DE10230769A1 - Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren - Google Patents
Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren Download PDFInfo
- Publication number
- DE10230769A1 DE10230769A1 DE10230769A DE10230769A DE10230769A1 DE 10230769 A1 DE10230769 A1 DE 10230769A1 DE 10230769 A DE10230769 A DE 10230769A DE 10230769 A DE10230769 A DE 10230769A DE 10230769 A1 DE10230769 A1 DE 10230769A1
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- acid
- inhalation
- group
- propellant
- suspension
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- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title claims abstract description 11
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 title claims abstract description 5
- 239000000812 cholinergic antagonist Substances 0.000 title claims abstract description 5
- 239000000203 mixture Substances 0.000 title claims description 39
- 239000002547 new drug Substances 0.000 title 1
- 208000023504 respiratory system disease Diseases 0.000 claims abstract description 6
- 239000000443 aerosol Substances 0.000 claims description 35
- 239000004480 active ingredient Substances 0.000 claims description 32
- 239000003814 drug Substances 0.000 claims description 30
- 239000000843 powder Substances 0.000 claims description 24
- 239000003380 propellant Substances 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 24
- 239000000725 suspension Substances 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 21
- -1 Bay-198004 Chemical compound 0.000 claims description 20
- 239000002253 acid Substances 0.000 claims description 17
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- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 4
- QVDKSPUZWYTNQA-UHFFFAOYSA-N enprofylline Chemical compound O=C1NC(=O)N(CCC)C2=NC=N[C]21 QVDKSPUZWYTNQA-UHFFFAOYSA-N 0.000 claims description 4
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- 230000002757 inflammatory effect Effects 0.000 claims description 4
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 claims description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 4
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- DPHDSIQHVGSITN-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide Chemical compound C1=C(C(=O)C(=O)NC=2C(=CN=CC=2Cl)Cl)C2=CC(O)=CC=C2N1CC1=CC=C(F)C=C1 DPHDSIQHVGSITN-UHFFFAOYSA-N 0.000 claims description 4
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- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims description 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 3
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- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10230769A DE10230769A1 (de) | 2002-07-09 | 2002-07-09 | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren |
| JP2004518566A JP2005532379A (ja) | 2002-07-09 | 2003-06-25 | 新規な抗コリン作動薬およびｐｄｅ−ｉｖ阻害剤を基本とする新規な医薬組成物 |
| CA002492026A CA2492026A1 (en) | 2002-07-09 | 2003-06-25 | New pharmaceutical compositions based on new anticholinergics and pde-iv inhibitors |
| EP03762509A EP1521576A1 (de) | 2002-07-09 | 2003-06-25 | Neue arzneimittelkompositionen auf der basis neuer anticholinergika und pde-iv-inhibitoren |
| PCT/EP2003/006668 WO2004004704A1 (de) | 2002-07-09 | 2003-06-25 | Neue arzneimittelkompositionen auf der basis neuer anticholinergika und pde-iv-inhibitoren |
| AU2003242755A AU2003242755A1 (en) | 2002-07-09 | 2003-06-25 | Novel pharmaceutical compositions comprising novel anticholinergic agents and pde-iv inhibitors |
| US10/614,365 US20040058950A1 (en) | 2002-07-09 | 2003-07-07 | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10230769A DE10230769A1 (de) | 2002-07-09 | 2002-07-09 | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10230769A1 true DE10230769A1 (de) | 2004-01-22 |
Family
ID=29761758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10230769A Withdrawn DE10230769A1 (de) | 2002-07-09 | 2002-07-09 | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1521576A1 (enExample) |
| JP (1) | JP2005532379A (enExample) |
| AU (1) | AU2003242755A1 (enExample) |
| CA (1) | CA2492026A1 (enExample) |
| DE (1) | DE10230769A1 (enExample) |
| WO (1) | WO2004004704A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2533786A1 (en) * | 2003-07-28 | 2005-02-17 | Boehringer Ingelheim International Gmbh | Medicaments comprising pde iv inhibitors and a novel anticholinergic and their use for treating respiratory disorders |
| US7071333B2 (en) | 2003-07-30 | 2006-07-04 | Bristol-Myers Squibb Company | Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same |
| CA2534120C (en) * | 2003-07-31 | 2012-09-11 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising anticholinergics and a betamimetic |
| CA2547394A1 (en) * | 2004-01-09 | 2005-07-28 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions based on a scopineester and nicotinamide derivatives |
| WO2005074982A2 (en) * | 2004-02-06 | 2005-08-18 | Meda Pharma Gmbh & Co. Kg | Combination of anticholinergics and inhibitors of phosphodiesterase type 4 for the treatment of respiratory diseases |
| DE102004046235A1 (de) * | 2004-09-22 | 2006-03-30 | Altana Pharma Ag | Arzneimittelzubereitung |
| EP1850831B1 (en) | 2005-02-25 | 2015-12-02 | CHIESI FARMACEUTICI S.p.A. | Pharmaceutical aerosol formulations for pressurized metered dose inhalers comprising a sequestering agent |
| EP2484382A1 (en) * | 2005-03-30 | 2012-08-08 | Schering Corporation | Medicament comprising a phosphodiesterase IV inhibitor in an inhalable form |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020052312A1 (en) * | 2000-05-30 | 2002-05-02 | Reiss Theodore F. | Combination therapy of chronic obstructive pulmonary disease using muscarinic receptor antagonists |
| AR029984A1 (es) * | 2000-07-27 | 2003-07-23 | Smithkline Beecham Corp | Metodo para reducir las exacerbaciones asociadas copd ambito |
| DE10050994A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung |
| DE10110772A1 (de) * | 2001-03-07 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
| CZ20033150A3 (cs) * | 2001-05-25 | 2004-06-16 | Pfizer Inc. | Inhibitor PDE4 a anticholinergní činidlo v kombinaci pro léčbu obstruktivních chorob dýchacích cest |
| GB0118373D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
-
2002
- 2002-07-09 DE DE10230769A patent/DE10230769A1/de not_active Withdrawn
-
2003
- 2003-06-25 JP JP2004518566A patent/JP2005532379A/ja active Pending
- 2003-06-25 WO PCT/EP2003/006668 patent/WO2004004704A1/de not_active Ceased
- 2003-06-25 EP EP03762509A patent/EP1521576A1/de not_active Withdrawn
- 2003-06-25 CA CA002492026A patent/CA2492026A1/en not_active Abandoned
- 2003-06-25 AU AU2003242755A patent/AU2003242755A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003242755A1 (en) | 2004-01-23 |
| WO2004004704A1 (de) | 2004-01-15 |
| CA2492026A1 (en) | 2004-01-15 |
| JP2005532379A (ja) | 2005-10-27 |
| EP1521576A1 (de) | 2005-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |