AR039689A1 - Difenilazetidinonas sustituidas, medicamentos que comprenden estos compuestos y su uso - Google Patents
Difenilazetidinonas sustituidas, medicamentos que comprenden estos compuestos y su usoInfo
- Publication number
- AR039689A1 AR039689A1 ARP030102142A ARP030102142A AR039689A1 AR 039689 A1 AR039689 A1 AR 039689A1 AR P030102142 A ARP030102142 A AR P030102142A AR P030102142 A ARP030102142 A AR P030102142A AR 039689 A1 AR039689 A1 AR 039689A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- phenyl
- cooh
- replaced
- radicals
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 35
- 229910052731 fluorine Inorganic materials 0.000 abstract 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- -1 COO-(C1-6) alkyl Chemical group 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 229910006069 SO3H Inorganic materials 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000002015 acyclic group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 102000015636 Oligopeptides Human genes 0.000 abstract 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000002016 disaccharides Chemical group 0.000 abstract 1
- 150000002337 glycosamines Chemical class 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 150000004044 tetrasaccharides Chemical group 0.000 abstract 1
- 150000004043 trisaccharides Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10227506A DE10227506A1 (de) | 2002-06-19 | 2002-06-19 | Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039689A1 true AR039689A1 (es) | 2005-03-09 |
Family
ID=29719281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030102142A AR039689A1 (es) | 2002-06-19 | 2003-06-17 | Difenilazetidinonas sustituidas, medicamentos que comprenden estos compuestos y su uso |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1517892B1 (https=) |
| JP (1) | JP2005533072A (https=) |
| CN (1) | CN1662493A (https=) |
| AR (1) | AR039689A1 (https=) |
| AT (1) | ATE478842T1 (https=) |
| AU (1) | AU2003242616B2 (https=) |
| BR (1) | BR0311940A (https=) |
| CA (1) | CA2490109A1 (https=) |
| DE (2) | DE10227506A1 (https=) |
| EC (1) | ECSP045498A (https=) |
| HN (1) | HN2003000183A (https=) |
| HR (1) | HRP20041203A2 (https=) |
| IL (1) | IL165791A0 (https=) |
| MA (1) | MA27252A1 (https=) |
| MX (1) | MXPA04012236A (https=) |
| MY (1) | MY135850A (https=) |
| NO (1) | NO20050073L (https=) |
| NZ (1) | NZ537304A (https=) |
| OA (1) | OA12868A (https=) |
| PA (1) | PA8576001A1 (https=) |
| PE (1) | PE20040577A1 (https=) |
| PL (1) | PL372690A1 (https=) |
| RS (1) | RS108504A (https=) |
| RU (1) | RU2315754C2 (https=) |
| SV (1) | SV2004001549A (https=) |
| TN (1) | TNSN04255A1 (https=) |
| TW (1) | TW200404774A (https=) |
| UY (1) | UY27851A1 (https=) |
| WO (1) | WO2004000804A1 (https=) |
| ZA (1) | ZA200409381B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| US7447226B2 (en) * | 2003-10-31 | 2008-11-04 | International Business Machines Corporation | Methods and apparatus for continuous connectivity between mobile device and network using dynamic connection spreading |
| EP1699759B1 (en) | 2003-12-23 | 2010-10-20 | AstraZeneca AB | Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity |
| CN101115726A (zh) | 2004-12-03 | 2008-01-30 | 先灵公司 | 作为cb1拮抗剂的取代哌嗪 |
| US8361999B2 (en) | 2005-04-04 | 2013-01-29 | Pontificia Universidad Catolica De Chile | Methods of treating cholesterol gallstone disease with ezetimibe |
| DE602006010870D1 (de) | 2005-06-20 | 2010-01-14 | Schering Corp | Als antagonisten von histamin h3 geeignete piperidinderivate |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
| EP2091915A1 (de) * | 2006-11-02 | 2009-08-26 | Sanofi-Aventis Deutschland GmbH | Neues mit piperazin-1-sulfonsäure substituiertes diphenylazetidinon mit verbesserten pharmakologischen eigenschaften |
| DE102007002260A1 (de) | 2007-01-16 | 2008-07-31 | Sanofi-Aventis | Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| CA2754384A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
| CN101993403B (zh) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
| MX2012001729A (es) | 2009-08-26 | 2012-06-13 | Sanofi Sa | Nuevos hidratos cristalinos de fluoroglicosido heteroaromatico, productos farmaceuticos que comprenden estos compuestos, y su empleo. |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| KR102919209B1 (ko) | 2018-08-10 | 2026-01-28 | 다이아핀 테라퓨틱스, 엘엘씨 | 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
| PT877750E (pt) * | 1995-10-31 | 2002-09-30 | Schering Corp | 2-azetidinonas substituidas por acucar uteis como agentes hipocolesterolemiantes |
| DE10042447A1 (de) * | 2000-08-29 | 2002-03-28 | Aventis Pharma Gmbh | Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports |
-
2002
- 2002-06-19 DE DE10227506A patent/DE10227506A1/de not_active Withdrawn
-
2003
- 2003-01-17 HN HN2003000183A patent/HN2003000183A/es unknown
- 2003-06-02 SV SV2003001549A patent/SV2004001549A/es not_active Application Discontinuation
- 2003-06-04 CA CA002490109A patent/CA2490109A1/en not_active Abandoned
- 2003-06-04 MX MXPA04012236A patent/MXPA04012236A/es active IP Right Grant
- 2003-06-04 BR BR0311940-8A patent/BR0311940A/pt not_active IP Right Cessation
- 2003-06-04 OA OA1200400330A patent/OA12868A/en unknown
- 2003-06-04 EP EP03760591A patent/EP1517892B1/de not_active Expired - Lifetime
- 2003-06-04 AT AT03760591T patent/ATE478842T1/de active
- 2003-06-04 RS YUP-1085/04A patent/RS108504A/sr unknown
- 2003-06-04 JP JP2004514660A patent/JP2005533072A/ja not_active Abandoned
- 2003-06-04 WO PCT/EP2003/005815 patent/WO2004000804A1/de not_active Ceased
- 2003-06-04 NZ NZ537304A patent/NZ537304A/en unknown
- 2003-06-04 RU RU2005101091/04A patent/RU2315754C2/ru not_active IP Right Cessation
- 2003-06-04 DE DE50313017T patent/DE50313017D1/de not_active Expired - Lifetime
- 2003-06-04 CN CN03814087XA patent/CN1662493A/zh active Pending
- 2003-06-04 AU AU2003242616A patent/AU2003242616B2/en not_active Ceased
- 2003-06-04 HR HR20041203A patent/HRP20041203A2/xx not_active Application Discontinuation
- 2003-06-04 PL PL03372690A patent/PL372690A1/xx not_active Application Discontinuation
- 2003-06-16 UY UY27851A patent/UY27851A1/es unknown
- 2003-06-17 TW TW092116319A patent/TW200404774A/zh unknown
- 2003-06-17 AR ARP030102142A patent/AR039689A1/es unknown
- 2003-06-18 PE PE2003000613A patent/PE20040577A1/es not_active Application Discontinuation
- 2003-06-18 MY MYPI20032289A patent/MY135850A/en unknown
- 2003-06-18 PA PA20038576001A patent/PA8576001A1/es unknown
-
2004
- 2004-11-22 ZA ZA200409381A patent/ZA200409381B/xx unknown
- 2004-12-08 MA MA27990A patent/MA27252A1/fr unknown
- 2004-12-15 IL IL16579104A patent/IL165791A0/xx unknown
- 2004-12-16 EC EC2004005498A patent/ECSP045498A/es unknown
- 2004-12-17 TN TNP2004000255A patent/TNSN04255A1/en unknown
-
2005
- 2005-01-06 NO NO20050073A patent/NO20050073L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HN2003000183A (es) | 2003-08-01 |
| BR0311940A (pt) | 2005-04-05 |
| NZ537304A (en) | 2005-10-28 |
| SV2004001549A (es) | 2004-03-19 |
| JP2005533072A (ja) | 2005-11-04 |
| TW200404774A (en) | 2004-04-01 |
| OA12868A (en) | 2006-09-15 |
| ECSP045498A (es) | 2005-03-10 |
| TNSN04255A1 (en) | 2007-03-12 |
| UY27851A1 (es) | 2003-12-31 |
| AU2003242616B2 (en) | 2008-12-11 |
| MXPA04012236A (es) | 2005-02-25 |
| RU2315754C2 (ru) | 2008-01-27 |
| WO2004000804A1 (de) | 2003-12-31 |
| DE50313017D1 (de) | 2010-10-07 |
| ZA200409381B (en) | 2006-05-31 |
| DE10227506A1 (de) | 2004-01-08 |
| IL165791A0 (en) | 2006-01-15 |
| MY135850A (en) | 2008-07-31 |
| RS108504A (sr) | 2007-02-05 |
| EP1517892B1 (de) | 2010-08-25 |
| CN1662493A (zh) | 2005-08-31 |
| AU2003242616A1 (en) | 2004-01-06 |
| EP1517892A1 (de) | 2005-03-30 |
| NO20050073L (no) | 2005-01-06 |
| ATE478842T1 (de) | 2010-09-15 |
| CA2490109A1 (en) | 2003-12-31 |
| RU2005101091A (ru) | 2005-07-10 |
| MA27252A1 (fr) | 2005-03-01 |
| PE20040577A1 (es) | 2004-10-11 |
| PA8576001A1 (es) | 2004-02-07 |
| PL372690A1 (en) | 2005-07-25 |
| HRP20041203A2 (en) | 2005-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |