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Bayer AG
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Bayer AG
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Priority to DEF20441ApriorityCriticalpatent/DE1027677B/en
Publication of DE1027677BpublicationCriticalpatent/DE1027677B/en
C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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Organic Low-Molecular-Weight Compounds And Preparation Thereof
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Patentansprüche:Patent claims:1. Verfahren zur Herstellung von Salzen der N-N'-Bis
- (3 - amino -ben zolsulf onyl) -benzidin-disulf onsäure-(2-2')
in einer besonders reinen, auch für pharmazeutische Zwecke brauchbaren Form aus roher N-N'-Bis-(3-amino-benzolsulfonyl)-benzidin-disulfonsäure-(2-2'),
dadurch gekennzeichnet, daß man die rohe Säure durch Lösen in wäßrigem Ammoniak unter Erwärmen,
Klären mit Tierkohle, erneutes Lösen des beim Erkalten ausfallenden Diammoniumsalzes in Wasser
und Zugabe von Mineralsäuren in die reine Säure überführt und diese in wäßriger Lösung in ihr Diammoniumsalz
oder in ihre Salze mit organischen Basen überführt.1. Process for the preparation of salts of the N-N'-Bis
- (3 - amino -benzenesulfonyl) -benzidine-disulfonic acid- (2-2 ')
in a particularly pure form, which can also be used for pharmaceutical purposes, from crude N-N'-bis- (3-aminobenzenesulfonyl) -benzidine-disulfonic acid- (2-2 '),
characterized in that the crude acid by dissolving in aqueous ammonia with heating,
Clarify with animal charcoal, redissolve the diammonium salt that precipitates out when it cools in water
and conversion of mineral acids into the pure acid and this in aqueous solution into its diammonium salt
or converted into their salts with organic bases.2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß man die gereinigte N-N'-Bis-(3-aminobenzolsulfonyl)-benzidin-disulfonsäure-(2-2')
in wäßriger Lösung in ihr Monomethylamin-, Dimethylamin-, Äthanolamin-, Diäthanolamin-, Triäthanolamin- oder
Methylglucaminsalz überführt.2. The method according to claim 1, characterized in that the purified N-N'-bis (3-aminobenzenesulfonyl) -benzidine-disulfonic acid- (2-2 ')
in aqueous solution in it monomethylamine, dimethylamine, ethanolamine, diethanolamine, triethanolamine or
Transferred methylglucamine salt.
DEF20441A1956-06-041956-06-04
Process for the preparation of salts of NiñN'-bis (3-aminobenzenesulfonyl) -benzidine-disulfonic acid- (2íñ2 ')
PendingDE1027677B
(en)