DE10229526A1 - Aqueous cosmetic and dermatological preparations containing water-soluble UV filter substances - Google Patents

Abstract

Aqueous cosmetic or dermatological preparations containing DOLLAR A (a) 0.05-15% by weight of 2-phenylbenzimidazole-5-sulfonic acid or one or more of its salts and / or 0.05-15% by weight of phenylene-1 , 4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid or one or more of its salts, DOLLAR A (b) 50-98.5% by weight water, DOLLAR A (c ) 0-30% by weight ethanol DOLLAR A (d) one or more wetting agents, selected from the group of surface-active or surface-active substances, DOLLAR A (e) if desired one or more moisturizers ("moisturizers"), DOLLAR A (f) optionally further cosmetic auxiliaries and / or additives, but fats, oils and waxes make up at most 5% by weight of the preparation and preferably no fats, oils and waxes are used, DOLLAR A (g) and the preparations are not emulsions.

Description

The present invention relates to aqueous cosmetic and dermatological preparations containing water-soluble UV filter substances.

The skin is the largest organ of the human. Among its many functions (e.g. for heat control and as a sensory organ) is the barrier function, which is drying out the skin (and ultimately the entire organism), probably the most important. At the same time, the skin acts as a protective device the penetration and absorption of substances coming from outside. causes this barrier function is through the epidermis, which acts as the outermost layer the actual protective cover across from of the environment. With about a tenth of the total thickness it is at the same time the thinnest Layer of skin.

The epidermis is a stratified one Tissue in which the outer layer, the stratum corneum, which is important for the barrier function Represents part. The skin model recognized today in the professional world by Elias (P.M. Elias, Structure and Function of the Stratum Corneum Permeability Barrier, Drug Dev. Res. 13, 1988, 97-105) the horny layer as a two-component system, similar to a brick wall (brick-mortar model). In this The horny cells (corneocytes) correspond to the bricks that model corresponds to complex lipid membrane in the intercellular spaces the mortar. This system essentially represents a physical barrier against hydrophilic substances, but due to its narrow and multilayer structure equally of lipophilic substances difficult to be happened.

Taking cosmetic skin care is primarily to understand that the natural function of the skin as Barrier against environmental influences (e.g. dirt, chemicals, microorganisms) and against loss from the body's own Substances (e.g. water, natural Fats, electrolytes) strengthened or is restored.

If this function is disrupted, it too amplified Absorption of toxic or allergenic substances or to infest Microorganisms and, as a result, toxic or allergic skin reactions come.

The aim of skin care is also to through daily Washing to compensate for the loss of fat and water in the skin. This is especially important when the natural regeneration ability is not sufficient. Moreover skin care products are intended to protect against environmental influences, especially from the sun and wind, protect and delay skin aging.

The present invention relates to also cosmetic and dermatological light protection formulations. Farther The present invention relates to preparations for cosmetic and dermatological treatment or prophylaxis of erythematous, inflammatory, allergic or autoimmune reactive symptoms, especially Dermatoses.

The harmful effects of the ultraviolet Part of the solar radiation on the skin is generally known. In dependence from their respective wavelength the rays have different effects on the organ skin: the So-called UV-C radiation with a wavelength that is less than 290 nm is absorbed by the ozone layer in the earth's atmosphere and therefore has no physiological meaning. In contrast, rays in the Range between 290 nm and 320 nm, the so-called UV-B range, an erythema, a simple sunburn or even more or less severe burns. As a maximum of the erythema effectiveness of the The narrower range around 308 nm is indicated in sunlight.

To protect against UV-B radiation numerous compounds are known, most of which are derivatives of 3-benzylidene camphor, 4-aminobenzoic acid, cinnamic acid, the salicylic acid, benzophenone and 2-phenylbenzimidazole.

You have mistakenly for a long time assumed that the Long-wave UV-A radiation with a wavelength between 320 nm and 400 nm just a negligible has biological effects and that accordingly the UV-B rays for the most light damage responsible for human skin. In the meantime, however proven by numerous studies that UV-A radiation with regard on the trigger photodynamic, especially phototoxic reactions and chronic changes of the skin far more dangerous than UV-B radiation. The damaging influence of UV-B radiation can also intensified by UV-A radiation become.

So it is among other things proved that even UV-A radiation is sufficient under normal everyday conditions, to quickly damage the collagen and elastin fibers that for the The structure and firmness of the skin are essential. This leads to chronic light-induced skin changes - the skin "ages" prematurely Appearance of light-aged skin include, for example Wrinkles and fine lines as well as an irregular, furrowed Relief. Can also the areas affected by light-induced skin aging have irregular pigmentation exhibit. Even the formation of brown spots, keratoses and even Carcinoma or malignant melanoma is possible. One through everyday UV exposure prematurely aged skin is also characterized by less activity of Langerhans cells and a mild, chronic inflammation.

Furthermore, very low doses of radiation can trigger photochemical reactions. This includes in particular the formation of free radicals, which in turn are uncontrolled due to their high reactivity can trigger subsequent reactions. To prevent such reactions, additional antioxidants and / or free radical scavengers can be added to the cosmetic or dermatological formulations. For example, it has been proposed to use vitamin E, a substance with a known antioxidant effect, in light protection formulations, but the effect achieved here falls far short of the hoped-for effect.

About 90% of those who reach Earth ultraviolet radiation consists of UV-A rays. While the UV-B radiation in dependence greatly varied by numerous factors (e.g. time of year and time of day or latitude), the UV-A radiation remains independent of year and day time or geographic factors day by day relative constant. At the same time, the majority of UV-A radiation penetrates into the living epidermis while about 70% of the UV-B rays are retained by the horny layer become.

Most people sunbathe People found it pleasant, but the negative consequences did not initially respected. However, there has been quite a change in recent years Awareness of the negative effects of excessive sun exposure are formed, which is why more and stronger protective sunscreen be applied.

Because the contributions of the different wavelength ranges UV light on skin changes caused by light are not fully clarified, one goes more today assume that preventive Protection against both UV-A and UV-B rays, for example by applying light protection filter substances in the form of a cosmetic or dermatological formulation on the skin, of fundamental Importance is. Cosmetic or dermatological agents should in thinner Layer applied to the skin, before the negative effects protect from solar radiation.

In general, the light absorption behavior of light protection filter substances very well known and documented, especially in most industrialized countries Positive lists for the use of such substances exist, which are quite strict Standards to the Create documentation. Depending on which area of the UV light is absorbed, a distinction is made between UV-B filters, UV-A filters and Broadband filter (which over the the entire range of UV-A and UV-B show a filter effect). By appropriate selection of the UV filter and its concentration in Sunscreen you have the option to influence the degree of shielding of the UV light. For the dosage The extinction values of the substances in the finished formulations can, however offer guidance at best, because through interactions With ingredients of the formulation or the skin itself, imponderables can arise occur. Furthermore, it is usually difficult to estimate in advance how evenly and the layer thickness of the filter substance in and on the horny layer the skin is distributed.

The effectiveness of sunscreen or the UV filter on which they are based is usually in biological efficacy tests determined under standardized conditions.

The sun protection factor (SPF, often too SPF (called sun protection factor) gives the extension of sun exposure by using the sunscreen he possible becomes. It is the quotient from the erythema threshold with sunscreen and erythema threshold time without sunscreen.

For testing the UV-A protection performance is usually uses the IPD method (IPD ≡ immediate pigment darkening). Here - similar to the determination of the sun protection factor - a value becomes determined, which indicates how much longer the one with the light stabilizer protected Skin can be irradiated with UV-A radiation until the same pigmentation occurs like the unprotected Skin.

Another, established throughout Europe Assessment methods is the Australian standard AS / NZS 2604: 1997. The absorption of the preparation measured in the UV-A range. To meet the standard, the preparation must absorb at least 90% of UV-A radiation in the range 320-360 nm.

To achieve high sun protection factors, W / O formulations are an advantage. However, W / O emulsions show of the prior art frequently unsatisfactory cosmetic properties. When using can corresponding preparations on the skin a greasy, shiny and sometimes leave a sticky impression and - especially on hairy skin - difficult spread out. Such preparations can therefore be used in individual cases not even marketable be because they are not accepted by consumers or judged negatively become.

An object of the present invention was therefore to remedy the disadvantages of the prior art.

Aqueous sunscreen formulations on the market do not achieve effective UV-A protection and poorly wet the skin. Moreover most formulations do not achieve a good feeling on the skin. The Feel products becomes dull and / or sticky. These problems should be addressed be, the product also cooling and should be clear.

Aqueous and usually also alcoholic solutions provide the basis for so-called tonics. These are facial tonics, which usually complete the facial care be applied to give the face a feeling of freshness and a refreshed look to rent. In addition to perfume and other additives, tonics are included in the Usually humectants such as glycerin.

The alcohol content of face lotions is usually in the range of 5-20% by weight. A higher ethanol content would sometimes be desirable in order to contain certain recipe components, e.g. par ingredients to be able to solve better, on the other hand, increased ethanol content often leads to skin irritation, at least for sensitive skin.

The aim was to remedy these problems.

• (a) 0,05–15 Gew.-% 2-Phenylbenzimidazol-5-sulfonsäure bzw. eines oder mehrerer ihrer Salze und/oder 0,05–15 Gew.-% Phenylen-1,4-bis-(2-benzimidazyl)-3,3'-5,5'-tetrasulfonsäure bzw. eines oder mehrerer ihrer Salze,
• (b) 50–98,5 Gew.-% Wasser,
• (c) 0–30 Gew.-% Ethanol
• (d) ein oder mehrere Benetzungsmittel, gewählt aus der Gruppe der oberflächenaktiven oder grenzflächenaktiven Substanzen,
• (e) gewünschtenfalls ein oder mehrere Feuchthaltemittel („Moisturizer")
• (f) gegebenenfalls weitere kosmetische Hilfs- und/oder Zusatzstoffe, wobei allerdings Fette, Öle und Wachse höchstens 5 Gew.-% der Zubereitung ausmachen und bevorzugt auf Fette, Öle und Wachse verzichtet wird,
• (g) und wobei die Zubereitungen keine Emulsionen darstellen.

Surprisingly, all of these tasks are solved by aqueous cosmetic or dermatological preparations containing

• (a) 0.05-15% by weight of 2-phenylbenzimidazole-5-sulfonic acid or one or more of its salts and / or 0.05-15% by weight of phenylene-1,4-bis- (2-benzimidazyl ) -3,3'-5,5'-tetrasulfonic acid or one or more of its salts,
• (b) 50-98.5 wt% water,
• (c) 0-30% by weight ethanol
• (d) one or more wetting agents selected from the group of surface-active or surface-active substances,
• (e) if desired, one or more moisturizers ("moisturizers")
• (f) optionally further cosmetic auxiliaries and / or additives, but fats, oils and waxes make up at most 5% by weight of the preparation and fats, oils and waxes are preferably dispensed with,
• (g) and the preparations are not emulsions.

Surprisingly, the preparations according to the invention form a stable aqueous dosage form with high sun protection factor, at the same time the skin moisturizing and -care effect improved, without causing a clouding of the Product comes through the ingredients.

A particular advantage is that the preparations according to the invention sprayable can be designed.

Another advantage of the preparations according to the invention is, that you the skin in extremely pleasant Cool way, especially if they contain ethanol. the 2.5 Wt .-% exceeds.

They describe EP-A-0 913 145 as well as that DE-GbM 297 14 940 Sunscreen in the form of a solution, characterized in that it comprises at least one UV-filtering compound dissolved in a solvent or solvent mixture and is free from emulsifiers, oils, fats, waxes and silicone compounds. For example, 2-phenylbenzimidazole-5-sulfonic acid is mentioned as a UV-filtering compound.

However, the state of the art could do not point the way to the present invention.

The 2-phenylbenzimidazole-5-sulfonic acid is characterized by the following structure:

Phenylene-1,4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid is characterized by the following structure:

Both substances are known light protection filter substances, the 2-phenylbenzimidazole-5-sulfonic acid predominantly in the UV-B range, the phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid predominantly absorbed in the UV-A range.

Preparations preferably contain according to the invention 0.5-5.0 % By weight of 2-phenylbenzimidazole-5-sulfonic acid or one or more of their salts.

Preparations also preferably contain according to the invention 0.5-5.0 % By weight of phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid or one or more of their salts.

According to the invention, it is advantageous the weight ratio from 2-phenylbenzimidazole-5-sulfonic acid to phenylene-1,4-bis (2-benzimidaryl) -3,3'-5,5'-tetrasulfonic acid the range from 5: 1 to 1: 5, preferably from the range from 3 : 1 to 1: 3, particularly preferably approximately 2: 1.

Also advantageous for the purposes of the present invention are the 1,4-di (2-oxo-10-sulfo-3-bornylidenemethyl) benzene (also: 3,3 '- (1,4-phenylenedimethylene) -bis- (7, 7-dimethyl-2-oxobicyclo- [2.2.1] hept-1-ylmethane sulfonic acid) and its salts (especially the corresponding 10-sulfato compounds, especially that corresponding sodium, potassium or triethanolammonium salt), which is also referred to as benzene-1,4-di (2-oxo-3-bornylidenemethyl-l0-sulfonic acid) and is characterized by the following structure:

Benzene-1,4-di (2-oxo-3-bornylidenemethyl-10-sulfonic acid) the INCI name Terephtalidene Dicampher Sulfonic Acid (CAS no .: 90457-82-2) and is for example under the trade name Mexoryl SX available from Chimex.

Further advantageous water-soluble UV-B and / or broadband filter substances in the sense of the present invention are z. B. sulfonic acid derivatives the 3-benzylidene camphor, such as. B. 4- (2-oxo-3-bornylidene methyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bornylidene methyl) sulfonic acid and their salts.

Such preparations according to the invention are advantageous which are characterized in that they prefer 0.5-25% by weight ethanol 5-20% by weight Contain ethanol, based on the total weight of the preparations.

As a wetting agent advantageous according to the invention can Surfactants and / or emulsifiers can be selected.

Surfactants are amphiphilic substances that can dissolve organic, non-polar substances in water. They are caused by their specific molecular structure with at least one hydrophilic and one hydrophobic part of the molecule, for a reduction the surface tension of water, wetting the skin, facilitating dirt removal and solution, a gentle rinse and ever as desired - for foam regulation.

• – anionische Tenside,
• – kationische Tenside,
• – amphotere Tenside und
• – nichtionische Tenside.

The hydrophilic parts of a surfactant molecule are mostly polar functional groups, for example -COO ^- , -OSO ₃ ^2- , -SO ₃ ^- , while the hydrophobic parts generally represent non-polar hydrocarbon radicals. Surfactants are generally classified according to the type and charge of the hydrophilic part of the molecule. There are four groups:

• - anionic surfactants,
• - cationic surfactants,
• - amphoteric surfactants and
• - nonionic surfactants.

Anionic surfactants generally have carboxylate, sulfate or sulfonate groups as functional groups. In an aqueous solution they form negatively charged organic ions in an acidic or neutral environment. Cationic surfactants are characterized almost exclusively by the presence of a quaternary ammonium group. In aqueous solution they form positively charged organic ions in an acidic or neutral environment. Amphoteric surfactants contain both anionic and cationic groups and accordingly behave like anionic or cationic surfactants in aqueous solution depending on the pH. They have a positive charge in a strongly acidic environment and a negative charge in an alkaline environment. In the neutral pH range, however, they are zwitterionic, as the following example should illustrate:
RNH ₂ ⁺ CH ₂ CH ₂ COOH X ^- (at pH = 2) X ^- = any anion, e.g. Cl ^-
RNH ₂ ⁺ CH ₂ CH ₂ COO ^- (at pH = 7)
RNHCH ₂ CH ₂ OOO ^- B ⁺ (at pH = 12) B ⁺ = any cation, e.g. Na ⁺

Are typical for non-ionic surfactants Polyether chains. Non-ionic surfactants form in an aqueous medium no ions.

A. Anionic surfactants

• 1. Acylglutamate, beispielsweise Natriumacylglutamat, Di-TEA-palmitoylaspartat und Natrium Caprylic/Capric Glutamat,
• 2. Acylpeptide, beispielsweise Palmitoyl-hydrolysiertes Milchprotein, Natrium Cocoylhydrolysiertes Soja Protein und Natrium-/Kalium-Cocoyl-hydrolysiertes Kollagen,
• 3. Sarcosinate, beispielsweise Myristoyl Sarcosin, TEA-lauroyl Sarcosinat, Natriumlauroylsarcosinat und Natriumcocoylsarkosinat,
• 4. Taurate, beispielsweise Natriumlauroyltaurat und Natriummethylcocoyltaurat,
• 5. Acyllactylate, Lauroyllactylat, Caproyllactylats
• 6. Alaninate

Carbonsäuren und Derivate, wie

• 1. Carbonsäuren, beispielsweise Laurinsäure, Aluminiumstearat, Magnesiumalkanolat und Zinkundecylenat,
• 2. Ester-Carbonsäuren, beispielsweise Calciumstearoyllactylat, Laureth-6-Citrat und Natrium PEG-4-Lauramidcarboxylat,
• 3. Ether-Carbonsäuren, beispielsweise Natriumlaureth-13-Carboxylat und Natrium PEG-6-Cocamide Carboxylat,

Anionic surfactants to be used advantageously
Acylamino acids (and their salts), such as

• 1. acylglutamates, for example sodium acylglutamate, di-TEA-palmitoylaspartate and sodium caprylic / capric glutamate,
• 2. acyl peptides, for example palmitoyl-hydrolyzed milk protein, sodium cocoyl-hydrolyzed soy protein and sodium / potassium-cocoyl-hydrolyzed collagen,
• 3. sarcosinates, for example myristoyl sarcosin, TEA lauroyl sarcosinate, sodium lauroyl sarcosinate and sodium cocoyl sarcosinate,
• 4. taurates, for example sodium lauroyl taurate and sodium methyl cocoyl taurate,
• 5. Acyl lactylate, lauroyl lactylate, caproyl lactylate
• 6. Alaninate

Carboxylic acids and derivatives, such as

• 1. carboxylic acids, for example lauric acid, aluminum stearate, magnesium alkanolate and zinc undecylenate,
• 2. ester carboxylic acids, for example calcium stearoyl lactylate, laureth-6 citrate and sodium PEG-4 lauramide carboxylate,
• 3. ether carboxylic acids, for example sodium laureth-13 carboxylate and sodium PEG-6 cocamide carboxylate,

• 1. Acyl-isethionate, z.B. Natrium-/Ammoniumcocoyl-isethionat,
• 2. Alkylarylsulfonate,
• 3. Alkylsulfonate, beispielsweise Natriumcocosmonoglyceridsulfat, Natrium C_12–14 Olefinsulfonat, Natriumlaurylsulfoacetat und Magnesium PEG-3 Cocamidsulfat,
• 4. Sulfosuccinate, beispielsweise Dioctylnatriumsulfosuccinat, Dinatriumlaurethsulfosuccinat, Dinatriumlaurylsulfosuccinat und Dinatriumundecylenamido-MEA-Sulfosuccinat

sowie
Schwefelsäureester, wie

• 1. Alkylethersulfat, beispielsweise Natrium-, Ammonium-, Magnesium-, MIPA-, TIPA-Laurethsulfat, Natriummyrethsulfat und Natrium C_12–13-Parethsulfat,
• 2. Alkylsulfate, beispielsweise Natrium-, Ammonium- und TEA-Laurylsulfat.

Phosphoric acid esters and salts, such as DEA-oleth-10-phosphate and dilaureth-4 phosphate,
Sulfonic acids and salts such as

• 1. acyl isethionate, for example sodium / ammonium cocoyl isethionate,
• 2. alkylarylsulfonates,
• 3. alkyl sulfonates, for example sodium coconut monoglyceride sulfate, sodium C _12-14 olefin sulfonate, sodium lauryl sulfoacetate and magnesium PEG-3 cocamide sulfate,
• 4. Sulfosuccinates, for example dioctyl sodium sulfosuccinate, disodium laureth sulfosuccinate, disodium lauryl sulfosuccinate and disodium undecylenamido MEA sulfosuccinate

such as
Sulfuric acid esters, such as

• 1. alkyl ether sulfate, for example sodium, ammonium, magnesium, MIPA, TIPA laureth sulfate, sodium myreth sulfate and sodium C _12-13 pareth sulfate,
• 2. Alkyl sulfates, for example sodium, ammonium and TEA lauryl sulfate.

B. Cationic surfactants

• 1. Alkylamine,
• 2. Alkylimidazole,
• 3. Ethoxylierte Amine und
• 4. Quaternäre Tenside.

Cationic surfactants to be used advantageously

• 1. alkylamines,
• 2. alkylimidazoles,
• 3. Ethoxylated amines and
• 4. Quaternary surfactants.

5. Esterquats

Quaternary surfactants contain at least an N atom covalently linked to 4 alkyl and / or aryl groups is. This leads to, independently from the pH value to a positive charge. Advantageous quaternary surfactants are Alkyl betaine, alkyl amidopropyl betaine and alkyl amidopropyl hydroxysulfain. Cationic surfactants can also be used are preferably chosen in the sense of the present invention from the group of quaternaries Ammonium compounds, especially benzyltrialkylammonium chlorides or bromides, such as, for example, benzyldimethylstearylammonium chloride, further alkyltrialkylammonium salts, for example cetyltrimethylammonium chloride or bromide, alkyldimethylhydroxyethylammonium chlorides or bromides, dialkyldimethylammonium chlorides or bromides, alkylamidethyltrimethylammonium ether sulfates, alkylpyridinium salts, for example lauryl or cetyl pyrimidinium chloride, imidazoline derivatives and compounds with a cationic character such as amine oxides, for example Alkyldimethylamine oxides or alkylaminoethyldimethylamine oxides. Advantageous especially cetyltrimethylammonium salts are to be used.

C. Amphoteric surfactants

• 1. Acyl-/dialkylethylendiamin, beispielsweise Natriumacylamphoacetat, Dinatriumacylamphodipropionat, Dinatriumalkylamphodiacetat, Natriumacylamphohydroxypropylsulfonat, Dinatriumacylamphodiacetat und Natriumacylamphopropionat,
• 2. N-Alkylaminosäuren, beispielsweise Aminopropylalkylglutamid, Alkylaminopropionsäure, Natriumalkylimidodipropionat und Lauroamphocarboxyglycinat.
• 3. N-Alkyl- oder N-Alkenylbetaine mit mindestens 12 C-Atomen, wie z. B. Lauryl-amidopropylbetain und Oleylamidopropylbetain

Amphoteric surfactants to be used advantageously

• 1. acyl- / dialkylethylenediamine, for example sodium acylamphoacetate, disodium acylamphodipropionate, disodium alkylamphodiacetate, sodium acylamphohydroxypropylsulfonate, disodium acylamphodiacetate and sodium acylamphopropionate,
• 2. N-alkylamino acids, for example aminopropylalkylglutamide, alkylaminopropionic acid, sodium alkyl limidodipropionate and lauroamphocarboxyglycinate.
• 3. N-alkyl or N-alkenyl betaines with at least 12 carbon atoms, such as. B. lauryl amidopropyl betaine and oleyl amidopropyl betaine

D. Non-ionic surfactants

• 1. Alkohole,
• 2. Alkanolamide, wie Cocamide MEA/DEA/MIPA,
• 3. Aminoxide, wie Cocoamidopropylaminoxid,
• 4. Ester, die durch Veresterung von Carbonsäuren mit Ethylenoxid, Glycerin, Sorbitan oder anderen Alkoholen entstehen,
• 5. Ether, beispielsweise ethoxylierte/propoxylierte Alkohole, ethoxylierte/propoxylierte Ester, ethoxylierte/propoxylierte Glycerinester, ethoxylierte/propoxylierte Cholesterine, ethoxylierte/propoxylierte Triglyceridester, ethoxyliertes propoxyliertes Lanolin, ethoxylierte/propoxylierte Polysiloxane, propoxylierte POE-Ether und Alkylpolyglycoside wie Laurylglucosid, Decylglycosid und Cocoglycosid.
• 6. Sucroseester, -Ether
• 7. Polyglycerinester, Diglycerinester, Monoglycerinester
• 8. Methylglucosester, Ester von Hydroxysäuren

Non-ionic surfactants to be used advantageously

• 1. alcohols,
• 2. alkanolamides, such as cocamides MEA / DEA / MIPA,
• 3. amine oxides, such as cocoamidopropylamine oxide,
• 4. esters which are formed by esterification of carboxylic acids with ethylene oxide, glycerol, sorbitan or other alcohols,
• 5. ethers, for example ethoxylated / propoxylated alcohols, ethoxylated / propoxylated esters, ethoxylated / propoxylated glycerol esters, ethoxylated / propoxylated cholesterols, ethoxylated / propoxylated triglyceride esters, ethoxylated propoxylated lanolin, ethoxylated / propoxylated polysiloxanes, propoxylated POE ethers and alkylpolyglycosides such as lauryl polyglycosides cocoglycoside.
• 6. sucrose esters, ether
• 7. Polyglycerol esters, diglycerol esters, monoglycerol esters
• 8. Methyl glucose esters, esters of hydroxy acids

The use is also advantageous a combination of anionic and / or amphoteric surfactants with one or more non-ionic surfactants.

• – der Fettalkoholethoxylate
• – der ethoxylierten Wollwachsalkohole,
• – der Polyethylenglycolether der allgemeinen Formel R-O-(-CH₂-CH₂-O-)_n-R',
• – der Fettsäureethoxylate der allgemeinen Formel R-COO-(-CH₂₂-CH₂-O-)_n-H,
• – der veretherten Fettsäureethoxylate der allgemeinen Formel R-COO-(-CH₂-CH₂-O-)_n-R',
• – der veresterten Fettsäureethoxylate der allgemeinen Formel R-COO-(-CH₂-CH₂-O-)_n-C(O)-R',
• – der Polyethylenglycolglycerinfettsäureester
• – der ethoxylierten Sorbitanester
• – der Cholesterinethoxylate
• – der ethoxylierten Triglyceride
• – der Alkylethercarbonsäuren der allgemeinen Formel R-O-(-CH₂-CH₂-O-)_n-CH₂-COOH nd n eine Zahl von 5 bis 30 darstellen,
• – der Polyoxyethylensorbitolfettsäureester,
• – der Alkylethersulfate der allgemeinen Formel R-O-(-CH₂-CH₂-O-)_n-SO₃-H
• – der Fettalkoholpropoxylate der allgemeinen Formel R-O-(-CH₂-CH(CH₃)-O-)_n-H,
• – der Polypropylenglycolether der allgemeinen Formel R-O-(-CH₂-CH(CH₃)-O-)_n-R',
• – der propoxylierten Wollwachsalkohole,
• – der veretherten Fettsäurepropoxylate R-COO-(-CH₂-CH(CH₃)-O-)_n-R',
• – der veresterten Fettsäurepropoxylate der allgemeinen Formel R-COO-(-CH₂-CH(CH₃)-O-)_n-C(O)-R',
• – der Fettsäurepropoxylate der allgemeinen Formel R-COO-(-CH₂-CH(CH₃)-O-)_n-H,
• – der Polypropylenglycolglycerinfettsäureester
• – der propoxylierten Sorbitanester
• – der Cholesterinpropoxylate
• – der propoxylierten Triglyceride
• – der Alkylethercarbonsäuren der allgemeinen Formel R-O-(-CH₂-CH(CH₃)O-)_n-CH₂-COOH
• – der Alkylethersulfate bzw. die diesen Sulfaten zugrundeliegenden Säuren der allgemeinen Formel R-O-(-CH₂-CH(CH₃)-O-)n^-SO₃-H
• – der Fettalkoholethoxylate/propoxylate der allgemeinen Formel R-O-X_n-Y_m-H,
• – der Polypropylenglycolether der allgemeinen Formel R-O-X_n-Y_m-R',
• – der veretherten Fettsäurepropoxylate der allgemeinen Formel R-COO-X_n-Y_m-R',
• – der Fettsäureethoxylate/propoxylate der allgemeinen Formel R-COO-X_n-Y_m-H,.

Emulsifiers to be used advantageously according to the invention can, for example, advantageously be selected from the group of O / W emulsifiers, for example from the group of polyethoxylated or polypropoxylated or polyethoxylated and polypropoxylated products, for example:

• - The fatty alcohol ethoxylates
• - the ethoxylated wool wax alcohols,
• The polyethylene glycol ether of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -R ',
• The fatty acid ethoxylates of the general formula R-COO - (- CH ₂₂ -CH ₂ -O-) _n -H,
• The etherified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -R ',
• The esterified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -C (O) -R ',
• - The polyethylene glycol glycerol fatty acid ester
• - The ethoxylated sorbitan esters
• - the cholesterol ethoxylates
• - The ethoxylated triglycerides
• The alkyl ether carboxylic acids of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -CH ₂ -COOH and n represent a number from 5 to 30,
• - the polyoxyethylene sorbitol fatty acid ester,
• - The alkyl ether sulfates of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -SO ₃ -H
• The fatty alcohol propoxylates of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H,
• The polypropylene glycol ether of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ',
• - the propoxylated wool wax alcohols,
• The etherified fatty acid propoxylates R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ',
• The esterified fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -C (O) -R ',
• The fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H,
• - the polypropylene glycol glycerol fatty acid ester
• - The propoxylated sorbitan esters
• - the cholesterol propoxylates
• - the propoxylated triglycerides
• - The alkyl ether carboxylic acids of the general formula RO - (- CH ₂ -CH (CH ₃ ) O-) _n -CH ₂ -COOH
• - The alkyl ether sulfates or the acids of these sulfates on the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) n ^- SO ₃ -H
• The fatty alcohol ethoxylates / propoxylates of the general formula ROX _n -Y _m -H,
• The polypropylene glycol ether of the general formula ROX _n -Y _m -R ',
• The etherified fatty acid propoxylates of the general formula R-COO-X _n -Y _m -R ',
• - The fatty acid ethoxylates / propoxylates of the general formula R-COO-X _n -Y _m -H ,.

According to the invention, the polyethoxylated or polypropoxylated or polyethoxylated and polypropoxylated O / W emulsifiers used are selected particularly advantageously from the group of substances with HLB values of 11-18, very particularly advantageously with HLB values of 14.5-15. 5, provided that O / W emulsifiers have saturated radicals R and R '. If the O / W emulsifiers have unsaturated radicals R and / or R ', or if isoalkyl derivatives are present, the preferred HLB value of such emulsifiers can also be lower or higher.

It is advantageous to choose the fatty alcohol ethoxylates from the group of the ethoxylated stearyl alcohols, cetyl alcohols, cetylstearyl alcohols (cetearyl alcohols). The following are particularly preferred:
Polyethylene glycol (13) stearyl ether (steareth-13), polyethylene glycol (14) stearyl ether (steareth-14), polyethylene glycol (15) stearyl ether (steareth-15), polyethylene glycol (16) stearyl ether (steareth-16), polyethylene glycol (17) stearyl ether ( Steareth-17), polyethylene glycol (18) stearyl ether (Steareth-18), polyethylene glycol (19) stearyl ether (Steareth-19), polyethylene glycol (20) stearyl ether (Steareth-20),
Polyethylene glycol (12) isostearyl ether (isosteareth-12), polyethylene glycol (13) isostearyl ether (isosteareth-13), polyethylene glycol (14) isostearyl ether (isosteareth-14), polyethylene glycol (15) isostearyl ether (isosteareth-15), polyethylene glycol (16) isostearyl ether ( Isosteareth-16), polyethylene glycol (17) isostearyl ether (isosteareth-17), polyethylene glycol (18) isostearyl ether (isosteareth-18), polyethylene glycol (19) isostearyl ether (isosteareth-19), polyethylene glycol (20) isostearyl ether (isosteareth-20),
Polyethylene glycol (13) cetyl ether (ceteth-13), polyethylene glycol (14) cetyl ether (ceteth-14), polyethylene glycol (15) cetyl ether (ceteth-15), polyethylene glycol (16) cetyl ether (ceteth-16), polyethylene glycol (17) cetyl ether ( Ceteth-17), polyethylene glycol (18) cetyl ether (ceteth-18), polyethylene glycol (19) cetyl ether (ceteth-19), polyethylene glycol (20) cetyl ether (ceteth-20),
Polyethylene glycol (13) isocetyl ether (isoceteth-13), polyethylene glycol (14) isocetyl ether (isoceteth-14), polyethylene glycol (15) isocetyl ether (isoceteth-15), polyethylene glycol (16) isocetyl ether (isoceteth-16), polyethylene glycol (17) isocetyl ether ( Isoceteth-17), polyethylene glycol (18) isocetyl ether (isoceteth-18), polyethylene glycol (19) isocetyl ether (isoceteth-19), polyethylene glycol (20) isocetyl ether (isoceteth-20),
Polyethylene glycol (12) oleyl ether (oleth-12), polyethylene glycol (13) oleyl ether (oleth-13), polyethylene glycol (14) oleyl ether (oleth-14), polyethylene glycol (15) oleyl ether (oleth-15), polyethylene glycol (12) lauryl ether ( Laureth-12), polyethylene glycol (12) isolauryl ether (Isolaureth-12).
Polyethylene glycol (13) cetyl stearyl ether (ceteareth-13), polyethylene glycol (14) cetyl stearyl ether (ceteareth-14), polyethylene glycol (15) cetyl stearyl ether (ceteareth-15), polyethylene glycol (16) cetyl stearyl ether (ceteareth-16), polyethylene glycol (17) Ceteareth-17), polyethylene glycol (18) cetylstearyl ether (Ceteareth-18), polyethylene glycol (19) cetylstearyl ether (Ceteareth-19), polyethylene glycol (20) cetylstearyl ether (Ceteareth-20).

It is also advantageous to choose the fatty acid ethoxylates from the following group:
Polyethylene glycol (20) stearate, polyethylene glycol (21) stearate, polyethylene glycol (22) stearate, polyethylene glycol (23) stearate, polyethylene glycol (24) stearate, polyethylene glycol (25) stearate, polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate, polyethylene glycol ( 14) isostearate, polyethylene glycol (15) isostearate, polyethylene glycol (16) isostearate, polyethylene glycol (17) isostearate, polyethylene glycol (18) isostearate, polyethylene glycol (19) isostearate, polyethylene glycol (20) isostearate, polyethylene glycol (21) isostearate, polyethylene glycol (22 isostearate, polyethylene glycol (23) isostearate, polyethylene glycol (24) isostearate, polyethylene glycol (25) isostearate, polyethylene glycol (12) oleate, polyethylene glycol (13) oleate, polyethylene glycol (14) oleate, polyethylene glycol (15) oleate, polyethylene glycol (16) oleate, Polyethylene glycol (17) oleate, polyethylene glycol (18) oleate, polyethylene glycol (19) oleate, polyethylene glycol (20) oleate As the ethoxylated alkyl ether carboxylic acid or its salt, sodium laureth-11 carboxylate v be used.

Sodium can be used as the alkyl ether sulfate Laureth 1-4 sulfate can be used advantageously.

As an ethoxylated cholesterol derivative Polyethylene glycol (30) cholesteryl ether can advantageously be used. Polyethylene glycol (25) soyasterol has also proven itself.

As ethoxylated triglycerides can be advantageous which uses polyethylene glycol (60) Evening Primrose Glycerides (Evening Primrose = evening primrose) Furthermore, it is advantageous the polyethylene glycol glycerol fatty acid esters from the group polyethylene glycol (20) glyceryl laurate, Polyethylene glycol (21) glyceryl laurate, polyethylene glycol (22) glyceryl laurate, Polyethylene glycol (23) glyceryl laurate, polyethylene glycol (6) glycerylcapra / caprinate, polyethylene glycol (20) glyceryl oleate, Polyethylene glycol (20) glyceryl isostearate, polyethylene glycol (18) glyceryl oleate / cocoat to choose.

It is also convenient that Sorbitan esters from the group polyethylene glycol (20) sorbitan monolaurate, polyethylene glycol (20) sorbitan monostearate, Polyethylene glycol (20) sorbitan monoisostearate, polyethylene glycol (20) sorbitan monopalmitate, Polyethylene glycol (20) sorbitan monooleate to choose.

Emulsifiers to be used advantageously according to the invention can, for example, advantageously be selected from the group of W / O emulsifiers, for example from the group of fatty alcohols having 8 to 30 carbon atoms, monoglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24 , in particular 12-18 carbon atoms, diglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12-18 carbon atoms, monoglycerol ethers of saturated and / or unsaturated, branched and / or unbranched alcohols a chain length of 8 to 24, in particular 12-18 C atoms, diglycerol ethers of saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 8 to 24, in particular 12-18 C atoms, propylene glycol esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12-18 C atoms, and sorbitan esters of saturated and / or unsaturated, branched and / or or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12-18 carbon atoms.

Particularly advantageous W / O emulsifiers are glyceryl monostearate, glyceryl monoisostearate, glyceryl monomyristate, Glyceryl monooleate, diglyceryl monostearate, diglyceryl monoisostearate, Propylene glycol monostearate, propylene glycol monoisostearate, propylene glycol monocaprylate, Propylene glycol monolaurate, sorbitan monoisostearate, sorbitan monolaurate, Sorbitan monocaprylate, sorbitan monoisooleate, sucrose distearate, Cetyl alcohol, stearyl alcohol, arachidyl alcohol, behenyl alcohol, Isobehenyl alcohol, selachyl alcohol, chimyl alcohol, polyethylene glycol (2) stearyl ether (Steareth-2), glyceryl monolaurate, glyceryl monocaprinate, glyceryl monocaprylate.

Water-soluble silicones can also be advantageous according to the invention can be used as a wetting agent, e.g. PEG-12 dimethicone, PEG / PPG-20/6-dimethicone, PEG / PPG-20/20-dimethicone.

Preparations preferably contain according to the present Invention 0.05-10 % By weight, preferably 0.1-3 % By weight of one or more wetting agents.

The moisturizers ("Moisturizers") can the group of usually for this Used substances selected become and stand out for usually characterized by a more or less pronounced hydroscopicity.

As a humectant can be advantageous Alcohols, diols or polyols of low C number, and their ethers find use, preferably propylene glycol, glycerol, ethylene glycol, Ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, Diethylene glycol monomethyl or monoethyl ether and analog products, low C number alcohols, e.g. Ethanol, isopropanol, 1,2-propanediol or especially glycerin.

Particularly advantageous in the sense Humectants to be used in the present ending can be selected from the group propylene glycol, glycerin, urea, dipropylene glycol, PEG-8, sodium lactate, butylene glycol, myristyl lactate, pentaerythrityl tetrapelargonate, Diglycerin, ethylhexylglycerol, isopropyl palmitate, ceramide 3, erythritol, Triethylene glycol, pentylene glycol, sorbitol, PEG-8 / SMDI copolymer, Betaine, trehalose, methyl propanediol, sodium PCA, hydrogenated polyisobutene, Isostearyl palmitate, sodium myristoyl glutamate, PEG-9 coconut fatty acid glycerides, Polyglycerin-3, polyglyceryl-3 caprate, ethoxydiglycol oleate, xylitol, Methyl propanediol, castor oil fatty acid maleate, Ethylhexyl cocoate, sodium hyaluronate, lactose.

Preparations preferably contain according to the present Invention 0.5-25 % By weight glycerol, preferably 1-10 % By weight of one or more humectants, preferably glycerol, based on the total weight of the preparations. It can be advantageous according to the invention be the preparations of the invention except or add one or more additional humectants in addition to glycerin.

The preparations according to the invention are advantageous Preserved, using the preservative or preservation aid preferably water soluble are.

In particular, the preparations according to the invention advantageously contain one or more substances selected from the group selected from the group of water-soluble preservatives, in particular 3-iodo-2-propynylbutylcarbamate, 4-hydroxybenzoic acid ester, phenoxyethanol,
Phenoxyethanol is particularly effective in acidic and neutral, but also in an alkaline environment and completely non-toxic. There is sufficient protection even in low concentrations. Because of its neutral taste, it quickly found its way into the pharmaceutical and cosmetic industry. However, its effect is mainly directed against gram-negative bacteria.

gekennzeichnet und stellt eine viskose Flüssigkeit von schwachem, leicht angenehmen Geruch und einem zusammenziehenden Geschmack dar. Phenoxyethanol wurde in der Natur nachgewiesen in tropischen Früchten, in Cichorium endivia sowie in grünem Tee (Camellia sinesis). Es hat einen milden, rosenähnlichen Duft und wird für Parfümkompositionen auch als Fixatur eingesetzt. Es ist mischbar mit Aceton, Ethylalkohol und Glycerin, löslich in Wasser und Fetten, z.B. Oliven- und Erdnußöl.Phenoxyethanol is by its chemical structure

characterized and represents a viscous liquid with a weak, slightly pleasant smell and a contracting taste. Phenoxyethanol has been found in nature in tropical fruits, in Cichorium endivia and in green tea (Camellia sinesis). It has a mild, rose-like fragrance and is also used as a fixative for perfume compositions. It is miscible with acetone, ethyl alcohol and glycerin, soluble in water and fats, e.g. olive and peanut oil.

According to the invention, phenoxyethanol is used in cosmetics or dermatological compositions used, a content 0.01-20.0 % By weight, based on the total weight of the composition accordingly. The compositions advantageously contain 0.02-10.0% by weight, particularly preferably 0.02-5.0% by weight of phenoxyethanol, very particularly advantageously 0.25-3.0% by weight, based on the total weight of the composition.

4-hydroxybenzoic acid esters (paraben esters, PHB esters) are used in free form or as sodium salts for the preservation of fish and meat products, mayonnaise, salad dressings, cosmetic preparations advice, drugs, etc. used.

The most important as a preservative 4-hydroxybenzoic acid are 4-hydroxybenzoic acid methyl esters, Ethyl 4-hydroxybenzoate, 4-hydroxybenzoate, 4-hydroxybenzoate. The methyl ester was also identified as a sex attractant for bitches in heat.

The often only methyl, ethyl, propyl, Butyl and isobutyl paraben called 4-hydroxybenzoic acid esters soluble in alcohol and ether, dissolve in alkali they are forming salt. The effect of the esters is directly proportional to chain length of the alkyl radical, conversely the solubility decreases with increasing chain length. As non-dissociating compounds, the esters are largely independent of pH and work in a pH range of 3.0–8.0. The antimicrobial mechanism of action is based on damage of the microbe membranes due to the surface activity of the PHB esters and on the Protein denaturation. Interactions with coenzymes also occur. The effect judges against fungi, yeasts and bacteria. Since PHB esters start at one Concentration of approx. 0.08% in the food to taste impairments to lead, use in food is declining sharply.

4-Hydroxybenzoic acid esters preferred according to the invention are methyl 4-hydroxybenzoate, ethyl 4-hydroxybenzoate, 4-hydroxybenzoate, Isopropyl 4-hydroxybenzoate, butyl 4-hydroxybenzoate, 4-Hydroxybenzoesäureisobutylester.

According to the 4-hydroxybenzoic acid ester used in cosmetic or dermatological compositions, grading 0.01-20.0 % By weight, based on the total weight of the composition accordingly. The compositions advantageously contain 0.02-10.0% by weight, particularly preferably 0.02-5.0 % By weight of one or more 4-hydroxybenzoic acid esters, very particularly advantageous 0.1-3.0 % By weight, in each case based on the total weight of the composition.

3-Iodo-2-propynyl butyl carbamate is characterized by the chemical structural formula

According to the invention, 3-iodo-2-propynyl butyl carbamate used in cosmetic or dermatological compositions, grading 0.01-20.0 % By weight, based on the total weight of the composition accordingly. The compositions advantageously contain 0.01-10.0% by weight, particularly preferably 0.01-5.0 % By weight of 3-iodo-2-propynyl butyl carbamate, very particularly advantageous 0.01-3.0 % By weight, based on the total weight of the composition.

Another beneficial water soluble Preservative in the sense of the present invention is hexamidine isethionate (4,4'-diamidino-α.ω-diphenoxyhexanisethionat).

Hexamidine isethionate is characterized by the chemical structural formula

Hexamidine isethionate is advantageous according to the invention used in cosmetic or dermatological compositions, grading 0.01-20.0 % By weight, based on the total weight of the composition accordingly. The compositions advantageously contain 0.02-10.0% by weight, particularly preferably 0.02-5.0 % By weight of phenoxyethanol, very particularly advantageously 0.05-0.15% by weight, based on the total weight of the composition.

Another beneficial water soluble Preservative in the sense of the present invention is DMDM Hydantoin (1,3-dimethylol-5,5-dimethylhydantoin).

DMDM Hydantoin is characterized by the chemical structural formula

DMDM hydantoin is advantageous according to the invention used in cosmetic or dermatological compositions, grading 0.01-20.0 % By weight, based on the total weight of the composition accordingly. The compositions advantageously contain 0.02-10.0% by weight, particularly preferably 0.02-5.0 % By weight of phenoxyethanol, very particularly advantageously 0.2-0.7% by weight, based on the total weight of the composition.

Another beneficial water soluble Preservative in the sense of the present extension is diazolidinyl urea (N- [1,3-bis (hydroxymethyl) -2,5-dioxo-4-imidazolidinyl] -N.N'-bis (hydroxymethyl) urea).

Diazolidinyl urea is characterized by the chemical structural formula

Diazolidinyl is advantageous according to the invention Urea in cosmetic or dermatological compositions used, a content of 0.01-20.0 % By weight, based on the total weight of the composition accordingly. The compositions advantageously contain 0.02-10.0% by weight, particularly preferably 0.02-5.0 % By weight of phenoxyethanol, very particularly advantageously 0.1-0.3% by weight, based on the total weight of the composition.

The cosmetic preparations in the For the purposes of the present extension also gel character if desired have, in addition to an effective content of the used according to the invention Substances and therefore usually solvents used, preferably water, still further organic thickeners, e.g. Gum arabic, xanthan gum, sodium alginate, starch and starch derivatives (e.g. distarch phosphate), Cellulose, cellulose derivatives, preferably methyl cellulose, hydroxymethyl cellulose, Hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose or inorganic thickeners, e.g. B. aluminum silicates such as for example organically modified or unmodified hectorites, Bentonite, or the like, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate, as well as in particular one or more thickeners, which or which advantageous chosen can be from the group silicon dioxide, polysaccharides or their derivatives, e.g. hyaluronic acid, Xanthan gum, particularly advantageous from the group of polyacrylates, preferably a polyacrylate from the group of the so-called carbopoles, for example carbopole types 980, 981, 1382, 2984, 5984, respectively individually or in combination.

The thickener is in that Gel e.g. in an amount between 0.1 and 30% by weight, preferably between 0.5 and 15 wt .-% included.

The following examples are intended clarify the present invention.

example 1 Wt .-% ethanol 10.00 glycerin 5.00 2-phenylbenzimidazole-5-sulfonic acid 3.00 Phenylene-1,4-bis- (2-benzimidaryl) -3,3'-5,5'-tetrasulfonic 2.00 PEG-40 Hydrogenated castor oil 0.50 cocoamidopropyl 0.50 phenoxyethanol 0.50 methylparaben 0.20 caustic soda PH value attitude Perfume qs water ad 100.00 Example 2 Wt .-% ethanol 20.00 Phenylene-1,4-bis- (2-benzimidaryl) -3,3'-5,5'-tetrasulfonic 5.00 2-phenylbenzimidazole-5-sulfonic acid 5.00 butylene 5.00 polysaccharide 1.00 PEG-12 dimethicone methylparaben 0.20 3-iodo-2-propynyl butyl carbamate 0.05 caustic soda PH value attitude Perfume qs water ad 100.00 Example 3 Wt .-% glycerin 5.00 PEG-8 2.50 2-phenylbenzimidazole-5-sulfonic acid 3.00 Phenylene-1,4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic 1.00 Carbomer 0.70 phenoxyethanol 0.45 xylitol 0.25 diazolidinyl 0.25 sodium hyaluronate 0.05 water ad 100.00 Example 4 Wt .-% methyl propanediol 6.00 Phenylene-1,4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic 6.00 2-phenylbenzimidazole-5-sulfonic acid 4.00 hydroxyethyl 0.50 Fucogel® 1000 0.30 lauryl glycoside 2.50 DMDM hydantoin 0.30 caustic soda PH value attitude water ad 100.00 Example 5 Wt .-% ethanol 15.00 Phenylene-1,4-bis- (2-benzimidaryl) -3,3'-5,5'-tetrasulfonic 5.00 2-phenylbenzimidazole-5-sulfonic acid 5.00 butylene 8.00 Polyacrylic acid, sodium salt 2.00 methylparaben 0.20 Polyethylene-20-stearyl ether 1.00 Mica, titanium dioxide, iron oxide 1.00 Perfume qs water ad 100.00 Example 6 Wt .-% ethanol 15.00 Phenylene-1,4-bis- (2-benzimidaryl) -3,3'-5,5'-tetrasulfonic 5.00 2-phenylbenzimidazole-5-sulfonic acid 5.00 butylene 8.00 Polyacrylic acid, sodium salt 2.00 methylparaben 0.20 , sodium 0.30 Unispheres © UE-507 1.00 Perfume qs water ad 100.00 Example 7 Wt .-% ethanol 5.00 Propane-1,2-diol 3.00 sorbitol 2.00 2-phenylbenzimidazole-5-sulfonic acid 3.00 Phenylene-l, 4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic 2.00 Polyethylene-20-stearyl ether 3.00 methylparaben 0.20 caustic soda PH value attitude Perfume qs water ad 100.00

Claims (8)

Containing aqueous cosmetic or dermatological preparations (a) 0.05-15% by weight of 2-phenylbenzimidazole-5-sulfonic acid or one or more of its salts and / or 0.05-15% by weight of phenylene-1,4-bis- (2-benzimidazyl ) -3,3'-5,5'-tetrasulfonic acid or one or more of its salts, (b) 50-98.5% by weight of water, (c) 0-30% by weight of ethanol (d) or more wetting agents selected from the group of surface-active or surface-active substances, (e) if desired, one or more moisturizers (“moisturizers”) (f) optionally further cosmetic auxiliaries and / or additives, but fats, oils and waxes at most 5% by weight .% of the preparation and preferably avoiding fats, oils and waxes, (g) and the preparations are not emulsions. Preparations according to Claim 1, containing 0.5-5.0% by weight 2-phenylbenzimidazole-5-sulfonic acid or one or more of their salts. Preparations according to Claim 1, containing 0.5-5.0% by weight Phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid or one or more of their salts. Preparations according to claim 1, characterized in that a weight ratio of 2-phenylbenzimidazole-5-sulfonic acid to phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid the range from 5: 1 to 1: 5, preferably from the range from 3 : 1 to 1: 3, particularly preferably approximately 2: 1, is selected. Preparations according to claim 1, characterized in that the or the humectant is chosen or become lower from the group of alcohols, diols or polyols C number, as well as their Find ethers, preferably propylene glycol, glycerol, Ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, -monoethyl or monobutyl ether, diethylene glycol monomethyl or -monoethyl ether and analog products, furthermore lower alcohols C number, e.g. Ethanol, isopropanol, 1,2-propanediol or in particular Glycerol. Preparations according to Claim 1, characterized in that they contain 0.5-25% by weight Glycerin, preferably 1-10 % By weight of one or more humectants, preferably glycerol, based on the total weight of the preparations. Preparations according to Claim 1, characterized in that they contain 0.5-25% by weight Ethanol, preferably 5-20% by weight, based on the total weight of the preparations. Preparations according to Claim 1, characterized in that they contain 0.05-10% by weight, preferably 0.1-3% by weight, based on the total weight of the preparations, one or more Contains wetting agents.