DE102006013431A1 - Use of estrogen, caffeine and finasteride derivatives for the cosmetic treatment of hair loss and/or stimulating the hair growth - Google Patents

Abstract

Use of estrogen, caffeine and finasteride derivatives for the cosmetic treatment of hair loss and/or stimulating the hair growth. Independent claims are included for: (1) a product exhibiting the estrogen, caffeine or their derivative and finasteride as a combined preparation; and (2) a method for treating hair loss and/or stimulating hair growth through a cosmetic treatment comprising locally applying the estrogen, caffeine or their derivative, on the skin and orally administering a dose unit of finasteride, where the steps takes place simultaneously, separately or sequentially. ACTIVITY : Dermatological. MECHANISM OF ACTION : 5alpha -Reductase inhibitor.

Description

The The present invention relates to a hair restorer with which In a cosmetic application in a person hair loss stopped and / or Hair growth should be stimulated.

Further The present invention relates to a cosmetic method, with which hair loss is stopped and / or hair growth stimulated should.

in the State of the art are various treatment options for cosmetic Treatment of hair loss known, the type of treatment depends in particular on the type of hair loss.

From Hair loss is generally talked about when about 60% of the hair, especially the main hair, fail. Et al become the following forms of hair loss: Genetic hair loss, Hair loss is over a longer one Period extends and acutely occurring hair loss.

From "androgenetic Alopecia, "one speaks with genetically caused hair loss that increases with aging Days occurs. Hair loss usually affects men in this case the 25th and 40th year of age, with the onset of hair loss often also already in younger ones Years is observed. The change is hormonally controlled, which on the one hand promotes beard growth, on the other hand for the propagation of sebaceous glands on the head, which in turn favors hair loss. Most androgenetic alopecia begins with the so-called receding hairline, which in the course of time become bald.

Further is under the "Alopecia areata "a local Hair loss understood, in the most circular areas not more are covered with hair. This hair loss often occurs men on. Alopecia areata may become one after a few months spontaneous hair restoration. However, in this case occurs often another burst of hair loss.

Of the Loss of total body hair will be as "alopecia universalis ". Causes of this hair loss can be infections, genetic and hormonal factors, consequences of drug treatment, psychological factors, i.a. be.

As already mentioned above, In the prior art, various therapies for cosmetic treatment Hair loss known, these are in particular after the Type and occurrence of hair loss; on the one hand oral administration forms and on the other hand applications that are topical can be applied. It is also known that hair loss through hair transplants / implantations to treat surgically.

So It is known, for example, the active ingredient finasteride for the treatment of to use androgenetic alopecia. Finasteride is a 5-α-reductase inhibitor and engages in the hormonal degradation of male testosterone in dihydrotestosterone (DHT). Certain hair follicles respond to DHT by reducing it the growth phase, which on the one hand hair loss and on the other hand reduced hair growth can result. Finasteride inhibits the Degrading testosterone in DHT, causing the growth phase in the hair follicles extended becomes.

It is also known, estrogens to use, which increase the growth rate of the hair. male Although hormones cause increased hair growth on the body, in the head area, however, have male Hormones have the opposite effect: they cause hair loss and Receding hairline. Therefore, currently estrogens that are similar to the hair follicles on the skin with an increase in cell division and thus increased growth act the hair, used for the treatment of Haaraus fall. The estrogens be as a therapeutic measure either orally administered or locally in the form of ointments or Hair Waters offered.

Lots the known in the art agents or drug combinations and methods of treating hair loss, however, often do not result the desired one Success. In particular, hereditary alopecia is to date no preparation on the market, with the convincing and good results in terms of stopping hair loss and / or Stimulation of hair growth can be achieved.

task The present invention is therefore a new active ingredient combination which also contributes to success in hereditary alopecia a cosmetic treatment of hair loss shows, or a method which is easy to apply and cosmetic Treatment of hair growth is suitable.

The The object underlying the invention is achieved by the use of a pharmaceutically acceptable amount of each estrogen, Caffeine and finasteride, or derivatives thereof, for simultaneous, separate or sequential cosmetic treatment or prevention hair loss and / or to stimulate hair growth.

The The object underlying the invention is further achieved by the use of (i) at least one estrogen and caffeine, or derivatives of estrogen and caffeine, in combination with (ii) finasteride for simultaneous, separate or successive cosmetic treatment or Prevention of hair loss and / or to stimulate hair growth.

The The object underlying the invention is complete in this way solved.

Of the Inventors of the present method could in their own experiments show that by using the three substances mentioned estrogen, Caffeine and finasteride surprisingly hair loss stopped locally and as a result observed a stimulation of hair growth could be.

The Combined use of the substances achieved in comparison to preparations, Hitherto known in the art, much better results. In particular, compared to the known in the art Use of finasteride in combination with estradiol, which in own Try hardly hair growth-promoting Showed effects with the combinatorial use according to the invention of estrogen, Caffeine and finasteride stopped hair loss and stimulated hair growth become. That the extra Caffeine use the effect of combinatorial use of estrogen and would improve finasteride, was completely surprising and not suggested by the prior art.

According to the present Invention, the substances are either simultaneously, separated or used sequentially. The dosage form of the substances depends on it from the respective use, where, for example, all three substances or but only two of them are in a common dosage form can, or all three substances are each in separate dosage forms in front. For the use can the substances either in a dosage form at the same time, or in separate dosage forms also simultaneously or else total be applied or taken separately. In addition, also can at least two of the substances that originally exist separately, be mixed before use.

In an embodiment the method according to the invention is preferred when components (i) and (ii) are separated Preparations for the use be presented.

at this embodiment become estrogen and caffeine on the one hand and finasteride on the other hand as separate Dosage forms provided. This has the advantage that the Combination of estrogen and caffeine are applied and / or ingested simultaneously can and the dosage form of finasteride regardless of the dosage form of the two substances is estrogen and caffeine.

In a further embodiment the use according to the invention is preferred when the component (i) for a local application, and the component (ii) for an oral intake is provided.

After that So, on the one hand estrogen and Caffeine applied locally, for example as a tincture. The tincture can on the area to be treated (usually the scalp), for example, rubbed in, massaged or gently tapped.

finasteride, that in this embodiment orally may be present, for example, in tablet or capsule form. This has the advantage that, for example, already on the market Dosage forms for Finasteride in tablet form for the use according to the invention can be used.

in the However, the scope of the present invention is not excluded if the finasteride is also present in a tincture, either in a separate or combined with estrogen and caffeine in one Tincture. It goes without saying that then the active ingredients in one Form must be present the transdermal passage of the active ingredients permits or effects. something similar when the active substances are in one (or separate) tablets, here must - if necessary by inclusion of appropriate aids - can be achieved that the Active ingredients reach their destination after oral ingestion.

In a further embodiment the method according to the invention is preferred when as an estrogen estrone (estrone), estradiol (Estradiol), estriol (Estriol) and / or synthetic estrogens be used.

estrogens are, as stated above, steroid hormones that the Promote hair growth can, and are formed in particular by the female body. To the naturally occurring estrogens include estrone, estradiol and estriol, wherein estradiol the most effective estrogen is. To the synthetic estrogens counting eg ethinyl estradiol, Stilbene, estradiol-17-alpha, mestranol, Polyöstradiol.

The invention further relates to a product comprising components (i) and (ii) as defined above, as a combined preparation for simultaneous, separate or sequential the cosmetic treatment or prevention of hair loss and / or the stimulation of hair growth.

Under the term "product" is present each provision of the three substances estrogen, caffeine and finasteride denotes, with which the substances either at least partially combined or provided all three substances separately but always for common use. So you can the products are present, for example, together or separately as a tincture, or but in the form of oral dosage forms, in particular Tablets. The product or dosage form may depend on the desired Use, i. dependent on the severity of hair loss, with regard to the person who is the Product applies, etc. be coordinated.

Further The present invention relates to a method for cosmetic Stimulation of hair growth and / or for the cosmetic treatment of Hair loss, comprising the steps of: locally applying (i) estrogen and caffeine, or derivatives of estrogen or caffeine, on the skin, and oral ingestion of (ii) one Dose unit finasteride, with the steps simultaneously, separately or consecutively.

This Procedure has the advantage that on the one hand affected by the hair loss Bodies, or bodies, possibly Hair loss will be affected by the local application the mixture of estrogen and caffeine are treated directly. The skin on which the mixture is applied, or underlying the affected skin hair follicles are thereby directly stimulated. The effect is through the oral Promote taking of finasteride or at all only triggered, so that it is advantageous that resorted to finasteride which is already available in tablet form on the market. The application of estrogen and the caffeine can again be in the form of a mixture, that contains the two components, or else the components are separated, as well in the form of tinctures, applied.

It it should be understood that those disclosed in the present invention Active substances, or their combination, in pharmaceutically acceptable Forms, and that the dosage forms - in addition to the substances mentioned - more Active substances and / or pharmaceutical carriers, adjuvants, suspending agents, Diluents, Binders, buffers, and the like, can have. A series of for Pharmaceutical dosage forms suitable substances is found in "A. Kibbe, Handbook of Pharmaceutical Excipients, 3rd ed. 2000, American Pharmaceutical Association and Pharmaceutical Press ".

at the method according to the invention is preferred if it is the repeated local application of estrogen and caffeine and repeated taking of finasteride in one Concentration and while a period of time that covers the stimulation of hair growth is sufficient.

The Duration of application and the concentrations of the active ingredients used are particularly dependent from the respective stage of commencement of use, i Prevention or direct treatment, as well as the extent of hair loss the person, as well as if necessary the compatibility the person opposite the active ingredients.

at the use according to the invention, or in the product according to the invention or the method is preferred when the estrogen is present in an amount of about 0.01 g to about 1 g, in particular of 0.1 g, and the caffeine in an amount of about 1 mg to about 5 mg, in particular of 2 mg, is used during the day.

Further is preferred if in the inventive use and the product and / or the procedure the finasteride in an amount of about 0.1 mg to about 2 mg, in particular of 1 mg, per day is used.

These Quantities have been found in own experiments to be advantageous. When using these amounts is also advantageous that on the one hand the avoided by the active ingredients possibly caused side effects but, on the other hand, successful stimulation of hair growth is effected.

With the use according to the invention, the Product and the method is provided with a treatment option, with which hair loss can be successfully treated cosmetically. These new drug combination was neither known in the art still suggested, since so far only the individual active ingredients separated were used.

Of the However, the inventor of the present use or method has found that compared to known in the art Drug combinations and methods the disclosed drug combination a significantly better stimulation of hair growth caused, in particular with genetically inherited hair loss.

It It is understood that the specified characteristics not only in each case specified combination, but also in other combinations or can be used in isolation, without the scope of the present To leave invention.

The following embodiment is intended to illustrate the present invention.

example

to the cosmetic treatment of hereditary alopecia were the Ingredients estradiol and caffeine as a tincture, and tablets containing finasteride, provided.

estradiol and caffeine were included in a tincture, in addition to those mentioned Ingredients other pharmaceutically acceptable carriers and conventional diluents contained. Finasteride was commercially purchased.

• – 1 × täglich 2 ml Östradiol (0,05 g) und Coffein (2 mg) lokal als Tinktur auftragen;
• – 1 × täglich Finasterid in Tablettenform, (1 mg Finasterid).

In the course of the review of an optimal dosage unit, the following dosage schedule was set up for the specific trial:

• - apply 2 ml of estradiol (0.05 g) and caffeine (2 mg) 1 × daily as a tincture;
• - 1 × daily finasteride in tablet form, (1 mg finasteride).

This Dosing schedule was over applied for several weeks to months. The thereby carried out cosmetic Treatment already showed effect after a few weeks, which meant that the hair loss could be stopped. In addition, there was more a few weeks to watch the growth of new hair.

Claims (10)

Use of a pharmaceutically acceptable Amount of each estrogen, Caffeine and finasteride, or derivatives thereof, for cosmetic treatment hair loss and / or to stimulate hair growth. Use of (i) at least one estrogen and caffeine, or derivatives of estrogen and caffeine, in combination with (ii) finasteride for simultaneous, separate or sequential cosmetic treatment or Prevention of hair loss and / or to stimulate hair growth. Use according to claim 2, characterized that components (i) and (ii) are separate preparations for use be presented. Use according to claim 2 or 3, characterized that the component (i) for a local application, and the ingredient (ii) for oral ingestion provided. Use according to one of Claims 1 to 4, characterized as estrogen, estrone, oestradiol, estriol and / or synthetic estrogens be used. Product comprising components (i) and (ii) as in any of the claims 2 to 5, as a combined preparation for simultaneous, separate or successive cosmetic treatment or prevention hair loss and / or to stimulate hair growth. Method of treating hair loss and / or to stimulate hair growth, through a cosmetic treatment, with the steps local application of (i) estrogen and caffeine, or derivatives of estrogen or caffeine, on the skin, and oral ingestion of (ii) one Dosage unit finasteride, taking the steps simultaneously, separately or consecutively. Method according to claim 7, characterized in that that it repeats the local application of (i) and the repeated Ingesting (ii) at a concentration and for a period of time, the for the stimulation of hair growth is sufficient. Use according to any one of claims 2 to 5, product according to claim 6, or method according to claim 7 or 8, characterized that the estrogen in an amount of about 0. 01 g to about 1 g, in particular of 0, 1 g, and the caffeine in an amount of about 1 mg to about 5 mg, / day in particular of 2 mg is used. Use according to any one of claims 2 to 5, or 10, product according to claim 6, or method according to claim 7 or 8, characterized characterized in that the finasteride in egg ner amount of about 0.1 mg about 2 mg, in particular of 1 mg, / day is used.