DE102008035848A1 - Patch, useful e.g. for attaching to skin for medical, cosmetic and/or orthopedic purposes, and to treat capsule inflammations, comprises a film comprising a carrier material provided with a therapeutically effective coating on both sides - Google Patents

Abstract

Patch comprises a film (1) comprising a carrier material, which is provided with a therapeutically effective coating (21, 22) on both sides. ACTIVITY : Antiinflammatory; Vulnerary. MECHANISM OF ACTION : None given.

Description

The The invention relates to a patch for application to the skin for medical, cosmetic and / or orthopedic purposes, having a carrier material, which with a therapeutic effective coating is provided.

Plasters are known in medicine and cosmetics in various forms. The present invention is concerned with patches for the transdermal administration of controlled amounts of active ingredient. In such patches, for example, the active ingredient can be dissolved or suspended in a polymer matrix film through which the active ingredient diffuses into the skin (cf. US 4,839,174 ).

The Known patches are only conditionally inflammatory for treatment Suitable areas. In particular, internal inflammations, for example on joints with capsule injury or the so-called tennis elbow, are usually by decommissioning by means of bandage and, where appropriate treated with medical support. such Treatments are tedious and can, especially in the case drug treatment, to significant impairments of the body.

To improve the treatment of internal inflammation is from the DE 103 06 187 A1 a plaster is known, which consists of an adhesive strip, on which an electrically conductive layer is adhered. The layer is arranged on the adhesive strip such that the circumferential outer edge of the adhesive strip is uncovered. The uncovered adhesive surface is used to fix the patch on the skin.

The known plaster meets the requirements placed on it. Depending on the choice of electrically conductive However, layer is on a relatively narrow range of action, for. B. inflammatory processes in a joint limited. Also, by using an adhesive strip on which then the coated film is applied, a thickness of the plaster caused, the negative influences in different applications the wearing comfort has. This occurs, for example, in the treatment of capsule inflammations in the area of the foot, in particular in the area of the toes, on, as the feet in the Usually housed in footwear.

at sporting activities are mostly about quite tight-fitting shoes that give the wearer a good feeling for contact with the ground. About that In addition, for example, ladies pumps are also very tight cut. In these or similar applications, the known Plaster can not be applied to the toes without loss of comfort, because of the thickness of the known patches creates a pressure point, which is located exactly on the site to be treated. By the Pressure points are the treatment results adversely affected; in the extreme case it can be at the pressure points come to redness to Hautaufschürfungen. Even when wearing compression stockings arise the problems mentioned.

in addition comes that the known patches hinder the tightening of the very tight compression stockings or the patches are removed when donning.

Here The invention aims to remedy this. The invention is the task The aim is to create a patch that will give good results improved from the prior art plaster and the Scope extended. In particular, the patch should be dependent from the biochemical situation on the patient's skin the treatment process can control themselves.

According to one In the first aspect of the invention, the plaster has a film which from a carrier material with one each therapeutically effective coating on the opposite sides of the carrier material. For application is one of Coatings arranged closer to the skin of the patient as the other one.

The Carrier material is z. B. a natural or artificial polymer, preferably a polyester. Especially is also a polyurethane matrix suitable as a carrier material. A matrix of polymer may in particular pores, d. H. Through openings have a penetration of skin sweat from the allows one to the other side of the substrate.

Experiments have shown that, in particular with a thin carrier layer of less than 100 μm thickness and in particular of less than 20 μm thickness, the coating further away from the skin contributes to the therapy (ie medical, cosmetic and / or orthopedic effect). Contribution may be made in one or more of the following ways:
With electrically conductive coatings (at least when the layer further away from the skin is electrically conductive), these influence the biochemical processes on, in and under the skin by means of electrically conductive contact and / or by capacitive action. For example, with electrically insulating carrier material and two electrically conductive coatings, the film forms an electrical capacitor. The effect of an electrochemical battery is achieved when on the opposite sides of different metal coatings are arranged and in the substrate skin sweat may occur as electrolyte, as is the case when using a substrate with through holes.

So In particular, the healing properties of a precious metal on the unfolded further away from the skin (eg, gold) although the precious metal is due to the carrier material is separated from the skin. At the same time z. B. the silver existing coating, which is located closer to the skin is (and preferably directly with the skin or secretions the skin, like sweat, is also in contact) Unfold silver known healing effects. Optionally available at any combination of coatings in addition a therapeutically active substance in the carrier material be contained or form the carrier material.

at Any kind of coatings can become the closer located coating and the substrate under the Influence of biochemical substances on and in the skin at least dissolve in places, leaving the coating on the secluded side of the film is approaching the skin or even gets in contact with the skin or the substances. Under "dissolve" is also understood that coating and substrate cracks or make holes. In particular, it can dissolve Then come when the skin sweat has a pH in the acidic Area has. In contrast, sweat in the alkaline area leave the carrier film intact, z. B. when the carrier material a polymer (eg polyester) less than 20 μm thick is. Therefore, the patch controls the therapy depending on the biochemical situation on the skin of the patient. Also serves the patch therefore as a diagnostic aid: If the skin sweat to Resolution of parts of the plaster leads allowed this concludes that the skin sweat has a pH in the acidic area and therefore has inflammatory processes may be present. In this case, the patch z. B. to be turned over, d. H. the coating on the opposite side is placed closer to the skin.

The Plasters can be fixed on the skin in various ways, whereby the species can also be combined with each other. At least one of the coatings may be in places on the surface be provided with adhesive. The carrier material can be self-adhesive be or have an adhesive application, wherein the coating can be recessed and / or the substrate over can protrude the edge of the coating. However, it is preferred that the plaster with an additional second backing layer combined. In this way, the plaster itself can be very thin be executed (see below). The second carrier layer is z. B. a full surface provided with adhesive fabric layer or other layer, as is usually the case with tapes is used. In this case, the patch can optionally with the glued one or the other coating on the second carrier layer be so that the unattached layer for contact to the skin remains free. The second carrier layer is z. B. on the edges of the dressing thus formed, so that it can be stuck to the skin. One or the other Dressing with the second carrier layer can be finished be offered in the retail or pharmacy. The patch however has the advantage that it is also available separately and therefore individually configurable depending on the application and therefore area size of the patch and type of fixation on the skin can vary.

Preferably has the plaster on the opposite sides coatings on, each made of an electrically conductive material consist in particular of metals (preferably, gold, silver, Copper and / or aluminum). Especially if through the plaster the effect of an electrochemical battery is achieved (see above) can thus achieve new therapeutic effects become: So z. Eg those from traditional Chinese Medicine not only electrically known meridians but over connected by the patch acting as an electrochemical battery, if the patch is placed on the skin accordingly. Around the penetration of sweat into the substrate To promote, the skin surface can be arranged Coating recesses, so that the skin sweat immediately can penetrate into the carrier material. At thinner However, coating (eg 10 nm to 100 nm thick) can also cause skin sweating diffuse through the coating.

According to one second aspect of the invention, the patch can also only a coating or two coatings as described above. In each Case is the thickness of the film (substrate and coating (s)) less than 100 μm, preferably less than 20 microns and is z. B. in the range of 12-15 microns.

Consequently is a plaster created that gives the good treatment results includes the known plaster, but at the same time due the extremely thin design does not interfere with wearing comfort or handling. In particular, the wearing comfort or the applicability even in tight footwear or compression stockings allows.

further developments and embodiments of the invention are in the subclaims specified. An embodiment of the invention is in the drawing and will be described in detail below. Show it:

1 the view of a patch according to the invention and

2 the elevated side view of the in 1 Plaster shown.

The patch chosen as the exemplary embodiment is a metallized polyester film 1 , It forms the carrier material for the plaster. The film has z. B. a thickness of 10 to 15 microns, in the embodiment 12 microns. The film can be stretchable. The elongation properties are in the longitudinal direction z. At 100 to 130%; the transverse strain is z. B. at about 100%.

The foil 1 is with a coating 2 Mistake. When coating 2 it can be a protective coating; preferably a gold or silver protective coating. Alternatively, it may be a powder coating, which is also preferably made of silver or gold, and those with the film 1 glued or otherwise attached thereto. The order quantity of the coating is z. B. 0.8 to 1.2 g / sqm. In the exemplary embodiment, the coating is on both sides of the film 1 applied, with the " 21 "Designated side with a coating of gold and those with" 22 "Designated other side is provided with a coating of silver. As an alternative to the powder coating, the gold and / or silver have been evaporated on the support material in vacuo (in particular in a high vacuum).

The foil 1 can be self-adhesive. The adhesive is spread over the entire surface of the patch, resulting in an exceptionally good adhesion of the skin. Alternatively, however, the film has no external adhesive but is fixed to the patient's skin by additional means (see above).

The foil 1 is z. B. not or only to a small extent permeable to air. As a result, sweat formation in the area of the plaster is promoted after fixing the film to the skin. The formation of sweat contributes to increased conductivity of the metallized film. The occurrence of sweat in connection with air dissolves gold or silver out of the foil, because the chloride present in the sweat prevents the formation of a protective layer on the gold, so that the atmospheric oxygen in combination with the relatively low pH of the moist skin Brings gold or silver in solution. As a result, the conductivity of the patch on the skin is increased, whereby the healing process is additionally optimized. In addition, sweating under the patch leads to softening of the skin, which further improves the healing process, for example in the case of scars. In addition, sweat eliminates impure body substances, which leads to an improvement of the metabolism. Also, the effects mentioned lead to skin sweat penetrating into the carrier material and thus also the coating on the side further away from the skin provides a therapeutic contribution.

The Plaster of the invention is preferably very thin (eg at most 20 microns thick). As a result, wearing the patch is also possible in areas, in which known patches affect the wearing comfort would cause. This is especially true in shoes, especially in the field of toes, or in ski boots in the field of known pressure points on the ankle, the tibia, etc. The same applies when wearing compression stockings, z. B. in venous or lymphatic weakness. In the mentioned areas is no space between skin and footwear or stocking, so that known Always apply "plaster" and thus the pressure is further increased at the respective point. This is avoided in the patch according to the invention; due to its extremely thin training the plaster is barely noticeable.

by virtue of the thin version of the invention Plasters is also the handling of compression stockings much simpler, since these are usually at the use of conventional patches peeling or scrubbing while strapping the stockings he follows. As a result, the patches lose their intended positioning, so that the effect can not be targeted. In the gossamer Paving according to the invention avoids this problem since the compression stockings unhindered over the Let go of plaster; in self-adhesive training over The entire surface of the plaster is also good adhesive properties caused adhesion to the skin when coating allow the stockings. Due to the good adhesive properties is also a detachment with prolonged wearing time avoided, so that the plaster according to the invention can be used easily over several days.

The provision of the coating on both sides of the plaster, especially when using different coatings on the two sides of the patch, for example the coating of gold on one side and silver on the other side according to the embodiment, offers the possibility of selecting a treatment depending on the application , Thus, the silver-coated side is typically placed closer to the skin to provide cooling and anti-inflammatory action that will calm and help reduce swelling. The gold-coated side is placed closer to the skin when heat is applied to the affected area is required because gold stimulates the blood circulation, which leads to an increased blood circulation, which triggers a warming effect. Thus, two different treatment and use cases are combined in the plaster according to the invention, so that only one plaster is to be stored in order to be able to treat both cases. The selection is made immediately before the use of the patch. For the user this has the advantage of being able to cover two treatment cases with only one plaster to be carried along.

As However, the one described above also carries the further away from the skin removed coating for therapy, especially if the substrate very is thin or in the course of the application dissolves.

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Cited patent literature

• - US 4839174 [0002]
• DE 10306187 A1 [0004]

Claims (13)

Patches for application to the skin for medical, cosmetic and / or orthopedic purposes, the plaster comprising a film ( 1 ), which consists of a carrier material having on both sides with a therapeutically effective coating ( 21 . 22 ) is provided. Plaster according to claim 1, characterized in that the film ( 1 ) including both coatings ( 21 . 22 ) has a thickness of less than 100 μm, preferably less than 20 μm. Plaster according to claim 1 or 2, characterized in that the film ( 1 ) is stretchable. Patch according to one or more of the preceding claims, characterized in that it is in the coating ( 2 ) on one side is a gold coating. Patch according to one or more of the preceding claims, characterized in that it is in the coating ( 2 ) on one side is a silver coating. Plaster according to one or more of the preceding claims, characterized in that the coating ( 2 ) is a protective coating on one side. Plaster according to one or more of the preceding claims, characterized in that the coating ( 2 ) is a powder coating on one side. Patch according to one or more of the preceding claims, characterized in that the coatings ( 21 . 22 ) on the opposite sides of different materials. Patch according to one or more of the preceding claims, characterized in that the coatings ( 21 . 22 ) on the opposite sides each consist of an electrically conductive material. Plaster according to the preceding claim, characterized characterized in that at least one of the electrically conductive Materials is a precious metal. Plaster according to one or more of the aforementioned Claims, characterized in that the carrier material consists of a polymer, in particular polyester. Plaster according to one or more of the aforementioned Claims, characterized in that the coating a thickness of less than 5 μm on at least one side, preferably less than 500 nm. Process for the preparation of a patch for application to the skin for medical, cosmetic and / or orthopedic purposes, in particular for the production of the plaster according to one of the preceding claims, wherein a film ( 1 ) of a carrier material on both sides with a therapeutically effective coating ( 21 . 22 ).