DE1467978A1 - Process for the production of Viscin from parts of plants of evening primrose (Oenothera) for pharmaceutical purposes - Google Patents

Description

Description.

Process for the production of viecin aua parts of plants from evening primrose (Oenothera) for pharmaceutical purposes.

The natural substance Viscin occurs mainly in the native mistletoe (Vieoum album, Loranthaceae family of belt flowers) and other foreign ones Species of the same '' family. This substance has been used as a remedy for centuries used and is currently included in several branded pharmaceutical products. Viecin is also found in other plant families, e.g. B. in the evening primrose (Genus Oenothera). In these the viscine content is lower than in allistula, however, its production on a technical scale offers considerable advantages: 1.) The Mistletoe does not reach a size until after about 8-10 years is worthwhile, and is only obtained when the host trees are felled, since the harvest is from the standing one Tree is too laborious, and a large part of the mistletoe is used as Christmas decorations sold. In contrast, the evening primrose can be used in any length of 1 year cultivate in the field.

2.) The eight candles require very light, sandy ones to thrive well Baths (similar to asparagus) that are inferior to most other crops are.

3.) Cultivation and harvest can largely be mechanized using Even more introduced machines The planting of the seedlings with the same device As with the cultivation of beet and tobacco seedlings, the harvest with harvesters, like them z. B. be used in the sugar beet harvest.

In contrast to the sugar beet harvest, the l. pure ground hardly adhere to the crop.

4.) The harvest takes place in winter after the completion of the field work. This advantage is particularly important if cultivation contracts with farmers are intended are.

5.) Cultivation in any Ivienges Sine mother plant yields 100,000 and more seeds.

Breeding of an evening primrose with a higher active ingredient content through combination crossing.

The viscine content of the different types of evening primrose is different high. In the American species it is highest in those found in California, with our locals in the Oenothera erythrosepala Borb.

(= Oe. Lamarekiana Ser.). It seems even more productive so far recognizable, the junction of the Oe. erythrosepala with the Californian Oe. Johansen to be with the complex combination (velans hJohansen). This combination breeding has been carried out over the past few years and has now been completed.

Raising and harvesting the plants.

The pre-swollen seeds are sown in spring in flower beds, then the saplings are planted mechanically in the field like young tobacco plants. Row sowing directly into the field is just as possible, only here is the later weed control not as easy as with the regularly spaced seedlings. That Planting out should be done in damp weather to allow for quick growth reach. Distance in the rows 25-30 cm. from row to row 40 - 50 cm. ln the course In the summer the little plants grow into large hoes and form at the same time strong taproots.

In late autumn and winter, the plants poke their rosette leaves for the most part and at the same time thicken their roots as storage organs. While This time the harvest must take place, as the plants are already in the early spring start shooting, at the same time lignify their roots and become unusable. mine Harvesting in the middle of winter, during pauses in frost, appears to be the most beneficial, since too This leads to the least amount of other work and the required collection harvester are free.

An extraction of the viscine from the above-ground parts of the plant is also possible, but requires modified rearing methods: In late winter Around AnPang liebruar, the seeds are strong for 24 hours at + 20- + 30 degrees C. dampened filter paper and then kept at a temperature for 24 hours exposed from -3 to -5 degrees C (cold shock). @ come after this cold treatment the seeds again in constant heat of + 20- + 30 degrees, but drying out must be avoided at all costs. As soon as the selmung begins (approximately after 1 week), The seeds are sown in cold frames and the seedlings planted in the field in April with 60 cm row spacing and 40 cm spacing in the individual row. After shooting of the plants, but before the beginning of flowering (around mid-June), they become Mowed and harvested as close as possible to the ground, after a few weeks a second cut of the regrown plants is carried out.

Processing of the material obtained.

The preparation of the roots is similar to how For sugar beet: The remains of the leaf rosettes are removed, the roots through vigorous hosing cleaned and then finely grated and removed, then Extraction with water increases the yield. The usual hot steam treatment for sugar curdling However, this is likely to lead to damage to the viscine.

Lus preferred extraction from the above-ground parts of the plant these are also ground and extracted. In this 2'all become important larger plant masses achieved on the same acreage, on the other hand in The viscine content of the roots is higher than that of the stems and leaves.

The further processing and purification of the active ingredient 6 Viscin is as done with the extraction from mistletoe, but probably has to be in some Points can be modified accordingly.

Claims (2)

Claim. The invention relates to a method for obtaining the active ingredient Viscin from plant parts of sachtkerzen (Oenothera) 1. characterized by that Viscin instead of the more difficult to obtain lAistelstrauch (Viscum) @ from field m. Eight-candle plants (Oenothera) grown in large 1 lengths can be won. 2.) The combination breeding of an evening primrose with a higher viscine content, characterized by the fact that 2 wild laughing candles with a high viscine content, Oenothera erytre erythrosepala from southwest Germany and Oe. Johansen from California, crossed to create a new form with an even higher active ingredient content for the field Cultivation according to 1.) to be obtained.