DE10227508A1 - Säuregruppen-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung - Google Patents

Säuregruppen-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung Download PDF

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Publication number
DE10227508A1
DE10227508A1 DE10227508A DE10227508A DE10227508A1 DE 10227508 A1 DE10227508 A1 DE 10227508A1 DE 10227508 A DE10227508 A DE 10227508A DE 10227508 A DE10227508 A DE 10227508A DE 10227508 A1 DE10227508 A1 DE 10227508A1
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DE
Germany
Prior art keywords
alkyl
phenyl
cooh
agonists
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10227508A
Other languages
German (de)
English (en)
Inventor
Gerhard Dr. Jaehne
Wendelin Dr. Frick
Stefanie Dr. Flohr
Andreas Dr. Lindenschmidt
Heiner Dr. Glombik
Werner Prof. Dr. Kramer
Hubert Dr. Heuer
Hans-Ludwig Dr. Schaefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DE10227508A priority Critical patent/DE10227508A1/de
Priority to UAA200500488A priority patent/UA78577C2/uk
Priority to SV2003001548A priority patent/SV2004001548A/es
Priority to EP03735535A priority patent/EP1517891B1/de
Priority to HR20041201A priority patent/HRPK20041201B3/xx
Priority to PCT/EP2003/005816 priority patent/WO2004000805A1/de
Priority to YUP-1084/04A priority patent/RS108404A/sr
Priority to KR10-2004-7020643A priority patent/KR20050008835A/ko
Priority to MXPA04012093A priority patent/MXPA04012093A/es
Priority to BR0311896-7A priority patent/BR0311896A/pt
Priority to CNB038143321A priority patent/CN100467448C/zh
Priority to RU2005101093/04A priority patent/RU2287522C2/ru
Priority to PL03372700A priority patent/PL372700A1/xx
Priority to JP2004514661A priority patent/JP2005533073A/ja
Priority to CA002490112A priority patent/CA2490112A1/en
Priority to OA1200400331A priority patent/OA12869A/en
Priority to HK05111396.2A priority patent/HK1079511B/xx
Priority to AU2003238210A priority patent/AU2003238210B2/en
Priority to PE2003000596A priority patent/PE20040564A1/es
Priority to UY27853A priority patent/UY27853A1/es
Priority to ARP030102144A priority patent/AR039690A1/es
Priority to TW092116321A priority patent/TW200413311A/zh
Priority to HN2003000185A priority patent/HN2003000185A/es
Priority to PA20038576101A priority patent/PA8576101A1/es
Priority to US10/463,388 priority patent/US7176193B2/en
Publication of DE10227508A1 publication Critical patent/DE10227508A1/de
Priority to MA27954A priority patent/MA27206A1/fr
Priority to IL16578904A priority patent/IL165789A0/xx
Priority to TNP2004000250A priority patent/TNSN04250A1/en
Priority to EC2004005497A priority patent/ECSP045497A/es
Priority to NO20050134A priority patent/NO20050134L/no
Priority to US11/643,890 priority patent/US7388004B2/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE10227508A 2002-06-19 2002-06-19 Säuregruppen-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung Withdrawn DE10227508A1 (de)

Priority Applications (31)

Application Number Priority Date Filing Date Title
DE10227508A DE10227508A1 (de) 2002-06-19 2002-06-19 Säuregruppen-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
UAA200500488A UA78577C2 (en) 2002-06-19 2003-04-06 Diphenylazetidinons with substituted acid groups, method for production thereof, drugs containing and use thereof
SV2003001548A SV2004001548A (es) 2002-06-19 2003-06-02 Difenilazetidinonas sustituidas en grupo acido, procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso
OA1200400331A OA12869A (en) 2002-06-19 2003-06-04 Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof.
HR20041201A HRPK20041201B3 (en) 2002-06-19 2003-06-04 Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof
PCT/EP2003/005816 WO2004000805A1 (de) 2002-06-19 2003-06-04 Säuregruppen-substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
YUP-1084/04A RS108404A (sr) 2002-06-19 2003-06-04 Difenil-azetidinoni supstituisani kiselinskim grupama, postupak za njihovu proizvodnju, lekovi koji sadrže ova jedinjenja i njihova primena
KR10-2004-7020643A KR20050008835A (ko) 2002-06-19 2003-06-04 산성 그룹에 의해 치환된 디페닐 아제티디논, 이의 제조방법, 당해 화합물을 함유하는 약제 및 이의 용도
MXPA04012093A MXPA04012093A (es) 2002-06-19 2003-06-04 Difenilazetidinonas sustituidas con grupos acidos, metodo para su produccion, medicamentos que comprenden dichos compuestos y su uso.
BR0311896-7A BR0311896A (pt) 2002-06-19 2003-06-04 Difenilazetidinonas substituìdas com grupos ácidos, processo para sua preparação, medicamentos contendo estes compostos e seu uso
CNB038143321A CN100467448C (zh) 2002-06-19 2003-06-04 被酸性基团取代的二苯基氮杂环丁酮、其制备方法、含有它们的药物及其用途
RU2005101093/04A RU2287522C2 (ru) 2002-06-19 2003-06-04 Замещенные кислотными группами дифенилазетидиноны, способ их получения, содержащие эти соединения лекарственные средства и их применение
PL03372700A PL372700A1 (en) 2002-06-19 2003-06-04 Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof
JP2004514661A JP2005533073A (ja) 2002-06-19 2003-06-04 酸性基によって置換されたジフェニルアゼチジノン、その製造方法、該化合物を含む医薬およびそれらの使用
CA002490112A CA2490112A1 (en) 2002-06-19 2003-06-04 Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof
EP03735535A EP1517891B1 (de) 2002-06-19 2003-06-04 Säuregruppen substituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
HK05111396.2A HK1079511B (en) 2002-06-19 2003-06-04 Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof
AU2003238210A AU2003238210B2 (en) 2002-06-19 2003-06-04 Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof
PE2003000596A PE20040564A1 (es) 2002-06-19 2003-06-16 Difenilazetidinonas sustituidas en grupo acido, procedimiento para su preparacion y medicamentos que comprenden estos compuestos
UY27853A UY27853A1 (es) 2002-06-19 2003-06-16 Difenilazetidinonas sustituidas en grupo acido, procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso.
ARP030102144A AR039690A1 (es) 2002-06-19 2003-06-17 Difenilazetidinonas sustituidas por grupos acidos, medicamentos que comprenden estos compuestos y su uso
TW092116321A TW200413311A (en) 2002-06-19 2003-06-17 Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
HN2003000185A HN2003000185A (es) 2002-06-19 2003-06-17 Difenilazetidinonas sustituidas en grupo acido, procedimiemto para su preparacion, medicamentos que comprenden estso compuestos y su uso.
PA20038576101A PA8576101A1 (es) 2002-06-19 2003-06-18 Difenilazetidinonas sustituidas en grupo acido, procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso
US10/463,388 US7176193B2 (en) 2002-06-19 2003-06-18 Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
MA27954A MA27206A1 (fr) 2002-06-19 2004-11-16 Azetidinones substituees par des groupements acides, procede pour leur preparation, medicaments contenant lesdits composes et utilisation de ceux-ci.
IL16578904A IL165789A0 (en) 2002-06-19 2004-12-15 Diphenyl azetidinones substituted by acidic groupsmethod for their production medicaments containin g said compounds and use thereof
TNP2004000250A TNSN04250A1 (en) 2002-06-19 2004-12-16 Diphenyl azetidinones substituted by acidic groups, method for their production, medicaments containing said compounds and use thereof.
EC2004005497A ECSP045497A (es) 2002-06-19 2004-12-16 "difenilazetidinonas sustituidas con grupos acidos, metodo para su producción, medicamentos que comprenden dichos compuestos y su uso"
NO20050134A NO20050134L (no) 2002-06-19 2005-01-11 Difenylazetidioner substituert med syregrupper, fremgangsmate for fremstilling av disse, medikamenter inneholdende disse forbindelser og deres anvendelse
US11/643,890 US7388004B2 (en) 2002-06-19 2006-12-22 Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10227508A DE10227508A1 (de) 2002-06-19 2002-06-19 Säuregruppen-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (1)

Publication Number Publication Date
DE10227508A1 true DE10227508A1 (de) 2004-01-08

Family

ID=29719283

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10227508A Withdrawn DE10227508A1 (de) 2002-06-19 2002-06-19 Säuregruppen-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Country Status (28)

Country Link
EP (1) EP1517891B1 (https=)
JP (1) JP2005533073A (https=)
KR (1) KR20050008835A (https=)
CN (1) CN100467448C (https=)
AR (1) AR039690A1 (https=)
AU (1) AU2003238210B2 (https=)
BR (1) BR0311896A (https=)
CA (1) CA2490112A1 (https=)
DE (1) DE10227508A1 (https=)
EC (1) ECSP045497A (https=)
HN (1) HN2003000185A (https=)
HR (1) HRPK20041201B3 (https=)
IL (1) IL165789A0 (https=)
MA (1) MA27206A1 (https=)
MX (1) MXPA04012093A (https=)
NO (1) NO20050134L (https=)
OA (1) OA12869A (https=)
PA (1) PA8576101A1 (https=)
PE (1) PE20040564A1 (https=)
PL (1) PL372700A1 (https=)
RS (1) RS108404A (https=)
RU (1) RU2287522C2 (https=)
SV (1) SV2004001548A (https=)
TN (1) TNSN04250A1 (https=)
TW (1) TW200413311A (https=)
UA (1) UA78577C2 (https=)
UY (1) UY27853A1 (https=)
WO (1) WO2004000805A1 (https=)

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Publication number Priority date Publication date Assignee Title
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
EP1699759B1 (en) 2003-12-23 2010-10-20 AstraZeneca AB Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
CN101115726A (zh) 2004-12-03 2008-01-30 先灵公司 作为cb1拮抗剂的取代哌嗪
US8361999B2 (en) 2005-04-04 2013-01-29 Pontificia Universidad Catolica De Chile Methods of treating cholesterol gallstone disease with ezetimibe
DE602006010870D1 (de) 2005-06-20 2010-01-14 Schering Corp Als antagonisten von histamin h3 geeignete piperidinderivate
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
CN103382174A (zh) * 2006-06-23 2013-11-06 雅培制药有限公司 作为组胺h3受体调节物的环丙胺衍生物
JP2010500300A (ja) 2006-08-08 2010-01-07 サノフィ−アベンティス アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
DE102007002260A1 (de) 2007-01-16 2008-07-31 Sanofi-Aventis Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CN101200443B (zh) * 2007-10-17 2011-06-29 中国药科大学 氮杂环丁酮衍生物、其制备方法及含有它们的药物组合
DE102007054497B3 (de) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
CA2754384A1 (en) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
MX2012001729A (es) 2009-08-26 2012-06-13 Sanofi Sa Nuevos hidratos cristalinos de fluoroglicosido heteroaromatico, productos farmaceuticos que comprenden estos compuestos, y su empleo.
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
KR102919209B1 (ko) 2018-08-10 2026-01-28 다이아핀 테라퓨틱스, 엘엘씨 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료

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US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
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IL156552A0 (en) * 2000-12-21 2004-01-04 Aventis Pharma Gmbh Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
HRP20030498A2 (en) * 2000-12-21 2005-04-30 Aventis Pharma Deutschland Gmbh Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism

Also Published As

Publication number Publication date
HN2003000185A (es) 2005-10-20
NO20050134D0 (no) 2005-01-11
JP2005533073A (ja) 2005-11-04
MXPA04012093A (es) 2005-04-19
NO20050134L (no) 2005-03-18
HRP20041201A2 (en) 2005-08-31
PA8576101A1 (es) 2004-02-07
AU2003238210A1 (en) 2004-01-06
RU2287522C2 (ru) 2006-11-20
BR0311896A (pt) 2005-04-05
IL165789A0 (en) 2006-01-15
AR039690A1 (es) 2005-03-09
UA78577C2 (en) 2007-04-10
HRPK20041201B3 (en) 2006-12-31
CA2490112A1 (en) 2003-12-31
TW200413311A (en) 2004-08-01
CN1662495A (zh) 2005-08-31
AU2003238210B2 (en) 2008-10-23
ECSP045497A (es) 2005-03-10
TNSN04250A1 (en) 2007-03-12
KR20050008835A (ko) 2005-01-21
HK1079511A1 (zh) 2006-04-07
RS108404A (sr) 2007-02-05
EP1517891B1 (de) 2013-04-03
EP1517891A1 (de) 2005-03-30
PL372700A1 (en) 2005-07-25
WO2004000805A1 (de) 2003-12-31
MA27206A1 (fr) 2005-01-03
RU2005101093A (ru) 2005-07-20
SV2004001548A (es) 2004-03-19
CN100467448C (zh) 2009-03-11
OA12869A (en) 2006-09-15
UY27853A1 (es) 2003-12-31
PE20040564A1 (es) 2004-10-25

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