DE112022004441T5 - Ionensensor und Verfahren zur Erfassung von zu erfassender Substanz - Google Patents
Ionensensor und Verfahren zur Erfassung von zu erfassender Substanz Download PDFInfo
- Publication number
- DE112022004441T5 DE112022004441T5 DE112022004441.1T DE112022004441T DE112022004441T5 DE 112022004441 T5 DE112022004441 T5 DE 112022004441T5 DE 112022004441 T DE112022004441 T DE 112022004441T DE 112022004441 T5 DE112022004441 T5 DE 112022004441T5
- Authority
- DE
- Germany
- Prior art keywords
- ion
- solution
- ion sensor
- electrode
- detection element
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 31
- 239000000126 substance Substances 0.000 title description 35
- 150000002500 ions Chemical class 0.000 claims abstract description 198
- 239000013076 target substance Substances 0.000 claims abstract description 55
- 239000000700 radioactive tracer Substances 0.000 claims abstract description 41
- 238000001514 detection method Methods 0.000 claims abstract description 30
- 230000008859 change Effects 0.000 claims abstract description 24
- 239000011261 inert gas Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- 239000000853 adhesive Substances 0.000 claims description 7
- 230000001070 adhesive effect Effects 0.000 claims description 7
- 229920005989 resin Polymers 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 238000006479 redox reaction Methods 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 113
- 230000027455 binding Effects 0.000 description 24
- 108091008102 DNA aptamers Proteins 0.000 description 22
- 230000000694 effects Effects 0.000 description 20
- 241001678559 COVID-19 virus Species 0.000 description 14
- 230000000740 bleeding effect Effects 0.000 description 12
- 239000000758 substrate Substances 0.000 description 12
- 241000700605 Viruses Species 0.000 description 10
- 238000001914 filtration Methods 0.000 description 10
- 239000001257 hydrogen Substances 0.000 description 10
- 229910052739 hydrogen Inorganic materials 0.000 description 10
- 230000004060 metabolic process Effects 0.000 description 10
- 239000000725 suspension Substances 0.000 description 10
- -1 V H H Proteins 0.000 description 9
- 239000007789 gas Substances 0.000 description 9
- 230000001681 protective effect Effects 0.000 description 9
- 239000011521 glass Substances 0.000 description 8
- 235000018102 proteins Nutrition 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 229910021607 Silver chloride Inorganic materials 0.000 description 7
- 239000010408 film Substances 0.000 description 7
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
- XZKIHKMTEMTJQX-UHFFFAOYSA-N 4-Nitrophenyl Phosphate Chemical compound OP(O)(=O)OC1=CC=C([N+]([O-])=O)C=C1 XZKIHKMTEMTJQX-UHFFFAOYSA-N 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 108091008104 nucleic acid aptamers Proteins 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 125000001424 substituent group Chemical group 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 5
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 5
- 108010090804 Streptavidin Proteins 0.000 description 5
- 239000012298 atmosphere Substances 0.000 description 5
- 238000004891 communication Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 229910001873 dinitrogen Inorganic materials 0.000 description 4
- 230000004927 fusion Effects 0.000 description 4
- BTJIUGUIPKRLHP-UHFFFAOYSA-N 4-nitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1 BTJIUGUIPKRLHP-UHFFFAOYSA-N 0.000 description 3
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 3
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000010409 thin film Substances 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 101710088194 Dehydrogenase Proteins 0.000 description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- 108010079855 Peptide Aptamers Proteins 0.000 description 2
- 108091008103 RNA aptamers Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 150000001345 alkine derivatives Chemical class 0.000 description 2
- 230000009830 antibody antigen interaction Effects 0.000 description 2
- 150000001540 azides Chemical class 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000003574 free electron Substances 0.000 description 2
- 238000000703 high-speed centrifugation Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 150000003573 thiols Chemical class 0.000 description 2
- BUHVIAUBTBOHAG-FOYDDCNASA-N (2r,3r,4s,5r)-2-[6-[[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]amino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound COC1=CC(OC)=CC(C(CNC=2C=3N=CN(C=3N=CN=2)[C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)C=2C(=CC=CC=2)C)=C1 BUHVIAUBTBOHAG-FOYDDCNASA-N 0.000 description 1
- 108010011958 1,3-propanediol dehydrogenase Proteins 0.000 description 1
- 108010051913 15-hydroxyprostaglandin dehydrogenase Proteins 0.000 description 1
- 102100030489 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Human genes 0.000 description 1
- 108030006016 2'-dehydrokanamycin reductases Proteins 0.000 description 1
- 108010015450 2,5-dioxovalerate dehydrogenase Proteins 0.000 description 1
- 108010069997 2-enoate reductase Proteins 0.000 description 1
- 108030001554 3-oxosteroid 1-dehydrogenases Proteins 0.000 description 1
- 102100031126 6-phosphogluconolactonase Human genes 0.000 description 1
- 108010029731 6-phosphogluconolactonase Proteins 0.000 description 1
- 108010002945 Acetoin dehydrogenase Proteins 0.000 description 1
- 108010031025 Alanine Dehydrogenase Proteins 0.000 description 1
- 108010031132 Alcohol Oxidoreductases Proteins 0.000 description 1
- 102000005751 Alcohol Oxidoreductases Human genes 0.000 description 1
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 description 1
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 description 1
- 102100024092 Aldo-keto reductase family 1 member C4 Human genes 0.000 description 1
- 101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 description 1
- 102100024085 Alpha-aminoadipic semialdehyde dehydrogenase Human genes 0.000 description 1
- 108090000444 Arsenate reductases Proteins 0.000 description 1
- 108010063172 Aspartate dehydrogenase Proteins 0.000 description 1
- 108020004652 Aspartate-Semialdehyde Dehydrogenase Proteins 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 description 1
- 108010049668 Betaine-Aldehyde Dehydrogenase Proteins 0.000 description 1
- 108090000209 Carbonic anhydrases Proteins 0.000 description 1
- 102000003846 Carbonic anhydrases Human genes 0.000 description 1
- 108010035722 Chloride peroxidase Proteins 0.000 description 1
- 108010089254 Cholesterol oxidase Proteins 0.000 description 1
- 108010074879 Cinnamoyl-CoA reductase Proteins 0.000 description 1
- 108030001393 Coproporphyrinogen dehydrogenases Proteins 0.000 description 1
- 108030006973 Cyclohexane-1,2-diol dehydrogenases Proteins 0.000 description 1
- 101710179429 D-arabinose 1-dehydrogenase Proteins 0.000 description 1
- 108010001539 D-lactate dehydrogenase Proteins 0.000 description 1
- 108030006102 D-xylose reductases Proteins 0.000 description 1
- 102000028526 Dihydrolipoamide Dehydrogenase Human genes 0.000 description 1
- 108010028127 Dihydrolipoamide Dehydrogenase Proteins 0.000 description 1
- 102100023319 Dihydrolipoyl dehydrogenase, mitochondrial Human genes 0.000 description 1
- 108090000204 Dipeptidase 1 Proteins 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 108010074122 Ferredoxins Proteins 0.000 description 1
- 108090000698 Formate Dehydrogenases Proteins 0.000 description 1
- 108010021582 Glucokinase Proteins 0.000 description 1
- 102000030595 Glucokinase Human genes 0.000 description 1
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 1
- 102000016901 Glutamate dehydrogenase Human genes 0.000 description 1
- 101710114810 Glycoprotein Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 102000012011 Isocitrate Dehydrogenase Human genes 0.000 description 1
- 108010075869 Isocitrate Dehydrogenase Proteins 0.000 description 1
- 108010057617 Lactaldehyde dehydrogenase Proteins 0.000 description 1
- 108010026217 Malate Dehydrogenase Proteins 0.000 description 1
- 102000013460 Malate Dehydrogenase Human genes 0.000 description 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
- 102000002247 NADPH Dehydrogenase Human genes 0.000 description 1
- 108030005696 NADPH-hemoprotein reductases Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 108020001991 Protoporphyrinogen Oxidase Proteins 0.000 description 1
- 102000005135 Protoporphyrinogen oxidase Human genes 0.000 description 1
- 108050008280 Shikimate dehydrogenase Proteins 0.000 description 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 1
- 101710167605 Spike glycoprotein Proteins 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010016370 Sulfite Dehydrogenase Proteins 0.000 description 1
- 102000013090 Thioredoxin-Disulfide Reductase Human genes 0.000 description 1
- 108010079911 Thioredoxin-disulfide reductase Proteins 0.000 description 1
- 108010015746 Uronate dehydrogenase Proteins 0.000 description 1
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 102000006635 beta-lactamase Human genes 0.000 description 1
- 229940075397 calomel Drugs 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 108010056578 diaminopimelate dehydrogenase Proteins 0.000 description 1
- ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000009878 intermolecular interaction Effects 0.000 description 1
- 230000008863 intramolecular interaction Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 108010087904 neutravidin Proteins 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 108060007223 rubredoxin Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/301—Reference electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4141—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for gases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Engineering & Computer Science (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021151177 | 2021-09-16 | ||
| JP2021-151177 | 2021-09-16 | ||
| PCT/JP2022/032626 WO2023042657A1 (ja) | 2021-09-16 | 2022-08-30 | イオンセンサ、及び被検出物質の検出方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE112022004441T5 true DE112022004441T5 (de) | 2024-07-25 |
Family
ID=85602173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE112022004441.1T Pending DE112022004441T5 (de) | 2021-09-16 | 2022-08-30 | Ionensensor und Verfahren zur Erfassung von zu erfassender Substanz |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240241078A1 (https=) |
| JP (1) | JP7666616B2 (https=) |
| CN (1) | CN117999476A (https=) |
| DE (1) | DE112022004441T5 (https=) |
| WO (1) | WO2023042657A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025187754A1 (ja) * | 2024-03-06 | 2025-09-12 | 株式会社デンソー | 検知器、検知装置、及び検知方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021151177A (ja) | 2020-03-13 | 2021-09-27 | 呉江玲 | 通信ケーブル用取付装置 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6459058A (en) * | 1987-08-31 | 1989-03-06 | Nec Corp | Enzyme immune sensor and enzyme immunoassay using said sensor |
| JPH0786500B2 (ja) * | 1988-05-09 | 1995-09-20 | 太陽誘電株式会社 | イオンセンサの検体滴下用電極部品 |
| AU711861B2 (en) * | 1996-04-25 | 1999-10-21 | Mcgill University | Biosensor device and method |
| JP2005106587A (ja) * | 2003-09-30 | 2005-04-21 | Horiba Biotechnology Co Ltd | 抗原抗体反応を用いた分析方法および装置 |
| JP4331181B2 (ja) * | 2006-03-30 | 2009-09-16 | 株式会社日立製作所 | 測定装置及び分析用素子 |
| JP6014480B2 (ja) * | 2012-12-07 | 2016-10-25 | 株式会社日立ハイテクノロジーズ | 生体分子計測装置および生体分子の計測方法 |
| JP6360294B2 (ja) * | 2013-11-19 | 2018-07-18 | 大日本印刷株式会社 | 溶液内蔵バイオセンサ |
| JP6372848B2 (ja) * | 2014-03-28 | 2018-08-15 | Tianma Japan株式会社 | Tftイオンセンサ並びにこれを用いた測定方法及びtftイオンセンサ機器 |
| US10249741B2 (en) * | 2014-05-13 | 2019-04-02 | Joseph T. Smith | System and method for ion-selective, field effect transistor on flexible substrate |
| US20190018004A1 (en) * | 2017-07-12 | 2019-01-17 | Robert Bosch Gmbh | System and Method for Single-Step ELISA via Local pH Modulation |
| JP2019028071A (ja) * | 2017-07-27 | 2019-02-21 | 国立研究開発法人産業技術総合研究所 | 生体分子濃度の電気化学的測定方法 |
| JP7212885B2 (ja) * | 2019-03-01 | 2023-01-26 | 株式会社デンソー | 複合体、及び計測方法 |
-
2022
- 2022-08-30 JP JP2023548393A patent/JP7666616B2/ja active Active
- 2022-08-30 WO PCT/JP2022/032626 patent/WO2023042657A1/ja not_active Ceased
- 2022-08-30 CN CN202280061670.7A patent/CN117999476A/zh active Pending
- 2022-08-30 DE DE112022004441.1T patent/DE112022004441T5/de active Pending
-
2024
- 2024-03-13 US US18/603,999 patent/US20240241078A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021151177A (ja) | 2020-03-13 | 2021-09-27 | 呉江玲 | 通信ケーブル用取付装置 |
Non-Patent Citations (1)
| Title |
|---|
| BUNSEKI KAGAKU Band 69, Nr. 7/8, Seiten 385-397 (2020 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023042657A1 (ja) | 2023-03-23 |
| CN117999476A (zh) | 2024-05-07 |
| JP7666616B2 (ja) | 2025-04-22 |
| US20240241078A1 (en) | 2024-07-18 |
| JPWO2023042657A1 (https=) | 2023-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Freitas et al. | Quantum dots as nanolabels for breast cancer biomarker HER2-ECD analysis in human serum | |
| Cid-Barrio et al. | Advances in absolute protein quantification and quantitative protein mapping using ICP-MS | |
| Hou et al. | An ultrasensitive competitive immunosensor for impedimetric detection of microcystin-LR via antibody-conjugated enzymatic biocatalytic precipitation | |
| Keating et al. | Potentiometric digoxin antibody measurements with antigen-ionophore based membrane electrodes | |
| Wang et al. | EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation | |
| DE3586951T2 (de) | Festphasendiffusionstextverfahren. | |
| JP4892686B2 (ja) | 酵素センサ、該酵素センサを使用した分析方法及びキット | |
| Song et al. | Bioelectrocatalytic detection of glycated hemoglobin (HbA1c) based on the competitive binding of target and signaling glycoproteins to a boronate-modified surface | |
| AU2005252853B2 (en) | Method | |
| DE112022004441T5 (de) | Ionensensor und Verfahren zur Erfassung von zu erfassender Substanz | |
| Wang et al. | A novel impedance enhancer for amperometric biosensor based ultrasensitive detection of matrix metalloproteinase-2 | |
| Zhang et al. | Horseradish peroxidase and antibody labeled gold nanoparticle probe for amplified immunoassay of ciguatoxin in fish samples based on capillary electrophoresis with electrochemical detection | |
| Halvorsen et al. | The utility of molecularly imprinted polymers for mass spectrometric protein and proteomics analysis | |
| US20170016916A1 (en) | Method for detecting cardiovascular disease biomarker | |
| AU2012304199B2 (en) | Electrochemical affinity sensor | |
| Zheng et al. | Phytic acid-based copper (ii) ion-selective electrode on graphene oxide for potentiometric immunoassay of breast cancer antigen 15-3 | |
| Shen et al. | A sensor for glycoproteins based on dendritic gold nanoparticles electrodeposited on a gold electrode and modified with a phenylboronic acid | |
| Aberl et al. | An ISFET-based FIA system for immunosensing | |
| Li et al. | Cu2+-mediated turn-on fluorescence biosensor based on DNA-templated silver nanoclusters for label-free and sensitive detection of adenosine triphosphate | |
| Wang et al. | Double‐layer nanogold and poly (amidoamine) dendrimer‐functionalized PVC membrane electrode for enhanced electrochemical immunoassay of total prostate specific antigen | |
| Florido et al. | Effect of proteins on the response of anion‐selective electrodes based on vitamin B12 derivatives | |
| Mesbah et al. | Contribution of CE to the analysis of protein or peptide biomarkers | |
| DE4344646A1 (de) | Vorrichtung für einen kompetitiven Immuno-Assay zur Bestimmung von Haptenen | |
| JP2002333419A (ja) | 免疫電極センサー | |
| WO1990014596A1 (de) | Verfahren und vorrichtung zur konzentrationsbestimmung eines antikörper-antigenpaares |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R012 | Request for examination validly filed |