 95 a ² / g,

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manufactured by Johns-Manville, New York, N.Y », USA) mixed.

The mixture is moistened with 700 ml of water until until a homogeneous thick paste is obtained, which is passed through a rotary wet granulator used in the pharmaceutical industry made of stainless steel soldered with a perforated plate with circular 2 mm holes will.

The obtained grains are dried in a vacuum oven at 45 ^° O for a period of 24 hours.

After drying, the Hasse is again put through a Stokee vibrating granulator and sieve device with an ASIM sieve No. 40 (sieve opening: 0.42 mm) is sent.

The powder is in a mechanical shaking sieve through * an ASOM No. 60 sieve (sieve opening: 0.25 mm) made of stainless steel Sieved steel. The fine particles (about 1450 are collected and can be used again as starting material for the granulation giner further batch · The on The fraction remaining on the sieve, i.e. grains between 0.42 and 0.25 mm in diameter, is collected. A 100 g aliquot the graded grain is thorough with 24,900 kg

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of a pre-mix substrate for Schw.einfv.tter (6 g 3? i3chniehl, 40 g corn meal, 15 g soy flour, 15 g eagle flakes, 10 g Grain flour, 4 g pett, 10 g water per 100 g of the premix substrate) mixed to obtain a final concentration of 2 g of chlorotetracycline hydrochloride per kg of premix.

To perform the stability tests, a 10 g sample of the formulation prepared in the manner described above is held at 65 ⁰ C in a sealed Pläschchen 87 hours long, while a 10 g sample of a mixture of chlortetracycline hydrochloride, Methyloellulose, CalfIc B and is treated in the same manner from the premix substrate in the same proportions.

The investigation carried out using both products (cylinder plate method using Baoillus cereus var.mycoides AtECC 9634 as test organism), using the non-heated granulate form and a mixture as a reference standard, shows that the chlorotetracyoline content in the granulate form is unchanged (100 #) while it has fallen in the non-granulated form to 77 i ".

Example 2

250 g methyl cellulose and 500 g zinc bacitracin (63 U / mg) are

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the thoroughly mixed with 750 ml of water. 500 g of Calflo E (a synthetic calcium silicate with a specific surface area τοη 95 m / g, which is manufactured by Johns-Manville, New York, HY, USA ) are then added, the mixing being continued until a homogeneous paste which is granulated by hand using a stainless steel wire (ASTM No. 40). The granules are dried in a vacuum oven at 40 ^° C. for a period of 24 hours.

The dried product is then passed through a 3? Itepatrick shredding machine, those with a stainless steel sieve with round holes with a diameter of 0.8 mm is provided.

The pulverized material is placed in a mechanical shaking screen equipped with an ASTM No. 40 stainless steel screen (screen opening: 0.42 mm) and an ASTM No. 60 stainless steel screen (screen opening: 0.25 mm) , sifted. The two extreme fractions (ie above 0.42 mm and below 0.25 mm) are recovered and can be used again from raw materials for the granulation of another batch. The middle fraction (755 g) with a grain diameter between 0.42 and 0.25 mm is collectedA 10 g aliquot is thoroughly obtained with 2 x 510 kg of a commercially available

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lichen mixture for feeding pigs (5 g feed meal, 5 g Fish meal, 4 g soybean meal, 10 g oatmeal, 28 g barley, 15 g corn, 10 g miIo, 5 g cassava, 2.5 g alfalfa, 3 g vitamin K, medium nutrient grade, 1 g dicalcium phosphate, 0.5 g sodium chloride, 0.25 g calcium carbonate and 10.75 g water per 100 g mixture) to set a final concentration of 100 units Bacitracin mixed per gram of mixture.

A stability test, which is carried out in the manner described in Example 1, shows that the effectiveness of the bacitracin (determined by the cylinder plate method using MicrococcuB flavus ATCO 10240) for the granulated form 61 # and only 44 f> for the non-granulated Shape is.

Example 3

100 g methyl cellulose and 250 g Vlrginiamycin (corresponding to 310 g virginiamycin standard) are thoroughly mixed with 250 g CalfIo E (a synthetic caloleum silicate with a special

fish surface area of 95 m ² / g manufactured by Johns-Manville, New-York, NY, USA).

The mixture is moistened with 400 ml of water until a homogeneous paste is obtained, which then passes through an ASTM No. 40 stainless steel sieve (sieve opening: 0.42 mm) is driven. The worm-like mass is then in

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dried in a vacuum oven for a period of 12 hours "at 45 ⁰ O".

The dried product is then through the same Sieve driven as described above and passed through an ASTM Hr. 60 made of stainless steel (sieve opening: 0.25 am) sifted.

A 6 g aliquot of the fraction between 0.25 in size and 0 »42 rom is collected and thoroughly mixed with 1t 544 kg of premix substrate for pig feed (6g fish meal, 40 g Corn flour, 15 g soy flour, 15 g oatmeal, 10 g grain flour, 4 g fat and 10 g water per 100 g of the premix substrate) for setting a final concentration of 2 g virginiamycin standard mixed per kg of premix.

A stability test, which is carried out in the manner described in Example 1, using a microbiological method (paper disk diffusion method on agar-agar using Corynebacterium xerosis NCTC 9755) to determine the effectiveness of the total antibiotic content and a chemical method (spectrophotometric absorbance 520 νψ. Of the reaction product with p-dimethylaminobenaaldehyde) to determine the effectiveness of the "factor M-like" component, results in an active substance for the granulated form

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95 > according to the chemical method and $ 97.5> according to the microbiological examination method. Under the same conditions, the corresponding values for the non-granulated form are 38 and 47 £

Example 4

17 g methyl cellulose, 16 g starch and 27.5 g virginiamycin (corresponding to 49 »5 g virginiamycin standard) are thoroughly mixed with 40 g CalfIo Ξ (a synthetic calcium silicate
with a specific surface area of 95 m / g, which is manufactured by Johns-Manville, New-York, N, Y., USA).

The mixture is moistened with 60 ml of water until
until a homogeneous paste is obtained, which then
is pressed through an ASTM No. 40 stainless steel sieve (sieve opening: 0.42 mm). The worm-like mass is dried in a vacuum oven at 45 ^{° C. for a period of 20 hours.}

The dried product is pressed through an ASTM # 40 sieve and then through a stainless ASTM No. (Sieve opening: 0.25 mm) sieved.

A 4 g aliquot of the fraction between 0.25 and 0.42 mm in size is collected and washed thoroughly with 981 g of a pre

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mix substrate for pig fattor (6 g fish meal, 40 g Corn flour, 15 g soy flour, 15 g oatmeal, 10 g grain flour, 4 g Pstt and 10 g water to 100 g of the premix subotrat) srur Allocation of a final concentration of 2 g of the virginiamycin standard mixed per kg of premix.

Carrying out a stability test as described in Example 1, using a microbiological method for determining the effectiveness of the total antibiotic content and a chemical method for determining the effectiveness of the "Paktor M-like" component (see Example 3), results for the granular form an efficacy of 93 ° i after the chemical method of analysis and of 96 1> by the microbiological üntersuchungsmethode. Under the same conditions, the corresponding values for the non-granulated form are 40 and 48 #, respectively.

Example 5

400 g of methyl cellulose and 12 g of virginiamycin (equivalent to 22 g Virginiamycin standard) are thoroughly in a kneading mixer with 800 g CalfIo E (a synthetic calcium silicate with a specific surface of 95 m / g, that of Johns-Manville, New-York, N.T., USA) and with 800 g Perlite J-2 (a silica manufactured by Johns-Manville, New-York, N.Y., USA).

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Pie mixture is moistened with 1350 ml of water as long as Mp a homo ^ eno hard pasto is obtained by a Rotary barrel granulator, which is equipped with a perforated stainless Steel plate provided with round holes with a diameter of 3 mm is sent.

The worm-like mass is ^{dried in a vacuum oven at 45 °} C. for a period of 48 hours and

sohliessend in a Fitzpatrick shredder that provided with a perforated stainless steel plate with circular holes with a diameter of 1.63 mm is to marry.

The powder is placed in a mechanical sieve shaking device, those with an ASTM No. 40 stainless steel sieve (sieve opening: 0.42 mm) and an ASTM No. 60 stainless steel sieve (sieve opening: 0.25 mm). The two extreme fractions (i.e. above 0.42 mm and below 0.25 are used for re-granulation, while the Fraction (1.400 kg), the grains of which have a diameter between 0.42 and 0.25 mm, is collected.

A 3 g aliquot is thoroughly mixed with 325 g of a commercially available additive for pig feed (5 g feed meal, 5 g Fish meal, 4 g soybean meal, 10 g oat flakes, 28 g barley, 15 g neck, 10 g miIo, 5 g manloka, 2.5 g alfalfa, 3 g vitamin K, Food grade, 1 g dicalcium phosphate, 0.5 g sodium hydroxide

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rid, 0.25 g calcium carbonate and 10.75 g water per 100 g of the Mixture) to set a final concentration of 100 mg virginiamycin standard per 1 kg of the mixture.

One carried out in the manner described in Example 1 Stability test using a microbiological method (see Example 3) to determine the effectiveness of the Total antibiotic content results in one for the Granulatfona Effectiveness of 87 # «Under the same conditions is the corresponding value for the non-granulated form 25 #.

Example 6

The procedure described in Example 5 is followed, with 800 g ^ dicalcium phosphate instead of 800 g Perlite J-2 can be used.

In this way a premix is obtained which, as the stability test described in Example 1 shows, an effectiveness of 83 pounds according to the microbiological investigation method (compare example 3) results. Under the same conditions the corresponding value for the non-granulated form is 28 #.

Example 7

100 g methyl cellulose and 250 g virginiamycin (corresponding to

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300 g virginiamycin standard) are thoroughly mixed with 250 g CalfIo C (a synthetic calcium silicate with a specific surface area of 175 m / g, manufactured by Johns-Manville, New-York, N.Y., USA).

The mixture is moistened with 400 ml of water until until a homogeneous paste is obtained, which then is pressed by means of a piston under a pressure of 5 kg / om through a perforated steel plate, which is round Has holes with a diameter of 0.5 ebb.

The worm-like mass is provided in a Vakuumofon over a period of 12 hours at 45 ⁰ C and dried in a laboratory hammer mill with a sieve of stainless steel whose round holes have einon Durohmesser mm 2, milled.

The product is initially passed through an ASTM # 40 sieve and an ASTM # 60 stainless steel sieve, collecting the intermediate fraction (250 g). The two other fractions are collected for re-granulation.

A 10 g aliquot of the interstitial fraction becomes 1.990 kg Premix substrates for soot feed (6g fish meal, 40 g

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Shark flour, 15 g soy flour, 15 g oat flakes, 10 g grain flour, 4g of fat and 10g of water per 100g of the pre-mixed mixture) to set a final concentration of 2.5 g of the Virginia « myoin standards mixed per kg of premix.

A stability test carried out in the manner described in Example 1 ', using a microbiological method to determine the effectiveness of the ocsamtantibiotic content and a chemical method to determine the effectiveness of the "factor M-like" component (compare example 3 in each case), results for the granulated 3? form an "effectiveness of 82 # according to the chemical investigation method and of 90 $> according to the microbiological investigation method. Under the same conditions the corresponding values for the non-granulated form are 25 and 30 #, respectively.

Example 8

The procedure described in Example 3 is repeated, except that the specified amount of Calflo E is replaced by various compounds listed in Table I below Extraction of gtet e is replaced. The respective stabilities which are given for each component are also summarized in Table Z (the

Antibiotic content is determined according to the ohemieohen method described in Example 3).

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Table I. Stability ^ Mineral compound 83.5 CalfIo C (1) 79 Magnesium carbonate 84 Calcium carbonate 79.8 Magnesia 90 Calium oxide 86 Aluminum oxide 80 Egg gel G (2) 81.8 AeroQiI standard (3)

(1) A synthetic alkali silicate having a specific

ο
95 πΐ / g surface area manufactured by Johns-Manville, New-York, N.-Y, USA.

(2) A purified silicon oxide produced by E. Merck, Darmstadt, will be produced.

(3) A purified silica having a specific surface area of 175 m / g, that made by DEGUSSA, Prankfurt will.

Example 9 If the procedure described in Example 3 is followed,

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however, the methyl celulose is replaced by the in the following Table II summarized various binders for the production of h «- is replaced. the The respective stabilityon are listed in connection with the respective binder in Table II (the antibiotic content is determined according to the chemical method described in Example 3).

Table II binder stability gelatin 88 Agar Agar 85 Carboxymethyl cellulose 88.5 Polyvinyl pyrrolidone 86 Example 10

1 g methylcellulose and 2 g pristinamycin (pharmaceutical Degree) are thoroughly mixed with 2 g of CalfIo E (a synthetic Calcium silicate with a specific surface area of 95 m / g » that is manufactured by Johns-Manville, New-York, Ν.Ϊ., USA) mixed.

The mixture is moistened with 4 ml of water until a homogeneous paste is obtained, which can then be passed through an ASTM sieve no. 40 made of stainless steel (sieve opening ι 0.42 ηα)

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is pressed. The wurmfönaige Hasse is dewatered in a vacuum oven for a period of 12 hours at 45 ⁰ C.

The dried product is then passed through the same Sieve "as described above" pressed and sieved through an ASTM Sleb No. 60 made of stainless steel (sieve opening: 0.25 mm).

Sin 1 g ~ aliquot of the fraction with a size between 0.25 and 0.42 mm is collected and washed thoroughly with 0.200 kg of a preservative substrate for soine feed (6 g Piso flour, 40 g Corn flour, 15 g soy flour, 15 g oat flakes, 10 g grain flour, 4 g fat and 10 g water per 100 g of the pre-mix substrate) mixed to adjust a final concentration of 2 mg of the antibiotic per g of the premix.

A stability test carried out in the manner described in Example 1, the chemical method used in Example 3 for determining the "Factor M" ^{being used to determine the effectiveness of "Factor PII 1 *, gives an effectiveness of 92 # for the granulated form.} Under the same conditions, the effectiveness of the non-granulated form drops to 74 #.

Example I '

1 s M "thylo" llO84 and 2 g Prooainpenlcillin are grttnd-

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borrowed with 2 g of CalfIo E (a synthetic calcium silicate with a specific surface of 95 m / gt that of Johns-Manville, New-York, N.Y., USA) mixed.

The mixture is moistened with 4 ml of water until a homogeneous fit is obtained, which is then pressed through an ASTM No. 40 sieve made of stainless steel (sieve opening: 0.42 mm). The wurmförmlge mass is dewatered in a vacuum oven for a period of 12 hours at 45 ⁰ O.

The dried product is then through the same Sieve, as described above, pressed and passed through an ASTM No. 60 stainless steel sieve (sieve opening: 0.25 mm) sifted.

A 1 g aliquot of the fraction whose particles are between 0.25 and 0.42 mm, is collected and washed thoroughly with 0.250 kg of a pig feed premixing substrate (6g fishmeal, 40g cornmeal, 15g soy flour, 15g oatmeal, 10 g of grain flour, 4 g of fat and 10 g of water per 100 g of the premix substrate) to set a final concentration of 1600 I.U. per gram of premix mixed.

I am in the manner described in Example 1 carried out stability test, but dlt tea duration 5 was instead

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87 hours and a microbiological method (cylinder plate method using Micrococcus pyogenee var, aureus AfüGC No. 6538P as test organism) is used to determine the effectiveness of the penicillin, gives an effectiveness of 87.7 # for the granulated form. Under the same conditions, the effectiveness of the non-granulated form drops to 71 % .

Example 12

1 g of methyl cellulose and 2 g of the "Factor M" of virginiamycin are thoroughly mixed with 2 g of CalfIo E (a synthetic calcium silicate with a specific surface area of 95 m / g, which is manufactured by Johns-Manville, New-York, N.Y., USA) mixed *

The mixture is moistened with 4 ml of water until a homogeneous paste is obtained, which is then pressed through an ASTM sieve No. 40 made of stainless steel (sieve opening: 0.42 mm). The worm-like mass is then dehydrated ^{in a vacuum oven at 45 ° C. for a period of 12 hours.}

The dried product is then pressed through the same sieve as described above and through an ASTM # 60 stainless steel slob (sieve opening: 0.25 BBn) sifted.

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A 1 g aliquot of the fraction whose small size is one size between 0.25 and 0.42 mm is collected and washed thoroughly with 0.200 kg of a premix substrate for soine feed (6g fishmeal, 40g cornmeal, 15g soy flour, 15g oatmeal, 10g grain flour, 4g fat and 10g water per 100 g of the Yormischungssubstrats) mixed to adjust a final concentration of 2 mg per g of the goal mixture.

A stability test carried out in the manner described in Example 1, wherein to determine the effectiveness of the "Factor M" using the chemical method given in Example 3 gives effectiveness for the granulated form from 98 #. Under the same conditions, the effectiveness of the non-granulated form drops to 62.5 #.

Example 13

The procedure described in Example 12 is followed, however, the amount of "Factor M" is replaced by 2 g of "Factor S".

A stability test carried out using the granulated form, using a spectrofluorimetric method (excitation at 312 mn, ¹ RmIe β ion at 444 mp) to determine the effectiveness of the "factor S ¹ ", gives an effectiveness of 99 #.

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Claims (13)

Claims 1. Antibiotic preparations for animal feed, characterized in that the antibiotic is in the form of a granulated product with a compatible mineral compound consisting of silicon oxide or the oxides of aluminum, calcium and magnesium or their carbonates and silicates, the mineral compound being a total specific Has a surface area of at least 5 m / g, a water absorption capacity of at least half its own weight and a solubility in water which is below 1/500 (weight / weight), the antibiotic and the mineral compound have been held together by a binder and the grains of the granulated product having a diameter of at least 0.05 mm and 0.1 to 70 # of the antibiotic 20-70 f> of the mineral compound, and from 1 to 50 56 of the binder (GewdLcht / weight basis) contain. 2. Preparation according to claim 1, characterized in that ■ dae antibiotic from at least one component of a vernamycin-like Mixture of antibiotics. 3. Preparation according to claim 2, characterized in that the veraamy one-armed antibiotic mixture is virginiamyoin. 109882/0511 BAO ORIGINAL 4. Preparation according to claim 2, characterized »that the veraamycin-like antibiotic mixture is pristine amyoin. 5. Preparation according to claim 1, characterized in that »the antibiotic is a tetracycline-like antibiotic. 6. Preparation according to claim 1, characterized in that »the antibiotic is a penicillin-like antibiotic . 7. Preparation according to claim 1 »characterized in that the antibiotic is bacitracin or a derivative of this compound. 8. Preparation according to one of claims 1-7 »characterized in that the compatible mineral compound is a
Is carbonate or a silicate. 9. Preparation according to claim 8, characterized in that the compatible mineral compound consists of calcium silicate. 10. Preparation naoh one of claims 1-7 »characterized in that that the compatible mineral compound aluminum oxide or silicon oxide. 109882/0511 BATH ORIGINAL 11. Preparation according to claims 1-10, characterized in that that the diameter of the grains is between 0.1 and 0.5 nm lies. 12. Premix for animal feed, characterized in that they are drinking at least one antibiotic preparation one of claims 1-11, distributed in a premix substrate, contains. 13. Sierfutter, characterized in that it is at least an antiblotic preparation according to one of the Claims 1-12 dispersed in a food substrate contains. 14. A process for the production of an antibiotic preparation according to any one of claims 1-11, characterized in that the antibiotic is mixed with the mineral compound and the binder and agglomerated, whereupon the agglomerate obtained is granulated and used to obtain cords with a diameter of at least 0, 05 ma is classified, with the amounts of antibiotic, mineral compound and binding agent between 0.1 and 70 #, 20 and 70 i> or 1 and 50 #. 15 «Method according to claim 14», characterized in that a disintegrating agent is added to the specified ingredients. 109882/0511 BATH ORIGINAL