DE1090824B - Process for the production of ointment bases with a thin consistency - Google Patents

Description

It is known that coconut oil, due to its lauric acid and lower fatty acid content, is unsuitable for use as an ointment base. Despite its good shelf life and beautiful color, coconut oil cannot be used because it irritates the skin. The fatty acid with 12 carbon atoms, the main component, is known to be irritating to the skin. On the other hand, it is known that fatty acid esters with a chain length of C ₈ to C _{12 increase} the resorbability of dissolved medicaments to a greater extent, but these esters are not suitable as an ointment base since they are liquid at room temperature.

It has now been found that ointment bases with a lardy consistency are produced in this way can be that mixtures of saturated fatty acids with 8 to 12 carbon atoms, preferably such mixtures, in which the proportion with 8 carbon atoms predominates, with mixtures of saturated fatty acids with 18 to 22 carbon atoms, of which one alone or more are used in a mixture with one another can, in a ratio of 50:50 to 75:25, preferably in a ratio of 60:40, with primary, saturated alcohols with at least two free hydroxyl groups, preferably glycerol, expediently in equivalent amounts, esterified in a manner known per se will.

In addition to glycerol, for example propylene glycol, pentaerythritol, Sorbitol and the like in question.

The ointment bases produced are extremely skin-friendly and have good penetration properties into the skin. Medicinal substances incorporated into the ointment bases produced according to the invention are excellently absorbed by the skin and ensure a good therapeutic effect. In addition, such an ointment base has excellent resistance, the natural one Fats or mixtures of oils and sebum, which are relatively unstable due to their proportion of unsaturated fatty acids are not own.

Esterification products have already been made from fatty acids with 12 to 16 carbon atoms and glycerol and these esterification products, if appropriate, glycerol esters of fatty acids having 16 to 20 carbon atoms added. However, because of their brittle consistency, such esters are not suitable as an ointment base.

It is also known synthetic low molecular weight fatty acids with 5 to 10 carbon atoms, which result from oxidation originate from hydrocarbons, to be partially esterified with polyhydric alcohols. Such However, esters are not considered to be because of their proportion of fatty acids with an odd number of carbon atoms To use ointment base, rather than a method of manufacture

of ointment bases
with a lardy consistency

Applicant:

Chemical works in Witten

Company with limited liability,

Witten, Arthur-Imhausen-Str. 92 a

Dx. Fritz Neuwald, Brammer via Nortorf,

and Dipl.-Chem. Dr. Rudolf Tuma, Witten,

have been named as inventors

Emulsifiers used for ointment bases known per se, such as Vaseline.

The ointment bases according to the invention are particularly suitable for incorporation of various types Medicines, especially dermatics, such as. B. hormones, vitamins, salicylic acid, bacteriostatics, Disinfectants, etc., well suited for therapeutic and cosmetic purposes because they are homogeneous Distribution of the active ingredients is achieved without special other measures and a segregation also after prolonged storage does not occur.

example 1

A mixture of 60%> C ₈ - to C ₁₂ fatty acids with 50% C ₈ -, 25 «A> C ₁₀ - and 25 ° / o C ₁₂ fatty acid and 40% C ₁₈ fatty acid is esterified with equivalent amounts of glycerol for 4 to 6 hours at 200 to 220 ° C and a vacuum, which is about 14 mm at the end of the esterification process, in the presence of known esterification catalysts, cooling and optionally refining of the esterification product obtained and subsequent treatment of the product for 2 to 3 hours at 180 ° C with superheated steam, a mixed glyceride is produced that can be used as an ointment base. Its penetration values according to ASTM D-217 are 261 when using the special cone with drop rod.

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The ointment base described has an excellent one Spreading effect on the skin and particularly good penetration into the skin.

Example 2

A mixture of 60% C ₈ to C ₁₂ fatty acids with 50% C ₈ , 35% C ₁₀ and 15% C ₁₂ fatty acid and 40 ° / o C ₁₈ fatty acid is esterified with equivalent amounts of glycerol in a mixed glyceride prepared in the manner described in Example 1. Its penetration values according to ASTM D-217 are 335 when using the special cone with drop rod.

Example 3

A mixture of 70 vol of C ₈ to C ₁₂ fatty acids with 35% C ₈ , 40% C ₁₀ and 25% C ₁₂ fatty acid and 30% C ₁₈ fatty acid is esterified with equivalent amounts of glycerol in the im In the manner described in Example 1, a mixed glyceride is prepared which is well suited as an ointment base.

Example 4

From a mixture of 55% C ₈ to C ₁₂ fatty acids with 50% C ₈ , 25% C ₁₀ and 25% C ₁₂ fatty acids and 45% C ₁₈ to C ₂₂ fatty acids with 55% C ₁₈ and 45 _{% C 20} to C ₂₂ fatty acids, a mixed glyceride is prepared in accordance with the procedure described in Example 1 by esterification with equivalent amounts of glycerol. The mixed glyceride is well suited as an ointment base and is very skin-friendly.

Example 5

According to Example 4, instead of% C ₈ to C ₁₂ fatty acids, 65% C ₈ to C ₁₂ fatty acids and instead of 45% C ₁₈ to C ₂₂ fatty acids,% C ₁₈ to C ₂₂ fatty acids esterified with equivalent amounts of glycerol and in this way produced a mixed glyceride that is well suited as an ointment base.

Claims (1)

PATENT CLAIM: Process for the production of ointment bases by esterifying mixtures of natural, saturated fatty acids with primary, saturated, at least dihydric alcohols, preferably Glycerin, expediently in equivalent amounts, characterized in that 50 to 75, especially 60 parts of a mixture of fatty acids with 8 to 12 carbon atoms in the molecule, especially one Mixture in which the proportion of fatty acids with 8 carbon atoms predominates, with 50 to 25, especially 40 parts of a fatty acid with 18 to 22 carbon atoms in the molecule or a mixture mixed several fatty acids with 18 to 22 carbon atoms in the molecule and the resulting mixture in esterified in a known manner. .Considered publications: German Patent No. 748 837; German patent application ρ 43192 IVa / 30h (announced on December 21, 1950); Schmidt-LaBaume, "Ointment-Powder-Externa", 2nd edition, 1944, Vol. I, p. 13. © 009 627/379 10.60