DE10227506A1 - Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung - Google Patents

Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung Download PDF

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Publication number
DE10227506A1
DE10227506A1 DE10227506A DE10227506A DE10227506A1 DE 10227506 A1 DE10227506 A1 DE 10227506A1 DE 10227506 A DE10227506 A DE 10227506A DE 10227506 A DE10227506 A DE 10227506A DE 10227506 A1 DE10227506 A1 DE 10227506A1
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DE
Germany
Prior art keywords
alkyl
phenyl
substituted
conh
agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10227506A
Other languages
German (de)
English (en)
Inventor
Gerhard Dr. Jaehne
Wendelin Dr. Frick
Stefanie Dr. Flohr
Andreas Dr. Lindenschmidt
Heiner Dr. Glombik
Werner Prof. Dr. Kramer
Hubert Dr. Heuer
Hans-Ludwig Dr. Schaefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DE10227506A priority Critical patent/DE10227506A1/de
Priority to HN2003000183A priority patent/HN2003000183A/es
Priority to SV2003001549A priority patent/SV2004001549A/es
Priority to EP03760591A priority patent/EP1517892B1/de
Priority to RU2005101091/04A priority patent/RU2315754C2/ru
Priority to HR20041203A priority patent/HRP20041203A2/xx
Priority to OA1200400330A priority patent/OA12868A/en
Priority to NZ537304A priority patent/NZ537304A/en
Priority to YUP-1085/04A priority patent/RS108504A/sr
Priority to CA002490109A priority patent/CA2490109A1/en
Priority to JP2004514660A priority patent/JP2005533072A/ja
Priority to PL03372690A priority patent/PL372690A1/xx
Priority to AT03760591T priority patent/ATE478842T1/de
Priority to CN03814087XA priority patent/CN1662493A/zh
Priority to DE50313017T priority patent/DE50313017D1/de
Priority to AU2003242616A priority patent/AU2003242616B2/en
Priority to MXPA04012236A priority patent/MXPA04012236A/es
Priority to PCT/EP2003/005815 priority patent/WO2004000804A1/de
Priority to BR0311940-8A priority patent/BR0311940A/pt
Priority to UY27851A priority patent/UY27851A1/es
Priority to ARP030102142A priority patent/AR039689A1/es
Priority to TW092116319A priority patent/TW200404774A/zh
Priority to PE2003000613A priority patent/PE20040577A1/es
Priority to MYPI20032289A priority patent/MY135850A/en
Priority to PA20038576001A priority patent/PA8576001A1/es
Priority to US10/463,807 priority patent/US7176194B2/en
Publication of DE10227506A1 publication Critical patent/DE10227506A1/de
Priority to ZA200409381A priority patent/ZA200409381B/xx
Priority to MA27990A priority patent/MA27252A1/fr
Priority to IL16579104A priority patent/IL165791A0/xx
Priority to EC2004005498A priority patent/ECSP045498A/es
Priority to TNP2004000255A priority patent/TNSN04255A1/en
Priority to NO20050073A priority patent/NO20050073L/no
Priority to US11/501,758 priority patent/US7579339B2/en
Priority to US11/544,718 priority patent/US7390790B2/en
Priority to US11/544,746 priority patent/US7407938B2/en
Withdrawn legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE10227506A 2002-06-19 2002-06-19 Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung Withdrawn DE10227506A1 (de)

Priority Applications (35)

Application Number Priority Date Filing Date Title
DE10227506A DE10227506A1 (de) 2002-06-19 2002-06-19 Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
HN2003000183A HN2003000183A (es) 2002-06-19 2003-01-17 Difenilazetidinonas sustituidas en anillo procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso.
SV2003001549A SV2004001549A (es) 2002-06-19 2003-06-02 Difenilazetidinonas sustituidas en anillo, procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso
PCT/EP2003/005815 WO2004000804A1 (de) 2002-06-19 2003-06-04 Ringsubstituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
RU2005101091/04A RU2315754C2 (ru) 2002-06-19 2003-06-04 Циклическизамещенные дифенилазетидиноны, применение их для получения лекарственного средства
HR20041203A HRP20041203A2 (en) 2002-06-19 2003-06-04 Ring-substituted diphenyl azetidinones, method for the production thereof, medicaments containing said compounds, and use thereof
OA1200400330A OA12868A (en) 2002-06-19 2003-06-04 Ring-substituted diphenyl azetidinones, method forthe production thereof, medicaments containing sa id compounds and use thereof.
NZ537304A NZ537304A (en) 2002-06-19 2003-06-04 Ring-substituted diphenyl azetidinones, method for the production thereof, medicaments containing said compounds, and use thereof
YUP-1085/04A RS108504A (sr) 2002-06-19 2003-06-04 Difenil azetidinoni supstituisani prsten, postupak za njihovu proizvodnju, lekovi koji sadrže ova jedinjenja i njihova primena
CA002490109A CA2490109A1 (en) 2002-06-19 2003-06-04 Ring-substituted diphenyl azetidinones, method for the production thereof, medicaments containing said compounds, and use thereof
JP2004514660A JP2005533072A (ja) 2002-06-19 2003-06-04 環置換されたジフェニルアゼチジノン、その製造方法、該化合物を含む医薬およびそれらの使用
PL03372690A PL372690A1 (en) 2002-06-19 2003-06-04 Ring-substituted diphenyl azetidinones, method for the production thereof, medicaments containing said compounds, and use thereof
AT03760591T ATE478842T1 (de) 2002-06-19 2003-06-04 Ringsubstituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
CN03814087XA CN1662493A (zh) 2002-06-19 2003-06-04 环取代的二苯基2-吖丁啶酮、其制备方法、含有所述化合物的药物及其用途
DE50313017T DE50313017D1 (de) 2002-06-19 2003-06-04 Ringsubstituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
AU2003242616A AU2003242616B2 (en) 2002-06-19 2003-06-04 Ring-substituted diphenyl azetidinones, method for the production thereof, medicaments containing said compounds, and use thereof
MXPA04012236A MXPA04012236A (es) 2002-06-19 2003-06-04 Difenilazetidinonas sustituidas en anillo, metodo para su produccion, medicamentos que comprenden estos compuestos y su uso.
EP03760591A EP1517892B1 (de) 2002-06-19 2003-06-04 Ringsubstituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
BR0311940-8A BR0311940A (pt) 2002-06-19 2003-06-04 Difenilazetidinonas substituìdas no anel, processo para produção das mesmas, medicamentos que contêm esses compostos e uso dos mesmos
UY27851A UY27851A1 (es) 2002-06-19 2003-06-16 Difenilazetidinonas sustituidas en anillo, procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso.
ARP030102142A AR039689A1 (es) 2002-06-19 2003-06-17 Difenilazetidinonas sustituidas, medicamentos que comprenden estos compuestos y su uso
TW092116319A TW200404774A (en) 2002-06-19 2003-06-17 Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
PE2003000613A PE20040577A1 (es) 2002-06-19 2003-06-18 Difenilazetidinonas sustituidas en anillo, procedimiento para su preparacion y medicamentos que las comprenden
MYPI20032289A MY135850A (en) 2002-06-19 2003-06-18 Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
PA20038576001A PA8576001A1 (es) 2002-06-19 2003-06-18 "difenilazetidinonas sustituidas en anillo, procedimiento para su preparacion , medicamentos que comprenden estos compuestos y su uso".
US10/463,807 US7176194B2 (en) 2002-06-19 2003-06-18 Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
ZA200409381A ZA200409381B (en) 2002-06-19 2004-11-22 Ring-substituted diphenyl azetidones, method for the production thereof, medicaments containing said compounds, and use thereof
MA27990A MA27252A1 (fr) 2002-06-19 2004-12-08 Diphenylazetidinones substituees, leur procede de preparation, medicaments contenant ces composes et leur utilisation
IL16579104A IL165791A0 (en) 2002-06-19 2004-12-15 Ring-substituted diphenyl azetidinones method for the production thereof medicaments containing saidcompounds and use thereof
EC2004005498A ECSP045498A (es) 2002-06-19 2004-12-16 "difenilazetidinonas sustituidas en anillo, metodo para su producción, medicamentos que comprenden estos compuestos y su uso"
TNP2004000255A TNSN04255A1 (en) 2002-06-19 2004-12-17 Ring-substituted diphenyl azetidinones, method for the production thereof, medicaments containing said compounds, and use thereof.
NO20050073A NO20050073L (no) 2002-06-19 2005-01-06 Ringsubstituerte difenylazetidinoner, deres fremstilling, deres anvendelse samt legemidler inneholdende forbindelsene
US11/501,758 US7579339B2 (en) 2002-06-19 2006-08-10 Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US11/544,718 US7390790B2 (en) 2002-06-19 2006-10-10 Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US11/544,746 US7407938B2 (en) 2002-06-19 2006-10-10 Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10227506A DE10227506A1 (de) 2002-06-19 2002-06-19 Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (1)

Publication Number Publication Date
DE10227506A1 true DE10227506A1 (de) 2004-01-08

Family

ID=29719281

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10227506A Withdrawn DE10227506A1 (de) 2002-06-19 2002-06-19 Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE50313017T Expired - Lifetime DE50313017D1 (de) 2002-06-19 2003-06-04 Ringsubstituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50313017T Expired - Lifetime DE50313017D1 (de) 2002-06-19 2003-06-04 Ringsubstituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Country Status (30)

Country Link
EP (1) EP1517892B1 (https=)
JP (1) JP2005533072A (https=)
CN (1) CN1662493A (https=)
AR (1) AR039689A1 (https=)
AT (1) ATE478842T1 (https=)
AU (1) AU2003242616B2 (https=)
BR (1) BR0311940A (https=)
CA (1) CA2490109A1 (https=)
DE (2) DE10227506A1 (https=)
EC (1) ECSP045498A (https=)
HN (1) HN2003000183A (https=)
HR (1) HRP20041203A2 (https=)
IL (1) IL165791A0 (https=)
MA (1) MA27252A1 (https=)
MX (1) MXPA04012236A (https=)
MY (1) MY135850A (https=)
NO (1) NO20050073L (https=)
NZ (1) NZ537304A (https=)
OA (1) OA12868A (https=)
PA (1) PA8576001A1 (https=)
PE (1) PE20040577A1 (https=)
PL (1) PL372690A1 (https=)
RS (1) RS108504A (https=)
RU (1) RU2315754C2 (https=)
SV (1) SV2004001549A (https=)
TN (1) TNSN04255A1 (https=)
TW (1) TW200404774A (https=)
UY (1) UY27851A1 (https=)
WO (1) WO2004000804A1 (https=)
ZA (1) ZA200409381B (https=)

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EP1699759B1 (en) 2003-12-23 2010-10-20 AstraZeneca AB Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
CN101115726A (zh) 2004-12-03 2008-01-30 先灵公司 作为cb1拮抗剂的取代哌嗪
US8361999B2 (en) 2005-04-04 2013-01-29 Pontificia Universidad Catolica De Chile Methods of treating cholesterol gallstone disease with ezetimibe
DE602006010870D1 (de) 2005-06-20 2010-01-14 Schering Corp Als antagonisten von histamin h3 geeignete piperidinderivate
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TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
JP2010500300A (ja) 2006-08-08 2010-01-07 サノフィ−アベンティス アリールアミノアリール−アルキル−置換イミダゾリジン−2,4−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用
EP2091915A1 (de) * 2006-11-02 2009-08-26 Sanofi-Aventis Deutschland GmbH Neues mit piperazin-1-sulfonsäure substituiertes diphenylazetidinon mit verbesserten pharmakologischen eigenschaften
DE102007002260A1 (de) 2007-01-16 2008-07-31 Sanofi-Aventis Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102007054497B3 (de) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
CA2754384A1 (en) 2009-03-06 2010-09-10 Lipideon Biotechnology Ag Pharmaceutical hypocholesterolemic compositions
CN101993403B (zh) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 氮杂环丁酮类化合物及医药应用
MX2012001729A (es) 2009-08-26 2012-06-13 Sanofi Sa Nuevos hidratos cristalinos de fluoroglicosido heteroaromatico, productos farmaceuticos que comprenden estos compuestos, y su empleo.
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
KR102919209B1 (ko) 2018-08-10 2026-01-28 다이아핀 테라퓨틱스, 엘엘씨 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료

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US5656624A (en) * 1994-12-21 1997-08-12 Schering Corporation 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents
PT877750E (pt) * 1995-10-31 2002-09-30 Schering Corp 2-azetidinonas substituidas por acucar uteis como agentes hipocolesterolemiantes
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Also Published As

Publication number Publication date
HN2003000183A (es) 2003-08-01
BR0311940A (pt) 2005-04-05
NZ537304A (en) 2005-10-28
SV2004001549A (es) 2004-03-19
JP2005533072A (ja) 2005-11-04
TW200404774A (en) 2004-04-01
OA12868A (en) 2006-09-15
ECSP045498A (es) 2005-03-10
TNSN04255A1 (en) 2007-03-12
UY27851A1 (es) 2003-12-31
AU2003242616B2 (en) 2008-12-11
MXPA04012236A (es) 2005-02-25
RU2315754C2 (ru) 2008-01-27
WO2004000804A1 (de) 2003-12-31
DE50313017D1 (de) 2010-10-07
ZA200409381B (en) 2006-05-31
IL165791A0 (en) 2006-01-15
MY135850A (en) 2008-07-31
RS108504A (sr) 2007-02-05
EP1517892B1 (de) 2010-08-25
CN1662493A (zh) 2005-08-31
AU2003242616A1 (en) 2004-01-06
EP1517892A1 (de) 2005-03-30
NO20050073L (no) 2005-01-06
AR039689A1 (es) 2005-03-09
ATE478842T1 (de) 2010-09-15
CA2490109A1 (en) 2003-12-31
RU2005101091A (ru) 2005-07-10
MA27252A1 (fr) 2005-03-01
PE20040577A1 (es) 2004-10-11
PA8576001A1 (es) 2004-02-07
PL372690A1 (en) 2005-07-25
HRP20041203A2 (en) 2005-06-30

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