DE10259506A1 - Appetite-and cholesterol-reducing agent comprises a low esterified polysaccharide and a different material which is swellable - Google Patents
Appetite-and cholesterol-reducing agent comprises a low esterified polysaccharide and a different material which is swellable Download PDFInfo
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- DE10259506A1 DE10259506A1 DE10259506A DE10259506A DE10259506A1 DE 10259506 A1 DE10259506 A1 DE 10259506A1 DE 10259506 A DE10259506 A DE 10259506A DE 10259506 A DE10259506 A DE 10259506A DE 10259506 A1 DE10259506 A1 DE 10259506A1
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- means according
- cellulose
- swellable
- acid
- polysaccharides
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- 239000005017 polysaccharide Substances 0.000 title claims abstract description 13
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- 239000000463 material Substances 0.000 title abstract 2
- 239000003638 chemical reducing agent Substances 0.000 title 1
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- 230000000694 effects Effects 0.000 claims abstract description 13
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- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A23L29/231—Pectin; Derivatives thereof
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/256—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
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- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A23L29/262—Cellulose; Derivatives thereof, e.g. ethers
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Abstract
Description
Die vorliegende Erfindung betrifft ein Mittel zur Erzeugung eines Sättigungseffekts, zur Gewichtsreduktion und zur Regulierung des Cholesterinhaushalts.The present invention relates to a means of producing a saturation effect, for weight loss and regulating cholesterol levels.
Es sind zahlreiche Versuche unternommen worden, auf medikamentösem Weg überflüssige Fettanreicherungen im menschlichen Körper abzubauen beziehungsweise deren Entstehung zu verhindern. Es gibt z.B. sogenannte Appetitzügler, die den Körper auf biochemischem Weg eine Abneigung zur Nahrungsaufnahme zu suggerieren versuchen. Diese Mittel haben zum Teil erhebliche schädliche Nebenwirkungen.Numerous attempts have been made on medication Get rid of unnecessary fat accumulations in the human body to dismantle or prevent their formation. There are e.g. so-called appetite suppressants, the body to suggest an aversion to food in a biochemical way to attempt. Some of these remedies have considerable harmful side effects.
Neben den zahlreichen bekannten Diätvorschlägen gibt es auch mechanische und elektromechanische Mittel, mit denen ein gezielter Fettabbau beziehungsweise Muskelaufbau erfolgen soll. Die Wirkung solcher Mittel ist jedoch sehr zweifelhaft.In addition to the numerous known diet proposals it also mechanical and electromechanical means with which a targeted fat loss or muscle building. However, the effect of such funds is very doubtful.
Aus der
Ferner sind aus
Aufgrund des ständig steigenden Gesundheitsbewußtseins ist jedoch eine weitere Verbesserung von Mitteln zur Erzeugung eines Sättigungseffekts von hoher medizinischer und wirtschaftlicher Relevanz.Because of the ever increasing health awareness however, is a further improvement in means of generating a saturation effect of high medical and economic relevance.
Aufgabe der vorliegenden Erfindung ist es, ein verbessertes Mittel zur oralen Einnahme zur Verfügung zu stellen, das eine höhere Magenverweilzeit aufweist als bekannte Mittel seiner Art und dadurch zu einem effektiveren Sättigungseffekt führt. Ferner sollte es zur Gewichtsreduzierung unter gleichzeitiger Regulierung des Cholesterinspiegels geeignet sein, da Übergewichtigkeit in der Regel mit einem überhöhten Cholesterinspiegel einhergeht. Darüber hinaus ist eine einfache Herstellung aus preiswerten Rohstoffen wünschenswert, die keine gesundheitlichen Risiken in sich bergen.Object of the present invention is an improved oral intake available too make that a higher Stomach dwell time is known as a means of its kind and thereby a more effective satiety effect leads. It should also help reduce weight while regulating it of cholesterol may be appropriate because obesity is usually with high cholesterol accompanied. Furthermore simple manufacture from inexpensive raw materials is desirable, that have no health risks.
Die vorliegende Aufgabe wird durch ein Mittel zur Erzeugung eines Sättigungseffektes, zur Gewichtsreduktion und zur Cholesterinsenkung enthaltend niederveresterte Polysaccharide und wenigstens eine weitere hiervon verschiedene Verbindung, die quellfähig ist, ausgenommen Aluminiumsalze von anionischen Polymeren, gelöst.The task at hand is accomplished by a means of producing a saturation effect, for weight loss and for lowering cholesterol containing low-esterified Polysaccharides and at least one other different from them Connection that swells is dissolved, with the exception of aluminum salts of anionic polymers.
Als niederveresterte Polysaccharide kommen niederveresterte Pectine, Xanthan, Tragant, Chondroitsulfat vorzugsweise zum Einsatz.As low-esterified polysaccharides come low-esterified pectins, xanthan, tragacanth, chondroite sulfate preferably used.
Hinsichtlich der niederveresterten Polymere ist auch der Einsatz niederveresterter Pektine erfindungsgemäß besonders bevorzugt. Pektine bestehen aus Ketten von α-1,4-glykosidisch verbundenen Galakturonsäure-Einheiten, deren Säuregruppen zu 20-80% mit Methanol verestert sind. Man unterscheidet zwischen hochveresterten (> 50%) und niedegveresterten (< 50%) Pektinen. Die Molmasse variiert zwischen 10-500 kDa. Die Gewinnung von Pektinen erfolgt durch saure Extraktion mit an sich bekannten Methoden gemäß dem Stand der Technik aus den inneren Anteilen von Citrusfruchtschalen, Obsttrestern oder Zuckerrübenschnitzeln. Die resultierenden Pektine (Apfel-Pektin, Citrus-Pektin) sind somit rein pflanzlich und weisen eine hohe Biokompatibilität auf. Sie können unter Wasseraufnahme Gele bilden.With regard to the low esterification Polymers, the use of low-ester pectins is also special according to the invention prefers. Pectins consist of chains of α-1,4-glycosidically linked galacturonic acid units, their acid groups are esterified to 20-80% with methanol. One distinguishes between highly esterified (> 50%) and low esterification (<50%) Pectins. The molar mass varies between 10-500 kDa. Pectins are obtained by acidic extraction using methods known per se according to the prior art the technology from the inner parts of citrus fruit peel, fruit pulp or Sugar beet pulp. The resulting pectins (apple pectin, citrus pectin) are thus purely vegetable and have a high biocompatibility. she can Form gels while absorbing water.
Auch hier ist der Einsatz von Pektingelen in Gegenwart zweiwertiger Kationen, wie Calcium oder Barium bekannt. Letzteres ist auch hier aufgrund seiner Toxizität für den Einsatz in Biomedizin jedoch nicht geeignet. Neben Calcium-Chlorid liefert auch Calcium-Glukonat geeignete zweiwertige Kationen. Denkbar ist auch der Einsatz von Magnesium-Salzen oder eine Mischung verschiedener physiologisch unbedenklicher zweiwertiger Kationen.Here too is the use of pectin gels in the presence of divalent cations, such as calcium or barium. The latter is also here due to its toxicity for use in biomedicine however not suitable. In addition to calcium chloride, calcium gluconate also provides suitable divalent cations. The use of magnesium salts or is also conceivable a mixture of different physiologically harmless divalent Cations.
Der erfindungsgemäße Einsatz von Pektinen zeichnet sich in vorteilhafter Weise dadurch aus, daß diese cholesterinsenkende Eigenschaften besitzen. Diese Eigenschaft ist im Sinne der vorliegenden Erfindung von Vorteil, da Übergewicht in der Regel mit einem erhöhten Cholesterinspiegel einhergeht.The use of pectins according to the invention draws is advantageously characterized in that this lowers cholesterol Possess properties. This property is in the sense of the present Invention advantageous because overweight usually with an elevated Cholesterol levels.
Neben den beschriebenen niederveresterten Polysacchariden ist in dem erfindungsgemäßen Mittel wenigstens eine weitere Verbindung enthalten, die quellfähig ist. Hierfür können zum Beispiel anorganische Stoffe wie MgCl2, CaSO4,: Na2CO3, CaCO3, Polykieselsäuren und Tonmineralien (wie Montmorillonite, Zeolithe, Kieselsäuren) oder organische Stoffe wie Mono- und/oder Disaccharide (Mannose, Glucose, Sucrose, Sorbit), Lactose, Weinsäure oder Harnstoff eingesetzt werden.In addition to the low-esterified polysaccharides described, the agent according to the invention contains at least one further compound which is capable of swelling. For this purpose, for example, inorganic substances such as MgCl 2 , CaSO 4 ,: Na 2 CO 3 , CaCO 3 , polysilicic acids and clay minerals (such as montmorillonites, zeolites, silicas) or organic substances such as mono- and / or disaccharides (mannose, glucose, sucrose, Sorbitol), lactose, tartaric acid or urea.
In einer Ausführung der vorliegenden Erfindung werden organische Polymere eingesetzt, bevorzugt solche die als Polyelektrolyte fungieren. Organische Polymere können bezüglich ihres Ursprungs beziehungsweise Synthese natürlich, halbsynthetisch oder synthetisch sein. Beispiele geeigneter Polymere sind Polyurethane, Polyacrylate, Poly(met)acrylsäureester, Homo- und Copolymere des Vinylacetats, Polyvinylacetat, Polyacrylsäure, Polyethylenglykol, Polyvinylpyrrolidon, Cellulose, Ether, Diethylcellulose oder Celluloseester, wie Cellulosediacetat, Cellulosetriacetat, Celluloseacetat-Propionat und Celluloseacetat, Methylcellulose, Hydroxypropylcellulose, Hydroxypropyl-methylcellulose, oder Natriumcarboxymethylcellulose (vorzugsweise solche Verbindungen mit höherer Viskosität); Butyrat, nieder substituierte Hydroxypropylcellulose, Carboxymethylcellulose (mit 2- oder 3-wertigen Kationen), Na-Stärkeglykolat, Glykosaminglykane wie Chondroitinsulfat oder Hyaluronsäure, Collagen, Albumin, Keratine, Conchagene, Fibroin, Elastine, Chitin.In one embodiment of the present invention, organic polymers are used, preferably those which act as polyelectrolytes. Organic polymers can be natural, semi-synthetic or synthetic with regard to their origin or synthesis. Examples of suitable polymers are polyurethanes, polyacrylates, poly (met) acrylic esters, homo- and copolymers of vinyl acetate, polyvinyl acetate, polyacrylic acid, polyethylene glycol, polyvinyl pyrrolidone, cellulose, ether, diethyl cellulose or cellulose esters, such as cellulose di acetate, cellulose triacetate, cellulose acetate propionate and cellulose acetate, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, or sodium carboxymethyl cellulose (preferably those compounds with higher viscosity); Butyrate, low-substituted hydroxypropyl cellulose, carboxymethyl cellulose (with 2 or 3-valent cations), sodium starch glycolate, glycosaminoglycans such as chondroitin sulfate or hyaluronic acid, collagen, albumin, keratin, conchagens, fibroin, elastins, chitin.
Bevorzugt werden Hydrokolloide, besonders bevorzugt auf Basis von Polysacchariden, eingesetzt.Hydrocolloids are preferred, particularly preferred based on polysaccharides.
Besonders bevorzugt ist der Einsatz von anionischen Polymeren. Hierzu zählen vorzugsweise Polysaccharide, insbesondere Polyuronsäure-haltige Polysaccharide. Besonders bevorzugt sind Alginsäuren, deren Derivate und Salze (Alginate). In einer bevorzugten Variante der Erfindung kommen alle anionischen Polymere mit Ausnahme der Aluminiumsalze in Betracht. Insbesondere sind die Aluminiumsalze der Alginsäuren jedoch ausgenommen. Aber auch alle anderen Uronsäure-haltigen Verbindungen können erfindungsgemäß zum Einsatz kommen. Erfindungsgemäß bevorzugt ist ferner der Einsatz von Cellulose oder Cellulosederivaten. Denkbar ist die Verwendung von synthetischen oder halbsynthetischen Cellulosederivaten, wie z.B. Carboxymethylcellulose oder von Polyacrylaten.Use is particularly preferred of anionic polymers. These preferably include polysaccharides, in particular polysaccharides containing polyuronic acid. Algic acids are particularly preferred, their derivatives and salts (alginates). In a preferred variant All anionic polymers except the Aluminum salts into consideration. In particular, the aluminum salts are the alginic however excluded. However, all other uronic acid-containing compounds can also be used according to the invention come. Preferred according to the invention is also the use of cellulose or cellulose derivatives. Conceivable is the use of synthetic or semi-synthetic cellulose derivatives, such as. Carboxymethyl cellulose or polyacrylates.
Unter Cellulose sind wasserunlösliche Polysaccharide der Bruttozusammensetzung (C6H10O5)n zu verstehen. Genauer gesagt handelt es sich um ein isotaktisches β-1,4-Polyacetal von Cellobiose (4-O-β-D-Glucopyranosyl-D-glucose).Cellulose means water-insoluble polysaccharides with a gross composition (C 6 H 10 O 5 ) n . More specifically, it is an isotactic β-1,4-polyacetal of cellobiose (4-O-β-D-glucopyranosyl-D-glucose).
Als Cellulosederivate werden im allgemeinen durch polymeranaloge Reaktionen chemisch modifizierte Cellulosen definiert. Sie umfassen sowohl Produkte, bei denen ausschließlich, z.B. über Veresterungs- und/oder Veretherungsreaktionen, Hydroxy-Wasserstoffatome der Anhydroglucose-Einheiten der Cellulose durch organische oder anorganische Gruppen substituiert sind, als auch solche, die unter formalem Austausch von Hydroxy-Gruppen der natürlichen Polymeren gegen funktionelle Gruppen, die nicht über ein Sauerstoffatom gebunden sind (z.B. Desoxycellulosen) bzw. über intramolekulare Wasserabspaltung (Anhydrocellulosen, Cellulosen) oder Oxidationsreaktionen (Aldehyd-, Keto- und Carboxycellulosen) gebildet werden. Auch Produkte, die unter Spaltung der C2,C3-Kohlenstoff-Bindung der Anhydroglucose-Einheiten anfallen (Dialdehyd- u. Dicarboxycellulosen), bei denen also die für die Cellulose charakteristischen Monomereinheit nicht mehr in Takt ist, werden zu den Cellulosederivaten gerechnet. Cellulosederivate sind auch über andere Reaktionen zugänglich, z.B. über Vernetzung- oder Pfropfcopolymerisations-Reaktionen.Chemically modified celluloses are generally defined as cellulose derivatives by polymer-analogous reactions. They include both products in which hydroxyl-hydrogen atoms of the anhydroglucose units of cellulose are substituted by organic or inorganic groups exclusively, for example via esterification and / or etherification reactions, as well as those with formal exchange of hydroxyl groups of the natural polymers against functional groups that are not bound via an oxygen atom (eg deoxycelluloses) or via intramolecular elimination of water (anhydrocelluloses, celluloses) or oxidation reactions (aldehyde, keto and carboxycelluloses). Products which cleave the C 2, C 3 carbon bond of the anhydroglucose units (dialdehyde and dicarboxy celluloses) and in which the monomer unit characteristic of the cellulose is no longer intact are also included in the cellulose derivatives. Cellulose derivatives are also accessible via other reactions, for example via crosslinking or graft copolymerization reactions.
Erfindungsgemäß vorteilhaft ist der Einsatz von Cellulose oder Cellulosederivaten in Gemisch mit Pectinen. Ebenso sind Mischungen enthaltend Alginsäure oder deren Derivate, wobei vorzugsweise Aluminiumsalze der Alginsäuren ausgenommen und Pektine bevorzugt sind.The use of is advantageous according to the invention Cellulose or cellulose derivatives in a mixture with pectins. As well are mixtures containing alginic acid or its derivatives, where preferably excluding aluminum salts of alginic acids and pectins are preferred.
Alginsäure ist eine lineare Polyuronsäure aus wechselnden Anteilen von D-Mannuronsäure und L-Guluronsäure, die durch β-glykosidische Bindungen miteinander verknüpft sind, wobei die Carboxylgruppen nicht verestert sind. Ein Molekül Alginsäure kann sich aus etwa 150-1050 Uronsäure-Einheiten zusammensetzen, wobei das durchschnittliche Molekulargewicht in einem Bereich von 30-200 kDa variieren kann.Alginic acid is a linear polyuronic acid changing proportions of D-mannuronic acid and L-guluronic, by β-glycosidic Bonds linked together are, wherein the carboxyl groups are not esterified. One molecule of alginic acid can consists of approximately 150-1050 uronic acid units with the average molecular weight in can vary in a range of 30-200 kDa.
Das Polysaccharid Alginsäure ist ein Bestandteil der Zellwänden von Braunalgen. Der Anteil der Alginsäure an der Trockenmasse der Algen kann hierbei bis zu 40% ausmachen. Die Gewinnung der Alginsäure erfolgt durch alkalische Extraktion mit an sich bekannten Methoden gemäß dem Stand der Technik. Die resultierende pulverförmige Alginsäure ist somit rein pflanzlich und weist eine hohe Biokompatibilität auf. Sie kann unter Bildung hochviskoser Lösungen die 300-fache Menge ihres Eigengewichtes an Wasser aufnehmen. In Gegenwart von mehrwertigen Kationen bildet Alginsäure sogenannte Gele. Die Bildung von Alginatgelen in Gegenwart zweiwertiger Kationen, wie Calcium oder Barium, sind bei Shapiro I., et al. (Biomaterials, 1997, 18: 583-90) beschrieben. Letzteres ist aufgrund seiner Toxizität für den Einsatz in Biomedizin jedoch nicht geeignet. Neben Calcium-Chlorid liefert auch Calcium-Glukonat geeignete zweiwertige Kationen. Denkbar ist auch der Einsatz von Magnesium-Salzen oder eine Mischung verschiedener physiologisch unbedenklicher zweiwertiger Kationen.The polysaccharide is alginic acid a component of the cell walls of brown algae. The proportion of alginic acid in the dry mass of Algae can make up to 40% of this. The alginic acid is obtained by alkaline extraction using methods known per se according to the prior art of the technique. The resulting powdered alginic acid is thus purely vegetable and has a high biocompatibility. she can form 300 times the amount with formation of highly viscous solutions absorb their own weight in water. In the presence of multivalent Cations form alginic acid so-called gels. The formation of alginate gels in the presence of divalent Cations such as calcium or barium are described in Shapiro I., et al. (Biomaterials, 1997, 18: 583-90). The latter is due to its toxicity for use not suitable in biomedicine. In addition to calcium chloride also supplies Calcium gluconate suitable divalent cations. That is also conceivable Use of magnesium salts or a mixture of different physiological harmless divalent cations.
Das erfindungsgemäße Mittel weist die beschriebenen Verbindungen vorzugsweise in pulverförmiger Ausführungsform auf. D.h., das Mittel kann als Adsorbat, Beadlet-Pulver, Granulat, Pellet, Extrudat und/oder Kombinationen davon vorliegen. Ebenso sind Einsatzformen denkbar, bei denen die Partikel beschichtet sind.The agent according to the invention has the described Compounds preferably in powdered form. That is, the mean can be used as adsorbate, beadlet powder, Granules, pellets, extrudates and / or combinations thereof are present. Use forms in which the particles are coated are also conceivable are.
Die Herstellung der erfindungsgemäß vorzugsweise
in Pulverform vorliegenden Mittel kann mit an sich bekannten Methoden
erfolgen. Hierzu zählt beispielsweise
die Herstellung von Sprühformulierungen.
Ein einsetzbares Verfahren und Aggregat hierfür sind beispielsweise in der
Neben dieser Herstellungsart sind auch weitere Verfahrensvarianten denkbar. Hierzu zählen z.B. Sprühtrocknungsprozesse oder die Herstellung von Adsorbaten in Wirbelschichten.In addition to this type of manufacture other process variants are also conceivable. These include e.g. Spray drying processes or the production of adsorbates in fluidized beds.
Zur Herstellung eines pulverförmigen erfidungsgemäßen Mittels kann beispielsweise eine Lösung der niederveresterten Polymere in Wasser hergestellt und z.B. unter Zugabe von Calciumsalzen eingedickt werden. Durch Einarbeiten von Luft und ggf. nach Zugabe von Tensiden kann ein Gel oder Schaum erhalten werden. Durch Einfrieren und anschließendes Gefriertrocknen wird aus dem Alginatgel oder -schaum ein Trockengel oder Trockenschaum (Schwamm) hergestellt. Die Herstellung der weiteren Verbindungen, die erfindungsgemäß quellfähig sein müssen, kann in analoger Weise erfolgen.To produce a powdery agent according to the invention, for example, a solution of the lower esterified polymers in water can be prepared and thickened, for example, with the addition of calcium salts. A gel or foam can be obtained by incorporating air and possibly adding surfactants. By freezing and then freeze-drying the alginate gel or foam a dry gel or dry foam (sponge) is made. The other compounds, which must be swellable according to the invention, can be prepared in an analogous manner.
Neben der Zugabe von anorganischen oder organischen Calciumsalzen, wie z.B. Calciumchlorid oder Calciumglukonat, ist auch die Verwendung von Magnesiumsalzen denkbar sowie von Mischungen verschiedener physiologisch unbedenklicher zweiwertiger oder dreiwertiger Kationen.In addition to the addition of inorganic or organic calcium salts, e.g. Calcium chloride or calcium gluconate, it is also conceivable to use magnesium salts and mixtures of different ones physiologically harmless divalent or trivalent cations.
Die Herstellung von Granulaten kann dadurch erreicht werden, dass in einem Mischer Trägerstoffe und/oder sprühgetrocknete Pulver sowie ggf. Zuschlagsstoffe vorgelegt und durch Zugabe der Wirkkomponenten und/oder Binder und/oder Zuschlagsstoffe kompakte Granulate erzeugt werden. In diesem Verfahren vorzugsweise eingesetzte Mischer sind z.B. Schaufelmischer oder Pflugscharmischer. Die flüssigen Komponenten können beispielsweise aufgetropft oder aufgesprüht werden, so dass eine pastöse, klebrige Phase entsteht. Über geeignete Wahl der Drehzahl der Mischwerkzeuge und/oder schnelllaufenden Messern wird die pastöse Phase verteilt und es entstehen kompakte Granulate. Sehr große Brocken werden durch Mischwerkzeuge und Messer zerteilt und andererseits feine Pulver agglomeriert. Durch Zugabe von Hüllschichten kann nachgeschaltet im Mischer bei geringerer Drehzahl der Mischwerkzeuge und stehenden Messer oder in einem bauartverwandten nachgeschalteten Mischer erfolgen.The production of granules can can be achieved by using carriers in a mixer and / or spray dried Powder and, if necessary, aggregates are submitted and by adding the active components and / or binders and / or additives produce compact granules become. Mixers are preferably used in this process e.g. Paddle mixer or ploughshare mixer. The liquid components can be dropped or sprayed on, for example, so that a pasty, sticky Phase arises. about suitable choice of the speed of the mixing tools and / or high-speed Knives become the pasty phase distributed and compact granules are formed. Very big chunks are cut up by mixing tools and knives and on the other hand fine powder agglomerated. By adding cladding layers can be added in the mixer at lower speed of the mixing tools and stationary Knives or in a design-related downstream mixer.
Das erfindungsgemäße Mittel kann in verschiedenen üblichen Darreichungsformen hergestellt werden. So kann es beispielsweise in Form von Tabletten, Kapseln, Dragees, als Granulat oder Pulver oder anderen Ausgestaltungen vorliegen.The agent according to the invention can be used in various conventional ways Dosage forms are produced. For example, it can in the form of tablets, capsules, dragees, as granules or powder or other configurations are available.
Das erfindungsgemäße Mittel kann auch weitere Hilfsstoffe und/oder Wirkstoffe enthalten.The agent according to the invention can also be other Contain auxiliary substances and / or active substances.
Unter „Hilfsstoffen" sind beispielsweise folgende Substanzen zu verstehen, die jedoch nicht limitierend für die vorliegende Erfindung sind: wasserunlösliche Hilfsstoffe oder Gemische davon, wie Lipide, u.a. Fettalkohole, z.B. Cetylalkohol, Stearylalkohol und Cetostearylalkohol; Glyceride, z.B. Glycerinmonostearat oder Gemische von Mono-, Di- und Triglyceriden pflanzlicher Öle; hydrierte Öle, wie hydriertes Rizinusöl oder hydriertes Baumwollsamenöl; Wachse, z.B. Bienenwachs oder Carnaubawachs; feste Kohlenwasserstoffe, Z.B. Paraffin oder Erdwachs; Fettsäuren, z.B. Stearinsäure; gewisse Cellulosederivate, z.B. Ethylcellulose oder Acetylcellulose; Polymere oder Copolymere, wie Polyalkylene, z.B. Polyäthylen, Polyvinylverbindungen, z.B. Polyvinylchlorid oder Polyvinylacetat, sowie Vinylchlorid-Vinylacetat-Copolymere und Copolymere mit Crotonsäure, oder Polymere und Copolymere von Acrylaten und Methacrylaten, z.B. Copolymerisate von Acrylsäureester und Methacrylsäuremethylester; oder Tenside, wie z.B. Polysorbat 80 oder Docusat.Under "auxiliaries" are, for example to understand the following substances, which, however, are not limiting for the present Invention are: water-insoluble Excipients or mixtures thereof, such as lipids, etc. Fatty alcohols, e.g. Cetyl alcohol, stearyl alcohol and cetostearyl alcohol; glycerides e.g. Glycerol monostearate or mixtures of mono-, di- and triglycerides vegetable oils; hydrogenated oils, like hydrogenated castor oil or hydrogenated cottonseed oil; waxes, e.g. Beeswax or carnauba wax; solid hydrocarbons, e.g. Paraffin or earth wax; fatty acids, e.g. stearic acid; certain cellulose derivatives, e.g. Ethyl cellulose or acetyl cellulose; polymers or copolymers such as polyalkylenes, e.g. Polyethylene, polyvinyl compounds, e.g. Polyvinyl chloride or polyvinyl acetate, as well as vinyl chloride-vinyl acetate copolymers and copolymers with crotonic acid, or polymers and copolymers of acrylates and methacrylates, e.g. Copolymers of acrylic acid esters and methyl methacrylate; or surfactants, e.g. Polysorbate 80 or Docusat.
Unter „Wirkstoffen" sind beispielsweise
Vitamine, Spurenelemente oder Arzneiwirkstoffe zu verstehen. Folgende
Substanzen sind beispielhaft aufgezählt, die jedoch nicht limitierend
für die
vorliegende Erfindung sind:
Beispiele für Appetitzügler sind: Amfepramon, Fenfluramin,
Fenproporex, Levopropylhexedrin, Mazindol, Mefenorex, Metamfepramon,
Norephedrin, Norpseudoephedrin.“Active ingredients” are to be understood to mean, for example, vitamins, trace elements or medicinal active ingredients. The following substances are listed by way of example, but are not limiting for the present invention:
Examples of appetite suppressants are: Amfepramon, Fenfluramin, Fenproporex, Levopropylhexedrin, Mazindol, Mefenorex, Metamfepramon, Norephedrin, Norpseudoephedrin.
Beispiele für Virustatika sind: Aciclovir, Cidofovir, Didanosin, Famciclovir, Foscarnet, Ganciclovir, Lamivudin, Ritonavir, Zalcitabin, Zidovudin.Examples of antivirals are: acyclovir, Cidofovir, didanosine, famciclovir, foscarnet, ganciclovir, lamivudine, Ritonavir, zalcitabine, zidovudine.
Beispiele für Vitamine sind: Alfacalcidol, Allithiamine, Ascorbinsäure, Biotin, Calcifediol, Calcitriol, Colecalciferol, Cyanocobalamin, Ergocalciferol, Folsäure, Hydroxocobalamin, Nicotinamid, Pantothensäure, Phytomenadion, Pyridoxin, Retinol, Riboflavin, Thiamin, Tocopherol, Transcalcifediol.Examples of vitamins are: alfacalcidol, Allithiamine, ascorbic acid, Biotin, calcifediol, calcitriol, colecalciferol, cyanocobalamin, Ergocalciferol, folic acid, Hydroxocobalamin, nicotinamide, pantothenic acid, phytomenadione, pyridoxine, Retinol, riboflavin, thiamine, tocopherol, transcalcifediol.
Unter Umständen kann hier zusätzlich eine retardierende Wirkstofffreisetzung erfolgen.Under certain circumstances, a retarding can also be used here Active ingredient release.
Außer den genannten Hilfsstoffen und Wirkstoffen kann das erfindungsgemäße Mittel zusätzlich Füll- Spreng-, Binde- und Gleitmittel sowie Trägerstoffe enthalten, die auf die Wirkstoftabgabe keinen entscheidenden Einfluß haben. Beispiele sind u.a. Bentonit (Aluminiumoxid-Siliciumoxid-hydrat), Kieselsäure, Cellulose (üblicherweise mikrokristalline Cellulose) oder Cellulosederivate, z.B. Methylcellulose, Natriumcarboxymethylcellulose, Zucker, wie Lactose, Stärken, z.B. Maisstärke oder Derivate davon, z.B. Natriumcarboxymethylstärke, Stärkeleister, Phosphorsäuresalze, z.B. Di- oder Tricalcioumphosphat, Gelatine, Stearinsäure oder geeignete Salze davon, z.B. Magnesiumstearat oder Calciumstearat, Talk, kollodiales Siliciumoxid und ähnliche Hilfsstoffe.Except for the additives mentioned and active ingredients, the agent according to the invention can additionally fill, detonate, Binders, lubricants and carriers contain, which have no decisive influence on the drug delivery. Examples include Bentonite (alumina-silica hydrate), silica, Cellulose (usually microcrystalline cellulose) or cellulose derivatives, e.g. Methylcellulose, Sodium carboxymethyl cellulose, sugars such as lactose, starches e.g. corn starch or derivatives thereof, e.g. Sodium carboxymethyl starch, starch paste, phosphoric acid salts, e.g. Di- or tricalcium phosphate, gelatin, stearic acid or suitable salts thereof, e.g. Magnesium stearate or calcium stearate, talc, colloidal silicon oxide and the like Excipients.
Das erfindungsgemäße Mittel kann zur Erzeugung eines Sättigungseffektes, zur Gewichtsreduktion und zur Regulierung des Cholesterinhaushalts eingesetzt werden. Außerdem ist es zur Herstellung einer Zusammensetzung zur Erzeugung eines Sättigungseffektes, zur Gewichtsreduktion und zur Regulierung des Cholesterinhaushalts geeignet.The agent according to the invention can be used for production a saturation effect, for weight loss and regulating cholesterol levels be used. Moreover it is used to make a composition to produce a Saturation effect, for weight loss and regulating cholesterol levels suitable.
Demgemäß kann das Mittel noch die Darmtätigkeit stimulierende Stoffe enthalten. Insbesondere kommen hier unverdauliche, jedoch die Darmtätigkeit fördernde Stoffe, vorzugsweise pflanzliche Naturbestandteile in Betracht. Beispiele hierfür sind Ballaststoffe.Accordingly, the agent can still bowel movements contain stimulating substances. In particular, indigestible however the bowel activity promotional Substances, preferably herbal natural ingredients. Examples of this are fiber.
Claims (11)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10259506A DE10259506A1 (en) | 2002-12-19 | 2002-12-19 | Appetite-and cholesterol-reducing agent comprises a low esterified polysaccharide and a different material which is swellable |
| AU2003293907A AU2003293907A1 (en) | 2002-12-19 | 2003-12-17 | Agent for decreasing appetite and for producing a satiation effect, for reducing weight and for lowering the cholesterol level |
| PCT/EP2003/014380 WO2004056375A1 (en) | 2002-12-19 | 2003-12-17 | Agent for decreasing appetite and for producing a satiation effect, for reducing weight and for lowering the cholesterol level |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10259506A DE10259506A1 (en) | 2002-12-19 | 2002-12-19 | Appetite-and cholesterol-reducing agent comprises a low esterified polysaccharide and a different material which is swellable |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10259506A1 true DE10259506A1 (en) | 2004-07-08 |
Family
ID=32477794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10259506A Withdrawn DE10259506A1 (en) | 2002-12-19 | 2002-12-19 | Appetite-and cholesterol-reducing agent comprises a low esterified polysaccharide and a different material which is swellable |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE10259506A1 (en) |
-
2002
- 2002-12-19 DE DE10259506A patent/DE10259506A1/en not_active Withdrawn
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