DE102006024911A1 - Solubilizate of plant extract that contains active agent, useful as additive for e.g. cosmetics, pharmaceuticals and foods, includes water and emulsifier - Google Patents

Abstract

Solubilizate (A) of a plant extract (B), which contains physiologically or pharmaceutically active agents (I), comprises about (by weight) 10-30% (B); 4-35% water (deionized, demineralized or distilled, one or more times) and 55-75% of an emulsifier (II) with hydrophilic-lipophilic balance (HLB) 9-16. An independent claim is included for a method for preparing (A).

Description

The boswellic acid (sometimes called boswellic acid) derived from vegetable resin, such as Olibanum, has been known as a home remedy for millennia. Essential active ingredients are, in particular, 3-acetyl-β-boswellic acid (molecular weight 498.73, C ₃₂ H ₅₀ O ₄ , CAS No. 5968-70-7) or 3-acetyl-11-keto-β-boswellic acid (molecular weight 512.73, C ₃₂ H ₄₈ O ₅ , CAS No. 67416-61-9).

With Various studies have shown that the acid mentioned also their derivatives in the following diseases and diseases as effective and alleviating: Asthma, chronic inflammation of all kinds, venous disorders, rheumatism, MS and others. Boswellic acid could also at the vitality and pain therapy can be used successfully.

One The problem is often that in the organism a sufficient Level of boswellic acid only very difficult to adjust and maintain.

Of the The invention is therefore based on the object, sufficient gifts and Settings of boswellic acid and / or their derivatives. This is what the invention looks like a concentrate that contains boswellic acid and / or one or more their derivatives, water and a micelle-forming, food safe Emulsifier with an HLB value of 9-18, its weight fraction on the concentrate at least six times the boswellic acid content is. The acid made hydrophilic by the micelles of the emulsifier their derivatives can be administered not only more easily but also in higher concentrations, so that the boswellic acid and their descendants much easier bioavailable are.

With contains particular advantage the concentrate is an extract containing about 85% boswellic acid and mostly from Boswellia Serrata. One for many Purpose suitable composition of the concentrate is characterized the invention characterized in that it consists of about 11.8 wt% extract, about 24.2 wt% deionized water and about 64 wt% emulsifier, the primarily a polysorbate, for example polysorbate 20, based on the total weight of the concentrate = 100%.

One Process for the preparation of the concentrate according to the invention provides that water with boswellic acid and / or one or more of their derivatives and the mixture to at least 80 ° C, preferred 87 ° C-93 ° C, heated, that a micelle-forming, food safe Emulsifier with an HLB value of 9-18 incorporated into the heated mixture, The mixture with the emulsifier well homogenized and after homogenization to about 50 ° C chilled becomes. As an emulsifier is appropriate Polysorbate, preferably polysorbate 20 used. Further recommends it is to use an extract containing about 85% boswellic acid and for example was won from Boswellia Serrata. Next is cheap, though The relationship the weight fraction of emulsifier to the weight fraction of boswellic acid to about 6: 1 selected becomes.

An embodiment of the invention is given below. The term "product water" is understood to mean a deionized, demineralized water. 118 g Frankincense extract 85%, powder (= 85% boswellic acid); Pfannenschmidt (AGT Material No .: 10111/029), cf. page 242 g Product water (AGT material no .: 10180) 640 g Lamesorb SML 20 (polysorbate 20); Cognis (AGT-Material-No .: 10520/016)

Execution:

• • product water mix with incense extract powder and heat (87-93 ° C).
• • Under Keep the temperature polysorbate 20 slowly in the mixture work in and homogenize everything well.
• • It Strong foaming occurs - this can be ignored provided that a clear solubilizate was visible at the bottom of the receptacle during sampling is
• • Let cool down and at about 50 ° C bottling.

Appearance:

Brownish, clear, viscous.

Storage conditions:

dark and cool (<25 ° C).

Processing information:

at the production on the production plant has to be ensured that the control of the clarity (= complete Micellierung) means Laser beam takes place.

Claims (8)

Concentrate containing boswellic acid and / or one or more of its derivatives, mainly from Boswellia Serrata, water and a micelles forming, food law harmless emulsifier with an HLB value of 9-18, its weight percentage on the concentrate at least six times the boswellic acid content is. Concentrate according to claim 1 containing an extract, that's about 85% boswellic acid having. Concentrate according to claim 2 containing about 11.8% by weight Extract, about 24.2 wt% deionized water and about 64 wt% emulsifier. Concentrate according to one of the preceding claims, in the emulsifier is a polysorbate, primarily polysorbate 20. Process for the preparation of a concentrate one of the preceding claims, in the deionized water with boswellic acid and / or one or more mixed their derivatives and the mixture is heated to about at least 80 ° C, that a micelle bildendender and food safe Emulsifier with an HLB value of 9-18 incorporated into the heated mixture and the mixture with the emulsifier well homogenized and after the Homogenization to about 50 ° C chilled becomes. A method according to claim 5, wherein as an emulsifier a polysorbate, suitably polysorbate 20 is used. A method according to claim 6 or 7, wherein an extract used, which contains about 85% boswellic acid. Method according to one of claims 5 to 7, wherein the relationship the weight fraction of emulsifier to the weight fraction of boswellic acid to about 6: 1 selected becomes.