DE102015112331B4 - Manufacturing process for antimicrobial substances - Google Patents

Abstract

A method of manufacturing antimicrobial nanoparticles containing medicinal herb constituents comprising the steps of: (a) drying Rheum Rhababarum, Sophora flavescens var. Flavescens, Forsythia suspensa, Coptis chinensis Franch, Rehmannia glutinosa, Anemarrhena asphodeloides and Scutellaria lateriflora in an oven at 50 ° C for about 6 (b) adding the nanopowders to a solution consisting of 95% by volume of ethanol, the weight ratio of nanopowders to solution being 1:20, heating a water tank with a container filled with it Solution to 50 ° C and extracting the ethanol, (c) adding water to the solution containing container after extracting for two hours, wherein the weight ratio of the nanopowders to water is 1:20, whereby a solution of antimicrobial herbal ingredients is obtained; and (d) drying and concentrating the solution with antimicrobial herbal ingredients in an enrichment machine under reduced pressure at 50 ° C for 6 to 12 hours to obtain antimicrobial nanoparticles containing herbal ingredients.

Description

BACKGROUND OF THE INVENTION

1. Technical area

The invention relates to the processing of antimicrobial substances, and more particularly to an antimicrobial fabricating process.

2. State of the art

Physically, clothing serves several purposes: it can protect against weather. It protects a wearer from rough surfaces and the like by forming a barrier between the skin and the environment. Clothes can be insulated against cold or hot conditions. Furthermore, garments can provide a sanitary protective layer, thus keeping infectious or toxic materials away from the body. Clothing may also provide protection against harmful radiation. In addition, fabrics with antimicrobial and other properties, such as odor absorption, have been developed. Usually, an antimicrobial fabric manufacturing process involves the displacement of filaments with zinc oxide, nano silver, and the like. Although fabric articles that have been treated by adding the metallic compounds to the yarns from which the fabric articles are made are good, the metallic components can present a health hazard.

Therefore, there is still a need for improvement.

In the publication EP 2 192 146 B1 Such a conventional process for producing fibers having antibacterial and odor eliminating properties is described. The production takes place here from a porous polyester premix with antibacterial and odor eliminating functions.

In addition, the document reveals US 2013/0034620 A1 Another conventional antimicrobial fabricating method is to produce antibacterial synthetic fibers by adding an aqueous antibacterial plant extract and wood vinegar to a fiber-forming polymer and to obtain antibacterial fibers with medicinal herb ingredients in the melt-spinning process. These antibacterial fibers can be further processed into an antibacterial fiber fleece and ultimately antibacterial clothing. The antibacterial plant extract is obtained by boiling the pulverized plant parts in water and then concentrating the extract by repeated filtration.

The publication EP 2 132 376 B1 further describes a conventional method in which antibacterial and deodorizing polymer-conjugate fibers are obtained by directly applying a fiber-treating agent to the fibers. The fiber treatment agent contains a plant extract, a nonionic surfactant and / or an anionic surfactant. From the antibacterial fibers antimicrobial everyday items such. As diapers, clothing, etc. are produced.

Additionally, the document describes EP 1 407 679 A1 a production process for liquid plant extracts containing an active ingredient and a plant powder for use as additives in foods.

SUMMARY OF THE INVENTION

Accordingly, it is an object of the present invention to provide a manufacturing process for antimicrobials comprising medicinal herbs ingredients, the process comprising the steps of: drying Rheum Rhababarum, Sophora flavescens var. Flavescens, Forsythia suspensa, Coptis chinensis Franch, Rehmannia glutinosa, Anemarrhena asphodeloides and Scutellaria lateriflora in an oven at 50 ° C for about 6 to 12 hours and grinding it into nanoscale powders, adding the nanopowders to a solution consisting of 95% by volume of ethanol, the weight ratio of nanopowder to solution being 1:20, Heating a water tank having a container with the solution filled therein to 50 ° C and extracting the ethanol, adding water to the solution in the container after extracting for two hours, wherein the weight ratio of the nanopowder to water is 1:20, whereby Solution with antimicrobial medicinal herbs d) delivering about 1 to 3 weight percent sodium dodecyl sulfate to the antimicrobial herbal ingredients solution for emulsification and adding about 5 weight percent acrylic resin to the emulsified solution to form the nanopowder-containing liposomes, adding the liposomes to a foam resin to form a Forming mixture and applying the mixture to the fabrics to fabricate fabrics comprising antimicrobial herbal ingredients.

The above and other objects, features and advantages of the invention will be apparent from the following detailed description taken in conjunction with the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

1 FIG. 3 is a flow chart illustrating a manufacturing process for antimicrobial nanoparticles with herbal ingredients in accordance with the present invention. FIG.

2 FIG. 3 is a flow chart illustrating a manufacturing process for antimicrobial fibers with herbal ingredients according to the present invention; FIG.

3 FIG. 3 is a flow chart illustrating a manufacturing process for antimicrobial agents with herbal ingredients according to the present invention. FIG.

4 shows seven photographs illustrating the growth of the species of Euglena in different environments,

5 FIG. 12 is a table showing results of a first test of antimicrobial capabilities of a substance treated with the antimicrobial solution of the invention with respect to a substance; and FIG

6 Figure 13 is a table showing results of a second test of antimicrobial capabilities of a fabric treated with the antimicrobial solution of the invention with respect to another fabric.

DETAILED DESCRIPTION OF THE INVENTION

In 1 FIG. 3 is a flow chart illustrating a manufacturing process for antimicrobial nanoparticles with herbal ingredients according to the present invention.

The method comprises:

Step 10 with the drying of Rheum Rhababarum, Sophora flavescens var. Flavescens, Forsythia suspensa, Coptis chinensis Franch, Rehmannia glutinosa, Anemarrhena asphodeloides and Scutellaria lateriflora in an oven at 50 ° C for about 6 to 12 hours and milling them into powders in nanoscale.

Step 20 of adding the nanopowder to a solution consisting of 95% by volume of ethanol, wherein the weight ratio of the nanopowders to the solution is 1:20, heating a water tank having a container with the solution filled therein to 50 ° C and extracting the nanopowder ethanol.

Step 30 with adding water to the solution in the container after extracting for two hours. This is necessary because ethanol may be lost during the heating step. As a result, the weight ratio of nanopowder to water is 1:20. What achieves a solution with antimicrobial herbal ingredients.

Step 40 of drying and concentrating the solution with antimicrobial herbal ingredients in an enrichment machine under reduced pressure at 50 ° C for 6 to 12 hours to obtain antimicrobial nanoparticles containing herbal ingredients.

Preferably, the respective proportions by weight of Rheum Rhababarum are 30 weight percent, Sophora flavescens var. Flavescens 10 weight percent, Forsythia suspense 10 weight percent, Coptis chinensis Franch 15 weight percent, Rehmannia glutinosa 15 weight percent, Anemarrhena asphodeloides 5 weight percent and Scutellaria lateriflora 15 weight percent based on the total weight of Rheum Rhababarum, Sophora flavescens var. Flavescens, Forsythia suspensa, Coptis chinensis Franch, Rehmannia glutinosa, Anemarrhena asphodeloides and Scutellaria lateriflora.

The nanopowders preferably have a size of 50 to 500 nanometers.

In 2 Figure 3 is a flow chart illustrating a manufacturing process for antimicrobial fibers with herbal ingredients according to the present invention.

The method comprises:

Step 10 with the drying of Rheum Rhababarum, Sophora flavescens var. Flavescens, Forsythia suspensa, Coptis chinensis Franch, Rehmannia glutinosa, Anemarrhena asphodeloides and Scutellaria lateriflora in an oven at 50 ° C for about 6 to 12 hours and milling them into powders in nanoscale.

Step 20 of adding the nanopowder to a solution consisting of 95% by volume of ethanol, wherein the weight ratio of the nanopowders to the solution is 1:20, heating a water tank having a container with the solution filled therein to 50 ° C and extracting the nanopowder ethanol.

Step 30 with adding water to the solution in the container after extracting for two hours. This is necessary because ethanol may be lost during the heating step. As a result, the weight ratio of nanopowder to water is 1:20. What achieves a solution with antimicrobial herbal ingredients.

Step 40 of drying and concentrating the solution with antimicrobial herbal ingredients in an enrichment machine under reduced pressure at 50 ° C for 6 to 12 hours to obtain antimicrobial nanoparticles containing herbal ingredients.

Step 50 of mixing the antimicrobial nanoparticles with medicinal herb constituents with polymer particles to form a mixture and producing antimicrobial fibers with medicinal herb components from the mixture.

In 3 Figure 3 is a flow chart illustrating a manufacturing process for antimicrobial agents with herbal ingredients according to the present invention.

The method comprises:

Step 10 with the drying of Rheum Rhababarum, Sophora flavescens var. Flavescens, Forsythia suspensa, Coptis chinensis Franch, Rehmannia glutinosa, Anemarrhena asphodeloides and Scutellaria lateriflora in an oven at 50 ° C for about 6 to 12 hours and milling them into powders in nanoscale.

Step 20 of adding the nanopowder to a solution consisting of 95% by volume of ethanol, wherein the weight ratio of the nanopowders to the solution is 1:20, heating a water tank having a container with the solution filled therein to 50 ° C and extracting the nanopowder ethanol.

Step 30 with adding water to the solution in the container after extracting for two hours. This is necessary because ethanol may be lost during the heating step. As a result, the weight ratio of nanopowder to water is 1:20. What achieves a solution with antimicrobial herbal ingredients.

Step 60 comprising adding about 1 to 3 weight percent sodium dodecyl sulfate to the antimicrobial herbal component solution for emulsification and adding about 5 weight percent acrylic resin to the emulsified solution to form the nanopowder-containing liposomes.

Step 70 of adding the liposomes to a tank of an application machine for mixing with foam resin to form a mixture and applying the mixture to fabrics to thereby produce fabrics comprising antimicrobial herbal ingredients. Alternatively, mixing the liposomes with dyes to form a mixture and applying the mixture to fabrics to thereby produce fabrics comprising antimicrobial herbal ingredients.

4 shows seven photographs illustrating the growth of the species of Euglena in different environments. In detail, species of Euglena are each given in antimicrobial solutions, such as nanozinc solution, silver oxide solution, and the antimicrobial herb ingredient solution of the present invention. These solutions are first examined after 24 hours and a second time after 48 hours. The following presents facts that have been observed by the present inventor: species of the Euglena live well in the solution with microbial herbal constituents of the invention during the first and second observations. Further, there are more microorganisms in the solution with herbal ingredients of the invention. The species of Euglena have died in the silver oxide solution at the first and second observation. This means that the silver oxide is lethal to Euglena. Some species of the Euglena have died in the nanozinc solution at the first observation and all species of the Euglena have died in the zinc solution at the second observation. This means that Nanozink is more or less harmful to Euglena.

In the light of the above observations, it is concluded that nanozinc and silver oxide, although antimicrobial, are metallic constituents harmful to the environment. In contrast, the antimicrobial herb ingredient solution of the invention is not only suitable for stopping or inhibiting the growth of microorganisms, but is also environmentally friendly. Furthermore, it does not irritate the skin or cause discomfort. In addition, the herbal ingredients are natural, do not pollute the environment and are environmentally friendly.

First test of the antimicrobial capabilities of the invention

First, 100 weight percent multi-microentangled web was added to the antimicrobial solution of the invention. Subsequently, a first test was performed on the antimicrobial capabilities of the treated fabric.

5 shows the results of the first test. It is noted that the term antimicrobial capabilities of samples is defined as (b-a) / b x 100%. CFU is an abbreviation for Colony Forming Unit. <means less. > means more. The test conditions are: machine wash for 12 minutes, at 80 ° F (-26.7 ° C) water temperature, set rotation speed and drying at a specified low temperature.

It has been found that the fabric treated with the invention has good antimicrobial properties before washing. Further, the fabric treated with the invention has 99% antimicrobial capability after a number of washes.

Second Test of Antimicrobial Properties of the Invention

Second, 100 weight percent polyester, 32 weight percent nylon, 25 weight percent cationic dye and 8 weight percent spandex were added to the antimicrobial solution of the invention. Next, a second test of the antimicrobial capabilities of the treated fabric was performed.

6 branches the results of the second test. It is noted that the term microbial properties of patterns is defined as (b - a) / b x 100%. CFU is an abbreviation for Colony Forming Unit. <means less. > means more. The test conditions are: machine wash for 12 minutes, at 80 ° F (-26.7 ° C) water temperature, set rotation speed and drying at a specified low temperature.

It has been found that the fabric treated with the invention has more than 99% antimicrobial capability after a number of washes.

While the invention has been described in terms of preferred embodiments, those skilled in the art will recognize that the invention can be practiced with modifications within the scope and scope of the appended claims.

Claims (7)

Manufacturing process for antimicrobial nanoparticles with medicinal herb constituents, comprising the process steps: (a) drying Rheum Rhababarum, Sophora flavescens var. Flavescens, Forsythia suspensa, Coptis chinensis Franch, Rehmannia glutinosa, Anemarrhena asphodeloides and Scutellaria lateriflora in an oven at 50 ° C for about 6 to 12 hours and grinding them into nano-sized powders, (b) adding the nanopowders to a solution consisting of 95% by volume of ethanol, wherein the weight ratio of nanopowder to solution is 1:20, heating a water tank with a container having the solution filled therein to 50 ° C and extracting the ethanol, (c) adding water to the solution containing container after extracting for two hours, wherein the weight ratio of the nanopowder to water is 1:20, thereby obtaining a solution with antimicrobial herbal ingredients, and (d) drying and concentrating the solution with antimicrobial herbal ingredients in an enrichment machine under reduced pressure at 50 ° C for 6 to 12 hours to obtain antimicrobial nanoparticles containing herbal ingredients. The method of claim 1, wherein Rumab Rhababarum is 30% by weight, Sophora flavescens var. Flavescens 10%, Forsythia suspension 10%, Coptis chinensis Franch 15%, Rehmannia glutinosa 15%, Anemarrhena asphodeloides 5% and Scutellaria lateriflora 15% Percent by weight based on the total weight of Rheum Rhababarum, Sophora flavescens var Flavescens, Forsythia suspensa, Coptis chinensis Franch, Rehmannia glutinosa, Anemarrhena asphodeloides and Scutellaria lateriflora. The method of claim 1, wherein the nanopowders have a size of about 50 to 500 nanometers. Manufacturing process for antimicrobial fibers with herbal ingredients, comprising the steps of: (a) drying Rheum Rhababarum, Sophora flavescens var. Flavescens, Forsythia suspensa, Coptis chinensis Franch, Rehmannia glutinosa, Anemarrhena asphodeloides and Scutellaria lateriflora in an oven at 50 ° C for about 6 to 12 hours and grinding them into nano-sized powders, (b) adding the nanopowders to a solution consisting of 95% by volume of ethanol, wherein the weight ratio of nanopowder to solution is 1:20, heating a water tank with a container having the solution filled therein to 50 ° C, and extracting the ethanol; (c) adding water to the solution containing container after extracting for two hours, wherein the weight ratio of the nanopowders to water is 1:20, whereby a solution of antimicrobial herbal ingredients is obtained, (d) drying and concentrating the solution with antimicrobial herbal ingredients in an enrichment machine under reduced pressure at 50 ° C for 6 to 12 hours to obtain antimicrobial nanoparticles containing herbal ingredients; (e) mixing the antimicrobial nanoparticles with herbal ingredients with polymer particles to form a mixture, and (f) forming antimicrobial fibers with medicinal herb components from the mixture. A method of manufacturing antimicrobial agents with medicinal herb constituents, comprising the steps of: (a) drying Rheum Rhababarum, Sophora flavescens var. Flavescens, Forsythia suspensa, Coptis chinensis Franch, Rehmannia glutinosa, Anemarrhena asphodeloides and Scutellaria lateriflora in an oven at 50 ° C for about 6 to 12 hours and grinding them into nanoscale powders; (b) adding the nanopowder to a solution consisting of 95% by volume of ethanol, wherein the weight ratio of nanopowder to solution is 1:20, heating a water tank with a container containing it (c) adding water to the solution containing container after extracting for two hours, wherein the weight ratio of the nanopowder to water is 1:20, whereby a solution of antimicrobial herbal ingredients is obtained , (e) adding about 1 to 3% by weight of sodium (m) adding about 5% by weight of acrylic resin to the emulsified solution to form the nanopowder-containing liposomes, (g) adding liposomes to the foaming resin to form a mixture, and (h) applying the mdodecyl sulfate to the antimicrobial herbal ingredients Mixture on fabrics for the production of antimicrobial substances with medicinal herbs components. The method of claim 5, comprising after step (f) the steps of (g1) delivering the liposomes to a tank of an application machine for mixing with foam resin to form a mixture, and (g2) applying the mixture to fabrics, thereby providing antimicrobial agents Medicinal herbs ingredients. The method of claim 5, comprising after step (f) the steps of (g3) mixing the liposomes with dyes to form a mixture, and (g4) applying the mixture to fabrics to produce antimicrobial agents having medicinal herb components.

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