DE1678482U - Schutzroehrchen zum abdecken der kanuele von injektionsspritzen. - Google Patents

Schutzroehrchen zum abdecken der kanuele von injektionsspritzen.

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Publication number
DE1678482U
DE1678482U DE1953E0005064 DEE0005064U DE1678482U DE 1678482 U DE1678482 U DE 1678482U DE 1953E0005064 DE1953E0005064 DE 1953E0005064 DE E0005064 U DEE0005064 U DE E0005064U DE 1678482 U DE1678482 U DE 1678482U
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DE
Germany
Prior art keywords
needle
cover
protective tube
injection syringe
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1953E0005064
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English (en)
Inventor
Lueder Hinrich Ellinghausen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE1953E0005064 priority Critical patent/DE1678482U/de
Publication of DE1678482U publication Critical patent/DE1678482U/de
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

1372 HELVTncACHiMiCAAm-Vol.öS.Fasc.SaöSIJ-Nr.OO
asu of *«. M.?. 105-106". - IR. (CHiCIi): 3400 (NH), 1770 (^lactam). 1750 (ester). 1680 (amide). - NMR. (CDQ.): 2.80 fo 3 H, OSO2CH3); 3.60 (s. 2 H, CH2); 4.21-4.58 (br.. 3 H, CHCH2O): 5.20 (i 4H. ZCH-Ok 531 (s, 1H, CH); 5.41 (dxd. /=5 and 8 Hz, 1 H, CÄNH); 7.02 (d. J = 8 Hz. 1 H-JfKk JAl is. Ϊ5H.Ph).
CseBsoNiOgS CaIc. C 60.60 H 5.05 N 4.71 S 538% -^ (59424) Found „60.78 „5.13 „4.83 „5.27%
CaIc. C 6137 H 4.98 N 5.65 S 4.30% Found „61.31 „5.01 „5.58 „4.41%
C3H37N3O11S (743.50)
t: ef <£batzyl 2-\Z t£hytnfL3/ax£=Bi-5-yf*taIoTiale(12). MEt3(O-OZ g, 02. mmol) was added to a. solution of 9b (0.1 g, 0.15 anao!) m 5 ml CBrCIr. lie solution was stirred at r.t. for 24 hj washed with water, dried and evaporated. Tie erode product was chromatographed on silica gel and eluted with CHCI3 to give the bkreSc ccmaausd 12. 20 mg (23%). - IR. (CH2Oj): 3410 (NH), 1780 Gff-lactam). 1750 (ester), 1725iearbams^ - NMR. (CDO3): 431 (nt. 2H1CHCS2O); 4.70-5.10 (nt. 2Hr CHCHN); 5.11-5.40 (nt &H.5 C&O and 2 CH): 730 (j., 21H, 4 Pb and NH). - CI.-MS.: 513 (Af++1 - PhCH2OC=O).
QrH33N3OSfOiTJJs CaIc. C 68.62 H 5.10 N 6.49% Found C 68.75 H 4.91 N 6.64%
aB&äs-i^aizyloxycarbonyl-S-hydroxy-J-phenylaceiamido and of äs-4-benzyloxycarbonyl- T-ßJbac?üxyctton?itxzio)-2-phenyIacetamido]-3-hydroxy-isooxacephems (Ha= and lib). Both ß-laasas lla, xsd. Ilk wert prepared by the same procedure front 8a and 8b and Ha obtained in 50% yield after 13 h. »mTe; Ilfcwas obtained in-10% yield after13 h and 50% starting material was recovered. After 2Z, k. llfc«as obemed in 30% yield, without recovery of starting material. Their spectra were similar aaspt forsarianons due to the amide side-chain.
A nmc cf criffiwEsacetic acid/CH2CI2 1:1 (IO ml) was added dropwise at 5° in 5 min to the hydrorcsasnj-f-^Szctasi S* (035Sg; 0.5 mmol) in 1 ml dry CH2Cl2. The mixture was stirred at r.t. for 13 k tfear cixgarsoo. CCU (50 ml) was- added, and the solution again evaporated. The crude product «as (±iüoiaioa23&ed on silica gel and after eiutiöa of impurities with CH2Cl? and CHCl3r 11* was sfined-wss AcQEl as a. foam (0.102 g). - ER. (CH2Cl2): 3200-3500 (NH. OH)." 1790 (/Mactarn), 1755 (ess=:?. I"35 iC=Cl E68O (amide). - NMR. (CDCI3): 2.89 (br.r 1 H, OH, exchanged with D2O); 330 (s. IE FbCB1): 3.61-4,00 (to 2H, CHCH2O); 4.09-4.51 (m. 2H, CHtHNH): 5.10 (s. 2 H.
ayy«·: 63« -.S. /=S Hz. IH. NB); 739. 7.23 (2s, 1OH, 2Ph). - CL-MS.: 391 (M++ 1-H2O). 233 t). 218'(AfN- 2- OH-PhCH2OOCC=C=O).
C-H2N-Cv -aJS.06. CaIc. C64.70 H4.90 N 6.86% Found C64.93 H5.06 N7.06%
D~z >-lIb a I=TtT^e: of 2 diastereoisomers). -IR-(CH2Cl2): 3300-3450 (NH. OH). 1790 (p-Ucui=. l"5- sisn ."5? (O1C=C). 1715 (carbamate), 1689 (amide). - NMR. (200 MHz. CDCi3): 331-5.?:: -η. IiL CHCH-O): 401 (br.. 1H. OH); 4.32 (dxd, V= 5 and 10 Hz. 1 H. CiWH): 5.01 (<£ /= II Έζ. 2 H. ^KCOOCH2)-. 5.13 Cn 2 H. CH2O); 5.20 (d, /=4 Hz. 1 H, CAPh): 5.81 {d. J= 8 Hz, 1H. NKCOc t.Il:-L /=5 Hz. IH. NHCOO); 732{nt, 15 H, Ph). - CI.-MS- 540 (M++1 - H,O)r 234
=O). 367 (M++2-OH-PhCH2OOCC=C=O).
C30H-N3OiifrT-ll! CaIc-. C64.63 H4.84- N7.54%- Found C6439 H4.75 N7.5i%
F>-zp~^y.r. _-' ±~:αττ·-.v-I-hydroxy-T-phenytacemmido-isooxacephem (10). Compound lla (0.20 g.
0.4S .-- — 3-1 "rr. A.COE: ~ith PdCI2 i60 mg) was hydrogenated at r.t. at 40 psi for 3 h. The mixture
was thir: zi^vt-z Jz:z ivap; ri:=d to give (he crude product as a fbanr. Crystallizalion from EtOAc/ether I: IC' gi-vi .'.Γ ;if4i'c: 10. m.p. 128-130°. - IR. (Nujol): 3150-3650 (OH. NH. COOH). 1783 [ß-iicu^ "Zi Z=Ci. liiO (amide). - NMR. (DMSO/CDClyD^): 3.52 (sr IH. CHM: 3.60-331 (Ot. IH. C-H-J-Tr; - ϊ'ϊ-i f: fm. ZH. CHCHND); 7.38 (y. 5 H, Ph).- CI.-MS.: 301 (AT-r I - H2O).300 Of--L-H1G-H IiH f tx-_2_OH-HOOCC=C=O). 118 (PhCH2C=SH).
Treir==: cf W ~r± CH2N2 gave die corresponding: methyl ester as an oil. - IR. (CH2CI2): 3200-55« ÖEL NHi. Π9ί t^-laciam). 1755 (ester). 1735 (O2C=C)^ 1680 (amide). - CI.-MS.: 333 {Λ/--ΙΓ.Κ;·>/--:-Η^0,. 118 (M^+2-OH-CH3OOCC=C=O).
Preparation ι arido-2-oxo-4-styr in 5 ml DMF an (5 mmot) NaNO2 and the product t and evaporated te 0 2 g (49%) as aa (ON=O). 1585, U 441 (2 qa, /=7 CiZ=CHEh); 6.79 8738 (C=O), 81. (C=CPh), 19.10(c -63.77(O=C-O
Ci8Hi9N5O6 C
Compound 1
1755 (ester), 1210 4H. 2CH2); 4.8' CH=CAPh); 73"
Ci8Hi9N5O6 (·
[1] G.H.Hakime. [2] E. Santaniello [3] T.W.Doylerl [A] G. H. Hakane [5] R.Locquin& [6] B. Belleau & <

Claims (1)

  1. &736.049-Z41253
    i a ! ? r 1 c
    SoiiEttar5hreüeii ssen
    als Ai*
    ater !«Iaht ier ZbBfOe tos.
DE1953E0005064 1953-12-24 1953-12-24 Schutzroehrchen zum abdecken der kanuele von injektionsspritzen. Expired DE1678482U (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE1953E0005064 DE1678482U (de) 1953-12-24 1953-12-24 Schutzroehrchen zum abdecken der kanuele von injektionsspritzen.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1953E0005064 DE1678482U (de) 1953-12-24 1953-12-24 Schutzroehrchen zum abdecken der kanuele von injektionsspritzen.

Publications (1)

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DE1678482U true DE1678482U (de) 1954-06-24

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Application Number Title Priority Date Filing Date
DE1953E0005064 Expired DE1678482U (de) 1953-12-24 1953-12-24 Schutzroehrchen zum abdecken der kanuele von injektionsspritzen.

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DE (1) DE1678482U (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0201611A1 (de) * 1985-05-10 1986-11-20 B. Braun-SSC AG Zwei-Kanülen-Spritze
EP0306606A1 (de) * 1985-05-10 1989-03-15 B. Braun-SSC AG Einweg-Injektionsspritze mit zwei Kanülen

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0201611A1 (de) * 1985-05-10 1986-11-20 B. Braun-SSC AG Zwei-Kanülen-Spritze
EP0306606A1 (de) * 1985-05-10 1989-03-15 B. Braun-SSC AG Einweg-Injektionsspritze mit zwei Kanülen

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