DE102008056094A1 - Method of concentrating bioactive substances from plants using minerals and forming reversible biomineral composite systems - Google Patents

Abstract

The present invention relates to a method for concentrating bioactive substances from at least one plant using at least one mineral to form a reversible, biomineral composite system comprising the following steps: a) digestion of the plant and conversion of the plant ingredients into at least one suspension, b) separation of the Cellulose components of the plant, in particular by means of filtration of the suspension, c) preparation of at least one dispersion of the suspension contained in the plant ingredients and at least one mineral, in particular a clay mineral, d) drying of the dispersion prepared in step c), and e) optionally disintegration of in the Dispersion aggregated parts. The result of these process steps is a material and form-fitting bond between particles of the mineral and the adsorbed and enclosed plant substances, which has been formed by physical adsorption and aggregate formation by drying. This composite is completely dissolvable again by addition of a suitable solvent.

Description

The The present invention relates to a method according to claim 1, and the biomineral composite system produced by the process according to claim 11.

It It is known that plants are complex organisms. Medical Of interest are individual building blocks, complex extracts, the whole Plant to its very essence, depending on the application. Most of time Accepts the knowledge that the plant, the more complete it is in the application flows in, compared to a similar one Synthetic product looks rounder and more effective, less unwanted Effects generated and more sustainable a pathological condition to be able to change, because of the multiplicity of the components a vegetable multi-substance mixture a whole bunch of effects is activated. When using an isolated molecule the likelihood is higher that the cause of the pathological condition seeks a new way and the effect of Molecule fizzle (adaptation).

The The material composition of the plant is the result of millennia Evolution. Plants assert themselves within the ecosystem against similar attackers like humans, they turn to Part of similar strategies to get rid of invading pathogens.

In In recent years, the paradigm of the pharmaceutical industry has become one Disease at a particular receptor with a molecule To combat (drug), relativized. heaped Resistance and strong side effects at the same time unsatisfactory Effect are the triggers. The pharmaceutical industry has that Potential of the multi-substance mixture discovers and starts molecules to combine (HIV / AIDS therapy).

It is known to plants from primary and secondary Plant substances exist. The primary plant substances have with the exception of fiber a nutritional effect and can be divided into carbohydrates, fats, proteins, Vitamins, minerals, trace elements and fiber. secondary Plant substances occur only in small quantities in plants and act protectively. They can be divided into the following groups carotenoids, phytosterols, glucosinolates, flavonoids, phenolic acids, Protease inhibitors, monoterpenes, phytoestrogens and sulfur compounds.

All in all There are currently about 30,000 different phytonutrients, also known as phytochemicals.

It it is assumed that secondary metabolites are considered as Result of an intensive interaction between plants and their environment - especially Predators - have developed. Many herbal secondary substances serve the plant as effective chemical defense against herbivores and pathogens. On the other hand, secondary metabolites attract as Coloring and flavoring pollen dispersing insects and seed-spreading Fruit eater on.

Lots The defenses are not just for the enemies of Plants poisonous, but also for the plants themselves. To escape self-destruction, plants have become developed three main strategies.

The Substances accumulate in special cells or tissues at. For example, resin collects in the Harz gorges, Alkaloids are stored in special hair or scales, and very often secondary metabolites accumulate in the vacuole. The release of the substances takes place first in tissue destruction.

The Plants form non-toxic precursors and a specific one appropriate enzyme system found in other compartments of the cell or in special cells. Only when the compartments are dissolve by injury, the enzymes come with the substances in contact and form the actual poisonous antibodies. Example: Alliin in garlic.

The Plants form protective substances only in response to an infection. These protective substances are called phytoalexins. Their education is limited focus only on the place of infection. The formation of phytoalexins is triggered by special signal substances (elicitors).

In many cases will only be destroyed by the Tissue cells and the resulting release of substances a chain of chemical reactions set in motion at the end pharmacologically active substances arise.

The Plant substances in their entirety form a multi-substance mixture, their components work together synergistically and thereby strengthen. The effects are multi-dimensional and have an effect on the whole organism. Depending on the plant and their However, profiles of bioactive substances may have individual effects be achieved especially.

investigations have shown that the effects of phytochemicals can generally be summarized as follows: antioxidant, anticarcinogenic, immunomodulatory, antimicrobial, antithrombotic, anti-inflammatory, regulates blood pressure, lowers cholesterol, blood glucose regulating, digestive.

For human health are the following phytochemicals in the order of importance of particular importance: glucosinolates, Phenolic acids, flavonoids, sulfur compounds, carotenoids.

It It is known that glucosinolates are especially in cruciferous (Brassicales) occur. In Central Europe they come mainly in cruciferous plants (Brassicaceae). To include the kale species such as Cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, Pak Choi, kohlrabi, turnip. In addition, count u. a. Radishes, rapeseed, mustard, horseradish and cress on this.

The non-toxic precursor glucosinolates and the appropriate enzyme system Myrosinase are in different compartments, the first be released upon destruction of the vacuoles and a Trigger glucosinolate hydrolysis (see Scheme 1).

The Product formation is highly dependent on the pH of the reaction environment. At a pH of 7 in particular isothiocyanates, at a pH of 3-4 thiocyanates and nitriles formed. There are currently about 120 glucosinolates and the corresponding hydrolysis products known.

scientific Investigations have shown that in particular the following Isothiocyanates an exceptionally positive spectrum of activity have (Scheme 2).

The cited isothiocyanates are bacteriostatic / bacteriocidal (high-dose), virostatic, antifungal, modulate impurity-metabolizing Enzymes that induce apoptosis, modulate histone deacetylation and affect estrogen status.

It It is known that the bioavailability of isothiocyanates strongly depends on the type of consumption, since the myrosinase is inactivated during cooking and also in the microwave.

So is the bioavailability after consumption of raw vegetables 30-50%, of cooked vegetables 10-15%, of isolated glucosinolates 10-15% and isolated Isothiocyanates 90%.

For Therapeutic applications is isolation of at room temperature non-volatile isothiocyanates of crucial importance. It does not depend on the isolation of the individual molecule, but the presence of the free isothiocyanates in the multi-substance mixture from primary and secondary plant substances essential for effectiveness. This mixture exists moreover, from several phases like a suspension from water and solid and from gaseous, liquid and solids that are in solution.

It It is known that for the extraction of a component from a solid or liquid mixture extraction is used as a physical separation process. For the concentration of a multi-substance mixture of several phases she is not suitable.

Farther It is known that for the enrichment of gases and liquids Adsorbents can also be used. In general Meaning, adsorption is a physical process involving substances on stick to the surface of another substance and to accumulate on its surface. The forces, which cause the attachment, are not chemical bonds, but only physical forces. Therefore, this form becomes the adsorption of exact physical adsorption or physisorption called. The adsorbed substance (adsorbate), however, forms with the Surface no chemical bond, but sticks due to weaker forces similar to the adhesion. As a rule, only van der Waal's forces appear. The physical adsorption is reversible.

The chemical adsorption (chemosorption) is due to a chemical bond between adsorbent and adsorbate, where it is forming a new chemical compound can come. Chemosorption is ongoing slower than the physical adsorption and is not reversible.

When Adsorbents come, for example, activated carbon, silica gel, molecular sieves (Zeolites) or bentonites in the form of beds or in structured form for practical use.

In medicine, activated carbon is mainly used to remove toxins from the gastrointestinal tract. For harmless diarrhea, z. As gastrointestinal influenza (gastroenteritis), are becoming more common used charcoal compresses. In poisoning emergencies, activated carbon is used in a larger amount to remove orally taken up poisons that are in the digestive tract or undergo enterohepatic circulation from the organism. Silica gel is used for drying wet chemical compounds.

zeolites have a variety of applications u. a. as ion exchanger for water softening, for example, EDTA substitute, Molecular sieve, desiccant or in the self-cooling beer keg. Furthermore, they are used for large-scale production needed by detergents. Zeolites can also be found in industrial catalysts use and are used in heat storage heaters installed.

bentonite, named after the Benton Formation, Fort Benton Montana, is a Rock, which is a mixture of different clay minerals and as the main ingredient montmorillonite (60-80%) contains what its strong water absorption and swelling capability explained. Further accompanying minerals are quartz, mica, feldspar, pyrite or also calcite. It is caused by weathering from volcanic ash.

clay minerals become different depending on the layer structure Divided into groups. These include the group of kaolinites, Smectites, illites and chlorites.

One well-known representative of the clay minerals is montmorillonite, which as a three-layer dioctahedral silicate with a tetrahedral layer octahedral layer tetrahedral layer structure belongs to the group of smectides.

montmorillonite is a three-layer silicate, which has a large swelling capacity and thixotropy. In addition, it is the ion exchange and capable of chemical and physical adsorption. The adsorption is largely over van der Waals forces and hydrogen bonds.

The Binding of organic compounds to montmorillonite completes usually involved by several mechanisms physical adsorption and chemosorption.

cationic Active ingredients are preferred to those contained in montmorillonite Cations exchanged and by chemosorption to the montmorillonite bound. These mechanisms are controlled by the pH.

The Binding of anionic agents to montmorillonite is preferred through physical adsorption, allowing the drug to release rapidly can be.

nonionic Active ingredients are often used by van der Waals forces and hydrogen bonds to the montmorillonite bound.

montmorillonite has a remarkable swelling capacity. Water causes the interlayer cations to hydrate can build up. The swelling process is called "intercrystalline Swelling ". Sodium montmorillonite may be the sixth take up to seven times its dry weight of liquid. In the presence of still small amounts of solvent if the layers remain well ordered, the solvent supply increases, Thus, the state of order is increasingly lost.

by virtue of the demonstrated physicochemical properties in particular Montmorillonite as a pharmaceutical excipient and as a bioactive Active substance, used in particular as detoxificant. Also can bound chemical agents and thus for drug preparation be used.

outgoing From the prior art, it is therefore the object of the present Invention to present a method by means of which composite systems can be provided, which is high in content bioactive substances, a high bioavailability and a have good shelf life and durability.

Of Furthermore, the composite systems should have low adsorbability of foreign substances and the possibility of direct tableting exhibit.

These The object is achieved by a method having the features of the claim 1 and a composite system with the features of claim 11 solved.

• a) Aufschluss einer Pflanze und Überführung der aufgeschlossenen Pflanzeninhaltsstoffe in mindestens eine Suspension,
• b) Abtrennung der Cellulosebestandteile der Pflanze, insbesondere mittels Filtration der Suspension,
• c) Herstellung einer Dispersion aus der die Pflanzeninhaltsstoffe enthaltenen Suspension und mindestens einem Mineral, insbesondere einem Tonmineral,
• d) Trocknung der in Schritt c) hergestellten Dispersion,
• e) gegebenenfalls Desintegration der in der Dispersion aggregierten Teile.

Accordingly, the inventive method for the concentration of bioactive substances, esp characterized by the use of at least one mineral in the form of reversible biomineral composite systems by the following process steps:

• a) digesting a plant and transferring the digested plant ingredients into at least one suspension,
• b) separation of the cellulose constituents of the plant, in particular by filtration of the suspension,
• c) production of a dispersion from the suspension containing the plant constituents and at least one mineral, in particular a clay mineral,
• d) drying of the dispersion prepared in step c),
• e) optionally disintegrating the parts aggregated in the dispersion.

By the cell disruption of plants, especially of hydrous Crop plants, the plant ingredients are transferred into a suspension. In this case, the cell water itself or a supplied solvent form the liquid phase. For cell disruption are preferred Rätzscheibenmühlen, hammer mills u. a. used with adapted screen plates. The process temperature is at a maximum of 35 ° C with minimal air entry. A high one Air entry can lead to the oxidation of bioactive substances. Therefore slowly running mills are indicated.

When plants to be grown are preferably drug and crop plants used.

When Crops are preferably water-containing fruits and vegetables used. Preferred fruits are blueberries, red and black Currants, red grapes and apples. preferred Vegetable varieties come from the group of the Kreuzblütengewächse Cabbage, radish, cress or broccoli. In general, only plants should be used in the immediate vicinity Growing close to consumers. That is why they differ the optimal plants depending on the climatic zone.

Of the Cell disruption causes the release of bioactive substances, in particular of phytochemicals. The release takes place from the vacuoles the plant cells, which preferably contain the bioactive substances. Depending on the plant, further enzymatic transformations may occur.

The Separation of the vegetable cellulose is preferably carried out by means a hydraulic filter press with adapted drainage filter elements. The mesh size of the filter elements should be approx. 900 μm. The cellulose ingredients of the plant affect by their relatively high proportion in the dry matter a maximum concentration of the bioactive Substances.

Of the obtained by cell disruption and subsequent filtration Press juice contains essentially all that is contained in the plant bioactive substances, especially phytochemicals. In the course of plant digestion enzymes are also released that undergo a chemical transformation can cause the bioactive substances contained in the press juice.

So does it happen z. B. in the digestion of Kreuzblütengewächsen to activate the enzyme myrosinase, which is the glucosinulate converted into the corresponding reactive isothiocyanates.

The Reaction time for conversion of phytonutrients by enzymatic Hydrolysis depends on the variety used. Thus, the required hydrolysis time for fruit juice between 1 to 3 h, especially 2 h, and vegetable juice between 3 to 8 hours, in particular 6 hours.

Of the Press juice obtained from the digestion of bioactive substances and their hydrolysis products is a multiphase mixture there. This Mixture also consists of several phases such as a suspension of water and solid and of gaseous, liquid and solid substances that are in solution.

The bioactive substances contained in the press juice are preferably secondary Plant substances, vitamins, minerals, carbohydrates, protein and Fats. The water content can be between 75 and 90%.

One Part of the bioactive substances contained in the press juice such. B. Vitamins show high oxidizability and high photosensitivity. Of Furthermore, the press juice has a high sensitivity to heat and cold on. So are the optimal temperatures for a press juice from fruit between -24 ° C and 40 ° C and for a press juice from vegetables between -45 Degrees Celsius and 49 ° C depending on the variety.

The dispersion of mineral and plant ingredients contained suspension containing the bioactive Substances, in particular phytochemicals and their hydrolysis products contains, has a ratio of 1 to 5 to 1 to 9. The ratio depends on the proportion of bioactive substances in each plant. The mineral carrier is preferably completely saturated, whereby a maximum concentration of bioactive substances is achieved.

The Dispersing time is about 8 hours with gentle stirring and a temperature of 35 ° C, preferably under vacuum. This leads to a preconcentration of the bioactive substances. The reaction vessel is preferably temperature-controlled, provided with a stirrer and for vacuum operation designed containers used.

While the dispersion takes place both the complete enzymatic conversion a part of the phytochemicals in new active Substances as well as the physical adsorption of bioactive substances the minerals.

When preferred minerals are smectite-containing clay mineral, in particular Bentonite or montmorillonite, or finely minced natural zeolite used.

The Minerals used have a high internal surface area and an optimum particle size of 1 to 10 μm, in particular of 2 μm. Furthermore, there are the minerals in cubic particle form.

The Preferred clay minerals are also high in content Water absorbency, good dispersibility and positive Characterized effects in humans and animals. They are as auxiliaries approved for human and animal use.

The Adsorption of bioactive substances, especially phytochemicals, takes place advantageously by means of physical adsorption, wherein prevents chemical adsorption by a basic pH becomes. The cohesive bond is reversible.

The Drying of the dispersion obtained in step c), which consists of the suspension and minerals contained in the phytochemicals composed at temperatures up to 49 ° C, in particular 20 to 45 ° C, depending on Profile of the bioactive substances of the respective plant.

to Drying, the dispersion is preferably in a thin Layer of a maximum of 2 mm arranged. The drying is preferably carried out under vacuum. Depending on the process engineering design Vacuum drying ovens, vacuum rotary thin film evaporators, Vacuum belt dryer or other systems are used.

By the drying process, the water from the layer gaps the minerals removed and the bioactive substances that are not physical adsorption were accumulated by a positive fit Tied together. The result is a reversible, biomineral Composite system.

In The consequence of adsorption and drying is a material and form-fitting Composite between the particles of the mineral and the adsorbed and enclosed botanicals, especially phytochemicals, produced.

It This leads to the formation of reversible aggregates by Addition of a suitable solvent, in particular of Water, can be brought into dispersion or disaggregated.

A adapted to the product maximum drying temperature between 30 to 49 ° C prevents or reduces the thermal decomposition of bioactive substances.

ever according to procedural design is possibly a disintegration the aggregated parts necessary. This process is preferred in opposing pin mills or in classifier mills carried out. Here is a maximum particle size of 30 microns desirable.

The can be produced by the process according to the invention biomineral composite system is a coarse crystalline powder with cubic particles. The cubic particles are particularly suitable good for direct tableting.

The powdery composite system is characterized by a low oxidizability, low photosensitivity, low Heat and cold sensitivity and low Adsorbierfähigkeit. By measuring the redox potential freshly prepared and after 1 year under the influence of light, air and temperature on stored samples there was no drop in the redox potential.

In one embodiment, the powdery Compound system high gastroresistance, high bioavailability and a high dispersibility.

The powdery composite system has in an advantageous manner a high content of bioactive substances, preferably in the front Small intestine section are included.

The maximum particle size of the powdery Composite system is preferably below the organoleptic threshold of 30 μm.

The Residual moisture of the powdery composite system is about 5%. In the preferred use of bentonite as a carrier material The powder can be used for direct tableting.

Of the Proportion of bioactive substances in the powdered composite system is based on the total amount about 30%, based on the amount of support material about 42%.

The Powder can be used as such or in various pharmaceutical preparation forms be present and administered. Advantageously, the powder for example in the form of tablets, capsules, juice, gel or cream administered.

By the binding according to the invention of the bioactive substances on the minerals it is now possible to use the bioactive Stabilize substances and convert them into a storable form.

Also allows the powdery invention Composite system administration of all, preferably contained in the press juice of the fruit and vegetables used bioactive substances. A time consuming and costly insulation individual active components is not necessary. Also offers this Approach the advantage of synergistic effects of bioactive substances exploit when using individual components in usually does not occur.

Prefers is the powdery invention Composite system for the prophylactic strengthening of the immune system, in cancer therapy and / or for the treatment of bacterial and used viral infections.

The The present invention is accomplished by the following embodiment explained in more detail.

1. cell disruption

For cell disruption, a plant with the following characteristics is used (Table 1): system Order: Cruciferae (Brassicales) Family: Cruciferous plants (Brassicaceae) Genus: Cabbage (Brassica) type: Turnips (Brassica rapa) Subspecies: Mushrooms (Brassica rapa ssp. Rapa) ingredients per 100 grams of fresh material carbohydrates 14.9 g from that available nutrients 8.9 g roughage 6.0 g water 80 g minerals 4.5 g sulfur 0.45 g fat 0.25 g Protein 0.89 g trace elements 9.85 mg from that silicon 8.85 mg iron 0.55 mg zinc 0.45 mg vitamins 49.0 mg from that vitamin C 28.5 mg niacin 8.9 mg Vitamin A 8.5 mg glucosinolate mg / 100 g fresh mass Arylglucosinolate 65 Alkenylglucosinolate 69 Indoglucosinolate 29 Alkylglucosinolate 45 other glucosinolates 19 Table 1

Of the The plant cells were disrupted with the Green Star juicer. It juices with powerful, but slowly rotating precision press rollers. At only 110 revolutions per minute, these press rolls grip like Gears into each other and gently squeeze the juices. A sieve element with 0.5 mm mesh size holds the cellulose components the plant cell largely back. The highly sensitive Enzymes and valuable vitamins are retained in the juice. The Juice yield is about 41% of the fresh produce used.

2. Dispersion

Subsequently becomes a dispersion of the plant juice with Friedland bentonite (FIM GmbH) in a mass ratio of 5: 1 produced.

The Friedland bentonites have the following characteristics.

The particle size distribution (sludge analysis, DIN 18123 ) <2.0 μm is 72% by mass, 2.0-6.3 μm is 10-15% by mass, 6.3-20 μm is 8-12% by mass, 20-63 μm is 1% by mass, <63 μm is 0, 2% by weight.

Friedland bentonites have a total content of clay minerals between 75 to 78%. There are 44 mass% alternating storage (muscovite montmorillonite mixed layer mineral), 16 mass% muscovite, 15 mass% kaolinite / chlorite, 1 mass% glauconite, 20 mass% quartz, 5 mass% feldspar, 2 mass% carbonates and 1 mass% Pyrite.

The chemical analysis gives the following composition: 58.98% SiO ₂ , 0.99% TiO ₂ , 19.47% Al ₂ O ₃ , 6.89% Fe ₂ O ₃ , 0.023% MnO, 2.05% MgO, 0 , 49% CaO, 0.89% Na ₂ O, 3.07% K ₂ O and <0.01% F.

The bulk density is 0.75 t / m ³ , the specific surface area 170 m ² / g, the pH 8.3, the humidity about 5%, the H ₂ O absorption 150% Enslin, the content of dioxins at 0.2 ng / kg, and cation exchange capacity 50-60 meq / 100g.

The Dispersing and reaction time is at a temperature of 35 ° C and with gentle stirring 8 h. After this Time, the bentonite has reached its full swelling capacity. Part of the bioactive substances were obtained by physical adsorption bound.

3. drying

The Creamy dispersion is made with a maximum layer thickness of 2 mm placed in a vacuum drying oven. The drying takes place at 35 ° C and under vacuum. The drying time is about 8 h. During this time, the water gets out of the layer gaps of bentonite and the bioactive substances that are not physical adsorption were accumulated by a positive fit Tied together. The result is a reversible, biomineral Composite system with larger aggregates with residual moisture 5%, which must be fed to disintegration.

4. Crushing

The Disintegration occurs with an opposing contraplex Pin mill of the company Alpine. The high impact speed represents the maximum particle size below 30 microns for sure. The mean particle size is 9 μm.

5. Reversible biomineral integrated system

The effected on the example of the plant Brassica rapa shown method a concentration of bioactive substances compared to Fresh mass by a factor of 6.5. On 100 g biomineral composite system (BMV) comes about 30 g bioactive substances and about 70 g bentonite. The The capacity of the bentonite is approx. 43% its own weight.

The Isothiocyanate concentration is 390 μg per 1 g BMV calculated from the glucosinolase content.

The bioactive substances are in the digestive tract after dispersion of the BMV with water in the upper part of the small intestine to the body issued. The now discharged bentonite can pass through the Gut its positive effects in terms of pollutant uptake, binding pathogenic germs, antifungal effect u. s. w. unfold. The Bentonite in the BMV is therefore not just the vehicle for the bioactive plant substances, but at the same time also active ingredient to regulate the digestive system.

About that In addition, due to the bentonite in BMV different galenic Dosage forms such as tablets, capsules, juice, gel, cream and others to be obtained.

In the following Table 2 is exemplified the process of the gradual concentration of plant ingredients. Cell disruption + sieve presses Dispersion + drying ingredients g / 100 g fresh mass g / 100 g of pressed juice g / 100 g bioactive substances g / 100 g reversible biomineral composite system carbohydrates 8.90 9.31 58.28 17.48 roughage 6.00 0.00 0.00 0.00 Protein and fats 1.10 1.20 7.46 2.24 water 79,00 83,50 0.00 0.00 minerals 4.72 5.25 32.41 9.72 trace elements 0.0099 0.0100 .0640 0.0190 vitamins 0.0460 .4900 .3010 0.0900 secondary plant compounds .2260 .2410 1.4860 0.4500 total 100.00 100.00 100.00 30.00 bentonite 70,00 reversible biomineral composite system 100.00 Table 2

The Table 2 shows the changes in the respective process stage or from measurements before and after drying.

So the present method allows concentration the minerals contained in the plant, trace elements, vitamins and phytochemicals and their administration in an enriched form of the biomineral composite system.

QUOTES INCLUDE IN THE DESCRIPTION

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Cited non-patent literature

• - DIN 18123 [0085]

Claims (14)

Method for concentrating bioactive substances from at least one plant using at least one Mineral for the formation of a reversible, biomineral composite system marked by the following process steps: a) digestion of the plant and transfer of the phytonutrients in at least a suspension, b) separation of the cellulose components of the Plant, in particular by filtration of the suspension, c) Preparation of at least one dispersion of the plant ingredients contained suspension and at least one mineral, in particular a clay mineral, d) drying the product prepared in step c) dispersion, e) optionally disintegrating in the dispersion aggregated parts. Method according to claim 1, characterized in that that as a plant uses a drug and / or a crop becomes. Method according to claim 2, characterized in that as useful plants, water-containing fruits and vegetables, in particular from the group of the cruciferous species (Brassicales) be used. Method according to claim 1, characterized in that that as a mineral smectite-containing clay mineral, in particular bentonite or montmorillonite, or finely comminuted natural zeolite become. Method according to claim 1, characterized in that that the dispersion from the plant ingredients contained Suspension and the mineral in a ratio of 1: 5 to 1: 9, depending on the plant produced. Method according to claim 5, characterized in that that at least part of the phytonutrients to the mineral is bound by physical adsorption. Method according to claim 1, characterized in that for drying, the dispersion in a thin layer of a maximum of 2 mm and placed under vacuum at temperatures dried between 20 and 49 ° C. Method according to claim 1, characterized in that that form aggregates during drying, the plant substances include positively. Method according to one of the preceding claims, characterized in that the biomineral composite system Addition of a suitable solvent is dispersed. Method according to claim 1, characterized in that that the disintegration with impact mills under training of particles with a maximum size of 30 μm is carried out. Biomineralic composite system manufacturable after a method according to any one of the preceding claims. Biomineralic composite system according to claim 11 characterized by low oxidizability, low photosensitivity, low heat and cold sensitivity, low Adsorbability, high bioavailability and high dispersibility. Biomineralic composite system according to claim 11 or 12 characterized by a residual moisture content of 5%. Biomineral composite system according to one of the claims 11 to 13 for the prophylactic strengthening of the immune system, Reduction of pathogenic germs, modulation of foreign substance-metabolizing Enzyme systems and reduction of oxidative processes.