DE10393086D2 - Transgene Ratte und ihre Verwendung im Tiermodell für die humane chorea huntington Erkrankung sowie Nukleinsäurekonstrukte, Vektoren und Zellen zu ihrer Erzeugung - Google Patents
Transgene Ratte und ihre Verwendung im Tiermodell für die humane chorea huntington Erkrankung sowie Nukleinsäurekonstrukte, Vektoren und Zellen zu ihrer ErzeugungInfo
- Publication number
- DE10393086D2 DE10393086D2 DE10393086T DE10393086T DE10393086D2 DE 10393086 D2 DE10393086 D2 DE 10393086D2 DE 10393086 T DE10393086 T DE 10393086T DE 10393086 T DE10393086 T DE 10393086T DE 10393086 D2 DE10393086 D2 DE 10393086D2
- Authority
- DE
- Germany
- Prior art keywords
- vectors
- cells
- human
- nucleic acid
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000023105 Huntington disease Diseases 0.000 title 1
- 238000010171 animal model Methods 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 238000011824 transgenic rat model Methods 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Plant Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10393086T DE10393086D2 (de) | 2002-05-14 | 2003-05-14 | Transgene Ratte und ihre Verwendung im Tiermodell für die humane chorea huntington Erkrankung sowie Nukleinsäurekonstrukte, Vektoren und Zellen zu ihrer Erzeugung |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10221344A DE10221344A1 (de) | 2002-05-14 | 2002-05-14 | Transgene Ratte und ihre Verwendung im Tiermodell für die humane Chorea Huntington Erkrankung sowie Nukleinsäurekonstrukte, Vektoren und Zellen zu ihrer Erzeugung |
DE10393086T DE10393086D2 (de) | 2002-05-14 | 2003-05-14 | Transgene Ratte und ihre Verwendung im Tiermodell für die humane chorea huntington Erkrankung sowie Nukleinsäurekonstrukte, Vektoren und Zellen zu ihrer Erzeugung |
PCT/DE2003/001546 WO2003095640A2 (de) | 2002-05-14 | 2003-05-14 | Transgene ratte als tiermodell für die humane chorea huntington erkrankung |
Publications (1)
Publication Number | Publication Date |
---|---|
DE10393086D2 true DE10393086D2 (de) | 2005-05-12 |
Family
ID=29413787
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10221344A Ceased DE10221344A1 (de) | 2002-05-14 | 2002-05-14 | Transgene Ratte und ihre Verwendung im Tiermodell für die humane Chorea Huntington Erkrankung sowie Nukleinsäurekonstrukte, Vektoren und Zellen zu ihrer Erzeugung |
DE10393086T Expired - Fee Related DE10393086D2 (de) | 2002-05-14 | 2003-05-14 | Transgene Ratte und ihre Verwendung im Tiermodell für die humane chorea huntington Erkrankung sowie Nukleinsäurekonstrukte, Vektoren und Zellen zu ihrer Erzeugung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10221344A Ceased DE10221344A1 (de) | 2002-05-14 | 2002-05-14 | Transgene Ratte und ihre Verwendung im Tiermodell für die humane Chorea Huntington Erkrankung sowie Nukleinsäurekonstrukte, Vektoren und Zellen zu ihrer Erzeugung |
Country Status (6)
Country | Link |
---|---|
US (1) | US20070044162A1 (de) |
EP (1) | EP1534826A2 (de) |
AU (1) | AU2003243893A1 (de) |
CA (1) | CA2523888A1 (de) |
DE (2) | DE10221344A1 (de) |
WO (1) | WO2003095640A2 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8150629B2 (en) | 2005-11-10 | 2012-04-03 | In Silico Biosciences | Method and apparatus for computer modeling of the interaction between and among cortical and subcortical areas in the human brain for the purpose of predicting the effect of drugs in psychiatric and cognitive diseases |
US9314005B2 (en) | 2009-07-01 | 2016-04-19 | Transposagen Biopharmaceuticals, Inc. | Genetically modified rat models for severe combined immunodeficiency (SCID) |
EP2460016A2 (de) * | 2009-07-30 | 2012-06-06 | Transposagen Biopharmaceuticals, Inc. | Genetisch modifizierte rattenmodelle für die pharmakokinetik |
WO2011046189A1 (ja) * | 2009-10-15 | 2011-04-21 | 国立大学法人京都大学 | 神経変性疾患のモデル細胞、その製造方法及びその用途 |
US9617230B2 (en) | 2014-12-22 | 2017-04-11 | Farmington Pharma Development | Creatine prodrugs, compositions and methods of use thereof |
WO2018183823A1 (en) * | 2017-03-31 | 2018-10-04 | Hera Testing Laboratories, Inc. | Novel immunodeficient rat for modeling human cancer |
CA3082184A1 (en) | 2017-12-01 | 2019-06-06 | Ultragenyx Pharmaceutical Inc. | Creatine prodrugs, compositions and methods of use thereof |
-
2002
- 2002-05-14 DE DE10221344A patent/DE10221344A1/de not_active Ceased
-
2003
- 2003-05-14 CA CA002523888A patent/CA2523888A1/en not_active Abandoned
- 2003-05-14 WO PCT/DE2003/001546 patent/WO2003095640A2/de not_active Application Discontinuation
- 2003-05-14 US US10/514,512 patent/US20070044162A1/en not_active Abandoned
- 2003-05-14 AU AU2003243893A patent/AU2003243893A1/en not_active Abandoned
- 2003-05-14 EP EP03749850A patent/EP1534826A2/de not_active Withdrawn
- 2003-05-14 DE DE10393086T patent/DE10393086D2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2523888A1 (en) | 2003-11-20 |
EP1534826A2 (de) | 2005-06-01 |
US20070044162A1 (en) | 2007-02-22 |
WO2003095640A2 (de) | 2003-11-20 |
DE10221344A1 (de) | 2003-12-04 |
AU2003243893A1 (en) | 2003-11-11 |
WO2003095640A3 (de) | 2004-01-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8139 | Disposal/non-payment of the annual fee |