DE10230769A1 - Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren - Google Patents
Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren Download PDFInfo
- Publication number
- DE10230769A1 DE10230769A1 DE10230769A DE10230769A DE10230769A1 DE 10230769 A1 DE10230769 A1 DE 10230769A1 DE 10230769 A DE10230769 A DE 10230769A DE 10230769 A DE10230769 A DE 10230769A DE 10230769 A1 DE10230769 A1 DE 10230769A1
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- acid
- inhalation
- group
- propellant
- suspension
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- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title claims abstract description 11
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 title claims abstract description 5
- 239000000812 cholinergic antagonist Substances 0.000 title claims abstract description 5
- 239000000203 mixture Substances 0.000 title claims description 39
- 239000002547 new drug Substances 0.000 title 1
- 208000023504 respiratory system disease Diseases 0.000 claims abstract description 6
- 239000000443 aerosol Substances 0.000 claims description 35
- 239000004480 active ingredient Substances 0.000 claims description 32
- 239000003814 drug Substances 0.000 claims description 30
- 239000000843 powder Substances 0.000 claims description 24
- 239000003380 propellant Substances 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 24
- 239000000725 suspension Substances 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 21
- -1 Bay-198004 Chemical compound 0.000 claims description 20
- 239000002253 acid Substances 0.000 claims description 17
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- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 4
- QVDKSPUZWYTNQA-UHFFFAOYSA-N enprofylline Chemical compound O=C1NC(=O)N(CCC)C2=NC=N[C]21 QVDKSPUZWYTNQA-UHFFFAOYSA-N 0.000 claims description 4
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- 230000002757 inflammatory effect Effects 0.000 claims description 4
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 claims description 4
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 4
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- DPHDSIQHVGSITN-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide Chemical compound C1=C(C(=O)C(=O)NC=2C(=CN=CC=2Cl)Cl)C2=CC(O)=CC=C2N1CC1=CC=C(F)C=C1 DPHDSIQHVGSITN-UHFFFAOYSA-N 0.000 claims description 4
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- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims description 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 3
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- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10230769A DE10230769A1 (de) | 2002-07-09 | 2002-07-09 | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren |
| EP03762509A EP1521576A1 (de) | 2002-07-09 | 2003-06-25 | Neue arzneimittelkompositionen auf der basis neuer anticholinergika und pde-iv-inhibitoren |
| PCT/EP2003/006668 WO2004004704A1 (de) | 2002-07-09 | 2003-06-25 | Neue arzneimittelkompositionen auf der basis neuer anticholinergika und pde-iv-inhibitoren |
| JP2004518566A JP2005532379A (ja) | 2002-07-09 | 2003-06-25 | 新規な抗コリン作動薬およびｐｄｅ−ｉｖ阻害剤を基本とする新規な医薬組成物 |
| CA002492026A CA2492026A1 (en) | 2002-07-09 | 2003-06-25 | New pharmaceutical compositions based on new anticholinergics and pde-iv inhibitors |
| AU2003242755A AU2003242755A1 (en) | 2002-07-09 | 2003-06-25 | Novel pharmaceutical compositions comprising novel anticholinergic agents and pde-iv inhibitors |
| US10/614,365 US20040058950A1 (en) | 2002-07-09 | 2003-07-07 | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10230769A DE10230769A1 (de) | 2002-07-09 | 2002-07-09 | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10230769A1 true DE10230769A1 (de) | 2004-01-22 |
Family
ID=29761758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10230769A Withdrawn DE10230769A1 (de) | 2002-07-09 | 2002-07-09 | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1521576A1 (enExample) |
| JP (1) | JP2005532379A (enExample) |
| AU (1) | AU2003242755A1 (enExample) |
| CA (1) | CA2492026A1 (enExample) |
| DE (1) | DE10230769A1 (enExample) |
| WO (1) | WO2004004704A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2533786A1 (en) * | 2003-07-28 | 2005-02-17 | Boehringer Ingelheim International Gmbh | Medicaments comprising pde iv inhibitors and a novel anticholinergic and their use for treating respiratory disorders |
| US7071333B2 (en) | 2003-07-30 | 2006-07-04 | Bristol-Myers Squibb Company | Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same |
| WO2005013994A1 (en) * | 2003-07-31 | 2005-02-17 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising anticholinergics and a betamimetic |
| JP2007517820A (ja) * | 2004-01-09 | 2007-07-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | スコピンエステル及びニコチンアミド誘導体を基にした新規な医薬組成物 |
| CA2550848C (en) * | 2004-02-06 | 2013-02-26 | Meda Pharma Gmbh & Co. Kg | Combination of anticholinergics and inhibitors of phosphodiesterase type 4 for the treatment of respiratory diseases |
| DE102004046235A1 (de) * | 2004-09-22 | 2006-03-30 | Altana Pharma Ag | Arzneimittelzubereitung |
| SG159550A1 (en) | 2005-02-25 | 2010-03-30 | Chiesi Farma Spa | Pharmaceutical aerosol formulations for pressurized metered dose inhalers comprising a sequestering agent |
| EP2484382A1 (en) * | 2005-03-30 | 2012-08-08 | Schering Corporation | Medicament comprising a phosphodiesterase IV inhibitor in an inhalable form |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020052312A1 (en) * | 2000-05-30 | 2002-05-02 | Reiss Theodore F. | Combination therapy of chronic obstructive pulmonary disease using muscarinic receptor antagonists |
| AR029984A1 (es) * | 2000-07-27 | 2003-07-23 | Smithkline Beecham Corp | Metodo para reducir las exacerbaciones asociadas copd ambito |
| DE10050994A1 (de) * | 2000-10-14 | 2002-04-18 | Boehringer Ingelheim Pharma | Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung |
| DE10110772A1 (de) * | 2001-03-07 | 2002-09-12 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und PDE-IV-Inhibitoren |
| PA8546001A1 (es) * | 2001-05-25 | 2003-12-30 | Pfizer | Un inhibidor de pde4 y un agente anticolinergico en combinacion para tratar enfermedades obstructivas de vias respiratorias |
| GB0118373D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
-
2002
- 2002-07-09 DE DE10230769A patent/DE10230769A1/de not_active Withdrawn
-
2003
- 2003-06-25 EP EP03762509A patent/EP1521576A1/de not_active Withdrawn
- 2003-06-25 AU AU2003242755A patent/AU2003242755A1/en not_active Abandoned
- 2003-06-25 CA CA002492026A patent/CA2492026A1/en not_active Abandoned
- 2003-06-25 JP JP2004518566A patent/JP2005532379A/ja active Pending
- 2003-06-25 WO PCT/EP2003/006668 patent/WO2004004704A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005532379A (ja) | 2005-10-27 |
| EP1521576A1 (de) | 2005-04-13 |
| WO2004004704A1 (de) | 2004-01-15 |
| AU2003242755A1 (en) | 2004-01-23 |
| CA2492026A1 (en) | 2004-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |