DE1178173B - Process for the production of a non-adhesive, tropicalized coating on gelatine rectal capsules - Google Patents

Process for the production of a non-adhesive, tropicalized coating on gelatine rectal capsules

Info

Publication number
DE1178173B
DE1178173B DESCH29902A DESC029902A DE1178173B DE 1178173 B DE1178173 B DE 1178173B DE SCH29902 A DESCH29902 A DE SCH29902A DE SC029902 A DESC029902 A DE SC029902A DE 1178173 B DE1178173 B DE 1178173B
Authority
DE
Germany
Prior art keywords
coating
tropicalized
adhesive
rectal capsules
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DESCH29902A
Other languages
German (de)
Inventor
Dr Arno Widmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Catalent Germany Eberbach GmbH
Original Assignee
Catalent Germany Eberbach GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catalent Germany Eberbach GmbH filed Critical Catalent Germany Eberbach GmbH
Priority to DESCH29902A priority Critical patent/DE1178173B/en
Priority to CH1449369A priority patent/CH504866A/en
Priority to LU41226D priority patent/LU41226A1/xx
Priority to GB617162A priority patent/GB924316A/en
Publication of DE1178173B publication Critical patent/DE1178173B/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A61K9/025—Suppositories; Bougies; Bases therefor; Ovules characterised by shape or structure, e.g. hollow layered, coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Description

BUNDESREPUBLIK DEUTSCHLAND DEUTSCHES WfTGsiSl· PATENTAMT Internat. Kl.: A 61k FEDERAL REPUBLIC OF GERMANY DEUTSCHES WfTGsiSl · PATENT OFFICE Internat. Class: A 61k

AUSLEGESCHRIFTEDITORIAL

Nummer: Aktenzeichen: Anmeldetag: Auslegetag:Number: File number: Registration date: Display day:

Deutsche KL: 30 h-9/03 German KL: 30 h -9/03

Sch 29902IV a/30 h
17. Februar 1961
17. September 1964Sch 29902IV a / 30 h
17th February 1961
17th September 1964

Es ist schon ein Verfahren vorgeschlagen worden (deutsche Auslegeschrift 1116 867), nach dem man tropenfeste Gelatine-Rektal-Kapseln gewinnen kann, deren Applikation ohne jede Schwierigkeit möglich ist. Man geht dabei so vor, daß man auf die Kapselzäpfchen einen solchen Überzug aufbringt, der mittels der Feuchtigkeit der Analschleimhaut oder nach vorhergehender Anfeuchtung mit Wasser auf der Oberfläche der Zäpfchen die Bildung einer Emulsion bewirkt. Man bringt zu diesem Zweck auf die Oberfläche der Rektal-Kapseln einen Emulgator und eine emulgierbare Substanz auf.A method has already been proposed (German Auslegeschrift 1116 867), according to which one Can win tropic-proof gelatin rectal capsules, their application without any difficulty is. One proceeds in such a way that one applies such a coating to the capsule suppository, which means the moisture of the anal mucosa or after previous moistening with water on the The surface of the suppositories causes the formation of an emulsion. One brings to the surface for this purpose the rectal capsules contain an emulsifier and an emulsifiable substance.

Es wurde nun gefunden, daß man eine mühelose Einführung der Kapseln überraschenderweise auch dann erzielt, wenn man auf die Kapseln einen Film aus Fettmassen, Silikonfetten, Wachsen, PoIyäthylenglykolen, Fettalkoholen oder geeigneten Lacken oder aus einer anderen geeigneten Substanz oder Substanzmischung, die entweder ein Emulgator oder eine emulgierbare Substanz ist, aufträgt. Als Emulgatoren kommen z. B. in Frage Dioctyl-natriumsulf osuccinat, Polyoxyäthylen - sorbitantri - stearat, Polyäthylenglykole, Glycerin-monostearat, Fettalkoholsulf onate, Fettalkoholschwefelsäureester, PoIyoxyäthylenfettsäureester. It has now been found that, surprisingly, an effortless introduction of the capsules is also possible then achieved when a film of fat masses, silicone fats, waxes, polyethylene glycols, Fatty alcohols or suitable lacquers or from another suitable substance or mixture of substances that are either an emulsifier or is an emulsifiable substance. As emulsifiers z. B. in question dioctyl sodium sulf osuccinate, polyoxyethylene sorbitan tristearate, polyethylene glycols, glycerine monostearate, fatty alcohol sulf onates, fatty alcohol sulfuric acid esters, polyoxyethylene fatty acid esters.

Beispielexample

Nachstehend ein charakteristisches Rezeptbeispiel: 4,0 g Laurylalkohol, 2,0 g Silikonfett,
1,0 g Octylalkohol, 0,5 g Silikonharz.Below is a typical recipe example: 4.0 g lauryl alcohol, 2.0 g silicone fat,
1.0 g octyl alcohol, 0.5 g silicone resin.

Sämtliche Stoffe werden in einem geeigneten Lösungsmittel, wie z. B. Trichloräthylen, Aceton od. a.,All substances are in a suitable solvent, such as. B. trichlorethylene, acetone or a.,

Verfahren zur Herstellung eines nicht
klebenden, tropenfesten Überzuges auf Gelatine-Rektal-Kapseln Method of making a no
adhesive, tropicalized coating on gelatine rectal capsules

Anmelder:Applicant:

R. P. Scherer G. m. b. H., Eberbach (Bad.)R. P. Scherer G. m. B. H., Eberbach (Bad.)

Als Erfinder benannt:Named as inventor:

Dr. Arno Widmann, Eberbach (Bad.)Dr. Arno Widmann, Eberbach (Bad.)

gelöst bzw. suspendiert und im Dragierkessel auf die Rektal-Kapseln aufgetragen. Anschließend wird zur Entfernung von Lösungsmittel ein klimatisierter Kaltoder Warmluftstrom eingeblasen.dissolved or suspended and applied to the rectal capsules in a coating pan. Then the Removal of solvent blown in an air-conditioned stream of cold or warm air.

Durch diese Behandlung werden gleichmäßige, matte Überzüge erhalten, die tropenfest sind und auch bei höheren Temperaturen nicht kleben. Die Applikation der Rektal-Kapseln ist auf diese Weise mit oder ohne vorheriges Anfeuchten mühelos und ohne irgendwelche störenden Erscheinungen möglich.This treatment gives uniform, matt coatings that are tropicalized and does not stick even at higher temperatures. The application of the rectal capsules is this way possible with or without previous moistening effortlessly and without any disturbing phenomena.

Claims (1)

Patentanspruch:Claim: Verfahren zur Herstellung eines nicht klebenden, tropenfesten Überzugs auf Gelatine-Rektal-Kapseln, dadurch gekennzeichnet, daß man eine emulgierbare Substanz oder ein Gemisch emulgierbarer Substanzen in einem Lösungsmittel löst oder suspendiert und die resultierende Lösung oder Suspension auf die Kapseln aufträgt.Process for the production of a non-adhesive, tropicalized coating on gelatine rectal capsules, characterized in that one emulsifiable substance or a mixture of emulsifiable substances in a solvent dissolves or suspends and the resulting solution or suspension on the capsules applies.
DESCH29902A 1961-02-17 1961-02-17 Process for the production of a non-adhesive, tropicalized coating on gelatine rectal capsules Pending DE1178173B (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DESCH29902A DE1178173B (en) 1961-02-17 1961-02-17 Process for the production of a non-adhesive, tropicalized coating on gelatine rectal capsules
CH1449369A CH504866A (en) 1961-02-17 1962-01-19 Coated gelatin rectal capsules
LU41226D LU41226A1 (en) 1961-02-17 1962-02-09
GB617162A GB924316A (en) 1961-02-17 1962-02-16 Improvements in and relating to the manufacture of suppositories

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DESCH29902A DE1178173B (en) 1961-02-17 1961-02-17 Process for the production of a non-adhesive, tropicalized coating on gelatine rectal capsules

Publications (1)

Publication Number Publication Date
DE1178173B true DE1178173B (en) 1964-09-17

Family

ID=7431567

Family Applications (1)

Application Number Title Priority Date Filing Date
DESCH29902A Pending DE1178173B (en) 1961-02-17 1961-02-17 Process for the production of a non-adhesive, tropicalized coating on gelatine rectal capsules

Country Status (3)

Country Link
DE (1) DE1178173B (en)
GB (1) GB924316A (en)
LU (1) LU41226A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56156212A (en) * 1980-05-08 1981-12-02 Eisai Co Ltd Surface treating method of soft capsule agent
GB9821620D0 (en) 1998-10-06 1998-11-25 Stanelco Fibre Optics Ltd Capsules

Also Published As

Publication number Publication date
LU41226A1 (en) 1962-04-09
GB924316A (en) 1963-04-24

Similar Documents

Publication Publication Date Title
DE1178173B (en) Process for the production of a non-adhesive, tropicalized coating on gelatine rectal capsules
DE1181863B (en) Process for the production of a rectal capsule coating
EP0259836A3 (en) Process for obtaining phosphatidyl choline from a phosphatide mixture
DE1235744B (en) Process for the production of silver images
DE1941472B2 (en) Process for hardening gelatin
DE1116867B (en) Process for the production of a rectal capsule coating
DE657861C (en) Process for the production of firmly adhering coatings made from cellulose esters on films made from glue or gelatine
DE748022C (en) Process for the production of foils, films, tapes, etc. Like. Made of super polyamides
DE1239463B (en) Use of polyether thioethers as foam stabilizers
AT232198B (en) Process for producing a rectal capsule coating
DE729782C (en) Process for the recovery of high quality gelatin from waste photographic material
DE746327C (en) Process for the production of hollow bodies
DE1263292B (en) Process to increase the breathability of polyurethane foils or coatings
CH510440A (en) Gelatin capsules coated with polyethylene glycol
DE870563C (en) Process for the production of choline emulsions
DE613262C (en) Process for the extraction and separation of the physiological substances influencing the calcium metabolism
DE830380C (en) Process for the preparation of a liniment
DE366421C (en) Process for the chemical treatment of limited pieces of long moving picture strips
DE743222C (en) Process for the preparation of wettable silicone formic anhydride
DE356371C (en) Means for etching or pickling brass
DE849305C (en) Process for the production of thin-walled, bottle-shaped vessels from solutions of film-forming plastics in the immersion process
DE621189C (en) Process for improving the mechanical properties of flat structures made from cellulose derivatives
DE701714C (en) Process for the production of durable water-soluble dry preparations of the circulatory hormone from pancreases of animals
DE907898C (en) Process for the production of choline emulsions
DE430952C (en) Device for stripping shaped coatings made of cellulose or cellulose derivatives from the mold